Article
Biochemistry & Molecular Biology
Si-Hong Kim, Mewuleddeg Zebro, Dong-Cheol Jang, Jeong-Eun Sim, Han-Kyeol Park, Kyeong-Yeon Kim, Hyung-Min Bae, Shimeles Tilahun, Sung-Min Park
Summary: This study aimed to address the challenges faced by the newly introduced 'Shine Muscat' grapevine cultivar in South Korea. Through experiments, a robust in vitro propagation method was established to produce disease-free grapes. Effective plant growth regulators were also identified to facilitate large-scale cultivation.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Agronomy
Wojciech Litwinczuk, Beata Jacek
Summary: The aim of this study was to investigate the effects of plant-growth regulators on the growth of paulownia plants and evaluate their usefulness in paulownia nurseries. The results showed that some regulators could stimulate stem elongation and thickening, with TE having a longer-lasting effect. However, TPA caused deformation in the stems and leaves of the plants, while other regulators inhibited stem diameter growth and leaf expansion in paulownia.
Article
Biochemistry & Molecular Biology
Mat Yunus Najhah, Hawa Z. E. Jaafar, Jaafar Juju Nakasha, Mansor Hakiman
Summary: The study found that in vitro-cultured callus of L. pumila var. alata displayed significantly higher antioxidant activities and total phenolic and flavonoid content compared to leaf extracts from in vitro plantlets and wild plants. This suggests that callus culture could potentially be utilized for antioxidant and polyphenolic production, meeting pharmaceutical and nutraceutical needs while also conserving the wild L. pumila var. alata.
Article
Plant Sciences
Anza-Tshilidzi Ramabulana, Paul A. Steenkamp, Ntakadzeni E. Madala, Ian A. Dubery
Summary: Plant cell culture can be manipulated using plant growth regulators to induce metabolic changes for the production of specialized metabolites. This study investigated different combination ratios of PGRs to induce metabolic changes in Bidens pilosa callus, revealing distinct metabolomic profiles dominated by chlorogenic acids. While organogenesis was not achieved, the results demonstrate the potential of using exogenous PGRs to manipulate plant metabolism for in vitro production of specialized metabolites.
Article
Horticulture
Irfan Ali Sabir, Xunju Liu, Songtao Jiu, Matthew Whiting, Caixi Zhang
Summary: The study found that the effects of plant growth regulators on sweet cherry fruit set can vary significantly, with different treatments yielding different results on different cultivars, indicating the need for further research to develop practical yield improvement programs.
Article
Genetics & Heredity
Olive Onyemaobi, Harriet Sangma, Gagan Garg, Xiaomei Wallace, Sue Kleven, Pipob Suwanchaikasem, Ute Roessner, Rudy Dolferus
Summary: The study demonstrates that wheat has the capability to adjust its water balance through different mechanisms under drought stress. Drought-tolerant wheat lines maintain stomatal conductance by suppressing ABA synthesis, and exhibit a stronger stress defence response. This highlights the importance of adapting to different environmental stressors for improved grain yield in wheat.
Article
Biotechnology & Applied Microbiology
Lidia dos Santos Pessanha, Victor Paulo Mesquita Aragao, Tadeu dos Reis de Oliveira, Kariane Rodrigues de Sousa, Vanildo Silveira, Claudete Santa-Catarina
Summary: This study investigated the in vitro propagation and ex vitro rooting of Dalbergia nigra and found that cytokinin, polyamines, and protein profiles play important roles in shoot development, while the balance between auxin and cytokinin affects ex vitro rooting.
PLANT CELL TISSUE AND ORGAN CULTURE
(2022)
Article
Plant Sciences
Ayaka Kinoshita, Hirokazu Tsukaya
Summary: Physiological experiments on the one-leaf plant species Monophyllaea glabra suggest that the fate of the cotyledons is determined by the biased auxin concentration between them and subsequent cytokinin levels. It was found that the fate determination of the microcotyledon is reversible. Contrary to previous suggestions, light quality was found to be not important in cotyledon fate determination in M. glabra.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Plant Sciences
Si-Min Li, Hong-Xiang Zheng, Xian-Sheng Zhang, Na Sui
Summary: Cytokinins are a class of phytohormones that regulate plant growth, development, and stress responses by interacting with transcription factors through a series of phosphorylation cascades. They also play a crucial role in crosstalk with other phytohormones to modulate plant development and stress reactions. This review provides a comprehensive overview of cytokinins as central regulators of plant biology and highlights areas for future research.
