Review
Medicine, General & Internal
Guojin Ou, Xiaojuan Liu, Yongmei Jiang
Summary: This meta-analysis reveals that specific HLA-DPB1 alleles are significantly associated with an increased antibody response to the HB vaccine, further elucidating the role of genetic factors in this immune response.
Article
Genetics & Heredity
Ana Valencia, Candelaria Vergara, Chloe L. Thio, Nicolas Vince, Venceslas Douillard, Alba Grifoni, Andrea L. Cox, Eric O. Johnson, Alex H. Kral, James J. Goedert, Alessandra Mangia, Valeria Piazzolla, Shruti H. Mehta, Gregory D. Kirk, Arthur Y. Kim, Georg M. Lauer, Raymond T. Chung, Jennifer C. Price, Salim Khakoo, Laurent Alric, Matthew E. Cramp, Sharyne M. Donfield, Brian R. Edlin, Michael P. Busch, Graeme Alexander, Hugo R. Rosen, Edward L. Murphy, Genevieve L. Wojcik, Mary Carrington, Pierre-Antoine Gourraud, Alessandro Sette, David L. Thomas, Priya Duggal, Continue Ignore
Summary: Spontaneous clearance of acute hepatitis C virus (HCV) infection is associated with specific amino acids in HLA-DQ beta 1. Fine-mapping the MHCII region revealed these key amino acids, explaining the allelic and SNP associations with HCV outcomes. This understanding could contribute to the design of vaccines promoting spontaneous clearance of HCV infection.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Immunology
N. Legrand, G. David, A. Rodallec, A. Gaultier, D. Salmon, A. Cesbron, L. Wittkop, F. Raffi, K. Gendzekhadze, C. Retiere, C. Allavena, K. Gagne
Summary: The genetic combinations of KIR/HLA affect the clearance and chronic infection conditions of NK and T cells in HIV-HCV co-infected individuals, with European subjects with spontaneous clearance characterized by specific KIR/HLA genetic features.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Haibing Gao, Xiangmei Wang, Huaxi Ma, Shenglong Lin, Dongqing Zhang, Wenjun Wu, Ziyuan Liao, Mengyun Chen, Qin Li, Minghua Lin, Dongliang Li
Summary: The role of genetic factors in the occurrence and progression of CHB is important. METTL16, an m(6)A regulator involved in mRNA intron splicing, participates in the progression of CHB fibrosis by regulating the m(6)A level and expression of HLA-DPB1.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
A. E. Ades, Fabiana Gordon, Karen Scott, Intira Jeannie Collins, Claire Thorne, Lucy Pembrey, Elizabeth Chappell, Eugenia Marine-Barjoan, Karina Butler, Giuseppe Indolfi, Diana M. Gibb, Ali Judd
Summary: Based on the largest purely prospective dataset assembled to date, this study found that 66% of confirmed vertically acquired hepatitis C virus infections clear spontaneously by age 5 years, rather than the 25%-40% assumed in current guidelines. Treatment before age 3 would avoid loss to follow-up but result in substantial overtreatment.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Elsa Gomez-Escobar, Julien Burlaud-Gaillard, Clara Visdeloup, Adeline Ribeiro E. Silva, Pauline Coutant, Philippe Roingeard, Elodie Beaumont
Summary: The study successfully increased the neutralizing potential of antibodies by using HBV-HCV SVPs bearing apoE, which is significant for the improvement of HCV vaccines.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Magda Rybicka, Eloi R. Verrier, Thomas F. Baumert, Krzysztof Piotr Bielawski
Summary: This study included 284 patients with chronic hepatitis B virus infection and found that certain genetic variations in DIO2, PPARG, GADD45A, and ATF3 were associated with liver fibrosis and cirrhosis in this population. Additionally, a variation in DIO2 was associated with hepatocellular carcinoma.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Edward J. Gane, Won Kim, Tien Huey Lim, Pisit Tangkijvanich, Jung-Hwan Yoon, William Sievert, Wattana Sukeepaisarnjaroen, Alexander J. Thompson, Vedran Pavlovic, Bernadette Surujbally, Cynthia Wat, Bob D. Brown, Hardean E. Achneck, Man-Fung Yuen
Summary: The study investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of RG6346, a double-stranded RNA interference agent, in healthy volunteers and patients with chronic HBV infection. The results showed that RG6346 was safe and well-tolerated, and led to reductions in hepatitis B surface antigen (HBsAg) levels, as well as sustained reductions in hepatitis B core-related antigen, HBV RNA, and HBV DNA levels. These findings support the potential use of RG6346 as part of a finite antiviral treatment regimen for patients with chronic HBV infection.
