Drugs, Nutrients, and Phytoactive Principles Improving the Health Span of Rodent Models of Human Age-Related Diseases

Metformin slows down aging and extends life span of female SHR mice

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis

(2011) Hidetaka Ota et al.   Journal of Atherosclerosis and Thrombosis

Recent advances in vertebrate aging research 2009

(2010) Steven Austad   AGING CELL

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin

(2010) Michel Lebel et al.   Annals of the New York Academy of Sciences

Antioxidants: Molecules, medicines, and myths

(2010) John M.C. Gutteridge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NF-κB inhibitory action of resveratrol: A probable mechanism of neuroprotection in experimental diabetic neuropathy

(2010) Ashutosh Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease

(2010) Mohd.Moshahid Khan et al.   BRAIN RESEARCH

Resveratrol ameliorates vasculopathy in STZ-induced diabetic rats: role of AGE-RAGE signalling

(2010) Yu-Hong Jing et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Long-term but Not Short-term Aspirin Treatment Attenuates Diabetes-associated Learning and Memory Decline in Mice

(2010) T. Wang et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats

(2010) Michael J. Ryan et al.   EXPERIMENTAL GERONTOLOGY

Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6–STAT3 signaling pathway

(2010) Yun Tian et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of different doses of resveratrol on body fat and serum parameters in rats fed a hypercaloric diet

(2010) M. T. Macarulla et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Optimal micronutrients delay mitochondrial decay and age-associated diseases

(2010) Bruce N. Ames   MECHANISMS OF AGEING AND DEVELOPMENT

Resveratrol, sirtuins, and the promise of a DR mimetic

(2010) Joseph A. Baur   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial redox metabolism: Aging, longevity and dietary effects

(2010) Melissa M. Page et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases

(2010) Carmela Rita Balistreri et al.   MEDIATORS OF INFLAMMATION

Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases

(2010) Albert Y. Sun et al.   MOLECULAR NEUROBIOLOGY

Nutritional supplementation for type 2 diabetes: a systematic review

(2010) Hannah E. Bartlett et al.   OPHTHALMIC AND PHYSIOLOGICAL OPTICS

Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants

(2009) Sang-Kyu Park et al.   AGING CELL

Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice

(2009) Yu Yamazaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Caloric restriction-induced life extension of rats and mice: A critique of proposed mechanisms

(2009) Edward J. Masoro   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential

(2009) Kate Petersen Shay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Daily ingestion of green tea catechins from adulthood suppressed brain dysfunction in aged mice

(2009) Keiko Unno et al.   BIOFACTORS

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

(2009) Jesse J Smith et al.   BMC Systems Biology

Aspirin Inhibits Fractalkine Expression in Atherosclerotic Plaques and Reduces Atherosclerosis in ApoE Gene Knockout Mice

(2009) Hong Liu et al.   CARDIOVASCULAR DRUGS AND THERAPY

N-Acetylcysteine Reduces the Severity of Atherosclerosis in Apolipoprotein E-Deficient Mice by Reducing Superoxide Production

(2009) Kana Shimada et al.   CIRCULATION JOURNAL

AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

(2009) J.-H. Um et al.   DIABETES

Adiponectin Expression Is Induced by Vitamin E via a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism

(2009) Jean-François Landrier et al.   ENDOCRINOLOGY

Central Administration of Resveratrol Improves Diet-Induced Diabetes

(2009) Giorgio Ramadori et al.   ENDOCRINOLOGY

Genetic Differences among C57BL/6 Substrains

(2009) Kazuyuki MEKADA et al.   EXPERIMENTAL ANIMALS

Vitamin C restores healthy aging in a mouse model for Werner syndrome

(2009) Laurent Massip et al.   FASEB JOURNAL

Elevation of oxidative-damage biomarkers during aging in F2 hybrid mice: Protection by chronic oral intake of resveratrol

(2009) Yee Ting Wong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferator-activated receptors

(2009) Fang Fang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects of blackberries on motor and cognitive function in aged rats

(2009) Barbara Shukitt-Hale et al.   NUTRITIONAL NEUROSCIENCE

Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice

(2009) F.E. Harrison et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Caloric restriction improves memory in elderly humans

(2009) A. V. Witte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Consuming a Diet Supplemented with Resveratrol Reduced Infection-Related Neuroinflammation and Deficits in Working Memory in Aged Mice

(2009) Jayne Abraham et al.   REJUVENATION RESEARCH

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Design of aging intervention studies: the NIA interventions testing program

(2008) N. L. Nadon et al.   AGE

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

(2008) Randy  Strong et al.   AGING CELL

Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?

(2008) Barry Halliwell   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals

(2008) Michael Lefevre et al.   ATHEROSCLEROSIS

Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity

(2008) Magdalini A. Papandreou et al.   BEHAVIOURAL BRAIN RESEARCH

Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats

(2008) Leonor Rivera et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Measuring Children’s Blood Pressure Matters

(2008) Samuel S. Gidding   CIRCULATION

Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways

(2008) J.-Y. Deng et al.   DIABETES

Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

(2008) D. M. Nathan et al.   DIABETES CARE

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model

(2008) Jason Lockrow et al.   EXPERIMENTAL NEUROLOGY

Resveratrol supplementation worsen the dysregulation of genes involved in hepatic lipid homeostasis observed in hyperhomocysteinemic mice

(2008) Christophe Noll et al.   FOOD AND CHEMICAL TOXICOLOGY

Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention

(2008) Dayong Wu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The “rejuvenatory” impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-γ coactivator-1α

(2008) Mark F. McCarty et al.   MEDICAL HYPOTHESES

Lifelong α-Tocopherol Supplementation Increases the Median Life Span of C57BL/6 Mice in the Cold but Has Only Minor Effects on Oxidative Damage

(2008) Colin Selman et al.   REJUVENATION RESEARCH

Epigallocatechin gallate attenuates experimental non-alcoholic steatohepatitis induced by high fat diet

(2007) Nalan Kuzu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY