Chemically Synthesized, Self‐Assembling Small Interfering RNA‐Prohead RNA Molecules Trigger Dicer‐Independent Gene Silencing

Lumasiran: First Approval

(2021) Lesley J. Scott et al.   DRUGS

Rational design for controlled release of Dicer-substrate siRNA harbored in phi29 pRNA-based nanoparticles

(2021) Daniel W. Binzel et al.   Molecular Therapy-Nucleic Acids

Givosiran: First Approval

(2020) Lesley J. Scott   DRUGS

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

The current state and future directions of RNAi-based therapeutics

(2019) Ryan L. Setten et al.   NATURE REVIEWS DRUG DISCOVERY

Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines

(2018) David Porciani et al.   Nature Communications

RNA Interference-Mediated Gene Silencing by Branched Tripodal RNAs Does Not Require Dicer Processing

(2018) Yanghee Kim et al.   Nucleic Acid Therapeutics

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression

(2018) Yi Xu et al.   Redox Biology

Dicer-independent processing of small RNA duplexes: mechanistic insights and applications

(2017) Elena Herrera-Carrillo et al.   NUCLEIC ACIDS RESEARCH

Human Argonaute3 has slicer activity

(2017) Mi Seul Park et al.   NUCLEIC ACIDS RESEARCH

Thermodynamic stabilities of three-way junction nanomotifs in prohead RNA

(2017) Alyssa C. Hill et al.   RNA

Overcoming Tamoxifen Resistance of Human Breast Cancer by Targeted Gene Silencing Using Multifunctional pRNA Nanoparticles

(2016) Yijuan Zhang et al.   ACS Nano

5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates

(2016) Rubina Parmar et al.   CHEMBIOCHEM

Three-way junction conformation dictates self-association of phage packaging RNAs

(2016) Yumeng Hao et al.   RNA Biology

Prohead RNA: a noncoding viral RNA of novel structure and function

(2016) Alyssa C. Hill et al.   Wiley Interdisciplinary Reviews-RNA

Hepatocyte-Specific Delivery of siRNAs Conjugated to Novel Non-nucleosidic TrivalentN-Acetylgalactosamine Elicits Robust Gene Silencing in Vivo

(2015) Kallanthottathil G. Rajeev et al.   CHEMBIOCHEM

Properties of short double-stranded RNAs carrying randomized base pairs: toward better controls for RNAi experiments

(2015) Julian A. Zagalak et al.   RNA

RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model

(2015) Tae Jin Lee et al.   Oncotarget

Regression of Gastric Cancer by Systemic Injection of RNA Nanoparticles Carrying both Ligand and siRNA

(2015) Daxiang Cui et al.   Scientific Reports

Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles

(2014) Kirill A. Afonin et al.   ACS Nano

Entropy-Driven One-Step Formation of Phi29 pRNA 3WJ from Three RNA Fragments

(2014) Daniel W. Binzel et al.   BIOCHEMISTRY

Efficient intracellular delivery and multiple-target gene silencing triggered by tripodal RNA based nanoparticles: A promising approach in liver-specific RNAi delivery

(2014) S. Sajeesh et al.   JOURNAL OF CONTROLLED RELEASE

Multifunctional RNA Nanoparticles

(2014) Kirill A. Afonin et al.   NANO LETTERS

Derivation and characterization of Dicer- and microRNA-deficient human cells

(2014) H. P. Bogerd et al.   RNA

RNA interference-mediated simultaneous silencing of four genes using cross-shaped RNA

(2013) Tae Yeon Lee et al.   MOLECULES AND CELLS

Argonaute2 expression is post-transcriptionally coupled to microRNA abundance

(2013) N. J. Martinez et al.   RNA

Enhanced intracellular delivery and multi-target gene silencing triggered by tripodal RNA structures

(2012) Chan Il Chang et al.   JOURNAL OF GENE MEDICINE

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

(2012) Anne Dallas et al.   NUCLEIC ACIDS RESEARCH

Branched, Tripartite-Interfering RNAs Silence Multiple Target Genes with Long Guide Strands

(2012) Chan Il Chang et al.   Nucleic Acid Therapeutics

Branched RNA nanostructures for RNA interference

(2011) Yuko Nakashima et al.   CHEMICAL COMMUNICATIONS

Different Sequences Show Similar Quaternary Interaction Stabilities in Prohead Viral RNA Self-assembly

(2011) Xiaobo Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly of Therapeutic pRNA-siRNA Nanoparticles Using Bipartite Approach

(2011) Yi Shu et al.   MOLECULAR THERAPY

Self-Assembling RNA Nanorings Based on RNAI/II Inverse Kissing Complexes

(2011) Wade W. Grabow et al.   NANO LETTERS

Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics

(2011) Dan Shu et al.   Nature Nanotechnology

RNAstructure: software for RNA secondary structure prediction and analysis

(2010) Jessica S Reuter et al.   BMC BIOINFORMATICS

Application of Phi29 Motor pRNA for Targeted Therapeutic Delivery of siRNA Silencing Metallothionein-IIA and Survivin in Ovarian Cancers

(2010) Pheruza Tarapore et al.   MOLECULAR THERAPY

The emerging field of RNA nanotechnology

(2010) Peixuan Guo   Nature Nanotechnology

Targeted delivery of anti-coxsackievirus siRNAs using ligand-conjugated packaging RNAs

(2009) Huifang M. Zhang et al.   ANTIVIRAL RESEARCH