Article
Multidisciplinary Sciences
B. David Persson, Lijo John, Karim Rafie, Michael Strebl, Lars Frangsmyr, Monika Z. Ballmann, Katja Mindler, Menzo Havenga, Angelique Lemckert, Thilo Stehle, Lars-Anders Carlson, Niklas Arnberg
Summary: This study reveals a noncanonical entry mechanism used by human adenoviruses, where CD46 interacts directly with the hexon protein to infect host cells. CD46 is identified as an important receptor for a large group of adenoviruses, inhibiting infection by 16 out of 17 investigated HAdV-D types.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Virology
Jack R. Hemsath, A. Manuel Liaci, Jeffrey D. Rubin, Brian J. Parrett, Shao-Chia Lu, Tien Nguyen, Mallory A. Turner, Christopher Y. Chen, Karolina Cupelli, Vijay S. Reddy, Thilo Stehle, M. Kathryn Liszewski, John P. Atkinson, Michael A. Barry
Summary: This study investigates the usage of CD46 receptor by Ad26 virus in different administration routes and its impact on infection efficiency. The results show that Ad26 can use CD46 as a receptor but its usage varies depending on the administration route. Ectopic expression of CD46 on cells enhances Ad26 infection, while tumor injection or intravenous injection shows lower infection efficiency. High-dose intravenous injection of Ad26 induces liver enzyme release and reduces white blood cell counts but does not cause thrombocytopenia.
JOURNAL OF VIROLOGY
(2022)
Article
Pediatrics
Malik Aydin, Sebastian Schellhorn, Stefan Wirth, Wenli Zhang, Anja Ehrhardt
Summary: Research on adenovirus (Ad) is increasingly important in virotherapy, vaccine development, tumors, and gene therapy. Characterization of rare Ad types 70, 73, and 74 is necessary, as they show interestingly low transduction rates in primary cells. Further investigation into the development of diagnostic and therapeutic concepts for these rare Ad types is crucial to prevent and treat opportunistic infections in susceptible patients, especially immunocompromised individuals.
Article
Materials Science, Multidisciplinary
Mossab Alzweighi, Rami Mansour, Jussi Lahti, Ulrich Hirn, Artem Kulachenko
Summary: The study proposes a multiscale approach combining modeling, numerical simulation, and experimental measurements to evaluate the influence of structural properties on the mechanical performance of fiber networks. Results indicate that spatial variability in density has the highest impact on the local strain field, while the fiber orientation angle with respect to drying restraints is the key influencer for mechanical response. The study also includes the influence of drying conditions during production process on fiber properties and validates the approach by comparing with measured strain fields and uniaxial responses.
Article
Multidisciplinary Sciences
Marta Perez-Illana, Marta Martinez, Gabriela N. Condezo, Mercedes Hernando-Perez, Casandra Mangroo, Martha Brown, Roberto Marabini, Carmen San Martin
Summary: Enteric adenovirus HAdV-F41 has unique capsid stability compared to other adenoviruses, with partially ordered elements reinforcing its stability. Additionally, the organization of its external minor coat protein IX differs from all previously characterized human and nonhuman mastadenoviruses, providing valuable insights for the development of vectors suitable for oral delivery or intestinal targeting.
Article
Oncology
Ryosuke Ono, Kosuke Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi
Summary: The study developed a novel OAd fully composed of OAd35, which recognizes CD46 as an infection receptor and showed efficient cell lysis activities similar to OAd5 in CAR-positive tumor cells, while exhibiting higher levels of cell lysis activities than OAd5 in CAR-negative tumor cells. OAd35 had lower proportions of neutralizing antibodies in adults compared to Ad5.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Materials Science, Multidisciplinary
Jianpeng Wu, Yu Wang, Junshuo Zhang, Chunyu Zhao, Ziyang Fan, Quan Shu, Xiaokang He, Shouhu Xuan, Xinglong Gong
Summary: In this study, a lightweight composite material with low thermal conductivity and high impact force dissipation is developed through infiltration and lamination. The versatile nature of this material makes it an ideal candidate for applications in transportation, military, and aerospace fields.
Article
Biochemistry & Molecular Biology
Zian Liu, Md Abul Hassan Samee
Summary: Single nucleotide mutation rates are important for human evolution and genetic diseases, but the principles underlying the variation remain unclear. A recent model proposed a connection between DNA shape and mutation rates, and showed that DNA shape-based models perform better than sequence-based models. These models accurately identify mutation hotspots and reveal the shape features underlying mutation rate variations. This work provides insights into the structural basis of nucleotide mutations and lays the foundation for future models to incorporate DNA shape.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jia-yuan Gong, Cui-jiao Wen, Ming-liang Tang, Rui-fang Duan, Juan-nan Chen, Jia-yu Zhang, Ke-wei Zheng, Yi-de He, Yu-hua Hao, Qun Yu, Su-ping Ren, Zheng Tan
Summary: The study examined the interactions between G-quadruplexes (G4s) and single nucleotide variations (SNVs) and their impact on gene expression, revealing that G4Vs can significantly influence the expression of host genes, particularly near transcription factor binding sites and enhancers. These findings highlight the importance of understanding genetic variations from a structural perspective in relation to physiological function and pathological implications.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Raphael L. Tsoukas, Wolfram Volkwein, Jian Gao, Maren Schiwon, Nora Bahlmann, Thomas Dittmar, Claudia Hagedorn, Eric Ehrke-Schulz, Wenli Zhang, Armin Baiker, Anja Ehrhardt
Summary: In this study, the authors systematically analyzed the receptor usage of different adenoviruses using a reporter gene-tagged adenovirus library and a human gene knockout model. They found that some adenoviruses are dependent on the CD46 or CAR receptor, and other receptors or attachment structures may also play a role in adenovirus transduction.
