Article
Medicine, General & Internal
Hongzhao Xu, Ye Jia, Xueyao Wang, Hui Wang, Jinyu Yu, Wu Hao
Summary: This article presents a case of LECT2-associated renal amyloidosis with IgA nephropathy. The patient presented with lower extremity edema, and renal biopsy confirmed the presence of eosinophilic material and fibril deposits in the interstitium, as well as IgA and IgG deposits and LECT2 expression. Electron microscopy further confirmed the existence of amyloidosis. After treatment, the patient's renal function and proteinuria improved.
Article
Immunology
Shuang Wang, Xiao-juan Yu, Dan-yang Li, Jin Xu, Su-xia Wang
Summary: This case report highlights the coexistence of ALECT2 amyloidosis with Sjogren's syndrome and systemic lupus erythematosus, which has not been previously reported. The findings suggest a possible association between ALECT2 amyloidosis and autoimmune diseases, although the causal relationship remains unclear.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Logan S. Richards, Maria D. Flores, Samantha Zink, Natalie A. Schibrowsky, Michael R. Sawaya, Jose A. Rodriguez
Summary: ALECT2 systemic amyloidosis is caused by deposition of leukocyte cell-derived chemotaxin-2 (LECT2) protein fibers. The structure of ALECT2 amyloid fibrils has been determined, revealing a stable core structure resistant to denaturing agents and proteases. This finding presents a potential new target for treating ALECT2 systemic amyloidosis.
Review
Immunology
Ming-Hui Zhu, Yan-Jun Liu, Chang-Yun Li, Fan Tao, Guan-Jun Yang, Jiong Chen
Summary: Leukocyte cell-derived chemotaxin-2 (LECT2) is a multifunctional secreted factor involved in various physiological and pathological processes, including immune processes and immune-related diseases. It interacts with cell surface receptors such as CD209a, Tie1, and Met, and can lead to amyloidosis in important tissues. The mechanisms of LECT2-mediated immune pathogenic conditions in different tissues are still not fully understood due to functional and signaling heterogeneity. This review provides a comprehensive understanding of LECT2's structure, function, signaling pathways, and potential applications in theranostics of immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Jiangfeng Qin, Weijie Sun, Hui Zhang, Zihao Wu, Jiapei Shen, Wenhai Wang, Yuanyuan Wei, Yanyan Liu, Yufeng Gao, Honghai Xu
Summary: This study found that low expression of LECT2 in hepatocellular carcinoma (HCC) is closely associated with poor prognosis, and LECT2 may affect the progression of HCC through various pathways. The expression of LECT2 is also correlated with immune cell infiltration and checkpoint molecules.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Hussam Almasri, Almurtada Razok, Ahmed Badi, Muneera Almohannadi, Abdo Lutf, Mahir Petkar, Abdelnaser Elzouki
Summary: Amyloidosis is a well-known disease with various types, including the recently identified LECT 2 type, which is common in certain ethnic backgrounds. It is crucial to diagnose this type accurately to prevent misdiagnosis and therapy-related complications. Clinical presentation typically involves slowly progressive kidney disease and mild hepatic impairment.
CLINICAL CASE REPORTS
(2021)
Article
Cell Biology
Xin Li, Pingping Lin, Ye Tao, Xin Jiang, Ting Li, Yunshan Wang, Chenjing Wang, Yu Cao
Summary: The study found that the expression of LECT2 is associated with disease progression and prognosis in PDAC, and its loss promotes malignant behaviors of the tumor. LECT2 inhibits the progression of PDAC by targeting HGF/MET to inhibit FOXM1 signaling, making it a potential biomarker and therapeutic target in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pathology
Mercedes A. de la Cruz Jasso, Juan M. Mejia-Vilet, Noemi del Toro-Cisneros, Diana E. Aguilar-Leon, Luis E. Morales-Buenrostro, Guillermo Herrera, Norma O. Uribe-Uribe
Summary: This autopsy study confirms the high prevalence of LECT2 amyloidosis in the Mexican population, with frequent amyloid deposition in the kidneys, liver, spleen, and adrenal glands.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuan Lin, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Zhi-Hao Huang, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou
Summary: There are currently no effective treatments for liver fibrosis, a disease that involves angiogenesis. The role of different microvessels in the liver during fibrogenesis is unclear, and it is difficult to treat liver fibrosis through vascular targeting. This study proposes a combined regulation of multiple different endothelial cell regulatory signaling pathways as a new strategy for liver fibrosis therapy.
