The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling

Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking

(2011) Paul Mellor et al.   BIOCHEMICAL JOURNAL

Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signaling

(2011) L. Buitrago et al.   BLOOD

Role and regulation of phosphatidylinositol 3-kinase   in platelet integrin  2 1 signaling

(2011) A. Consonni et al.   BLOOD

Distinct Roles for Rap1b Protein in Platelet Secretion and Integrin αIIbβ3Outside-in Signaling

(2011) Guoying Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Pyk2–Vav1 complex is recruited to β3-adhesion sites to initiate Rho activation

(2009) Chunlei Gao et al.   BIOCHEMICAL JOURNAL

Genetic evidence for a predominant role of PI3K  catalytic activity in ITAM- and integrin-mediated signaling in platelets

(2009) I. Canobbio et al.   BLOOD

Protein-tyrosine kinase CAKβ/PYK2 is activated by binding Ca2+/calmodulin to FERM F2 α2 helix and thus forming its dimer

(2008) Takayuki Kohno et al.   BIOCHEMICAL JOURNAL

Identification of Fc RIIa as the ITAM-bearing receptor mediating  IIb 3 outside-in integrin signaling in human platelets

(2008) B. Boylan et al.   BLOOD

Analysis of Fyn function in hemostasis and  IIb 3-integrin signaling

(2008) K. B. Reddy et al.   JOURNAL OF CELL SCIENCE

Phosphoinositide 3-Kinase p110  Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

(2008) E. Ciraolo et al.   Science Signaling