Article
Virology
Bahman Abedi Kiasari, Fatemeh Hoda Fallah, Mohammad Kazem Koohi, Phelipe Magalhaes Duarte, Sina Salajegheh Tazerji, Mohamed Fawzy
Summary: This study found that the respiratory tract can be infected by SV40 in immunocompetent patients, and it may serve as a route of transmission or a site for virus persistence. Moreover, the high rate of co-infection suggests that SV40 may not be involved in respiratory diseases.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yool Lee, Chaeun Oh, Jin Kim, Myong-Suk Park, Woo Kyun Bae, Kyung Hyun Yoo, Seungwoo Hong
Summary: The activation of dioxygen plays a crucial role in aerobic life, with metal ions' redox versatility being essential for processes involving reactive oxygen species. Synthetic metal complexes have shown potential in activating dioxygen and generating ROS, with implications for cancer treatment and the development of potent antitumor agents.
Article
Oncology
Stefano Menghini, Matej Vizovisek, Jonathas Enders, Simone Schuerle
Summary: The use of bacteria in cancer immunotherapy shows promise in overcoming the limitations of conventional treatments. Anaerobic bacteria have the ability to accumulate and replicate in hypoxic areas of solid tumors, leading to enhanced immunostimulatory effects. This study explores the iron-scavenging abilities of Magnetospirillum magneticum bacteria in hypoxic regions of solid tumors and their metabolic effects on cancer cells.
CANCER & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Hao Luo, Yan Lin, Tao Liu, Fei-Liao Lai, Chun-Ting Zhang, Feng Gao, Ren Zhang
Summary: Essential genes are necessary for an organism's survival under specific conditions. Recent advancements in identifying human essential genes have been driven by the successful use of CRISPR/Cas9 technology. The release of DEG 15 database shows significant progress, with a large increase in the number of essential genes in eukaryotes and prokaryotes. The database offers built-in analysis modules and customizable BLAST tools for enhanced essential gene analysis.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yi-Tzu Chen, Chiao-Wen Lin, Chun-Wen Su, Wei-En Yang, Chun-Yi Chuang, Shih-Chi Su, Ming-Ju Hsieh, Shun-Fa Yang
Summary: Magnolol, a natural compound extracted from Chinese herbal medicine, can inhibit cell proliferation and induce apoptosis in oral cancer cell lines through upregulating cleaved caspase-3 and HO-1 expression, as well as activating the JNK1/2 and p38 pathways. This study suggests that magnolol may serve as a therapeutic approach for oral cancer through JNK1/2- and p38-mediated caspase activation.
Article
Multidisciplinary Sciences
Asli Okan, Necdet Demir, Berna Sozen
Summary: Diabetes mellitus has profound effects on the female mammalian reproductive system and early embryonic development, mainly by triggering ER-stress induced apoptotic cascade. This study provides new insights into understanding the pathological effects of diabetes on ovarian function and early embryo development.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Sanath Kumar Janaka, Brian J. Snow, Ryan T. Behrens, David T. Evans
Summary: Tetherin is a protein that prevents viruses from detaching from infected cells by physically tethering them to cellular membranes. SIV Nef downmodulates simian tetherin to overcome this restriction in nonhuman primate hosts. In addition to counteracting tetherin, SIV Nef has a number of other functions, including downmodulating other proteins from the cell surface. Researchers have engineered an infectious molecular clone of SIV with substitutions in Nef that separate tetherin antagonism from other Nef functions. This study demonstrates the importance of tetherin antagonism for optimal replication of SIV in primary CD4(+) T cells.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Austin M. Jeffries, Alexander J. Suptela, Ian Marriott
Summary: This study found that ZBP1 serves as a restriction factor for HSV-1 infection and is associated with the induction of both necroptotic and apoptotic cell death pathways in primary murine astrocytes.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Biochemistry & Molecular Biology
Likai Ji, Yan Wang, Liying Zhou, Juan Lu, Siwen Bao, Quan Shen, Xiaochun Wang, Yuwei Liu, Wen Zhang
Summary: The outbreaks caused by RNA and DNA viruses pose serious threats to human health. Understanding the mechanisms of different members of the E3s families that mediate the RLR and cGAS-STING pathways can help prevent and treat virus-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Marie-Claire Fitzgerald, Philip J. O'Halloran, Sean A. Kerrane, Triona Ni Chonghaile, Niamh M. C. Connolly, Brona M. Murphy
Summary: Systems-level analysis of apoptosis protein expression and signaling interactions can differentiate between medulloblastoma cell lines with different responses to chemotherapy. BCL-XL and MCL-1 were identified as key anti-apoptotic proteins in medulloblastoma, with distinct protective roles. We provide rationale for further evaluation of BCL-XL and MCL-1 inhibitors in medulloblastoma treatment.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Megan H. Orzalli, Aleksandra Prochera, Laurellee Payne, Avi Smith, Jonathan A. Garlick, Jonathan C. Kagan
Summary: During viral infection, inhibition of protein synthesis triggers pyroptosis in human keratinocytes, leading to the release of inflammatory cytokines. MCL-1 and BCL-xL act as sensors of translation shutdown, contributing to antiviral defense by inhibiting virus replication.
Article
Plant Sciences
Romina B. Agostini, Federico Ariel, Sebastian P. Rius, Walter A. Vargas, Valeria A. Campos-Bermudez
Summary: Inoculation of maize roots with Trichoderma leads to epigenetic marks in genes related to plant defense pathways, resulting in enhanced immunity against Colletotrichum infection. The activation of plant responses is mediated by priming mechanisms, involving changes in phytohormone levels and chromatin structure. This study provides insights into the interplay between phytohormones and epigenetic regulation in the long-lasting defense response of maize plants to Trichoderma inoculation.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Cell Biology
Chi-Wei Chen, Ming-Ju Hsieh, Po-Chung Ju, Yi-Hsien Hsieh, Chun-Wen Su, Yen-Lin Chen, Shun-Fa Yang, Chiao-Wen Lin
Summary: In this study, the therapeutic effect and mode of action of the curcumin analog, HO-3867, against human oral squamous cell carcinoma (OSCC) cells were explored. The results showed that HO-3867 effectively suppressed the growth of OSCC cells and induced apoptosis through the c-Jun N-terminal kinase (JNK)1/2 pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Reproductive Biology
Carolin Lisa Michaela Ludwig, Simon Bohleber, Rebecca Lapp, Alexander Rebl, Eva Katrin Wirth, Martina Langhammer, Ulrich Schweizer, Joachim M. M. Weitzel, Marten Michaelis
Summary: The development and maturation of ovarian follicles is a complex and highly regulated process, which is essential for successful ovulation. The FL1 mouse model, a unique selection experiment for increased female reproductive performance, provides insights into the regulation of folliculogenesis.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Tuyen Duong Thanh Nguyen, Yan Wang, Tuyen N. Bui, Rossana Lazcano, Davis R. Ingram, Min Yi, Varshini Vakulabharanam, Linjie Luo, Marc A. Pina, Cansu Karakas, Mi Li, Nicole M. Kettner, Neeta Somaiah, Peter J. Hougton, Osama Mawlawi, Alexander J. Lazar, Kelly K. Hunt, Khandan Keyomarsi
Summary: Treatment strategies with CDK4/6 inhibitors followed by DNA-damaging agents showed synergistic killing of Rb-positive sarcomas and can be noninvasively monitored using functional imaging and serum biomarkers. This approach provides a potential avenue for novel targeted therapies in sarcomas with intact Rb signaling.