Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects

Rhesus monkey model for concurrent analyses of in vivo selectivity, pharmacokinetics and pharmacodynamics of aldosterone synthase inhibitors

(2015) Tian-Quan Cai et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Aldosterone Synthase Inhibitors as Promising Treatments for Mineralocorticoid Dependent Cardiovascular and Renal Diseases

(2014) Qingzhong Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Pyridyl- or Isoquinolinyl-Substituted Indolines and Indoles as Potent and Selective Aldosterone Synthase Inhibitors

(2014) Lina Yin et al.   JOURNAL OF MEDICINAL CHEMISTRY

LCI699, a Potent 11β-hydroxylase Inhibitor, Normalizes Urinary Cortisol in Patients With Cushing's Disease: Results From a Multicenter, Proof-of-Concept Study

(2013) Xavier Bertagna et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

(2013) Erik L. Meredith et al.   ACS Medicinal Chemistry Letters

Aldosterone synthase inhibition in humans

(2012) Michel Azizi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function

(2011) Matthew D. Taves et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of a Novel Aldosterone Synthase Inhibitor for Treatment of Primary Hypertension

(2011) David A. Calhoun et al.   CIRCULATION

Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors

(2011) René St-Jacques et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Aldosterone Synthase Inhibition With LCI699

(2010) Laurence Amar et al.   HYPERTENSION

BLOCKADE OF ALDOSTERONE PRODUCTION AS A NOVEL APPROACH TO THE MANAGEMENT OF HIGH BLOOD PRESSURE: EFFICACY AND TOLERABILITY OF THE ALDOSTERONE SYNTHASE INHIBITOR LCI699 IN PATIENTS WITH STAGE 1-2 HYPERTENSION

(2010) William B. White et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

(2010) Faiez Zannad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors

(2009) Daniel LaSala et al.   ANALYTICAL BIOCHEMISTRY

The mammalian mineralocorticoid receptor: tying down a promiscuous receptor

(2009) Elise P. Gomez-Sanchez   EXPERIMENTAL PHYSIOLOGY

Glucocorticoids Activate Cardiac Mineralocorticoid Receptors During Experimental Myocardial Infarction

(2009) Anastasia S. Mihailidou et al.   HYPERTENSION

Aldosterone and Angiotensin II Synergistically Stimulate Migration in Vascular Smooth Muscle Cells Through c-Src-Regulated Redox-Sensitive RhoA Pathways

(2008) A.C. Montezano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Corticotropin Tests for Hypothalamic-Pituitary- Adrenal Insufficiency: A Metaanalysis

(2008) Rasa Kazlauskaite et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Treatment of Adrenocorticotropin-Dependent Cushing’s Syndrome: A Consensus Statement

(2008) B. M. K. Biller et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM