☆ 4.2 Article

Relationship between HLA-DPA1 mRNA expression and susceptibility to hepatitis B

JOURNAL OF VIRAL HEPATITIS (2019)

Journal

JOURNAL OF VIRAL HEPATITIS

Volume 26, Issue 1, Pages 155-161

Publisher

WILEY

DOI: 10.1111/jvh.13012

Keywords

Gene expression; hepatitis B virus; HLA-DP antigens; rs3077

Categories

Gastroenterology & Hepatology Infectious Diseases Virology

Funding

CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-3-024]
Sichuan Science and Technology [2017RZ0047]
Ministry of Science and Technology of China [2014EG150133]

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Abstract

Chronic hepatitis B virus (HBV) infection is influenced by both viral and host factors. In genome-wide association studies, the human leucocyte antigen HLA-DPA1 and related polymorphism rs3077 were found to be associated with susceptibility to and spontaneous clearance of HBV infection. Here, we evaluated the association between HLA-DPA1 mRNA expression and the risk of HBV infection. HLA-DPA1 and rs3077 polymorphisms were investigated in 169 patients with chronic HBV and 217 healthy controls (HCs) from Sichuan Han blood donors using sequence-based typing and meta-analysis for HLA-DPA1 alleles. HLA-DPA1 mRNA levels were measured by real-time polymerase chain reaction. The results showed that HLA-DPA1 and rs3077 were associated with HBV infection in the Sichuan population. Rs3077T and DPA1*01:03 played protective roles in HBV infection, and rs3077C and DPA1*02:02 increased susceptibility to HBV infection. We found that the HLA-DPA1 mRNA expression was decreased in the CHB group; in particular, the 3077CT, 3077TT, DPA1*01:03 and DPA1*02:01 alleles showed a significant decrease. Our results demonstrated, for the first time, that expression of HLA-DPA1 alleles and rs3077 affected the risk of HBV infection. Genotypes with lower HLA-DPA1 expression had a greater susceptibility to HBV infection. Thus, further independent studies are needed to strengthen the associations of these polymorphisms with susceptibility to and clearance of HBV infection in Chinese populations.

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Article Oncology

Impact of perioperative allogeneic blood transfusion on the long-term prognosis of patients with different stage tumors after radical resection for hepatocellular carcinoma

Tao Peng, Liming Wang, Hongyuan Cui, Xiying Li, Min Liu, Jingjing Yu, Jianxiong Wu, Guohua Zhao, Zhong Liu

Summary: This study demonstrates that perioperative allogeneic blood transfusion has negative impacts on the long-term prognosis of patients with early-stage hepatocellular carcinoma after radical resection, but has no impact on the long-term prognosis of patients with non-early-stage tumors.

EJSO (2021)

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Article Infectious Diseases

Epidemiological survey and screening strategy for dengue virus in blood donors from Yunnan Province

Ling Li, Ying Li, Shaofang Lu, Jing Dong, Haixia Xu, Qian Zhang, Rong Weng, Yundi Yin, Rui He, Peng Fang, Hua Shi, Yinghan Yu, Ji Wu, Zhong Liu, John R. Hess

Summary: DENV prevalence among donors at the Xishuangbanna Blood Center in Yunnan was 26.53%, with significant differences noted by occupation, education, and ethnicity. This study provides important data for the development of DENV screening strategies for clinical use.

BMC INFECTIOUS DISEASES (2021)

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Article Medicine, Research & Experimental

Analysis of viral load in different specimen types and serum antibody levels of COVID-19 patients

Ling Li, Chianru Tan, Jia Zeng, Chen Luo, Shi Hu, Yanke Peng, Wenjuan Li, Zhixiong Xie, Yueming Ling, Xuejun Zhang, E. Deng, Haixia Xu, Jue Wang, Yudi Xie, Yaling Zhou, Wei Zhang, Yong Guo, Zhong Liu

Summary: This study collected nasopharyngeal swabs, anal swabs, saliva, blood, and urine specimens from patients with a course of disease ranging from 7 to 69 days. It was found that the positive detection rate was highest in nasopharyngeal swabs, followed by anal swabs. There was no significant correlation between antibody levels and days after symptom onset or viral load.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Hematology

First annual report of Chinese haemovigilance network

Yonghua Yin, Xue Tian, Ling Li, Yujie Kong, Jue Wang, Feng Lin, Ning Song, Qiang Chen, Jia Gan, Tao Peng, Xiying Li, Yanyun Wu, Hongwei Ge, Hongjie Wang, Jingmei Jiang, Lianjun Bai, Hongwen Ji, Guohua Zhao, Yuguang Huang, Zhong Liu

Summary: This report provides the first comprehensive overview of transfusion-related adverse reactions in China, highlighting that allergic reactions and FNHTR are the most common adverse symptoms. Most adverse reactions resulted in hospitalization or prolongation of hospitalization for patients, with the ratio of serious adverse reactions being 8.2%.

VOX SANGUINIS (2021)

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Article Hematology

Donor tolerability of convalescent plasma donation

Rui He, Hui Lin, Songli Xie, Qilu Lv, Yujie Kong, Ling Li, Haixia Xu, Jue Wang, Wenjuan Li, Peng Fang, Yanyun Wu, Zhong Liu

Summary: This study evaluated the short-term donor tolerability of convalescent plasma donation and found that all adverse events were mild vasovagal without relation to factors like weight, sex, or blood type. Overall, the donation of convalescent plasma is safe, but mitigation of risk factors associated with adverse events can further enhance donor tolerability.

