Article
Fisheries
Jie Sun, Qiuxin Yan, Zhihao Zhang, Ting Xu, Ye Gong, Weijia Li, Kangsen Mai, Qinghui Ai
Summary: Endoplasmic reticulum (ER) homeostasis is important in cell physiological functions and ER stress is often associated with inflammation. This study investigated the impact of Glucoseregulated protein 78 (GRP78) on ER stress and inflammation in large yellow croaker. The results showed that TG-induced ER stress and inflammation in macrophages could be attenuated by the overexpression of GRP78, while the inhibition of GRP78 further induced the ER stress and inflammation.
Review
Biochemistry & Molecular Biology
Dong-Oh Moon
Summary: This review provides a comprehensive analysis of the multifaceted role of calcium in apoptosis regulation, focusing on its associated signaling pathways and molecular mechanisms. It explores the impact of calcium on apoptosis through its effects on various cellular compartments and highlights its connection to ER stress. Additionally, it discusses the interplay between calcium and proteins such as calpains, calmodulin, and Bcl-2 family members, and its role in regulating caspase activation and pro-apoptotic factor release. Understanding the complex relationship between calcium and apoptosis is crucial for identifying potential treatment options for diseases associated with imbalanced cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Changsheng Yan, Yuan Ma, He Li, Jitao Cui, Xiaoyu Guo, Gang Wang, Liang Ji
Summary: The study aimed to investigate the role of endoplasmic reticulum stress (ERS) in promoting caspase-1-dependent pancreatic acinar cell pyroptosis via the protein kinase R-like ER kinase (PERK) pathway to aggravate acute pancreatitis (AP). Findings showed that ERS enhances caspase-1-dependent pyroptosis and pyroptotic injury through the PERK pathway, exacerbating AP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yiwei Xu, Jie Chen, Jianguo Chen, Junlin Teng
Summary: In endoplasmic reticulum stress, EI24 protein promotes cell adaptation to ER stress by coordinating the unfolded protein response and calcium signaling, thus playing a role in anti-apoptosis.
Article
Environmental Sciences
Sujuan Zhao, Chunyang Yuan, Xun Tuo, Chengfan Zhou, Qihong Zhao, Tong Shen
Summary: The study demonstrated that MCLR induced an increase in Ca2+ concentration in TM4 cells, leading to activation of apoptotic pathways. The use of the Ca2+ chelator Bapta-AM partially reversed MCLR-induced apoptosis, confirming the involvement of calcium homeostasis disruption. Additionally, MCLR activated the ER apoptotic pathway by activating caspase-12.
Article
Biology
Shunsuke Saito, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Kazutoshi Mori, David Ron
Summary: This study provides new evidence that aggregation-prone non-glycosylated Seipin activates ER stress and apoptosis through inactivating the major ER calcium pump SERCA2b, shedding light on the causal relationship between ER stress and neurodegenerative diseases.
Article
Cell Biology
Tamutenda Chidawanyika, Rajarshi Chakrabarti, Kathryn S. Beauchemin, Henry N. Higgs, Surachai Supattapone
Summary: The study found that SEC24A plays an important role in regulating Ca2+ flux between the endoplasmic reticulum and mitochondria, which impacts processes dependent on mitochondrial Ca2+ levels such as autophagy and apoptosis.
