Directed evolution of anti-HER2 DARPins by SNAP display reveals stability/function trade-offs in the selection process

Selection-Based Discovery of Druglike Macrocyclic Peptides

(2014) Toby Passioura et al.   Annual Review of Biochemistry

PURE ribosome display and its application in antibody technology

(2014) Takashi Kanamori et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Comprehensive Biophysical Description of Pairwise Epistasis throughout an Entire Protein Domain

(2014) C. Anders Olson et al.   CURRENT BIOLOGY

An experimental framework for improved selection of binding proteins using SNAP display

(2014) Gillian Houlihan et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Multiplex single-molecule interaction profiling of DNA-barcoded proteins

(2014) Liangcai Gu et al.   NATURE

Next-generation antibodies

(2014) James B. Evans et al.   NATURE REVIEWS DRUG DISCOVERY

Computational design of a leucine-rich repeat protein with a predefined geometry

(2014) Sebastian Rämisch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

(2013) Florian Klein et al.   CELL

SNAP Display - an In Vitro Method for the Selection of Protein Binders

(2013) Gillian Houlihan et al.   CURRENT PHARMACEUTICAL DESIGN

mRNA display: from basic principles to macrocycle drug discovery

(2013) Kristopher Josephson et al.   DRUG DISCOVERY TODAY

A single mutation in the core domain of the lac repressor reduces leakiness

(2013) Pietro Gatti-Lafranconi et al.   Microbial Cell Factories

Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation

(2013) Feng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro affinity screening of protein and peptide binders by megavalent bead surface display

(2013) L. Diamante et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2

(2013) Christian Jost et al.   STRUCTURE

Monoclonal antibody therapeutics: history and future

(2012) Nicholas APS Buss et al.   CURRENT OPINION IN PHARMACOLOGY

SNAP Dendrimers: Multivalent Protein Display on Dendrimer-Like DNA for Directed Evolution

(2011) Miriam Kaltenbach et al.   CHEMBIOCHEM

DARPins and other repeat protein scaffolds: advances in engineering and applications

(2011) Ykelien L Boersma et al.   CURRENT OPINION IN BIOTECHNOLOGY

Biosimilar, biobetter and next generation therapeutic antibodies

(2011) Alain Beck   mAbs

A De Novo Protein Binding Pair By Computational Design and Directed Evolution

(2011) John Karanicolas et al.   MOLECULAR CELL

Beyond natural antibodies: the power of in vitro display technologies

(2011) Andrew R M Bradbury et al.   NATURE BIOTECHNOLOGY

A roadmap to generate renewable protein binders to the human proteome

(2011) Karen Colwill et al.   NATURE METHODS

High Affinity Antigen Recognition of the Dual Specific Variants of Herceptin Is Entropy-Driven in Spite of Structural Plasticity

(2011) Jenny Bostrom et al.   PLoS One

Synthetic single-framework antibody library integrated with rapid affinity maturation by VL shuffling

(2011) E.- C. Brockmann et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Engineered protein scaffolds as next-generation antibody therapeutics

(2009) Michaela Gebauer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Directed enzyme evolution: climbing fitness peaks one amino acid at a time

(2009) Cara A Tracewell et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins

(2009) Harald Kolmar   CURRENT OPINION IN PHARMACOLOGY

Stability effects of mutations and protein evolvability

(2009) Nobuhiko Tokuriki et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural Bases for Stability–Function Tradeoffs in Antibiotic Resistance

(2009) Veena L. Thomas et al.   JOURNAL OF MOLECULAR BIOLOGY

The potential of microfluidic water-in-oil droplets in experimental biology

(2009) Yolanda Schaerli et al.   Molecular BioSystems

Optimizing Protein Stability In Vivo

(2009) Linda Foit et al.   MOLECULAR CELL

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

(2009) Christian Heinis et al.   Nature Chemical Biology

An efficient method to assemble linear DNA templates for in vitro screening and selection systems

(2009) Viktor Stein et al.   NUCLEIC ACIDS RESEARCH

Determining kinetics and affinities of protein interactions using a parallel real-time label-free biosensor, the Octet

(2008) Yasmina Abdiche et al.   ANALYTICAL BIOCHEMISTRY

Picomolar Affinity Fibronectin Domains Engineered Utilizing Loop Length Diversity, Recursive Mutagenesis, and Loop Shuffling

(2008) Benjamin J. Hackel et al.   JOURNAL OF MOLECULAR BIOLOGY

Efficient Selection of DARPins with Sub-nanomolar Affinities using SRP Phage Display

(2008) Daniel Steiner et al.   JOURNAL OF MOLECULAR BIOLOGY

How Protein Stability and New Functions Trade Off

(2008) Nobuhiko Tokuriki et al.   PLoS Computational Biology