Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression

Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor α-positive breast cancer

(2014) N Andruska et al.   ONCOGENE

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

(2013) Gabriel Leprivier et al.   CELL

Phase II study of fulvestrant 250mg/month in patients with recurrent or metastatic endometrial cancer: A study of the Arbeitsgemeinschaft Gynäkologische Onkologie

(2013) Günter Emons et al.   GYNECOLOGIC ONCOLOGY

Structure-based Discovery of Antagonists of Nuclear Receptor LRH-1

(2013) Cindy Benod et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response

(2012) H. Wong et al.   CLINICAL CANCER RESEARCH

Src Inhibition with Saracatinib Reverses Fulvestrant Resistance in ER-Positive Ovarian Cancer Models In Vitro and In Vivo

(2012) F. Simpkins et al.   CLINICAL CANCER RESEARCH

Hazard of Breast Cancer-Specific Mortality among Women with Estrogen Receptor-Positive Breast Cancer after Five Years from Diagnosis: Implication for Extended Endocrine Therapy

(2012) Ke-Da Yu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

Estrogen Regulates Hepcidin Expression via GPR30-BMP6-Dependent Signaling in Hepatocytes

(2012) Yasumasa Ikeda et al.   PLoS One

SH2D4A regulates cell proliferation via the ERα/PLC-γ/PKC pathway

(2011) Tingting Li et al.   BMB Reports

The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation

(2011) A Y Ali et al.   ONCOGENE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells

(2010) Paul T. R. Thiruchelvam et al.   BREAST CANCER RESEARCH AND TREATMENT

Reduced Dose and Intermittent Treatment with Lapatinib and Trastuzumab for Potent Blockade of the HER Pathway in HER2/neu-Overexpressing Breast Tumor Xenografts

(2010) Mothaffar F. Rimawi et al.   CLINICAL CANCER RESEARCH

A Noncompetitive Small Molecule Inhibitor of Estrogen-regulated Gene Expression and Breast Cancer Cell Growth That Enhances Proteasome-dependent Degradation of Estrogen Receptor α

(2010) Nicole M. Kretzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

(2009) Sandra J.M. Healy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY