Influence of Allosteric Regulators on Individual Steps in the Reaction Catalyzed byMycobacterium tuberculosis2-Hydroxy-3-oxoadipate Synthase

TCA Cycle Involved Enzymes SucA and Kgd, as well as MenD: Efficient Biocatalysts for Asymmetric C–C Bond Formation

(2013) Maryam Beigi et al.   ORGANIC LETTERS

Many of the functional differences between acetohydroxyacid synthase (AHAS) isozyme I and other AHASs are a result of the rapid formation and breakdown of the covalent acetolactate-thiamin diphosphate adduct in AHAS I

(2012) Inna Belenky et al.   FEBS Journal

Bifunctionality of the Thiamin Diphosphate Cofactor: Assignment of Tautomeric/Ionization States of the 4′-Aminopyrimidine Ring When Various Intermediates Occupy the Active Sites during the Catalysis of Yeast Pyruvate Decarboxylase

(2012) Anand Balakrishnan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Determination of Pre-Steady-State Rate Constants on the Escherichia coli Pyruvate Dehydrogenase Complex Reveals That Loop Movement Controls the Rate-Limiting Step

(2012) Anand Balakrishnan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Observation of Thiamin-Bound Intermediates and Microscopic Rate Constants for Their Interconversion on 1-Deoxy-d-xylulose 5-Phosphate Synthase: 600-Fold Rate Acceleration of Pyruvate Decarboxylation by d-Glyceraldehyde-3-phosphate.

(2012) Hetalben Patel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Assignment of Function to Histidines 260 and 298 by Engineering the E1 Component of theEscherichia coli2-Oxoglutarate Dehydrogenase Complex; Substitutions That Lead to Acceptance of Substrates Lacking the 5-Carboxyl Group

(2011) Da Jeong Shim et al.   BIOCHEMISTRY

Functional Plasticity and Allosteric Regulation of α-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism

(2011) Tristan Wagner et al.   CHEMISTRY & BIOLOGY

1-Deoxy-d-xylulose 5-Phosphate Synthase Catalyzes a Novel Random Sequential Mechanism

(2011) Leighanne A. Brammer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conversion of Pyruvate Decarboxylase into an Enantioselective Carboligase with Biosynthetic Potential

(2011) Danilo Meyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteogenomic Analysis ofMycobacterium tuberculosisBy High Resolution Mass Spectrometry

(2011) Dhanashree S. Kelkar et al.   MOLECULAR & CELLULAR PROTEOMICS

Activity-Based Metabolomic Profiling of Enzymatic Function: Identification of Rv1248c as a Mycobacterial 2-Hydroxy-3-oxoadipate Synthase

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

Metabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation

(2009) Victoria I. Bunik et al.   BIOCHEMICAL JOURNAL

An Intramolecular Switch Regulates Phosphoindependent FHA Domain Interactions in Mycobacterium tuberculosis

(2009) T. J. Nott et al.   Science Signaling

High accuracy mass spectrometry analysis as a tool to verify and improve gene annotation using Mycobacterium tuberculosis as an example

(2008) Gustavo A de Souza et al.   BMC GENOMICS

Regulation of glutamate metabolism by protein kinases in mycobacteria

(2008) Helen M. O'Hare et al.   MOLECULAR MICROBIOLOGY

Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes

(2008) Alexander Kaplun et al.   Nature Chemical Biology