Article
Urology & Nephrology
Zeyad R. Schwen, James L. Liu, Andrew T. Gabrielson, Hiten D. Patel, Mohit Gupta, Steven P. Rowe, Amin S. Herati, Phillip M. Pierorazio
Summary: The study found that testicular ultrasound significantly underestimated the pathologic size of masses less than 2 cm, while tumor volume measurements may be more accurate in predicting benign pathology compared to maximum diameter measurements. Further research is needed to confirm these findings.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Pathology
Agnese Orsatti, Maria Sirolli, Francesca Ambrosi, Tania Franceschini, Francesca Giunchi, Eugenia Franchini, Marco Grillini, Francesco Massari, Veronica Mollica, Federico Mineo Bianchi, Maurizio Colecchia, Michelangelo Fiorentino, Costantino Ricci
Summary: This study found differential expression and modulation of SOX2 and PRAME during the reprogramming of germ cell tumors, supporting a complex pathogenetic model where the interactions between these two molecules are crucial in determining the fate of GCTT.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Acoustics
F. Moro, L. M. Castellano, D. Franchi, E. Epstein, D. Fischerova, W. Froyman, D. Timmerman, G. F. Zannoni, G. Scambia, L. Valentin, A. C. Testa, F. Mascilini
Summary: This study retrospectively described the clinical and ultrasound characteristics of rare malignant ovarian germ cell tumors, providing insight into the unique features of embryonal carcinoma, non-gestational choriocarcinoma, and malignant mixed germ cell tumor. The findings can aid in improving awareness and diagnostic accuracy of these rare malignant tumors.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Pathology
Costantino Ricci, Francesca Ambrosi, Tania Franceschini, Francesca Giunchi, Maria Eugenia Maracci, Maria Sirolli, Agnese Orsatti, Federico Chiarucci, Eugenia Franchini, Matteo Borsato, Francesco Massari, Veronica Mollica, Federico Mineo Bianchi, Maurizio Colecchia, Andres Martin Acosta, Michelangelo Fiorentino
Summary: In this study, H&E and OCT4/CD34 staining were tested for detecting lymphovascular invasion (LVI) in germ cell tumors of the testis (GCTT). The inter-observer agreement for both H&E and OCT4/CD34 was assessed, and the consensus diagnosis on both stains was compared with the original diagnosis to evaluate pT restaging and identify sources of disagreement.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Medicine, General & Internal
Giuseppe Gargano, Antonio Oliviero, Francesco Oliva, Nicola Maffulli
Summary: SiRNA can participate in the process of tendon healing and identify potential therapeutic targets. However, there is controversy over the regulation of genes and growth factors involved in tendon diseases and healing processes by siRNAs.
BRITISH MEDICAL BULLETIN
(2021)
Article
Multidisciplinary Sciences
Manabu Yoshikawa, Yong-Woon Han, Hirofumi Fujii, Shu Aizawa, Tatsuya Nishino, Masayuki Ishikawa
Summary: In plants, siRNAs are amplified through cleavage by RISCs and play a crucial role in target repression. RDR6, SGS3, and SDE5 work together to ensure the specificity and efficiency of siRNA amplification and target inhibition in plants.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemical Research Methods
Jaewook Lee, Jang Hyuk Bang, Yeong Chae Ryu, Byeong Hee Hwang
Summary: SiRNA-7 has been identified as a potential therapeutic for triple-negative breast cancer by selectively inhibiting cell viability and reducing tumor growth in a xenograft mouse model. It targets cancer-related genes and shows minimal effects on normal cells. The strategy of using multiple suppressing small interfering RNAs also holds promise for treating diseases associated with gene overexpression.
