Review
Cardiac & Cardiovascular Systems
Norman R. Williams, Hannah Patrick, Francesca Fiorentino, Alexander Allen, Manuj Sharma, Misel Milosevic, Fergus Macbeth, Tom Treasure
Summary: The objective of this review was to assess the nature and tone of the published responses to the Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) randomized controlled trial. The study found that most of the citations did not adequately represent the PulMiCC data and the overall textual tone was dismissive. Despite the trial being underpowered, there was an acceptance that the 5-year survival rate was higher than widely assumed.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Letter
Oncology
Tim Batchelor, Jurjees Hasan, Fergus Macbeth, Michael Shackcloth, Tom Treasure
Summary: Pulmonary metastasectomy for sarcoma lacks proven benefits, and should be questioned in light of a randomized controlled trial in colorectal cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Severin Schmid, Heiko Becker, Ralph Fritsch, Johannes Bausch, Natalie Hunter, Carolin Jenkner, Mohamed Hassan, Bernward Passlick
Summary: This multicentre prospective randomised controlled trial aims to investigate the effects of pulmonary metastasectomy in patients with resectable pulmonary metastases from colorectal carcinoma. The study aims to demonstrate a difference in overall survival, as well as explore other endpoints such as quality of life and impact of mutational status. Designing well-powered trials in metastasised colorectal cancer has been challenging due to the heterogeneity and complexity of the disease and treatment trajectories.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hayley M. Fenton, Paul J. Finan, Richard Milton, Michael Shackcloth, John C. Taylor, Tom Treasure, Eva J. A. Morris
Summary: The study revealed significant variation in the rates of pulmonary metastasectomy for colorectal cancer across the English NHS and a 5-year survival rate of 50.8% following the surgery.
COLORECTAL DISEASE
(2021)
Article
Oncology
Martijn van Dorp, Constantia Trimbos, Wilhelmina H. Schreurs, Chris Dickhoff, David J. Heineman, Bart Torensma, Geert Kazemier, Frank J. C. van den Broek, Ben J. Slotman, Max Dahele
Summary: In this retrospective cohort study, pulmonary metastasectomy and SABR showed comparable overall survival, local recurrence-free survival, and complication rates in patients with colorectal pulmonary metastases, despite significantly lower progression-free survival and local control rates in the SABR group.
Article
Gastroenterology & Hepatology
Hong Xu, Raymond S. Y. Tang, Thomas Y. T. Lam, Guijun Zhao, James Y. W. Lau, Yunpeng Liu, Qi Wu, Long Rong, Weiran Xu, Xue Li, Sunny H. Wong, Shuntian Cai, Jing Wang, Guanyi Liu, Tantan Ma, Xiong Liang, Joyce W. Y. Mak, Hongzhi Xu, Peng Yuan, Tingting Cao, Fudong Li, Zhenshi Ye, Zhang Shutian, Joseph J. Y. Sung
Summary: This multicenter randomized controlled trial found that AI-assisted colonoscopy improves polyp detection and characterization in an asymptomatic population. AI-assisted colonoscopy can increase the adenoma detection rate and the detection ability of both expert and non-expert endoscopists.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Ju Sik Yun, Eunchong Kim, Kook Joo Na, Sang Yun Song, In Seok Jeong, Sang Gi Oh
Summary: This study confirms the effectiveness of thoracoscopic metastasectomy for colorectal cancer (CRC) and identifies several prognostic factors such as age, pathological stage, preoperative carcinoembryonic antigen level. Older age and prior extrathoracic metastasis are independent poor prognostic factors. Overall, VATS for pulmonary metastasectomy for CRC can be performed safely with comparable long-term survival rates to other studies.
