Increased Sequence Coverage through Combined Targeting of Variant and Conserved Epitopes Correlates with Control of HIV Replication

HIV-1 Conserved-Element Vaccines: Relationship between Sequence Conservation and Replicative Capacity

(2013) M. Rolland et al.   JOURNAL OF VIROLOGY

Frequent and Variable Cytotoxic-T-Lymphocyte Escape-Associated Fitness Costs in the Human Immunodeficiency Virus Type 1 Subtype B Gag Proteins

(2013) C. L. Boutwell et al.   JOURNAL OF VIROLOGY

HIV-1 p24gag Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice

(2013) Viraj Kulkarni et al.   PLoS One

Fitness Costs of Mutations at the HIV-1 Capsid Hexamerization Interface

(2013) Siriphan Manocheewa et al.   PLoS One

Extreme Genetic Fragility of the HIV-1 Capsid

(2013) Suzannah J. Rihn et al.   PLoS Pathogens

Correlates of Protective Cellular Immunity Revealed by Analysis of Population-Level Immune Escape Pathways in HIV-1

(2012) J. M. Carlson et al.   JOURNAL OF VIROLOGY

Modeling Protein Evolution with Several Amino Acid Replacement Matrices Depending on Site Rates

(2012) S. Q. Le et al.   MOLECULAR BIOLOGY AND EVOLUTION

Vaccine-induced CD8+ T cells control AIDS virus replication

(2012) Philip A. Mudd et al.   NATURE

TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection

(2012) Huabiao Chen et al.   NATURE IMMUNOLOGY

CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control

(2012) Beatriz Mothe et al.   PLoS One

Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens

(2012) Sampa Santra et al.   VIROLOGY

Role of Transmitted Gag CTL Polymorphisms in Defining Replicative Capacity and Early HIV-1 Pathogenesis

(2012) Jessica L. Prince et al.   PLoS Pathogens

Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection

(2012) Matthew R. Henn et al.   PLoS Pathogens

Clonotype and Repertoire Changes Drive the Functional Improvement of HIV-Specific CD8 T Cell Populations under Conditions of Limited Antigenic Stimulation

(2011) L. Janbazian et al.   JOURNAL OF IMMUNOLOGY

Demographic Processes Affect HIV-1 Evolution in Primary Infection before the Onset of Selective Processes

(2011) J. T. Herbeck et al.   JOURNAL OF VIROLOGY

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection

(2011) Yi Liu et al.   PLoS One

Intra- and Inter-clade Cross-reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials

(2011) Lycias Zembe et al.   PLoS One

Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

(2011) V. Dahirel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical evaluation of HIV-1 therapeutic ex vivo dendritic cell vaccines expressing consensus Gag antigens and conserved Gag epitopes

(2011) Liguo Niu et al.   VACCINE

Fine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes

(2010) Michael S Bennett et al.   AIDS

DIVEIN: a web server to analyze phylogenies, sequence divergence, diversity, and informative sites

(2010) Wenjie Deng et al.   BIOTECHNIQUES

Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity

(2010) I. Hoof et al.   JOURNAL OF IMMUNOLOGY

HIV Immune Escape at an Immunodominant Epitope in HLA-B*27-Positive Individuals Predicts Viral Load Outcome

(2010) P. Ammaranond et al.   JOURNAL OF IMMUNOLOGY

Enhanced Anti-HIV Functional Activity Associated with Gag-Specific CD8 T-Cell Responses

(2010) B. Julg et al.   JOURNAL OF VIROLOGY

Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

(2010) Andrej Košmrlj et al.   NATURE

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys

(2010) Dan H Barouch et al.   NATURE MEDICINE

Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys

(2010) Sampa Santra et al.   NATURE MEDICINE

Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

(2010) Morgane Rolland et al.   PLoS One

Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity

(2009) Nicole Frahm et al.   AIDS

Functional properties and epitope characteristics of T-cells recognizing natural HIV-1 variants

(2009) U. Malhotra et al.   VACCINE

HIV Dynamics in Seminal Plasma during Primary HIV Infection

(2008) Joanne Stekler et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients

(2008) Paul A. Goepfert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cross‐Clade Detection of HIV‐1–Specific Cytotoxic T Lymphocytes Does Not Reflect Cross‐Clade Antiviral Activity

(2008) Michael S. Bennett et al.   JOURNAL OF INFECTIOUS DISEASES

Broad and Gag-Biased HIV-1 Epitope Repertoires Are Associated with Lower Viral Loads

(2008) Morgane Rolland et al.   PLoS One

Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag

(2008) Jonathan M. Carlson et al.   PLoS Computational Biology

Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells

(2008) Hendrik Streeck et al.   PLOS MEDICINE