BIOTECHNOLOGY JOURNAL
(2023)
Review
Cell Biology
Hara Kang, Yun Ji Ga, Soo Hyun Kim, Young Hoon Cho, Jung Won Kim, Chaeyeon Kim, Jung-Yong Yeh
Summary: RNA has become a revolutionary tool in battling emerging infectious diseases, particularly in response to the COVID-19 pandemic. RNAi therapeutics have shown potential in reducing disease-associated genes, and nucleic acid-based therapies have emerged as alternative treatments. However, there are obstacles to overcome in the use of siRNA-based antiviral therapies, including off-target effects and drug resistance.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Teresa Chioccarelli, Marina Migliaccio, Antonio Suglia, Francesco Manfrevola, Veronica Porreca, Nadia Diano, Sonia Errico, Silvia Fasano, Gilda Cobellis
Summary: The study demonstrates that early exposure to BPA can lead to sustained and site-specific accumulation of BPA in epididymal fat in adulthood, becoming a risk factor for reproductive endocrine pathways associated with ECS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Yue Che, Carolin Buddensieck, Peter Albers, Achim Lusch, Christian Winter, Robert Grosse Siemer, Andreas Hiester
Summary: The oncologic benefit of postchemotherapy residual tumor resection (RTR) in patients with germ cell tumors and elevated serum tumor markers (STMs) remains unclear. Analysis of the data showed that a preoperative serum level of AFP >= 30 mu g/l and viable cancer in the RTR specimens were significant predictors of relapse after first line chemotherapy. In addition, the prognosis of patients with elevated markers and surgery after second or later line therapy is poor regardless of the tumor marker levels.
JOURNAL OF UROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Alyssa C. Hill, Daniel van Leeuwen, Verena Schlosser, Alok Behera, Bogdan Mateescu, Jonathan Hall
Summary: RNA interference (RNAi) mediated by siRNA-3WJ, which is a fusion of siRNA with the phi29 3WJ motif, can enter the RNAi pathway through Dicer cleavage and achieve gene silencing. It has been found that siRNA-3WJs are effective even in Dicer-deficient or Argonaute 2-deficient cells, and they work best when the antisense strand of the siRNA duplex is positioned 5' of the 3WJ.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Jelena Rakocevic, Milan Dobric, Rada Vucic, Matija Furtula, Ivan Zaletel, Katarina Milutinovic, Ana Ilijevski, Milica Labudovic Borovic, Miloje Tomasevic, Milos Bajcetic
Summary: The PCSK9 enzyme interferes with LDL cholesterol metabolism. Inhibiting PCSK9 lowers LDL cholesterol levels. Monoclonal antibodies targeting PCSK9 have shown strong and persistent effects, but require frequent subcutaneous injections. Inclisiran, a synthesized siRNA, inhibits PCSK9 synthesis and provides sustained LDL cholesterol lowering with twice-yearly applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Qianqian Fan, Zhen Yang, Yuhan Li, Yiyun Cheng, Yiwen Li
Summary: This study designed and synthesized a family of cationic polycatechols for siRNA delivery, which showed enhanced siRNA binding capability and influenced the delivery efficiency. The results demonstrate that these polycatechols could be developed as a promising class of siRNA delivery systems for gene therapy.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Pathology
Yan Zhou, Aimi Rothrock, Paari Murugan, Faqian Li, Lihong Bu
Summary: PRAME preferentially expresses in pure seminomas or the seminomatous component of mixed GCT, making it a potential diagnostic marker for seminomas.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Review
Medicine, General & Internal
Giuseppe Gargano, Giovanni Asparago, Filippo Spiezia, Francesco Oliva, Nicola Maffulli
Summary: Small interfering RNAs (siRNAs) have potential therapeutic applications in osteoporosis and can be used to study metabolic processes and identify new drug targets. However, it is challenging to predict the in vivo response of siRNAs and drugs based on in vitro studies.
