Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity
出版年份 2015 全文链接
标题
Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity
作者
关键词
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出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 19, Pages E2467-E2476
出版商
Proceedings of the National Academy of Sciences
发表日期
2015-04-01
DOI
10.1073/pnas.1422934112
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A Common Cancer-Associated DNA Polymerase Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading
- (2014) D. P. Kane et al. CANCER RESEARCH
- Replicative DNA polymerase mutations in cancer
- (2014) Ellen Heitzer et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Polymerase Proofreading-Associated Polyposis
- (2014) James M. Church DISEASES OF THE COLON & RECTUM
- DNA Replication Error-Induced Extinction of Diploid Yeast
- (2014) A. J. Herr et al. GENETICS
- Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication
- (2014) Eve Shinbrot et al. GENOME RESEARCH
- New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis
- (2014) Laura Valle et al. HUMAN MOLECULAR GENETICS
- Proper functioning of the GINS complex is important for the fidelity of DNA replication in yeast
- (2014) Ewa Grabowska et al. MOLECULAR MICROBIOLOGY
- The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology
- (2013) O. D. Abaan et al. CANCER RESEARCH
- Human Pol ɛ-dependent replication errors and the influence of mismatch repair on their correction
- (2013) Anderson Ayuk Agbor et al. DNA REPAIR
- Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools
- (2013) A. Gupta et al. GENETICS
- Emergence of DNA Polymerase Antimutators That Escape Error-Induced Extinction in Yeast
- (2013) L. N. Williams et al. GENETICS
- DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer
- (2013) David N. Church et al. HUMAN MOLECULAR GENETICS
- A Substitution in the Fingers Domain of DNA Polymerase δ Reduces Fidelity by Altering Nucleotide Discrimination in the Catalytic Site
- (2013) Marc J. Prindle et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Germline and somatic polymerase ϵ and δ mutations define a new class of hypermutated colorectal and endometrial cancers
- (2013) Sarah Briggs et al. JOURNAL OF PATHOLOGY
- Use of Quantitative Mass Spectrometric Analysis to Elucidate the Mechanisms of Phospho-priming and Auto-activation of the Checkpoint Kinase Rad53in Vivo
- (2013) Eric S.-W. Chen et al. MOLECULAR & CELLULAR PROTEOMICS
- Effect of dNTP pool alterations on fidelity of leading and lagging strand DNA replication in E. coli
- (2013) Damian Gawel et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Integrated genomic characterization of endometrial carcinoma
- (2013) Gad Getz et al. NATURE
- Signatures of mutational processes in human cancer
- (2013) Ludmil B. Alexandrov et al. NATURE
- The burden of faulty proofreading in colon cancer
- (2013) Somasekar Seshagiri NATURE GENETICS
- Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence
- (2013) Katherine M. Aird et al. Cell Reports
- Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype
- (2012) Marta B Davidson et al. EMBO JOURNAL
- Recurrent R-spondin fusions in colon cancer
- (2012) Somasekar Seshagiri et al. NATURE
- Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
- (2012) Claire Palles et al. NATURE GENETICS
- Lesion bypass by S. cerevisiae Pol ζ alone
- (2011) Jana E. Stone et al. DNA REPAIR
- AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis
- (2011) Rob U. Onyenwoke et al. MOLECULAR BIOLOGY OF THE CELL
- Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli
- (2011) S. Gon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutator Suppression and Escape from Replication Error–Induced Extinction in Yeast
- (2011) Alan J. Herr et al. PLoS Genetics
- Ixr1 Is Required for the Expression of the Ribonucleotide Reductase Rnr1 and Maintenance of dNTP Pools
- (2011) Olga Tsaponina et al. PLoS Genetics
- Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase
- (2010) H. Niida et al. GENES & DEVELOPMENT
- Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint
- (2010) Dinesh Kumar et al. NUCLEIC ACIDS RESEARCH
- Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools
- (2010) D. Kumar et al. NUCLEIC ACIDS RESEARCH
- The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage
- (2010) Bethany L. Andreson et al. NUCLEIC ACIDS RESEARCH
- Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases
- (2010) S. A. Nick McElhinny et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Participation of DNA Polymerase in Replication of Undamaged DNA in Saccharomyces cerevisiae
- (2009) M. R. Northam et al. GENETICS
- Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ
- (2009) Michael K Swan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A cancer-associated DNA polymerase variant modeled in yeast causes a catastrophic increase in genomic instability
- (2009) D. L. Daee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA polymerase and proofreading suppress discrete mutator and cancer phenotypes in mice
- (2009) T. M. Albertson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae
- (2008) Ewa T. Lis et al. DNA REPAIR
- Dif1 Controls Subcellular Localization of Ribonucleotide Reductase by Mediating Nuclear Import of the R2 Subunit
- (2008) X. Wu et al. MOLECULAR AND CELLULAR BIOLOGY
- Differential Regulation of the Cellular Response to DNA Double-Strand Breaks in G1
- (2008) Jacqueline H. Barlow et al. MOLECULAR CELL
- Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
- (2008) Nasim Sabouri et al. NUCLEIC ACIDS RESEARCH
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