JOURNAL OF HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Wen-Juei Jeng, George Papatheodoridis, Anna S. F. Lok
Summary: Hepatitis B virus (HBV) infection is a significant global public health problem, with a large number of chronic infections and deaths reported every year. Diagnosis of HBV infection requires serological testing for specific antibodies. Treatment mainly focuses on preventing liver disease progression and development of complications. Efforts are being made to develop new therapies that aim for a functional cure, while prevention strategies include universal vaccination and improved screening and diagnosis. Achieving the goal of eliminating HBV infection by 2030 requires a comprehensive approach.
Review
Medicine, General & Internal
Marianne Martinello, Sunil S. Solomon, Norah A. Terrault, Gregory Dore
Summary: Hepatitis C virus (HCV) is a serious liver disease that can lead to hepatitis and hepatocellular carcinoma. WHO has called for the elimination of HCV infection by 2030, but there are still a significant number of infections and deaths. The development of direct-acting antiviral therapy shows promise, but efforts are needed to strengthen screening, linkage to care, and treatment.
Article
Infectious Diseases
Alicja E. Grzegorzewska, Adrianna Mostowska, Monika K. Swiderska, Wojciech Marcinkowski, Ireneusz Stolarek, Marek Figlerowicz, Pawel P. Jagodzinski
Summary: In haemodialysis patients, the association of rs368234815 with spontaneous HCV clearance is better than that documented for other IFNL3/IFNL4 polymorphisms only in the additive mode of inheritance. However, identifying the homozygosity in the variant G allele of rs368234815 means a more potent prediction of persistent HCV infection in haemodialysis subjects than observed in the case of the variant homozygosity of other tested IFNL3/IFNL4 polymorphisms.
BMC INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Tai-Chung Tseng, Chun-Jen Liu, Wan-Ting Yang, Chen-Yang Hsu, Chun-Ming Hong, Tung-Hung Su, Cheng-Hsueh Tsai, Chi-Ling Chen, Hung-Chih Yang, Chen-Hua Liu, Hsiu-Hsi Chen, Pei-Jer Chen, Jia-Horng Kao
Summary: In patients with chronic hepatitis B virus infection, higher levels of HBcrAg are associated with increased risk of cirrhosis. Among patients with intermediate viral load, HBcrAg <10 KU/mL defines a low-risk group for disease progression.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Immunology
Wen-Chang Wang, Yu-Shiang Lin, Yin-Fan Chang, Chih-Ching Yeh, Chien-Tien Su, Jin-Shang Wu, Fu-Hsiung Su
Summary: In this study, HLA-DPA1 was primarily associated with the long-term response of primary infantile HBVac, while HLA-DPB1 and HLA-DQB1 exhibited associations with the HBV booster vaccination.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Rosario Quiroga Ferrufino, Camila Rodrigues, Gerusa Maria Figueiredo, Daniel Gleison, Silvia Yapura, Maria Laura Mariano de Matos, Steven S. S. Witkin, Maria Cassia Mendes-Correa
Summary: The study aimed to describe the clinical and epidemiological characteristics of recently acquired hepatitis C virus (HCV) infection and the frequency of its spontaneous clearance in people living with HIV. Medical records of PLWH at an HIV outpatient clinic in Sao Paulo, Brazil were reviewed, and individuals who acquired HCV infection between January 2015 and December 2017 were identified. The factors associated with subsequent spontaneous clearance of HCV were analyzed.
