Article
Chemistry, Physical
Shuang Gao, Xiaoming Li, Jingyu Jiang, Lixia Zhao, Ying Fu, Fei Ye
Summary: The electrospun thiophanate methyl/hydroxypropyl-beta-cyclodextrin (TM/HP β CD) inclusion complex nanofibers demonstrated enhanced water solubility, thermal stability, and antifungal activity, offering potential for environmentally safe application of thiophanate methyl (TM).
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Applied
Hao Yin, Chenxiao Wang, Jin Yue, Yun Deng, Shunshan Jiao, Yanyun Zhao, Jie Zhou, Ting Cao
Summary: In this study, cyclodextrin was used to encapsulate 1,8-cineole to enhance the thermal stability of essential oils. The optimal conditions for encapsulation were identified using the response surface methodology, and the release behavior and kinetics of the inclusion complexes were investigated.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Medicinal
Emma Adriana Ozon, Marian Novac, Daniela Gheorghe, Adina Magdalena Musuc, Mirela Adriana Mitu, Iulian Sarbu, Valentina Anuta, Adriana Rusu, Simona Petrescu, Irina Atkinson, Dumitru Lupuliasa
Summary: The novelty of this study lies in the development of new orodispersible tablets containing nifedipine as the active ingredient. The study successfully prepared inclusion complexes of nifedipine with two derivatives of beta-cyclodextrin and analyzed their physicochemical properties. Orodispersible tablets containing the inclusion complexes were also successfully manufactured.
Article
Pharmacology & Pharmacy
Maria Elena Gamboa-Arancibia, Nelson Caro, Alexander Gamboa, Javier Octavio Morales, Jorge Enrique Gonzalez Casanova, Diana Marcela Rojas Gomez, Sebastian Miranda-Rojas
Summary: This study aims to increase the solubility and stability of lurasidone hydrochloride, a drug used for treating schizophrenia and bipolar depression, by forming higher-order inclusion complexes with hydroxypropyl-beta-cyclodextrin. The results show that the formation of inclusion complexes significantly increases the solubility of the drug, which is proportional to the inclusion ratio. Additionally, the drug's crystalline state is transformed into an amorphous state, enhancing its stability. Therefore, the formation of higher-order inclusion complexes is a successful strategy to improve the solubility and stability of lurasidone hydrochloride.
Article
Food Science & Technology
Dan Shen, Xia Chang, Liling Zhou, Dandan Hao, Zhongxiang Fang, Yang Shan, Lvhong Huang, Gaoyang Li
Summary: In this study, an inclusion complex of citral within hydroxypropyl-beta-cyclodextrin was prepared using ultrasound technique. The complex showed improved thermal stability and antifungal properties. Additionally, treatment with the complex effectively extended the shelf life of strawberries.
Article
Chemistry, Physical
Thi Lan Pham, T. R. Usacheva, D. A. Alister, Thi Thu Ha Nguyen, N. V. Tukumova, N. N. Kuranova, Xuan Minh Vu, Thi My Hanh Le, Quang Tung Nguyen, Dai Lam Tran
Summary: The thermodynamic parameters of the complexation between rutin and hydroxypropyl-beta-cyclodextrin in water-ethanol solvents were investigated. The stability of the complex decreased with increasing ethanol concentration, and the change in Gibbs energy was primarily influenced by the enthalpy factor. The effect of different solvents showed that water had a greater impact on the interaction between rutin and hydroxypropyl-beta-cyclodextrin.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biophysics
Yuanfang Li, Jinhua Zhou, Jiaxuan Gu, Qingqing Shao, Yong Chen
Summary: This study confirmed the enhanced antibacterial activity of levofloxacin when included in hydroxypropyl-beta-cyclodextrin (HPβCD). The research also explored the potential application of HPβCD as a chiral selector or drug nanocarrier for levofloxacin in antibacterial therapies.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
Nutsarun Wangsawangrung, Chasuda Choipang, Sonthaya Chaiarwut, Pongpol Ekabutr, Orawan Suwantong, Piyachat Chuysinuan, Supanna Techasakul, Pitt Supaphol
Summary: This study developed a polyvinyl alcohol hydrogel loaded with quercetin/cyclodextrin inclusion complex, which demonstrated enhanced stability and solubility. The hydrogel showed biocompatibility with cells and exhibited higher antioxidant activity compared to free quercetin. It can be considered as a delivery system for wound-healing applications.
Article
Thermodynamics
Dzhovidon Kabirov, Teresa Silvestri, Marcella Niccoli, Tatiana Usacheva, Laura Mayol, Marco Biondi, Concetta Giancola
Summary: This study investigates the formation of inclusion complexes between the semisynthetic hydroxypropyl-beta-cyclodextrin (HPβCD) and CURC. Various experimental conditions were tested to evaluate the formation, stability, and efficacy of the complexes.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Engineering, Chemical
Abdul Ahad, Yousef A. Bin Jardan, Mohammad Raish, Abdullah M. Al-Mohizea, Fahad Al-Jenoobi
Summary: The aim of this study was to enhance the solubility and dissolution rate of sinapic acid (SA) by formulating a binary inclusion complex with hydroxypropyl-beta-cyclodextrin (HP beta CD) using solvent evaporation technology. The results showed that the inclusion complex significantly improved the solubility of SA and exhibited stronger antioxidant activity compared to pure SA.