Article
Peripheral Vascular Disease
Mengqiu Wei, Jun Liu, Hailin Pan, Ziting Zhou, Kai Guo
Summary: Studies show that elevated LECT-2 levels are associated with metabolic disorders and arteriosclerosis risk, especially in CAD patients. High LECT-2 levels are linked to increased risk of MACE in AMI patients. LECT-2 levels may serve as a diagnostic and prognostic marker for CAD.
Article
Biochemistry & Molecular Biology
Jeung-Hoi Ha, Ho-Chou Tu, Stephan Wilkens, Stewart N. Loh
Summary: Aggregation of circulating protein LECT2 leads to ALECT2, with zinc-binding and I40V mutation playing important roles. Experimental results show that LECT2 can form amyloid fibrils in vitro without other proteins, and removal of bound zinc is necessary. The I40V mutation destabilizes the zinc-free conformation, suggesting a mechanism for ALECT2 development.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Anteneh Getachew, Nasir Abbas, Kai You, Zhen Yang, Muzammal Hussain, Xinping Huang, Ziqi Cheng, Shenglin Tan, Jiawang Tao, Xiaorui Yu, Yan Chen, Fan Yang, Tingcai Pan, Yingying Xu, Guosheng Xu, Yuanqi Zhuang, FeiMa Wu, Yinxiong Li
Summary: The study found that serum amyloid A1 (SAA1) acts as a chemokine to recruit hepatic stellate cells (HSCs) towards injury loci through the TLR2 receptor, initiating PI3K-dependent signaling and regulating cell directional migration.
Article
Multidisciplinary Sciences
Marcus Lowe, Antony Payton, Arpana Verma, Judith Worthington, Isla Gemmell, Patrick Hamilton, William Ollier, Titus Augustine, Kay Poulton
Summary: This study found 22 HLA types associated with increased renal function, and 11 types associated with decreased renal function. Many of these HLA types commonly inherit together in established haplotypes, which could have important applications for the diagnosis and treatment of renal disease.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Moritz Schanz, Martin Kimmel, Mark Dominik Alscher, Kerstin Amann, Christoph Daniel
Summary: TIMP-2 and IGFBP7 are markers of tubular stress and have been used as biomarkers for risk assessment of acute kidney injury. This study analyzed their expression in kidney biopsies of patients with renal disease and found that they were significantly upregulated compared with healthy controls. The intensity of their expression correlated with the extent of renal damage.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Nutrition & Dietetics
Sundus Malaikah, Scott A. Willis, Joseph Henson, Jack A. Sargeant, Thomas Yates, Alice E. Thackray, Fernanda R. Goltz, Matthew J. Roberts, Danielle Bernard-Deshong, Guruprasad P. Aithal, David J. Stensel, James A. King
Summary: In this study, the associations between cardiorespiratory fitness, physical activity, sedentary time, and the circulating concentrations of LECT2 and FGF21 were examined. Increased cardiorespiratory fitness was associated with lower concentrations of LECT2 and FGF21, while moderate-to-vigorous intensity physical activity was associated with higher FGF21 concentrations. Sedentary time showed no significant association with the concentrations of these hepatokines. These findings suggest that cardiorespiratory fitness and different activity behaviors may independently influence the inter-organ cross-talk through regulating the circulating concentrations of hepatokines.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Medicine, Research & Experimental
David Mathews, Ying Dong, Laura B. Higginbotham, Steven C. Kim, Cynthia P. Breeden, Elizabeth A. Stobert, Joseph Jenkins, J. Yun Tso, Christian P. Larsen, Andrew B. Adams
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Surgery