Article
Integrative & Complementary Medicine
Andrew McCombie, Jennifer Jordan, Roger Mulder, Kishion Dee, Ee Lin Ong, Fernanda Fernandez Zimmermann, Chris Frampton, Frank Frizelle
Summary: This study aimed to compare the effectiveness of a 4-week group-based mindfulness intervention and a psychoeducation and cognitive behavioural skills learning support active control group in reducing psychological distress in colorectal cancer patients. The results showed that both interventions were associated with a reduction in depression symptoms at 8 weeks. However, the active control group had a greater improvement in generic mental quality of life scores at 8 weeks compared to the mindfulness group.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Erin M. Corsini, Kyle G. Mitchell, Arlene Correa, Van K. Morris, Mara B. Antonoff
Summary: Colorectal cancer location may affect survival after pulmonary metastasectomy, with patients with left-sided tumors experiencing a survival benefit. Additional research is needed to confirm these findings and assess the impact of tumor location on prognosis in patients eligible for pulmonary metastasectomy.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anu E. Obaro, Andrew A. Plumb, Steve Halligan, Susan Mallett, Paul Bassett, Paul McCoubrie, Rachel Baldwin-Cleland, Carmen Ugarte-Cano, Phillip Lung, Janice Muckian, Rajapandian Ilangovan, Arun Gupta, Charlotte Robinson, Antony Higginson, Ingrid Britton, Rebecca Greenhalgh, Uday Patel, Evgenia Mainta, Anmol Gangi, Stuart A. Taylor, David Burling
Summary: This study aimed to investigate the impact of a one-day individualized training program on the diagnostic sensitivity of experienced radiologists in detecting 6-mm or larger lesions in CT colonography (CTC) scans, as well as the durability of the improvement and any associated factors. The results showed that the training intervention led to a significant improvement in sensitivity, and this improvement was maintained at 6 and 12 months after the intervention.
Article
Surgery
Saba Balvardi, Nicolo Pecorelli, Tanya Castelino, Petru Niculiseanu, Mohsen Alhashemi, Alexander Sender Liberman, Patrick Charlebois, Barry Stein, Franco Carli, Nancy E. Mayo, Liane S. Feldman, Julio F. Fiore
Summary: This study aimed to assess the impact of staff-directed facilitation of early mobilization on postoperative recovery of pulmonary function and pulmonary complications after colorectal surgery. However, the results showed no significant difference in pulmonary function recovery or reduction in postoperative pulmonary complications between the two groups.
Article
Oncology
Gustavo C. L. Gossling, Marcio F. Chedid, Fernando S. Pereira, Rafaela K. da Silva, Leonardo B. Andrade, Nicolas Peruzzo, Mauricio G. Saueressig, Gilberto Schwartsmann, Aparna R. Parikh
Summary: This study aimed to identify clinicopathological and molecular features associated with progression-free survival (PFS) and overall survival (OS) after pulmonary metastasectomy for metastatic colorectal cancer. The findings suggest that disease-free interval, synchronous presentation, and number and size of lesions are significant prognostic factors for OS, while presenting with more than one lesion is predictive for PFS but not for OS.
Article
Gastroenterology & Hepatology
Timothy Yen, FeiFei Qin, Vandana Sundaram, Edgar Asiimwe, Tina Storage, Uri Ladabaum
Summary: The study found that using CCRAT risk assessment did not increase participation or intent for colorectal cancer screening. Risk stratification may motivate individuals classified as higher CRC risk to complete screening, but inadvertently discourage screening among those not identified as higher risk.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Woo Sik Yu, Mi Kyung Bae, Jung Kyu Choi, Young Ki Hong, In Kyu Park
Summary: The study aimed to investigate the prognostic factors for overall survival in patients who had undergone pulmonary metastasectomy for colorectal cancer. It found that pulmonary metastasectomy provided long-term survival for patients, with female sex, distally located colorectal cancer, and high-volume hospital centers being positive prognostic factors for survival.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
A. Bourmaud, Y. Benoist, F. Tinquaut, C. Allary, J. Ramone-Louis, M. Oriol, J. Kalecinski, V. Dutertre, N. Lechopier, M. Pommier, S. Rousseau, A. Dumas, P. Amiel, V. Regnier, V. Buthion, F. Chauvin
Summary: The objective of this study was to assess the effectiveness of a Patient Navigation Intervention targeting deprived patients for Colo-Rectal Cancer (CRC) screening participation. A cluster randomized controlled trial was conducted in 5 districts, with Peer Lay Patient Navigators recruited to operate in deprived areas. The intervention group showed a 23% increase in participation and a 26% reduction in time delay to participating. Factors modulating the effect of the intervention included closeness of navigator profiles to the targeted population, navigators' abilities to adapt their modus operandi, and facilitating attachment structure.