Article
Pediatrics
Simon C. Ling, Hsing-Hua S. Lin, Karen F. Murray, Philip Rosenthal, Douglas Mogul, Norberto Rodriguez-Baez, Sarah Jane Schwarzenberg, Jeffrey Teckman, Kathleen B. Schwarz
Summary: The study found that many children with chronic HBV infection in the US and Canada remain at risk of progressive liver disease due to active hepatitis, but major clinical outcomes such as cirrhosis, cancer, and death were rare. Many children who met treatment criteria did not receive treatment.
JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Ling Li, Wei Zhang, Yu Hu, Xunliang Tong, Shangen Zheng, Juntao Yang, Yujie Kong, Lili Ren, Qing Wei, Heng Mei, Caiying Hu, Cuihua Tao, Ru Yang, Jue Wang, Yongpei Yu, Yong Guo, Xiaoxiong Wu, Zhihua Xu, Li Zeng, Nian Xiong, Lifeng Chen, Juan Wang, Ning Man, Yu Liu, Haixia Xu, E. Deng, Xuejun Zhang, Chenyue Li, Conghui Wang, Shisheng Su, Linqi Zhang, Jianwei Wang, Yanyun Wu, Zhong Liu
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Urology & Nephrology
Tian Tao, Jue Wang, Song Lei, Zhangxue Hu
Summary: The pathogenesis of idiopathic membranous nephropathy involves autoantibodies and genetic factors, particularly HLA genes. Rare cases of idiopathic membranous nephropathy in twins provide valuable insights into the genetic and molecular mechanisms of the disease.
JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, Research & Experimental
Ling Li, Chianru Tan, Jia Zeng, Chen Luo, Shi Hu, Yanke Peng, Wenjuan Li, Zhixiong Xie, Yueming Ling, Xuejun Zhang, E. Deng, Haixia Xu, Jue Wang, Yudi Xie, Yaling Zhou, Wei Zhang, Yong Guo, Zhong Liu
Summary: This study collected nasopharyngeal swabs, anal swabs, saliva, blood, and urine specimens from patients with a course of disease ranging from 7 to 69 days. It was found that the positive detection rate was highest in nasopharyngeal swabs, followed by anal swabs. There was no significant correlation between antibody levels and days after symptom onset or viral load.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Hematology
Yonghua Yin, Xue Tian, Ling Li, Yujie Kong, Jue Wang, Feng Lin, Ning Song, Qiang Chen, Jia Gan, Tao Peng, Xiying Li, Yanyun Wu, Hongwei Ge, Hongjie Wang, Jingmei Jiang, Lianjun Bai, Hongwen Ji, Guohua Zhao, Yuguang Huang, Zhong Liu
Summary: This report provides the first comprehensive overview of transfusion-related adverse reactions in China, highlighting that allergic reactions and FNHTR are the most common adverse symptoms. Most adverse reactions resulted in hospitalization or prolongation of hospitalization for patients, with the ratio of serious adverse reactions being 8.2%.
Article
Hematology
Rui He, Hui Lin, Songli Xie, Qilu Lv, Yujie Kong, Ling Li, Haixia Xu, Jue Wang, Wenjuan Li, Peng Fang, Yanyun Wu, Zhong Liu
Summary: This study evaluated the short-term donor tolerability of convalescent plasma donation and found that all adverse events were mild vasovagal without relation to factors like weight, sex, or blood type. Overall, the donation of convalescent plasma is safe, but mitigation of risk factors associated with adverse events can further enhance donor tolerability.