Article
Biochemistry & Molecular Biology
Yu-Xin Zhang, Xin-Feng Wang, Yu-Qian Niu, Yu-Guo Wang, Wen-Ju Zhang, Zhi-Ping Song, Ji Yang, Lin-Feng Li
Summary: This study identified abundant genomic structural variations (SVs) in the Panax genus, which are thought to have occurred during repeated polyploidizations/(re)diploidizations. These SVs were found to be involved in important pathways related to secondary metabolites, photosynthesis, and basic cellular activities. Metabolic analyses of Panax species revealed high diversity of primary and secondary metabolites at both tissue and interspecific levels, particularly in ginsenoside biosynthesis genes. Furthermore, ginsenosides, as major triterpenoidal saponins found exclusively in Panax, were shown to provide protection against insect herbivores. This study provides insights into how polyploidization-derived SVs contribute to phenotypic novelty and plant adaptation.
Article
Virology
Yoshihito Nagura, Kei Fujiwara, Kentaro Matsuura, Etsuko Iio, Yasuhito Tanaka, Hiromi Kataoka
Summary: Complex structural variations (SVs) were identified in HBV strains from non-human primates (NHPs) in addition to human HBV strains, indicating potential genetic diversity in other hepadnaviruses. These data suggest that complex SVs could play a role in genetic diversity within hepadnaviruses.
Article
Biotechnology & Applied Microbiology
Zhenyang Liao, Xunxiao Zhang, Shengcheng Zhang, Zhicong Lin, Xingtan Zhang, Ray Ming
Summary: Structural variations (SVs) play a crucial role in the domestication process of papaya, with deletion being prevalent in the evolution of the papaya genome. SVs show co-expression relationships with genes and tissues, contributing to biological growth and environmental responses. Domesticated SVs genes are associated with environmental adaptability, reproductive traits, and agronomic characteristics.
Article
Chemistry, Multidisciplinary
Jesus Rivera, Satoshi Murata, Maryam Sadat Hosseini, Adwait A. Trikanad, Robin James, Allison Pickle, Nicholas Yaraghi, Nana Matsumoto, Wen Yang, Dilworth Y. Parkinson, Harold S. Barnard, Pablo Zavattieri, Atsushi Arakaki, David Kisailus
Summary: Beetles use their elytra to protect their hindwings, with different species having evolved varying levels of protection to suit their environmental needs. Analysis reveals mechanical and microstructural differences in elytra among beetle species, impacting their hardness, stiffness, and resistance to mechanical stresses.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Zhaowu Zhang, Rob van Treuren, Ting Yang, Yulan Hu, Wenhui Zhou, Huan Liu, Tong Wei
Summary: This study characterized a large number of SVs in the lettuce genome, uncovering potential causal SVs associated with agronomic traits like seed coat color and leaf anthocyanin content. The findings provide a valuable genomic resource for future lettuce breeding.
Meeting Abstract
Chemistry, Multidisciplinary
Sangita Venkataraman, S. Sundaram, R. Selvarajan, H. S. Savithri
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES
(2017)
Review
Virology
Sangita Venkataraman, Burra V. L. S. Prasad, Ramasamy Selvarajan
Article
Biochemical Research Methods
Sangita Venkataraman, Seshidhar P. Reddy, Jackie Loo, Neeraja Idamakanti, Paul L. Hallenbeck, Vijay S. Reddy
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
(2008)
Article
Biochemistry & Molecular Biology
S. Kundhavai Natchiar, Sangita Venkataraman, Tina-Marie Mullen, Glen R. Nemerow, Vijay S. Reddy
JOURNAL OF MOLECULAR BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Mauricio Carrillo-Tripp, Craig M. Shepherd, Ian A. Borelli, Sangita Venkataraman, Gabriel Lander, Padmaja Natarajan, John E. Johnson, Charles L. Brooks, Vijay S. Reddy
NUCLEIC ACIDS RESEARCH
(2009)
Article
Biochemistry & Molecular Biology
Sangita Venkataraman, Seshidhar P. Reddy, Jackie Loo, Neeraja Idamakanti, Paul L. Hallenbeck, Vijay S. Reddy
Article
Virology
Lars Pache, Sangita Venkataraman, Glen R. Nemerow, Vijay S. Reddy
Article
Genetics & Heredity
Mariya Rashid, Shubham Mittal, Sangita Venkataraman
Article
Biochemical Research Methods
V Sangita, GL Lokesh, PS Satheshkumar, V Saravanan, CS Vijay, HS Savithri, MRN Murthy
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2005)
Article
Biochemical Research Methods
V Sangita, PS Satheshkumar, HS Savithri, MRN Murthy
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2005)
Article
Biochemistry & Molecular Biology
V Sangita, GL Lokesh, PS Satheshkumar, CS Vijay, V Saravanan, HS Savithri, MRN Murthy
JOURNAL OF MOLECULAR BIOLOGY
(2004)
Article
Biochemistry & Molecular Biology
PS Satheshkumar, GL Lokesh, V Sangita, V Saravanan, CS Vijay, MRN Murthy, HS Savithri
JOURNAL OF MOLECULAR BIOLOGY
(2004)