Ronald F. Parsons, Arslan Zahid, Shalini Bumb, Hannah Decker, Harold C. Sullivan, Frances Eun-Hyung Lee, Idelberto Raul Badell, Mandy L. Ford, Christian P. Larsen, Thomas C. Pearson, Annette M. Jackson, Dong-Feng Chen, Matthew Levine, Malek Kamoun, Robert A. Bray, Howard M. Gebel
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Urology & Nephrology
Samih H. Nasr, Christopher P. Larsen, Christophe Sirac, Jason D. Theis, Camille Domenger, Sophie Chauvet, Vincent Javaugue, Jonathan J. Hogan, Samar M. Said, Surendra Dasari, Julie A. Vrana, Ellen D. McPhail, Lynn D. Cornell, Eve Vilaine, Ziad A. Massy, Jean-Jacques Boffa, David Buob, Stephanie Toussaint, Thomas Guincestre, Guy Touchard, Vivette D. D'Agati, Nelson Leung, Frank Bridoux
KIDNEY INTERNATIONAL
(2020)
Article
Surgery
Geeta Karadkhele, Julien Hogan, Wairimu Magua, Weiwen Zhang, Idelberto Raul Badell, Aneesh Mehta, Marshall Lyon, Stephen Pastan, Thomas C. Pearson, Christian P. Larsen
Summary: In CMV high-risk kidney transplant recipients, belatacept-based maintenance immunosuppression may increase the risk of primary CMV infection and prolong the course of viral replication. While patients treated with belatacept showed a trend towards lower graft survival, this conclusion was not statistically significant. Further studies are needed to confirm these findings and explore the relationship between belatacept treatment and CMV outcomes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Editorial Material
Immunology
Peter S. Heeger, Christian P. Larsen, Dorry L. Segev
Summary: Organ transplant patients exhibit poor immune responses to COVID-19 vaccines, highlighting the need to design specific vaccine strategies to protect this vulnerable population from SARS-CoV-2 infection.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Aileen C. Johnson, Joan Zhang, H. Cliff Sullivan, Chris Wiebe, Robert Bray, Howard Gebel, Christian P. Larsen
Summary: Eplet mismatch has an impact on transplant recipient outcomes, and accurate assessment requires high-resolution HLA typing. To simplify eplet analysis, we developed a software tool that can impute high-resolution data from low-resolution data and calculate overall and single molecule eplet mismatch. Compared to existing tools, this tool shows high consistency in eplet mismatch and provides rapid and reproducible imputation and mismatch calculation.
Editorial Material
Surgery
Kenneth A. Newell, Christian P. Larsen
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Letter
Urology & Nephrology
Johann Morelle, Tiffany Caza, Hanna Debiec, Selda Aydin, Aaron Storey, Pierre Ronco, Christopher Larsen
KIDNEY INTERNATIONAL
(2022)
Article
Immunology
Wairimu Magua, Aileen C. Johnson, Geeta M. Karadkhele, Idelberto R. Badell, Payaswini Vasanth, Aneesh K. Mehta, Kirk A. Easley, Kenneth A. Newell, Joseph B. Rickert, Christian P. Larsen
Summary: Belatacept-treated high-risk kidney transplant recipients showed difficulty in sustaining viral control compared to tacrolimus-treated recipients, indicating the need for modified management protocols or avoidance of initial belatacept use in high-risk recipients.
TRANSPLANT INFECTIOUS DISEASE
(2022)
Editorial Material
Surgery
Flavio Vincenti, Klemens Budde, Josep Grinyo, Lionel Rostaing, Allan D. Kirk, Christian P. Larsen
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Zeljko Dvanajscak, Patrick D. Walker, L. Nicholas Cossey, Nidia C. Messias, Christie L. Boils, Michael B. Kuperman, Christopher P. Larsen
KIDNEY INTERNATIONAL
(2019)
Article
Surgery
Brendan P. Lovasik, Rebecca Zhang, Jason M. Hockenberry, Justin D. Schrager, Stephen O. Pastan, Andrew B. Adams, Sumit Mohan, Christian P. Larsen, Rachel E. Patzer
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)