PLANT CELL REPORTS
(2021)
Review
Plant Sciences
Valeria Cavallaro, Alessandra Pellegrino, Rosario Muleo, Ivano Forgione
Summary: Plant tissue cultures rely on artificial light sources for growth and metabolism. By controlling light quality, intensity, and duration, desired plant characteristics can be achieved and energy can be saved. However, the effects of light on in vitro propagation are conflicting, due to various factors and the lack of a standardized protocol.
Article
Plant Sciences
Xiaobing Zhao, Jinjin Song, Qiuxia Zeng, Yaying Ma, Hanmei Fang, Liyuan Yang, Ban Deng, Juan Liu, Jingping Fang, Liping Zuo, Jingjing Yue
Summary: In vitro organogenesis is a multistep process controlled by the balance between auxin and cytokinin. An efficient and reproducible protocol for papaya callus formation and shoot regeneration was established, with differential gene expression analysis revealing key regulators of phytohormone modulation and transduction processes, including transcription factors. Key TFs, CpLBD19 and CpESR1, were identified as potential regulators of callus induction and shoot formation in papaya, suggesting a regulatory network similar to that in Arabidopsis.
JOURNAL OF PLANT PHYSIOLOGY
(2021)
Review
Plant Sciences
Xi Chen, Steven M. Smith, Sergey Shabala, Min Yu
Summary: This review summarizes the current knowledge of how hormones play essential roles in plant responses to boron and how they affect plant growth and development. Hormones are found to mediate the physiological disorders caused by boron deficiencies and excesses. Boron deficiency inhibits root elongation, while boron excess induces the production of reactive oxygen species. Plants adapt to boron deficiency and toxicity through the modulation of hormone production and signaling.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Plant Sciences
Matthew J. van Voorthuizen, Jiancheng Song, Ondrej Novak, Paula E. Jameson
Summary: The use of plant growth regulators to enhance wheat and barley yields by altering cytokinin levels showed no significant improvement, potentially due to the inability to change yield components. Analysis of endogenous cytokinin content revealed slight changes under specific conditions.
Article
Plant Sciences
Matthew J. van Voorthuizen, Jaroslav Nisler, Jiancheng Song, Lukas Spichal, Paula E. Jameson
Summary: The study showed that INCYDE significantly increased seed yield in Rapid Cycling Brassica rapa, while TD-K had a transient effect on the regulation of BrCKX3.
Article
Plant Sciences
Ma. del Carmen Orozco-Mosqueda, Gustavo Santoyo, Bernard R. Glick
Summary: Phytohormones are important regulators of plant growth and development, and also produced by plant growth-promoting bacteria. These bacterial phytohormones can modulate plant physiology and genetics, and have beneficial effects on plant growth. This review highlights the recent advances in understanding the functions and potential applications of bacterial phytohormones in agriculture.
Review
Neurosciences
Shee Man Voon, Khuen Yen Ng, Soi Moi Chye, Anna Pick Kiong Ling, Kenny Gah Leong Voon, Yiing Jye Yap, Rhun Yian Koh
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2020)
Review
Neurosciences
Jet Shee Teng, Yin Yin Ooi, Soi Moi Chye, Anna Pick Kiong Ling, Rhun Yian Koh
Summary: Parkinson's disease is a common neurodegenerative disease characterized by symptoms such as resting tremor, stiffness, bradykinesia, and muscular rigidity. Immunotherapies have emerged as a new approach to Parkinson's disease treatment due to limitations of current treatments, showing positive outcomes by targeting aggregated alpha-synuclein species.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2021)
Review
Engineering, Chemical
Ming Guan Ng, Chew Hee Ng, Khuen Yen Ng, Soi Moi Chye, Anna Pick Kiong Ling, Rhun Yian Koh
Summary: Cancer is a leading cause of death globally, and chemotherapy has many drawbacks, making the search for better anticancer drugs from natural sources crucial. S. crispus is a herbal medicinal plant with high vitamin and mineral content, as well as therapeutic phytochemicals, with numerous studies demonstrating its potential anticancer effects.
Review
Neurosciences
Zhi Xin Chew, Chooi Ling Lim, Khuen Yen Ng, Soi Moi Chye, Anna Pick Kiong Ling, Rhun Yian Koh
Summary: Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by reduced dopamine levels. Inhibitors of monoamine oxidase B (MAO-B) are used to alleviate symptoms by preserving functional levels of dopamine. The first MAO-B inhibitor used therapeutically was selegiline, followed by rasagiline, which has superior efficacy. Safinamide, a reversible MAO-B inhibitor, was recently approved as an add-on therapy for mid- or late-stage PD. MAO-B inhibitors may have potential neuroprotective and disease modifying effects, but further investigation is needed.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Food Science & Technology
Bernadette Xin-Jie Tune, Anna Pick-Kiong Ling, Kenny Gah-Leong Voon, Ying-Pei Wong
Summary: The flavonoid orientin, known for its antioxidative properties, was investigated for potential antiviral effects against DENV2 in this study. However, the results showed that orientin did not exhibit any antiviral effects on THP-1 cells infected with DENV2.