Article
Green & Sustainable Science & Technology
Shuang Gao, Lei Zong, Yuhang Zhang, Yang Zhang, Xinyu Guo, Guanhua Guo, Lixia Zhao, Fei Ye, Ying Fu
Summary: Pentachloronitrobenzene/hydroxypropyl-γ-cyclodextrin inclusion complex nanofibers (PCNB/HPfiCDIC-NF) were prepared via polymer-free electrospinning to establish a rapidly dissolving water-based drug delivery system. The formation of PCNB/HPfiCD-IC enhanced the water solubility and thermal stability of PCNB. The antifungal activity of PCNB/HPfiCD-ICNF was 2.13 times higher than that of pure PCNB. The formulation of PCNB/HPfiCD-IC-NF could effectively improve the solvability, thermal stability, and antifungal activity of PCNB.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Biophysics
Shuang Gao, Yanyan Liu, Jingyu Jiang, Xiaoming Li, Fei Ye, Ying Fu, Lixia Zhao
Summary: The study successfully prepared thiram/HP/3CD-ICNF nanofiber through electrospinning, establishing a quick dissolving drug delivery system. The system showed improved water solubility, thermal stability, and antifungal activity, contributing to the development of rapidly dissolving green pesticides.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Nan Liu, Huan-Ping Chen, Zi-Meng Yang, Ming-Yu Xia, Dong Wang, Ling-He Zang, Dong-Chun Liu
Summary: This study demonstrates that the inclusion complex of resibufogenin with beta-cyclodextrin and 2-hydroxypropyl-beta-cyclodextrin has improved solubility and retained antitumor activity, with less gastric mucosa irritation. This complex could be a promising strategy for delivering poorly water-soluble anticancer agents like resibufogenin.
Article
Chemistry, Applied
Changyue Deng, Chuan Cao, Yingying Zhang, Jingwei Hu, Yongqiang Gong, Mingming Zheng, Yibin Zhou
Summary: The formation and stabilization mechanisms of inclusion complexes between beta-cyclodextrin and five C10 aroma molecules were investigated using experimental methods and molecular dynamics simulation. The inclusion complexes had a new crystal structure and better thermal stability. The aroma molecules induced conformational changes in the inclusion complexes, with van der Waals interactions being the main driving force for their spontaneous entry into the cavity.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Applied
Xiaohui Xi, Jialing Huang, Shengyang Zhang, Qian Lu, Zhengfeng Fang, Cheng Li, Qing Zhang, Yuntao Liu, Hong Chen, Aiping Liu, Shuxiang Liu, Caixia Wang, Shanshan Li, Bin Hu
Summary: This study prepared the inclusion complex (IC) of nutmeg essential oil (NEO) with 2-hydroxypropyl ss-cyclodextrin (HP-ss-CD) by the coprecipitation method, overcoming the poor stability and low aqueous solubility of NEO in food. The optimal conditions were an inclusion temperature of 36 degrees C, time of 247 min, stirring speed of 520 r/min, and wall-core ratio of 12:1, resulting in a recovery of 80.63%. The formation of IC was confirmed by various techniques, and it was found that encapsulation improved the thermal stability, antioxidant, and nitrite scavenging activities of NEO. Moreover, the release of NEO from IC can be controlled by regulating the temperature and relative humidity. Overall, NEO/HP-ss-CD IC has great potential for application in the food industry.