JOURNAL OF CLINICAL APHERESIS (2021)

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Article Hematology

A possible dose-response equation: Viral load after plasma infusion in COVID-19 patients and anti-SARS-CoV-2 antibody titers in convalescent plasma

Rui He, Jue Wang, Zhenmeng Wang, Yu Liu, Haixia Xu, Xuejun Zhang, E. Deng, Yundi Yin, Xin Ji, Xiaoyu Guan, Qi Ren, Caixia Wu, Yongjun Chen, Ling Li, Wei Zhang, Zhong Liu

Summary: This study proposed a potential estimation equation for evaluating the dose of high antibody titer convalescent plasma, which could assist in the rational allocation of plasma with high antibody titers and provide an individualized treatment strategy for convalescent plasma therapy.

TRANSFUSION MEDICINE (2022)

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Article Hematology

Development of the Chinese Haemovigilance Network and reporting of adverse transfusion reactions from 2018 to 2020

Xue Tian, Yujie Kong, Jue Wang, Rui He, Ling Li, Zhong Liu

Summary: This report describes the development of the Chinese Haemovigilance Network (CHN) and evaluates its role in advancing blood transfusion safety by analyzing reported adverse transfusion reactions (ATRs) from 2018 to 2020. The study found that the establishment of CHN has increased ATR recognition and management, although under-reporting of ATRs still occurs in many Chinese hospitals.

VOX SANGUINIS (2022)

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Editorial Material Cell Biology

Detection of a novel HLA-B allele, HLA-B48:54 in a Chinese individual

Xin Ji, Chen Luo, Jue Wang, Qiang Chen, Liu Zhong

Summary: A novel HLA-B*48:54 allele was discovered in an individual from China's Sichuan province.

HLA (2022)

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Editorial Material Cell Biology

Identification of a novel HLA-C08 allele, HLA-C08:242 in a Chinese individual

Chen Luo, Xin Ji, Zhong Liu, Qiang Chen, Jue Wang

Summary: The novel HLA-C*08:242 allele was identified in an individual from the Sichuan province of China.

HLA (2022)

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Editorial Material Cell Biology

Description of the novel HLA-A allele, HLA-A*02:937 in a Chinese individual

ZhiHang He, Xin Ji, Chen Luo, Qiang Chen, Jue Wang

Summary: The sentence describes a nucleotide change at codon 182 of exon 3 (ACG>GCG) between HLA-A*02:937 and HLA-A*02:07:01:01.

HLA (2022)

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Article Immunology

Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants

Yudi Xie, Lei Liu, Jue Wang, Yaqiong Zheng, Chen Luo, Wenxu Ni, Zhihang He, Xin Zhao, Yan Liu, Yingyu He, Shangen Zheng, Ling Li, Zhong Liu

Summary: Among the 64 plasma samples of COVID-19 convalescents, whether vaccinated or not, Omicron (B.1.1.529) escaped the neutralizing antibodies, with a significantly decreased neutralization activity compared to WT. And two-dose of the vaccine could significantly raise the average neutralization of Omicron in convalescent individuals.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Hematology

Investigating the Correlation Between HLA-II Gene Polymorphism and RhE Alloimmunization in Pregnant Chinese Women

Wenling Shang, Guojin Ou, Xin Ji, Jian Chen, Jue Wang, Yongmei Jiang

Summary: The study aimed to verify the correlation between HLA-II gene polymorphisms and RhE alloimmunization in pregnant Chinese women through HLA-II typing and DR-RhE structural prediction. The results showed a significant positive association between the HLA-DRB1*09:01-DQA1*03:02-DQB1*03:03 haplotype and anti-E. One E-derived anchoring peptide (219FWPSVNSPL227) was predicted to bind to the HLA-DRB1*09:01 molecule. This study demonstrated that HLA-II haplotypes are associated with allo-anti-E antibodies in pregnant women from Sichuan Province, China.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION (2023)

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Article Medical Laboratory Technology

Transfusion-Related Acute Lung Injury Caused by HLA-II Antibodies: A Case Report

Xinxin Hao, Jue Wang, Tiegang Li, Qiushi Wang

Summary: This study retrospectively analyzed the etiology of a suspected case of transfusion-related acute lung injury (TRALI) after blood transfusion, and found that the patient's condition was related to HLA genes and HLA antibodies.

LABORATORY MEDICINE (2023)

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Article Cell Biology

Frequency and molecular basis of CD36 deficiency among platelet donors in Kunming, China

Qilu Lyu, Mozhen Peng, Qiang Chen, Xin Ji, Zhijiang Wang, Qian Li, Zhihui Zhang, Zhen Luo, Yonghua Yin, Pincan Su, Sentot Santoso, Jue Wang

Summary: This study identified the incidence of CD36 deficiency among platelet donors in Kunming and investigated the molecular basis of this deficiency. It was found that 1.68% of the donors had CD36 deficiency, with 0.24% having type I deficiency and 1.44% having type II deficiency. Heterozygous mutations were detected in these individuals, which may contribute to the CD36 deficiency.

PLATELETS (2023)

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