The Syk-kinase inhibitor R406 impairs platelet activation and monocyte tissue factor expression triggered by heparin-PF4 complex directed antibodies

PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model

(2010) M. P. Reilly et al.   BLOOD

Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia

(2010) L. Rauova et al.   BLOOD

CLEC-2 activates Syk through dimerization

(2010) C. E. Hughes et al.   BLOOD

Spleen tyrosine kinases: biology, therapeutic targets and drugs

(2010) Mauro Riccaboni et al.   DRUG DISCOVERY TODAY

A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function

(2010) Hervé Falet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Standardization of platelet-derived microparticle enumeration by flow cytometry with calibrated beads: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop

(2010) R. LACROIX et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcγRIIa and the integrin β3 cytoplasmic domain

(2009) Cunji Gao et al.   JOURNAL OF CLINICAL INVESTIGATION

Thrombin generation and heparin-induced thrombocytopenia

(2009) B. TARDY-PONCET et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Heparin-induced thrombocytopenia

(2009) A. GREINACHER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets

(2009) J. C. SPALTON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Treatment of rheumatoid arthritis with a syk kinase inhibitor: A twelve-week, randomized, placebo-controlled trial

(2008) Michael E. Weinblatt et al.   ARTHRITIS AND RHEUMATISM

Identification of Fc RIIa as the ITAM-bearing receptor mediating  IIb 3 outside-in integrin signaling in human platelets

(2008) B. Boylan et al.   BLOOD

Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk

(2008) A. Podolanczuk et al.   BLOOD

Heparin-induced thrombocytopenia: a historical perspective

(2008) J. G. Kelton et al.   BLOOD