JOURNAL OF CELL SCIENCE
(2021)
Article
Immunology
Hong-Lei Wang, Fen-Qiao Chen, Li-Juan Wu
Summary: The study found that ephedrine has therapeutic effects on the development of chronic obstructive pulmonary disease (COPD). It can alleviate cell death, oxidative stress, and inflammatory response by reducing reactive oxygen species (ROS) levels. Additionally, ephedrine can suppress endoplasmic reticulum (ER) stress signaling and mitigate cigarette smoke-induced damage to cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hao Zhao, Yue Xu, Xinlei Song, Qingchen Zhang, Yajie Wang, Haiyan Yin, Xiaohui Bai, Jianfeng Li
Summary: The study aimed to investigate the mechanism(s) of cisplatin on auditory cells in vitro, focusing on the changes in calcium homeostasis and related channels. Cisplatin induced apoptosis in auditory cells through ER stress and mitochondrial pathway, accompanied by alterations in calcium homeostasis. Interestingly, IP3R dissociation from beclin-1 may play a role in autophagy activation under cisplatin insult.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Narjes Nasiri-Ansari, Chrysa Nikolopoulou, Katerina Papoutsi, Ioannis Kyrou, Christos S. Mantzoros, Georgios Kyriakopoulos, Antonios Chatzigeorgiou, Vassiliki Kalotychou, Manpal S. Randeva, Kamaljit Chatha, Konstantinos Kontzoglou, Gregory Kaltsas, Athanasios G. Papavassiliou, Harpal S. Randeva, Eva Kassi
Summary: This study demonstrates that empagliflozin treatment can reduce glucose, cholesterol, and triglyceride levels in NAFLD mice, decrease hepatic lipogenic and inflammatory gene expression, and attenuate NAFLD progression by promoting autophagy, reducing ER stress, and inhibiting apoptosis in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Hasan Simsek, Sefa Kucukler, Cihan Gur, Nurhan Akaras, Fatih Mehmet Kandemir
Summary: Lead acetate is a dangerous toxic heavy metal that can cause kidney damage in both humans and animals. Sinapic acid, a compound found in fruits and vegetables, has antioxidant, anti-inflammatory, and anticancer properties. This study used biochemical, molecular, and histological methods to investigate the effects of sinapic acid on lead acetate-induced nephrotoxicity in rats. The results showed that sinapic acid attenuated the kidney damage caused by lead acetate, improving renal function and reducing oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Hasan Simsek, Sefa Kucukler, Cihan Gur, Nurhan Akaras, Fatih Mehmet Kandemir
Summary: Sinapic acid (SNP) can attenuate lead acetate-induced nephrotoxicity by reducing oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Duc-Vinh Pham, Prakash Shrestha, Thi-Kem Nguyen, Junhyeung Park, Mahesh Pandit, Jae-Hoon Chang, Soo Young Kim, Dong-Young Choi, Sung Soo Han, Inho Choi, Gyu Hwan Park, Jee-Heon Jeong, Pil-Hoon Park
Summary: MSC3D enhances the survival and functional capabilities of MSCs by decreasing the activation of NLRP3 inflammasomes through alleviation of ER stress in an autophagy-dependent manner. Downregulation of NLRP3 inflammasome signaling plays a critical role in the enhanced therapeutic efficacy of MSC spheroids.
Article
Fisheries
Yi-Hong Chen, Bin-Bin Li, Jin-Quan Fan, Qian-Ming Hong, Ze-Yu Yan, Xin-Jun Yang, Ke-Cheng Lu, Guo-Liang Chen, Ming Li, Wen Huang
Summary: Endoplasmic reticulum (ER)-stress is an important cause of aquatic animal diseases. This study investigated the influence of ER-stress in Litopenaeus vannamei using RNA-Seq, and identified differentially expressed genes (DEGs) related to ER-stress, immune, and metabolism. The study also suggested that ER-stress might play an important role in the immune response of shrimp.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nicholas B. B. Gill, Presley D. D. Dowker-Key, Katelin Hubbard, Brynn H. H. Voy, Jay Whelan, Mark Hedrick, Ahmed Bettaieb
Summary: By 2050, it is estimated that at least 700 million people will need hearing therapy, while 2.5 billion will suffer from hearing loss. Sensorineural hearing loss (SNHL) is caused by the death of cochlear hair cells in the inner ear, resulting in the inability to convert fluid waves into neural electric signals. Phytochemicals, such as ginsenosides found in ginseng, have shown potential in treating SNHL due to their anti-inflammatory, antioxidant, and anti-apoptotic properties. In this study, the effects of ginsenoside Rc (G-Rc) on primary murine sensory hair cell survival were investigated, and the results demonstrated that G-Rc promoted cell survival, differentiation, and reduced inflammation, endoplasmic reticulum stress, and apoptosis. Further studies are needed to explore the molecular mechanisms of G-Rc as a potential adjuvant for SNHL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)