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES
(2022)
Review
Neurosciences
Gargi Joshi, Anna Pick Kiong Ling, Soi Moi Chye, Rhun Yian Koh
Summary: The behavior of an individual changes throughout life due to the development of the central nervous system (CNS) and the changing properties of cerebrospinal fluid (CSF). CSF abnormalities at different ages are associated with psychological and physical changes, such as impacts on growth, mood, anxiety, sleep, memory, and neurodegenerative diseases.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Engineering, Chemical
Pavitra Murthy, Nur Adania Shaibie, Chooi Ling Lim, Anna Pick Kiong Ling, Soi Moi Chye, Rhun Yian Koh
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by interstitial lung scarring. Herbal medicines, such as Traditional Chinese Medicine (TCM), have shown promise as alternative treatments for IPF due to their natural properties and therapeutic effects.
Review
Biotechnology & Applied Microbiology
Yung Cheng Tan, Asqwin Uthaya Kumar, Ying Pei Wong, Anna Pick Kiong Ling
Summary: In recent years, the exponential growth of biological information in plant biotechnology has driven the development of bioinformatic tools and methodologies for studying plant genomes. However, challenges posed by the complexity of plant genomes have limited the progress in this field compared to animal genomics.
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chee Hoe Cheah, Anna Pick Kiong Ling, Ying Pei Wong, Rhun Yian Koh, Sobri Hussein
Summary: This study demonstrates the anti-neuroinflammatory properties of chloroform extract derived from in vitro Panax ginseng root culture. The extract increases the production of the anti-inflammatory cytokine IL-10, while not significantly affecting the production of pro-inflammatory cytokines NO, TNF-alpha, and IL-6.
REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Food Science & Technology
Bernadette Xin-Jie Tune, Anna Pick-Kiong Ling, Kenny Gah-Leong Voon, Ying-Pei Wong
Summary: This study investigated the effects of orientin on THP-1 cells infected with DENV2 and found that orientin did not exhibit antiviral activity against the virus or significantly affect cell viability.
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES
(2021)
Article
Parasitology
M. M. T. Yew, J. Q. Lip, A. P. K. Ling
Summary: Since the first reported case series on SARS-CoV-2-induced neurological manifestations in Wuhan in April 2020, various studies have been published reporting diverse symptoms of COVID-19 infection related to the nervous system. The virus binds to the ACE2 receptor in different parts of the body, allowing entry into the body and causing various neurological complications. These complications can occur through direct invasion or indirectly through immune system overstimulation, leading to autoimmune diseases.
TROPICAL BIOMEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Asqwin Uthaya Kumar, Anna Pick Kiong Ling
Summary: Chloroplast transformation is a significant genetic engineering approach that has shown advantages over nuclear genome transformation. Through vector design and incorporation of selectable markers, chloroplast transformation can be achieved, leading to various applications in agriculture and environmental science. Further research is needed to explore new knowledge and additional applications of chloroplast transformation in biotechnology.
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Integrative & Complementary Medicine
Chien Yi Koay, Anna Pick Kiong Ling, Ying Pei Wong, Rhun Yian Koh, Sobri Hussein
Summary: The methanol extract of P. ginseng root culture did not demonstrate significant anti-inflammatory effects on NO and IL-6 levels, but it may have potential anti-neuroinflammatory and pro-neuroinflammatory properties by downregulating TNF-alpha and IL-10 levels respectively.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2021)
Review
Immunology
Asqwin Uthaya Kumar, Kirthikah Kadiresen, Wen Cong Gan, Anna Pick Kiong Ling
Summary: COVID-19 has become a global pandemic, causing over a million deaths. Plant-based vaccines are gaining attention for their cost-effectiveness and efficient manufacturing process. Many companies worldwide are racing to develop an effective vaccine using the plant system amid challenges faced in the development process.
CLINICAL AND EXPERIMENTAL VACCINE RESEARCH
(2021)
Review
Biology
Azrin S. Zulcafli, Chooiling Lim, Anna P. Ling, Soimoi Chye, Rhunyian Koh
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2020)