Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity

RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth

(2015) Kathleen A. Wilson-Edell et al.   Oncotarget

Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability

(2015) Tae-Hyung Kim et al.   Oncotarget

Advances in the treatment of hematologic malignancies using immunoconjugates

(2014) M. C. Palanca-Wessels et al.   BLOOD

Immunotoxins for leukemia

(2014) A. S. Wayne et al.   BLOOD

L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way

(2014) Anupama Narla et al.   BRITISH JOURNAL OF HAEMATOLOGY

Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front-line therapy of pleural mesothelioma and correlation of tumor response with serum mesothelin, megakaryocyte potentiating factor, and cancer antigen

(2014) Raffit Hassan et al.   CANCER

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia

(2014) Anna Aspesi et al.   GENE

Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer

(2014) Y. Peng et al.   JOURNAL OF NEUROSCIENCE

Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling

(2014) B. Dave et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pair-wise comparison analysis of differential expression of mRNAs in early and advanced stage primary colorectal adenocarcinomas

(2014) T. P. Lau et al.   BMJ Open

Cytolethal Distending Toxins Require Components of the ER-Associated Degradation Pathway for Host Cell Entry

(2014) Aria Eshraghi et al.   PLoS Pathogens

The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol

(2013) Monika Słomińska-Wojewódzka et al.   BIOCHEMICAL JOURNAL

A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of theWDR85Gene

(2013) Hui Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A CREB3–ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens

(2013) Jan H. Reiling et al.   NATURE CELL BIOLOGY

The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network

(2013) Shanow Uthman et al.   PLoS Genetics

Insights into Diphthamide, Key Diphtheria Toxin Effector

(2013) Wael Abdel-Fattah et al.   Toxins

Immunotoxins: The Role of the Toxin

(2013) Antonella Antignani et al.   Toxins

Antibody-Drug Conjugates in Cancer Therapy

(2012) Eric L. Sievers et al.   Annual Review of Medicine

SLC33A1/AT-1 Protein Regulates the Induction of Autophagy Downstream of IRE1/XBP1 Pathway

(2012) Mariana Pehar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

(2012) Arvin C. Dar et al.   NATURE

Cytosolic Entry of Shiga-Like Toxin A Chain from the Yeast Endoplasmic Reticulum Requires Catalytically Active Hrd1p

(2012) Shuyu Li et al.   PLoS One

Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy

(2012) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of Hematologic Malignancies with Immunotoxins and Antibody-Drug Conjugates

(2011) D. J. FitzGerald et al.   CANCER RESEARCH

Genome-Wide RNAi Screens Identify Genes Required for Ricin and PE Intoxications

(2011) Dimitri Moreau et al.   DEVELOPMENTAL CELL

A guide to taming a toxin - recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer

(2011) John E. Weldon et al.   FEBS Journal

Several ADP-ribosylation Factor (Arf) Isoforms Support COPI Vesicle Formation

(2011) Vincent Popoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RPL36 as a prognostic marker in hepatocellular carcinoma

(2011) Myeong Jun Song et al.   PATHOLOGY INTERNATIONAL

Eeyarestatin 1 Interferes with Both Retrograde and Anterograde Intracellular Trafficking Pathways

(2011) Mina-Olga Aletrari et al.   PLoS One

Vigilance and Validation: Keys to Success in RNAi Screening

(2010) Frederic D. Sigoillot et al.   ACS Chemical Biology

In VitroActivities of the Multifunctional RNA Silencing Polymerase QDE-1 ofNeurospora crassa

(2010) Antti P. Aalto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diphthamide biosynthesis requires an organic radical generated by an iron–sulphur enzyme

(2010) Yang Zhang et al.   NATURE

Characterization of a Chinese Hamster Ovary Cell Mutant Having a Mutation in Elongation Factor-2

(2010) Pradeep K. Gupta et al.   PLoS One

The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound with a Membrane-Binding Domain and a p97/VCP Inhibitory Group

(2010) Qiuyan Wang et al.   PLoS One

Cholera Toxin: An Intracellular Journey into the Cytosol by Way of the Endoplasmic Reticulum

(2010) Naomi L. B. Wernick et al.   Toxins

Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum

(2009) B. C. S. Cross et al.   JOURNAL OF CELL SCIENCE

Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

(2009) Frederic D. Bushman et al.   PLoS Pathogens

A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity

(2008) J. E. Weldon et al.   BLOOD

Differential Cellular Internalization of Anti-CD19 and -CD22 Immunotoxins Results in Different Cytotoxic Activity

(2008) X. Du et al.   CANCER RESEARCH

Inhibition of p97-dependent Protein Degradation by Eeyarestatin I

(2008) Qiuyan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STRING 8--a global view on proteins and their functional interactions in 630 organisms

(2008) L. J. Jensen et al.   NUCLEIC ACIDS RESEARCH