Article
Biochemistry & Molecular Biology
Rossana Visigalli, Bianca Maria Rotoli, Francesca Ferrari, Maria Di Lascia, Benedetta Riccardi, Paola Puccini, Valeria Dall'Asta, Amelia Barilli
Summary: In this study, the expression and activity of ABC transporters in human alveoli were analyzed. The results showed that MRP1 was the only transporter expressed and functional at the basolateral side, while the other studied transporters were not expressed on the apical membrane. This suggests the presence of unidentified transporters involved in drug efflux from alveolar epithelium.
Article
Cardiac & Cardiovascular Systems
Genki Ichihara, Yoshinori Katsumata, Yuki Sugiura, Yuta Matsuoka, Rae Maeda, Jin Endo, Atsushi Anzai, Kohsuke Shirakawa, Hidenori Moriyama, Hiroki Kitakata, Takahiro Hiraide, Shinichi Goto, Seien Ko, Yuji Iwasawa, Kazuhisa Sugai, Kyohei Daigo, Shinya Goto, Kazuki Sato, Ken-ichi Yamada, Makoto Suematsu, Masaki Ieda, Motoaki Sano
Summary: This study found that glutathione release during ischemia-reperfusion (IR) is primarily dependent on the transporter MRP1, and its release induces ferroptosis. Suppression of glutathione release attenuates ferroptosis and reduces myocardial infarct size following IR.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Su Mon Shwe, Sivaprasath Prabu, Dapeng Jing, Kanglai He, Zhenying Wang
Summary: The Cry1Ah and Vip3Aa19 proteins have a synergistic interaction in controlling the Yellow peach moth. Cry1Ah has a higher binding affinity for midgut receptors compared to Vip3Aa19, and there is no competition between them.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Guichun Liu, Wei Liu, Ruoping Zhao, Jinwu He, Zhiwei Dong, Lei Chen, Wenting Wan, Zhou Chang, Wen Wang, Xueyan Li
Summary: The study identified multiple ABC transporter and Rab protein family members in the genome of the swallowtail butterfly, revealing their significant role in body coloration. This provides new insights into the morphological development of butterflies.
Review
Pharmacology & Pharmacy
Patrick T. Ronaldson, Thomas P. Davis
Summary: Ischemic stroke is a major cause of morbidity and mortality globally. Despite positive results in preclinical studies, only one compound has advanced to Phase III clinical trial evaluation. This may be due to the neglect of transport mechanisms at the blood-brain barrier and neurovascular unit. This review highlights the role of BBB transporters in drug delivery and their expression in different brain cell types.
Article
Pharmacology & Pharmacy
Lukas Cerveny, Sara Karbanova, Rona Karahoda, Hana Horackova, Lucie Jiraskova, Mohammed Naji Husaen Ali, Frantisek Staud
Summary: The nucleoside analog entecavir (ETV) is a first-line pharmacotherapy for chronic hepatitis B in adult and pediatric patients. However, insufficient data on placental transfer and pregnancy effects limit its recommended use in women after conception. This study investigated the contribution of various transporters to the placental kinetics of ETV and found that ENTs, but not CNTs, ABCB1, ABCG2, and ABCC2, significantly affect ETV transport across the placenta.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Cell Biology
Zhuo-Xun Wu, Yuqi Yang, Jing-Quan Wang, Silpa Narayanan, Zi-Ning Lei, Qiu-Xu Teng, Leli Zeng, Zhe-Sheng Chen
Summary: The study confirmed that MLN7243 is a substrate of ABCG2, and overexpression of ABCG2 leads to resistance in cancer cells against MLN7243. Combining MLN7243 with ABCG2 inhibitors may enhance the therapeutic efficacy for tumors with high ABCG2 levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Toxicology
Jing Nie, Jiabei Zhou, Yi Shen, Ruimiao Lin, Haihong Hu, Kui Zeng, Huichang Bi, Min Huang, Lushan Yu, Su Zeng, Jing Miao
Summary: The study investigates the interaction between five triazole fungicides and human renal transporters, revealing their potential to inhibit renal drug transporter activity at low concentrations and induce nephrotoxicity. One of the fungicides, triticonazole, was found to be a substrate for OAT1 and OAT3, and an inhibitor for OCT2. Tebuconazole and penconazole inhibited OCTN2 activity, while tebuconazole, triticonazole, hexaconazole, penconazole, and uniconazole inhibited MATE1 activity. Tebuconazole and hexaconazole inhibited MATE2-K activity.