JOURNAL OF CLINICAL APHERESIS
(2021)
Article
Hematology
Rui He, Jue Wang, Zhenmeng Wang, Yu Liu, Haixia Xu, Xuejun Zhang, E. Deng, Yundi Yin, Xin Ji, Xiaoyu Guan, Qi Ren, Caixia Wu, Yongjun Chen, Ling Li, Wei Zhang, Zhong Liu
Summary: This study proposed a potential estimation equation for evaluating the dose of high antibody titer convalescent plasma, which could assist in the rational allocation of plasma with high antibody titers and provide an individualized treatment strategy for convalescent plasma therapy.
TRANSFUSION MEDICINE
(2022)
Article
Hematology
Xue Tian, Yujie Kong, Jue Wang, Rui He, Ling Li, Zhong Liu
Summary: This report describes the development of the Chinese Haemovigilance Network (CHN) and evaluates its role in advancing blood transfusion safety by analyzing reported adverse transfusion reactions (ATRs) from 2018 to 2020. The study found that the establishment of CHN has increased ATR recognition and management, although under-reporting of ATRs still occurs in many Chinese hospitals.
Editorial Material
Cell Biology
Xin Ji, Chen Luo, Jue Wang, Qiang Chen, Liu Zhong
Summary: A novel HLA-B*48:54 allele was discovered in an individual from China's Sichuan province.
Editorial Material
Cell Biology
Chen Luo, Xin Ji, Zhong Liu, Qiang Chen, Jue Wang
Summary: The novel HLA-C*08:242 allele was identified in an individual from the Sichuan province of China.
Editorial Material
Cell Biology
ZhiHang He, Xin Ji, Chen Luo, Qiang Chen, Jue Wang
Summary: The sentence describes a nucleotide change at codon 182 of exon 3 (ACG>GCG) between HLA-A*02:937 and HLA-A*02:07:01:01.
Article
Immunology
Yudi Xie, Lei Liu, Jue Wang, Yaqiong Zheng, Chen Luo, Wenxu Ni, Zhihang He, Xin Zhao, Yan Liu, Yingyu He, Shangen Zheng, Ling Li, Zhong Liu
Summary: Among the 64 plasma samples of COVID-19 convalescents, whether vaccinated or not, Omicron (B.1.1.529) escaped the neutralizing antibodies, with a significantly decreased neutralization activity compared to WT. And two-dose of the vaccine could significantly raise the average neutralization of Omicron in convalescent individuals.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Wenling Shang, Guojin Ou, Xin Ji, Jian Chen, Jue Wang, Yongmei Jiang
Summary: The study aimed to verify the correlation between HLA-II gene polymorphisms and RhE alloimmunization in pregnant Chinese women through HLA-II typing and DR-RhE structural prediction. The results showed a significant positive association between the HLA-DRB1*09:01-DQA1*03:02-DQB1*03:03 haplotype and anti-E. One E-derived anchoring peptide (219FWPSVNSPL227) was predicted to bind to the HLA-DRB1*09:01 molecule. This study demonstrated that HLA-II haplotypes are associated with allo-anti-E antibodies in pregnant women from Sichuan Province, China.
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2023)
Article
Medical Laboratory Technology
Xinxin Hao, Jue Wang, Tiegang Li, Qiushi Wang
Summary: This study retrospectively analyzed the etiology of a suspected case of transfusion-related acute lung injury (TRALI) after blood transfusion, and found that the patient's condition was related to HLA genes and HLA antibodies.
LABORATORY MEDICINE
(2023)
Article
Cell Biology
Qilu Lyu, Mozhen Peng, Qiang Chen, Xin Ji, Zhijiang Wang, Qian Li, Zhihui Zhang, Zhen Luo, Yonghua Yin, Pincan Su, Sentot Santoso, Jue Wang
Summary: This study identified the incidence of CD36 deficiency among platelet donors in Kunming and investigated the molecular basis of this deficiency. It was found that 1.68% of the donors had CD36 deficiency, with 0.24% having type I deficiency and 1.44% having type II deficiency. Heterozygous mutations were detected in these individuals, which may contribute to the CD36 deficiency.
