A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines

Blocking of p38 and transforming growth factor β receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis

(2012) David Gárate et al.   ARTHRITIS AND RHEUMATISM

Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients

(2012) Dàlia Raϊch-Regué et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction — A comparative study of human clinical-applicable DC

(2011) Martine A. Boks et al.   CLINICAL IMMUNOLOGY

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients

(2011) N. Giannoukakis et al.   DIABETES CARE

The STATus of PD-L1 (B7-H1) on tolerogenic APCs

(2011) Tina L. Sumpter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLR2 signaling improves immunoregulation to prevent type 1 diabetes

(2011) Christophe M. Filippi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chemokine CXCL12 Uses CXCR4 and a Signaling Core Formed by Bifunctional Akt, Extracellular Signal-regulated Kinase (ERK)1/2, and Mammalian Target of Rapamycin Complex 1 (mTORC1) Proteins to Control Chemotaxis and Survival Simultaneously in Mature Dendritic Cells

(2011) Cristina Delgado-Martín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative study of clinical grade human tolerogenic dendritic cells

(2011) M Naranjo-Gómez et al.   Journal of Translational Medicine

Differential effects of monophosphoryl lipid A and cytokine cocktail as maturation stimuli of immunogenic and tolerogenic dendritic cells for immunotherapy

(2011) Dàlia Raïch-Regué et al.   VACCINE

Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis

(2010) R. A. Harry et al.   ANNALS OF THE RHEUMATIC DISEASES

Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis

(2010) Frederick Arce et al.   ARTHRITIS AND RHEUMATISM

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

(2010) S. Gregori et al.   BLOOD

Development of Dendritic Cell-Based Immunotherapy for Autoimmunity

(2010) Catharien M. U. Hilkens et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Tolerogenic Dendritic Cells Generated with Different Immunosuppressive Cytokines Induce Antigen-Specific Anergy and Regulatory Properties in Memory CD4 + T Cells

(2010) Honorio Torres-Aguilar et al.   JOURNAL OF IMMUNOLOGY

Tolerogenic Dendritic Cells Induce CD4+CD25hiFoxp3+ Regulatory T Cell Differentiation from CD4+CD25-/loFoxp3- Effector T Cells

(2010) H. Huang et al.   JOURNAL OF IMMUNOLOGY

GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms

(2010) Palash Bhattacharya et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells

(2009) Klára Sochorová et al.   CLINICAL IMMUNOLOGY

Induction of Treg by monocyte-derived DC modulated by vitamin D3or dexamethasone: Differential role for PD-L1

(2009) Wendy W. J. Unger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A

(2009) Caglar Cekic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR Triggering on Tolerogenic Dendritic Cells Results in TLR2 Up-Regulation and a Reduced Proinflammatory Immune Program

(2009) S. Chamorro et al.   JOURNAL OF IMMUNOLOGY

Tryptophan Deprivation Induces Inhibitory Receptors ILT3 and ILT4 on Dendritic Cells Favoring the Induction of Human CD4+CD25+ Foxp3+ T Regulatory Cells

(2009) M. Brenk et al.   JOURNAL OF IMMUNOLOGY

Dexamethasone transforms lipopolysaccharide-stimulated human blood myeloid dendritic cells into myeloid dendritic cells that prime interleukin-10 production in T cells

(2008) Brenda M. Bosma et al.   IMMUNOLOGY

LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells

(2008) A. E. Anderson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Migration of Dendritic Cell Subsets and their Precursors

(2007) Gwendalyn J. Randolph et al.   Annual Review of Immunology