BRITISH MEDICAL BULLETIN
(2023)
Article
Oncology
Tetsuya Yoshida, Susumu Kageyama, Takahiro Isono, Takeshi Yuasa, Ryoji Kushima, Akihiro Kawauchi, Tokuhiro Chano
Review
Biochemistry & Molecular Biology
Susumu Kageyama, Hiromi Ii, Keiko Taniguchi, Shigehisa Kubota, Tetsuya Yoshida, Takahiro Isono, Tokuhiro Chano, Taku Yoshiya, Kosei Ito, Tatsuhiro Yoshiki, Akihiro Kawauchi, Susumu Nakata
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Review
Biochemistry & Molecular Biology
Tokuhiro Chano, Sofia Avnet
JOURNAL OF BIOCHEMISTRY
(2018)
Article
Oncology
Shiro Wakinoue, Tokuhiro Chano, Tsukuru Amano, Takahiro Isono, Fuminori Kimura, Ryoji Kushima, Takashi Murakami
Article
Oncology
Tsukuru Amano, Tokuhiro Chano, Takahiro Isono, Fuminori Kimura, Ryoji Kushima, Takashi Murakami
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Eiki Hanada, Susumu Kageyama, Ryosuke Murai, Shigehisa Kubota, Hiromi Ii, Susumu Nakata, Hiroko Kita, Akihiro Kawauchi, Tokuhiro Chano
ANTICANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Keiko Taniguchi, Hiromi Ii, Susumu Kageyama, Hiroko Takagi, Tokuhiro Chano, Akihiro Kawauchi, Susumu Nakata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Fumi Yoshino, Tsukuru Amano, Yajuan Zou, Jian Xu, Fuminori Kimura, Yoshio Furusho, Tokuhiro Chano, Takashi Murakami, Li Zhao, Naoki Komatsu
Article
Oncology
Hiroko Takagi, Hiromi Ii, Susumu Kageyama, Eiki Hanada, Keiko Taniguchi, Taku Yoshiya, Tokuhiro Chano, Akihiro Kawauchi, Susumu Nakata
ANTICANCER RESEARCH
(2019)
Article
Orthopedics
Michihito Ishizawa, Hidetoshi Okabe, Keiji Matsumoto, Shigeru Morimoto, Sinsuke Hukuda, Tokuhiro Chano
Summary: In schwannomas of the extremities showing target sign in T2-weighted images, histopathologically, the peripheral areas were suggested to be mucinous degeneration of the epineurium or perineurium, while the central areas were composed of truly neoplastic cells.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2021)
Article
Oncology
Shigehisa Kubota, Tetsuya Yoshida, Susumu Kageyama, Takahiro Isono, Takeshi Yuasa, Junji Yonese, Ryoji Kushima, Akihiro Kawauchi, Tokuhiro Chano
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Tsukuru Amano, Atsushi Murakami, Takashi Murakami, Tokuhiro Chano
Summary: Ovarian clear cell carcinomas (OCCCs) are resistant to conventional anti-cancer drugs and often arise from endometriosis associated with strong oxidative stress. The oxidative stress tolerance properties are involved in the survival and cancer stemness of OCCC cells. Therapeutic approaches need improvement, with multi-combinatorial treatments expected to improve patient outcomes.
Review
Health Care Sciences & Services
Tsukuru Amano, Tokuhiro Chano, Fumi Yoshino, Fuminori Kimura, Takashi Murakami
Article
Oncology
Sofia Avnet, Tokuhiro Chano, Annamaria Massa, Gloria Bonuccelli, Silvia Lemma, Luigi Falzetti, Giulia Grisendi, Massimo Dominici, Nicola Baldini
AMERICAN JOURNAL OF CANCER RESEARCH
(2019)
Article
Oncology
Takahiro Isono, Tokuhiro Chano, Tetsuya Yoshida, Ai Makino, Shohei Ishida, Masafumi Suzaki, Susumu Kageyama, Akihiro Kawauchi, Junji Yonese, Takeshi Yuasa
AMERICAN JOURNAL OF CANCER RESEARCH
(2019)
