Update on emerging drugs for sarcopenia – age-related muscle wasting

Sca-1-Expressing Nonmyogenic Cells Contribute to Fibrosis in Aged Skeletal Muscle

(2011) M. Hidestrand et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nuclear Apoptosis Contributes to Sarcopenia

(2009) Stephen E. Alway et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Effects of combined strength and sprint training on regulation of muscle contraction at the whole-muscle and single-fibre levels in elite master sprinters

(2008) A. Cristea et al.   Acta Physiologica

Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation

(2008) Julian Falutz et al.   AIDS

Are big muscles necessarily good muscles?

(2008) Amelie Nadeau et al.   ANNALS OF NEUROLOGY

A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy

(2008) Kathryn R. Wagner et al.   ANNALS OF NEUROLOGY

Aging, Disability and Frailty

(2008) Eva Topinková   ANNALS OF NUTRITION AND METABOLISM

Antisense Treatment for Myasthenia Gravis

(2008) Jon D. Sussman et al.   Annals of the New York Academy of Sciences

Mecasermin

(2008) Gillian M Keating   BIODRUGS

Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness

(2008) James G. Ryall et al.   BIOGERONTOLOGY

ANABOLIC AGENTS FOR IMPROVING MUSCLE REGENERATION AND FUNCTION AFTER INJURY

(2008) Gordon S Lynch et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Diabetes, Sarcopenia, and Frailty

(2008) John E. Morley   CLINICS IN GERIATRIC MEDICINE

Old Friends in New Constellations - the Hematopoetic Growth Factors G-CSF, GMCSF, and EPO for the Treatment of Neurological Diseases

(2008) M. Maurer et al.   CURRENT MEDICINAL CHEMISTRY

Is There A Relationship Between Insulin Resistance and Frailty Syndrome?

(2008) Giuseppe Paolisso et al.   CURRENT PHARMACEUTICAL DESIGN

Signal Transduction Pathway through Activin Receptors as a Therapeutic Target of Musculoskeletal Diseases and Cancer

(2008) Kunihiro TSUCHIDA et al.   ENDOCRINE JOURNAL

Metabolic Remodeling in Adipocytes Promotes Ciliary Neurotrophic Factor-Mediated Fat Loss in Obesity

(2008) Seamus Crowe et al.   ENDOCRINOLOGY

Tissue ageing: Do insights into molecular mechanisms of ageing lead to new therapeutic strategies?

(2008) Andreas Simm et al.   EXPERIMENTAL GERONTOLOGY

Sarcopenia and frailty: A clinician’s controversial point of view

(2008) J.M. Bauer et al.   EXPERIMENTAL GERONTOLOGY

Mecasermin rinfabate: rhIGF-I/rhIGFBP-3 complex: iPLEX™

(2008) Rachel M Williams et al.   Expert Opinion on Drug Metabolism & Toxicology

Neurotrypsin cleaves agrin locally at the synapse

(2008) Alexander Stephan et al.   FASEB JOURNAL

PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson’s disease

(2008) Naomi P. Visanji et al.   FASEB JOURNAL

Synthesis and Biological Evaluation of Novel 2,4-Diaminoquinazoline Derivatives asSMN2Promoter Activators for the Potential Treatment of Spinal Muscular Atrophy

(2008) John Thurmond et al.   JOURNAL OF MEDICINAL CHEMISTRY

CNTF: a target therapeutic for obesity-related metabolic disease?

(2008) Vance B. Matthews et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Activity-Induced Synaptic Capture and Exocytosis of the Neuronal Serine Protease Neurotrypsin

(2008) R. Frischknecht et al.   JOURNAL OF NEUROSCIENCE

The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics

(2008) C.Simone Fishburn   JOURNAL OF PHARMACEUTICAL SCIENCES

Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study

(2008) Carla MM Prado et al.   LANCET ONCOLOGY

Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle

(2008) Emanuele Marzetti et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Drug-screening platform based on the contractility of tissue-engineered muscle

(2008) Herman Vandenburgh et al.   MUSCLE & NERVE

Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System

(2008) Bastian G. Brinkmann et al.   NEURON

Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease

(2008) Gordon S. Lynch et al.   PHYSIOLOGICAL REVIEWS

Signaling in Muscle Atrophy and Hypertrophy

(2008) Marco Sandri   PHYSIOLOGY

Exercise-Induced Activation of STAT3 Signaling Is Increased with Age

(2008) Marissa K. Trenerry et al.   REJUVENATION RESEARCH

Human Sarcopenia Reveals an Increase in SOCS-3 and Myostatin and a Reduced Efficiency of Akt Phosphorylation

(2008) Bertrand Léger et al.   REJUVENATION RESEARCH

Mitochondrial function and apoptotic susceptibility in aging skeletal muscle

(2007) Béatrice Chabi et al.   AGING CELL

Preparation, Characterization, and Application of Biotinylated and Biotin−PEGylated Glucagon-Like Peptide-1 Analogues for Enhanced Oral Delivery

(2007) Su Young Chae et al.   BIOCONJUGATE CHEMISTRY

Tissue Selectivity of the Anabolic Steroid, 19-Nor-4-Androstenediol-3β,17β-Diol in Male Sprague Dawley Rats: Selective Stimulation of Muscle Mass and Bone Mineral Density Relative to Prostate Mass

(2007) Stephanie T. Page et al.   ENDOCRINOLOGY

Systemic administration of β2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses

(2006) James G Ryall et al.   BRITISH JOURNAL OF PHARMACOLOGY