Article
Chemistry, Inorganic & Nuclear
N. V. Chizhova, O. V. Mal'tseva, R. S. Kumeev, N. Zh. Mamardashvili
RUSSIAN JOURNAL OF INORGANIC CHEMISTRY
(2018)
Article
Chemistry, Physical
V. A. Golubev, D. L. Gurina, R. S. Kumeev
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A
(2018)
Article
Engineering, Biomedical
A. Grzeczkowicz, J. Gruszczynska-Biegala, M. Czeredys, A. Kwiatkowska, M. Strawski, M. Szklarczyk, M. Kozbial, J. Kuznicki, L. H. Granicka
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Article
Chemistry, Physical
Mikhail Agafonov, Tatyana Volkova, Roman Kumeev, Ekaterina Chibunova, Irina Terekhova
JOURNAL OF MOLECULAR LIQUIDS
(2019)
Article
Chemistry, Applied
Iliya Kritskiy, Tatyana Volkova, Artem Surov, Irina Terekhova
CARBOHYDRATE POLYMERS
(2019)
Article
Chemistry, Physical
Tatyana Volkova, Roman Kumeev, Nataliya Kochkina, Irina Terekhova
JOURNAL OF MOLECULAR LIQUIDS
(2019)
Article
Materials Science, Biomaterials
Iliya Kritskiy, Tatyana Volkova, Tatyana Sapozhnikova, Anton Mazur, Peter Tolstoy, Irina Terekhova
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Materials Science, Multidisciplinary
Tatyana Volkova, Artem Surov, Irina Terekhova
JOURNAL OF MATERIALS SCIENCE
(2020)
Article
Materials Science, Multidisciplinary
Martyna Janeczko, Konrad Cyprych, Malgorzata Kozbial, Jaroslaw Mysliwiec
ORGANIC ELECTRONICS
(2020)
Article
Chemistry, Multidisciplinary
Mikhail Agafonov, Anna Garibyan, Irina Terekhova
Summary: This study aimed to improve the dissolution properties of poorly soluble drug SSZ by encapsulating it in γCD-MOF, which was successfully achieved through impregnation and co-crystallization methods. Characterization and release behavior of the obtained composites were investigated using various methods, showing significantly improved release of SSZ from γCD-MOF. Different release kinetic models were compared and analyzed.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Chemistry, Physical
Anna Garibyan, Ekaterina Delyagina, Mikhail Agafonov, Ilya Khodov, Irina Terekhova
Summary: Baricitinib's solubility was found to be pH dependent, with slight solubility at pH 4-12 and better solubility in acidic and strongly alkaline media. The use of cyclodextrins improved the physicochemical properties of baricitinib, and the formation of host-guest complexes was studied. The influence of cyclodextrin structure and baricitinib's ionization state on complex formation and the impact of cyclodextrins on solubility and membrane permeability were analyzed.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
E. S. Delyagina, M. A. Agafonov, A. A. Garibyan, I. V. Terekhova
Summary: A metal-organic framework based on gamma-cyclodextrin and K+ cations is proposed as a delivery system for niflumic acid, and its effects on the release kinetics and membrane permeability of niflumic acid are investigated.
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
Article
Chemistry, Physical
Nataliya Kochkina, Maria Nikitina, Mikhail Agafonov, Ekaterina Delyagina, Irina Terekhova
Summary: In this study, a topical hydrogel based on iota-carrageenan, methotrexate, and cyclodextrin was developed to reduce the side effects of systemic drug administration. It was found that complexation with β-cyclodextrin affects the release rate and mechanism of methotrexate, as well as the permeability of the drug through the skin. The prepared hydrogel can be proposed as a topical drug delivery system for the treatment of skin cancer and autoimmune diseases.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Pharmacology & Pharmacy
Ekaterina Delyagina, Anna Garibyan, Mikhail Agafonov, Irina Terekhova
Summary: Metal-organic frameworks based on cyclodextrins have potential as drug delivery systems due to their properties such as large surface area, variable pore size, and biocompatibility. In this study, the incorporation of tolfenamic acid in a metal-organic framework based on gamma-cyclodextrin and potassium cations was investigated. The inclusion of tolfenamic acid improved its dissolution profile but reduced its membrane permeability. The encapsulation of different NSAIDs in this metal-organic framework was also compared, considering the impact of NSAID structure on loading capacity.
Article
Chemistry, Inorganic & Nuclear
M. A. Agafonov, E. V. Alexandrov, N. A. Artyukhova, G. E. Bekmukhamedov, V. A. Blatov, V. V. Butova, Y. M. Gayfulin, A. A. Garibyan, Z. N. Gafurov, Yu. G. Gorbunova, L. G. Gordeeva, M. S. Gruzdev, A. N. Gusev, G. L. Denisov, D. N. Dybtsev, Yu. Yu. Enakieva, A. A. Kagilev, A. O. Kantyukov, M. A. Kiskin, K. A. Kovalenko, A. M. Kolker, D. Kolokolov, Y. M. Litvinova, A. A. Lysova, N. V. Maksimchuk, Y. V. Mironov, Yu. V. Nelyubina, V. V. Novikov, V. I. Ovcharenko, A. V. Piskunov, D. M. Polyukhov, V. A. Polyakov, V. G. Ponomareva, A. S. Poryvaev, G. V. Romanenko, A. V. Soldatov, M. V. Solovyeva, A. G. Stepanov, I. V. Terekhova, O. Yu. Trofimova, V. P. Fedin, M. V. Fedin, O. A. Kholdeeva, A. Yu. Tsivadze, U. Chervonova, A. I. Cherevko, V. F. Shul'gin, E. S. Shutova, D. G. Yakhvarov
Summary: This review summarizes the current research fields of metal-organic frameworks (MOFs) developed by Russian scientific institutions and universities in the last 5-10 years, including design, synthesis, topological description, and prediction of MOF properties, development of chemical engineering and modification methods, investigation using modern physicochemical techniques, and creation of functional materials based on porous frameworks.
JOURNAL OF STRUCTURAL CHEMISTRY
(2022)
