Response of Hepatitis C Virus to Long-Term Passage in the Presence of Alpha Interferon: Multiple Mutations and a Common Phenotype

Modulation of the type I interferon pathways by culture-adaptive hepatitis C virus core mutants

(2012) Ju-Il Kang et al.   FEBS LETTERS

Cell Culture-Adaptive Mutations Promote Viral Protein-Protein Interactions and Morphogenesis of Infectious Hepatitis C Virus

(2012) J. Jiang et al.   JOURNAL OF VIROLOGY

Viral Quasispecies Evolution

(2012) E. Domingo et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1

(2012) Anna S. Lok et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Cell Culture Adapted HCV JFH1 Variant That Increases Viral Titers and Permits the Production of High Titer Infectious Chimeric Reporter Viruses

(2012) Shuanghu Liu et al.   PLoS One

Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains

(2012) Y.-P. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The impact of quasispecies dynamics on the use of therapeutics

(2012) Celia Perales et al.   TRENDS IN MICROBIOLOGY

Type 1 Interferons and Antiviral CD8 T-Cell Responses

(2012) Raymond M. Welsh et al.   PLoS Pathogens

eIF2A mediates translation of hepatitis C viral mRNA under stress conditions

(2011) Joon Hyun Kim et al.   EMBO JOURNAL

Sequence and Phenotypic Analysis for Resistance Monitoring in Hepatitis C Virus Drug Development: Recommendations From the HCV DRAG

(2011) Ann D. Kwong et al.   GASTROENTEROLOGY

The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C

(2011) Stefan Zeuzem et al.   HEPATOLOGY

Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders

(2011) Kazuaki Chayama et al.   HEPATOLOGY

Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy

(2011) Makoto Kadokura et al.   Hepatology International

Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir

(2011) Simone Susser et al.   JOURNAL OF CLINICAL VIROLOGY

Hepatitis C virus: How genetic variability affects pathobiology of disease

(2011) Kazuaki Chayama et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Analysis of Interferon Signaling by Infectious Hepatitis C Virus Clones with Substitutions of Core Amino Acids 70 and 91

(2011) Y. Funaoka et al.   JOURNAL OF VIROLOGY

Novel Mutations in a Tissue Culture-Adapted Hepatitis C Virus Strain Improve Infectious-Virus Stability and Markedly Enhance Infection Kinetics

(2011) M. V. Pokrovskii et al.   JOURNAL OF VIROLOGY

Sequence heterogeneity of NS5A and core proteins of hepatitis C virus and virological responses to pegylated-interferon/ribavirin combination therapy

(2011) Ahmed El-Shamy et al.   MICROBIOLOGY AND IMMUNOLOGY

Generation of a Cell Culture-Adapted Hepatitis C Virus with Longer Half Life at Physiological Temperature

(2011) Chon Saeng Kim et al.   PLoS One

Analysis of the Complete Open Reading Frame of Genotype 2b Hepatitis C Virus in Association with the Response to Peginterferon and Ribavirin Therapy

(2011) Makoto Kadokura et al.   PLoS One

Tempo and mode of inhibitor-mutagen antiviral therapies: A multidisciplinary approach

(2011) J. Iranzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

(2011) M. H. Powdrill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Insights into the HCV Quasispecies and Compartmentalization

(2011) Patrizia Farci   SEMINARS IN LIVER DISEASE

Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1

(2011) Sibnarayan Datta et al.   Virology Journal

Review article: specifically targeted anti-viral therapy for hepatitis C - a new era in therapy

(2010) C. M. Lange et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Turning Hepatitis C into a Real Virus

(2010) Catherine L. Murray et al.   Annual Review of Microbiology

Resistance Analysis of the Hepatitis C Virus NS5A Inhibitor BMS-790052 in an In Vitro Replicon System

(2010) R. A. Fridell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

dsRNA and the innate antiviral immune response

(2010) Stephanie J DeWitte-Orr et al.   Future Virology

Hepatitis C pharmacogenetics: State of the art in 2010

(2010) Nezam H. Afdhal et al.   HEPATOLOGY

NMR Structure and Ion Channel Activity of the p7 Protein from Hepatitis C Virus

(2010) Roland Montserret et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection

(2010) Mina Nakagawa et al.   JOURNAL OF GASTROENTEROLOGY

Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients

(2010) Christoph Sarrazin et al.   JOURNAL OF HEPATOLOGY

Tracking the Evolution of Multiple In Vitro Hepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing

(2010) T. Verbinnen et al.   JOURNAL OF VIROLOGY

Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system

(2010) Christopher T Jones et al.   NATURE BIOTECHNOLOGY

Hepatitis C Virus Controls Interferon Production through PKR Activation

(2010) Noëlla Arnaud et al.   PLoS One

Mixing the right hepatitis C inhibitor cocktail

(2010) Michael A. Gelman et al.   TRENDS IN MOLECULAR MEDICINE

A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

(2010) Rubén Agudo et al.   PLoS Pathogens

Structural and functional diversity of viral IRESes

(2009) Laurent Balvay et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Hepatitis C Virus Blocks Interferon Effector Function by Inducing Protein Kinase R Phosphorylation

(2009) Urtzi Garaigorta et al.   Cell Host & Microbe

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Quantitative Deep Sequencing Reveals Dynamic HIV-1 Escape and Large Population Shifts during CCR5 Antagonist Therapy In Vivo

(2009) Athe M. N. Tsibris et al.   PLoS One

Compensatory mutations in NS3 and NS5A proteins enhance the virus production capability of hepatitis C reporter virus

(2009) Qingxia Han et al.   VIRUS RESEARCH

Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells

(2008) Svetlana Marukian et al.   HEPATOLOGY

Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy

(2008) Ahmed El‐Shamy et al.   HEPATOLOGY

Diagnosis, management, and treatment of hepatitis C: An update

(2008) Marc G. Ghany et al.   HEPATOLOGY

Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2

(2008) Ilya M Terenin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus

(2008) R. S. Russell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus Attenuation by Genome-Scale Changes in Codon Pair Bias

(2008) J. R. Coleman et al.   SCIENCE

Isolation and gene analysis of interferon α-resistant cell clones of the hepatitis C virus subgenome

(2008) Tohru Noguchi et al.   VIROLOGY

Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus

(2008) Christoph Welsch et al.   GENOME BIOLOGY

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

(2007) R. E. Randall et al.   JOURNAL OF GENERAL VIROLOGY

Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient

(2007) Maria Cubero et al.   VIROLOGY