Article
Oncology
Lesley Fallowfield, Lucy Matthews, Shirley May, Valerie Jenkins, David Bloomfield
Article
Obstetrics & Gynecology
J. Barrett, V. Jenkins, V. Farewell, U. Menon, I. Jacobs, J. Kilkerr, A. Ryan, C. Langridge, L. Fallowfield
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2014)
Article
Oncology
Lesley Fallowfield, Lucy Matthews, Adele Francis, Valerie Jenkins, Daniel Rea
Article
Health Care Sciences & Services
Valerie Shilling, Rachel Starkings, Valerie Jenkins, David Cella, Lesley Fallowfield
QUALITY OF LIFE RESEARCH
(2018)
Article
Oncology
V. Jenkins, I. Solis-Trapala, H. Payne, M. Mason, L. Fallowfield, S. May, L. Matthews, S. Catt
Article
Health Policy & Services
Sebastian Hinde, Chloi Theriou, Shirley May, Lucy Matthew, Amy Arbon, Lesley Fallowfield, David Bloomfield
HEALTH POLICY AND TECHNOLOGY
(2019)
Article
Health Care Sciences & Services
Valerie Shilling, Rachel Starkings, Valerie Jenkins, David Cella, Lesley Fallowfield
QUALITY OF LIFE RESEARCH
(2019)
Article
Oncology
L. Fallowfield, I Solis-Trapala, R. Starkings, S. Catt, S. May, V Jenkins
BREAST CANCER RESEARCH AND TREATMENT
(2019)
Letter
Oncology
Fergus Macbeth, Dame Lesley Fallowfield
BRITISH JOURNAL OF CANCER
(2020)
Letter
Oncology
Lesley Fallowfield, Shirley May, Valerie Jenkins
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2020)
Article
Oncology
L. J. Fallowfield, D. Farewell, H. Jones, S. L. May, S. L. Catt, R. L. Starkings, V. L. Jenkins
Summary: Comparing knowledge levels of gene expression profiling (GEP) tests and recurrence risks after reading an information leaflet versus watching an information film, it was found that watching the film improved knowledge and was preferred by participants.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Lesley Fallowfield, Ivonne Solis-Trapala, Rachel Starkings, Shirley May, Lucy Matthews, Diana Eccles, D. Gareth Evans, Clare Turnbull, Gillian Crawford, Valerie Jenkins
Summary: This study developed and evaluated an educational workshop called TRUSTING, which aimed to improve healthcare professionals' ability to discuss the risks and uncertainties of genetic testing. The workshop significantly improved participants' knowledge, communication skills, and self-confidence.
BRITISH JOURNAL OF CANCER
(2022)
Article
Medicine, Research & Experimental
Sally Wheelwright, Lucy Matthews, Valerie Jenkins, Shirley May, Daniel Rea, Pat Fairbrother, Claire Gaunt, Jennie Young, Sarah Pirrie, Matthew G. Wallis, Lesley Fallowfield
Summary: Recruitment to the LORIS study was challenging despite strategies aimed at both patients and site staff. The most common reasons for accepting randomisation were altruism and belief in the trial's efficacy, while concerns about randomisation and external influences were the most frequent reasons for declining. Communication workshops improved site staff knowledge and confidence, but only half said they would participate in the study themselves.
Article
Oncology
James Dilley, Aleksandra Gentry-Maharaj, Andy Ryan, Matthew Burnell, Ranjit Manchanda, Jatinderpal Kalsi, Naveena Singh, Robert Woolas, Aarti Sharma, Karin Williamson, Tim Mould, Lesley Fallowfield, Stuart Campbell, Steven J. Skates, Alistair McGuire, Mahesh Parmar, Ian Jacobs, Usha Menon
Summary: This study aims to compare symptoms in pre-clinical and clinically diagnosed early-stage cancers. The results suggest that early symptoms of early-stage cancer may be related to gastrointestinal issues and systemic fatigue, indicating the need to reconsider alert symptoms for early ovarian cancer.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Usha Menon, Aleksandra Gentry-Maharaj, Matthew Burnell, Andy Ryan, Naveena Singh, Ranjit Manchanda, Jatinderpal K. Kalsi, Robert Woolas, Rupali Arora, Laura Casey, Anne Dawnay, Aarti Sharma, Karin Williamson, Sophia Apostolidou, Lesley Fallowfield, Alistair J. Mcguire, Stuart Campbell, Steven J. Skates, Ian J. Jacobs, Mahesh K. B. Parmar
Summary: This article presents the results of the UKCTOCS study, which found that screening can detect high-grade serous cancer at earlier stages and potentially improve short-term treatment outcomes. However, the potential survival benefit for patients with high-grade serous cancer was small, likely due to limited gains in early detection and treatment improvement, as well as tumor biology.
