Developmental roles of protein N-terminal acetylation

An Organellar Nα-Acetyltransferase, Naa60, Acetylates Cytosolic N Termini of Transmembrane Proteins and Maintains Golgi Integrity

(2015) Henriette Aksnes et al.   Cell Reports

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females

(2014) Bernt Popp et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects

(2014) Line M. Myklebust et al.   HUMAN MOLECULAR GENETICS

A splice donor mutation inNAA10results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome

(2014) Taraneh Esmailpour et al.   JOURNAL OF MEDICAL GENETICS

NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2

(2014) Haejin Yoon et al.   Nature Communications

The DAF-16 FOXO Transcription Factor Regulates natc-1 to Modulate Stress Resistance in Caenorhabditis elegans, Linking Insulin/IGF-1 Signaling to Protein N-Terminal Acetylation

(2014) Kurt Warnhoff et al.   PLoS Genetics

Potential Involvement of N-Terminal Acetylation in the Quantitative Regulation of the ε Subunit of Chloroplast ATP Synthase under Drought Stress

(2013) Saki HOSHIYASU et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Stem cell metabolism in tissue development and aging

(2013) N. Shyh-Chang et al.   DEVELOPMENT

N-terminal Acetylation Stabilizes N-terminal Helicity in Lipid- and Micelle-bound α-Synuclein and Increases Its Affinity for Physiological Membranes

(2013) Igor Dikiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates

(2013) Dimitrios Zattas et al.   MOLECULAR BIOLOGY OF THE CELL

Control of Protein Quality and Stoichiometries by N-Terminal Acetylation and the N-End Rule Pathway

(2013) Anna Shemorry et al.   MOLECULAR CELL

The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle

(2013) Nadia Arnaudo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N-Terminal Acetylation by NatC Is Not a General Determinant for Substrate Subcellular Localization in Saccharomyces cerevisiae

(2013) Henriette Aksnes et al.   PLoS One

N -α-Acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression

(2012) Huiyu Xu et al.   CARCINOGENESIS

Drosophila Psidin Regulates Olfactory Neuron Number and Axon Targeting through Two Distinct Molecular Mechanisms

(2012) D. Stephan et al.   JOURNAL OF NEUROSCIENCE

Comparative Large Scale Characterization of PlantversusMammal Proteins Reveals Similar and IdiosyncraticN-α-Acetylation Features

(2012) Willy V. Bienvenut et al.   MOLECULAR & CELLULAR PROTEOMICS

Protein N-terminal acetyltransferases in cancer

(2012) T V Kalvik et al.   ONCOGENE

Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis

(2012) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB

(2012) P. Van Damme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein N-terminal acetyltransferases: when the start matters

(2012) Kristian K. Starheim et al.   TRENDS IN BIOCHEMICAL SCIENCES

Using VAAST to Identify an X-Linked Disorder Resulting in Lethality in Male Infants Due to N-Terminal Acetyltransferase Deficiency

(2011) Alan F. Rope et al.   AMERICAN JOURNAL OF HUMAN GENETICS

N-α-Acetyltransferase 10 Protein Suppresses Cancer Cell Metastasis by Binding PIX Proteins and Inhibiting Cdc42/Rac1 Activity

(2011) Kuo-Tai Hua et al.   CANCER CELL

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival

(2011) Caroline H. Yi et al.   CELL

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

(2011) Jin Zhang et al.   EMBO JOURNAL

Proteome-derived Peptide Libraries Allow Detailed Analysis of the Substrate Specificities of Nα-acetyltransferases and Point to hNaa10p as the Post-translational Actin Nα-acetyltransferase

(2011) Petra Van Damme et al.   MOLECULAR & CELLULAR PROTEOMICS

The Human N-Alpha-Acetyltransferase 40 (hNaa40p/hNatD) Is Conserved from Yeast and N-Terminally Acetylates Histones H2A and H4

(2011) Kristine Hole et al.   PLoS One

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

(2011) D. C. Scott et al.   SCIENCE

Towards a Functional Understanding of Protein N-Terminal Acetylation

(2011) Thomas Arnesen   PLOS BIOLOGY

N-Terminal Acetylation Inhibits Protein Targeting to the Endoplasmic Reticulum

(2011) Gabriella M. A. Forte et al.   PLOS BIOLOGY

NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation

(2011) Petra Van Damme et al.   PLoS Genetics

Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell Proliferation

(2010) Ji Hae Seo et al.   CANCER RESEARCH

Drosophila variable nurse cells encodes arrest defective 1 (ARD1), the catalytic subunit of the major N-terminal acetyltransferase complex

(2010) Ying Wang et al.   DEVELOPMENTAL DYNAMICS

The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast

(2010) A. T. Coulton et al.   JOURNAL OF CELL SCIENCE

Profiling ofN-Acetylated Protein Termini Provides In-depth Insights into the N-terminal Nature of the Proteome

(2010) Andreas O. Helbig et al.   MOLECULAR & CELLULAR PROTEOMICS

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation

(2010) Chih-Wen Chu et al.   MOLECULAR BIOLOGY OF THE CELL

The developmental transcriptome of Drosophila melanogaster

(2010) Brenton R. Graveley et al.   NATURE

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

Phosphorylation of ARD1 by IKKβ contributes to its destabilization and degradation

(2009) Hsu-Ping Kuo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human Naa50p (Nat5/San) Displays Both ProteinNα- andNϵ-Acetyltransferase Activity

(2009) Rune Evjenth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockdown of Human N -Terminal Acetyltransferase Complex C Leads to p53-Dependent Apoptosis and Aberrant Human Arl8b Localization

(2009) K. K. Starheim et al.   MOLECULAR AND CELLULAR BIOLOGY

Arrest Defective-1 Controls Tumor Cell Behavior by Acetylating Myosin Light Chain Kinase

(2009) Dong Hoon Shin et al.   PLoS One

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

(2009) T. Arnesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Identification and Functional Characterization of N-Terminally Acetylated Proteins in Drosophila melanogaster

(2009) Sandra Goetze et al.   PLOS BIOLOGY

Identification of the humanNα-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression

(2008) Kristian K. Starheim et al.   BIOCHEMICAL JOURNAL

Differential requirements of a mitotic acetyltransferase in somatic and germ line cells

(2008) Ana Pimenta-Marques et al.   DEVELOPMENTAL BIOLOGY

Synthetic Lethal Screens Identify Gene Silencing Processes in Yeast and Implicate the Acetylated Amino Terminus of Sir3 in Recognition of the Nucleosome Core

(2008) T. van Welsem et al.   MOLECULAR AND CELLULAR BIOLOGY

Implication of human N-α-acetyltransferase 5 in cellular proliferation and carcinogenesis

(2008) A Ametzazurra et al.   ONCOGENE

Yeast Nα-terminal acetyltransferases are associated with ribosomes

(2007) Bogdan Polevoda et al.   JOURNAL OF CELLULAR BIOCHEMISTRY