TOXICOLOGY IN VITRO
(2023)
Article
Pharmacology & Pharmacy
Sana-Kay Whyte-Allman, Rupert Kaul, Reina Bendayan
Summary: In this study, we found that exposure to an HIV pseudotype virus led to a significant increase in the expression of ABC drug efflux transporters in CD4(+) T-cells, which was attenuated by mTOR inhibitors. Furthermore, inhibition of P-gp or MRP1 activity resulted in lower concentrations of proinflammatory cytokines in supernatants of PBMC exposed to the virus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Majtnerova Pavlina, Capek Jan, Petira Filip, Handl Jiri, Rousar Tomas
Summary: A spectrofluorometric assay was developed to detect nuclear condensation and fragmentation in intact cells induced by various apoptotic inducers. This method showed similar sensitivity to the TUNEL assay but with the benefits of being fast, cost-effective, and high throughput. The spectrofluorometric assay could potentially become a routine method for characterizing cell death processes.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Jun Yu, Hao Chen, Jiangmei Xu, Peng Zhou
Summary: Autoimmune diseases result from the immune response of the body to its own antigens, and their pathogenesis is not yet fully understood. Most autoimmune diseases cannot be cured effectively by drugs, so the treatment strategy focuses on symptom relief and balancing the body's autoimmune function. Abnormal expression of ATP-binding cassette (ABC) transporters plays a direct role in the pathogenesis of autoimmune diseases and drug resistance, posing a significant challenge for drug therapy. This article reviews the interaction between ABC transporters and the pathogenesis of autoimmune diseases to provide research progress and new ideas for drug development in this field.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Cell Biology
Cornelia Thoeni, Catia T. Perciani, Diana Nakib, Damra Camat, Ian D. McGilvray, Sonya A. MacParland, Sandra Fischer
Summary: ATP-binding cassette transporters play a crucial role in regulating bile constituent transport and dysfunction can lead to cholestasis and liver damage. This study found that ABCB4 is the only transporter that shows increased expression in hepatocytes of PSC patients. Quantitative ABCB4 analysis may be useful for the histopathological diagnosis of PSC.
Article
Chemistry, Medicinal
Yingnan Zhao, Yanping Li, Qinhui Liu, Qin Tang, Zijing Zhang, Jinhang Zhang, Cuiyuan Huang, Hui Huang, Guorong Zhang, Jian Zhou, Jiamin Yan, Yan Xia, Zhiyong Zhang, Jinhan He
Summary: The research shows that Cana can facilitate cholesterol efflux in the liver and intestine by activating AMPK to increase the expression of ABC transporters ABCG5 and ABCG8, leading to increased biliary and fecal cholesterol excretion. This may be a partial reason for improving cardiovascular disease.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Pharmacology & Pharmacy
Dirk Theile, Pauline Wizgall
Summary: Acquired multidrug resistance in tumor diseases is often linked to overexpression of ATP-binding cassette transporters like P-glycoprotein. This overexpression can be experimentally achieved by exposure to cytotoxic drugs, with two opposite mechanisms potentially explaining this phenomenon.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Laura Alvarez-Fernandez, Alex Gomez-Gomez, Noemi Haro, Alba M. Garcia-Lino, Ana Alvarez, Oscar J. Pozo, Gracia Merino
Summary: The ATP-binding cassette G2 (ABCG2) is an efflux transporter that impacts the bioavailability, tissue accumulation, and secretion of xenobiotics and endogenous compounds. This study characterized the role of ABCG2 in the distribution and secretion of melatonin and its metabolites. The researchers found that ABCG2 transported melatonin and its metabolites and that mice lacking Abcg2 exhibited higher plasma concentrations of melatonin metabolites, increased tissue accumulation, and lower milk concentrations compared to wild-type mice. These findings demonstrate the critical role of ABCG2 in the biodistribution and therapeutic activity of melatonin and its metabolites.
JOURNAL OF PINEAL RESEARCH
(2023)