Article
Geriatrics & Gerontology
Alessia Geremia, Roberta Sartori, Martina Baraldo, Leonardo Nogara, Valeria Balmaceda, Georgia Ana Dumitras, Stefano Ciciliot, Marco Scalabrin, Hendrik Nolte, Bert Blaauw
Summary: During cancer cachexia, impaired mTORC1 signaling leads to reduced protein synthesis rates in skeletal muscle. Conversely, activation of Akt-mTORC1 signaling can completely reverse muscle loss and force reduction, and prevent the increase in protein degradation observed in muscles from tumor-bearing animals. These findings suggest that skeletal muscle maintains its anabolic capacities during cancer cachexia, potentially explaining the beneficial effects of exercise in cancer patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Paula Ketilly Nascimento Alves, Andre Cruz, William J. Silva, Siegfried Labeit, Anselmo Sigari Moriscot
Summary: miR-29c overexpression in skeletal muscle leads to hypertrophy and increased protein synthesis despite the downregulation of AKT/mTOR pathway components post-electrotransfer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Mingliang Li, Ying Wei, Zhiyuan Feng, Muyi Cai, Yaguang Xu, Ruizeng Gu, Yongqing Ma, Xingchang Pan
Summary: The study demonstrated that dipeptides isolated from corn peptides can regulate the Akt-mTOR and NF-kappa B signaling pathways, with the potential to promote skeletal muscle growth.
Article
Plant Sciences
Ahyoung Yoo, Young Jin Jang, Jiyun Ahn, Chang Hwa Jung, Tae Youl Ha
Summary: DMBQ was shown to increase skeletal muscle mass and performance by regulating the AKT/mTOR signaling pathway and enhancing mitochondrial function, which might be beneficial for the treatment and prevention of skeletal muscle atrophy.
Article
Biochemistry & Molecular Biology
Martina Baraldo, Leonardo Nogara, Georgia Ana Dumitras, Achille Homere Tchampda Dondjang, Alessia Geremia, Marco Scalabrin, Clara Turk, Frederik Telkamp, Lorena Zentilin, Mauro Giacca, Marcus Kruger, Bert Blaauw
Summary: Loss of Raptor diminishes muscle hypertrophy and force increase after Akt activation, indicating mTORC1 as the key mediator of Akt-dependent muscle growth regulating the mitochondrial proteome critical for enhancing muscle force.
Article
Cell Biology
Rafael A. Casuso, Saad Al Fazazi, Francisco J. Ruiz-Ojeda, Julio Plaza-Diaz, Ascension Rueda-Robles, Jeronimo Aragon-Vela, Jesus R. Huertas
Summary: The study tested whether supplementing hydroxytyrosol, the main polyphenol in olive oil, during exercise would modify the molecular regulators of glucose uptake. Results showed that a low-to-moderate dose of hydroxytyrosol might alter the beneficial effect of training on basal AKT phosphorylation and Rac1 activity in rats.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Engineering, Multidisciplinary
Shabir Ahmad, Aman Ullah, Ali Akgul, Thabet Abdeljawad
Summary: This article extends the fractional third order dispersive PDE under singular and non-singular fractional operators using the notion of fuzziness. It investigates fuzzy dispersive PDEs in different dimensions under different fractional operators and provides general algorithm and numerical results. The numerical results confirm the generalized nature of solutions in the fuzzy sense compared to fractional-order solutions.
ALEXANDRIA ENGINEERING JOURNAL
(2021)
Article
Nutrition & Dietetics
Jiaqi Cui, Lin Song, Rui Wang, Shuyuan Hu, Zhao Yang, Zengtie Zhang, Bo Sun, Wei Cui
Summary: This study suggests that maternal metformin during gestation and lactation has the potential to overcome the negative effects of perinatal exposure to a high-fat diet in offspring. This is achieved by altering myogenesis, mitochondrial biogenesis, and dynamics through the AMPK/mTOR pathways in skeletal muscle.
Article
Multidisciplinary Sciences
Haiwen Li, Peipei Wang, Chen Zhang, Yuanbojiao Zuo, Yuan Zhou, Renzhi Han
Summary: In this study, Li et al. demonstrate that BVES acts as a negative feedback regulator of ADCY9-cAMP signaling in skeletal muscle, promoting muscle mass and function maintenance. BVES interacts with and negatively regulates ADCY9's activity, leading to the inhibition of the PKA signaling cascade and the prevention of ubiquitin proteasome degradation and autophagy initiation.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Apoorva H. Nagendra, Mohd Altaf Najar, Bipasha Bose, Shenoy P. Sudhee
Summary: Fluoride at high doses is known to be toxic to the musculoskeletal system, primarily affecting bone and cartilage cells. However, there is limited research on the toxicity of fluoride to skeletal muscle. This study found that during skeletal fluorosis, muscle is also affected. Short-term exposure to sodium fluoride (NaF) led to muscle hypertrophy through activation of the IGF1/PI3/Akt/mTOR signaling pathway, while long-term exposure resulted in muscle atrophy due to activation of the ubiquitin-proteasome pathway. Differentially expressed proteins were identified and characterized using proteomic analysis.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Clinical Neurology
Quentin Giraud, Coralie Spiegelhalter, Nadia Messaddeq, Jocelyn Laporte
Summary: BIN1-related centronuclear myopathies can be prevented and partially reversed by overexpression of myotubularin in mice. This research provides a potential therapeutic strategy for BIN1- and DNM2-linked centronuclear myopathies.
Review
Pharmacology & Pharmacy
Lin Yin, Na Li, Weihua Jia, Nuoqi Wang, Meidai Liang, Xiuying Yang, Guanhua Du
Summary: Skeletal muscle is crucial for various bodily functions, but pathological issues can lead to muscle wasting and atrophy, characterized by weakness and reduced mass. While exercise is effective, it is not universally applicable, highlighting the need for further research into treatment options.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Nutrition & Dietetics
Anna G. Beaudry, Michelle L. Law
Summary: Cancer cachexia is a syndrome of bodily wasting and functional decline. Nutritional support, particularly amino acid supplementation, is important in managing cachexia. Leucine has been found to increase protein synthesis and decrease degradation. Current research suggests that a leucine-rich diet can attenuate cachexia symptoms, but further studies are needed to explore its effects on protein turnover, immune response, and tumor growth.
Article
Biochemistry & Molecular Biology
A. Paula Irazoqui, Cintia A. Menendez, H. Sebastian Steingruber, Agustina Gonzalez, Gustavo A. Appignanesi, Claudia G. Buitrago, Dario C. Gerbino
Summary: In this study, four new compounds based on acridone were synthesized and tested for their biological activity in cells. The results showed that certain compounds effectively inhibited Akt activation in cells, and compound 3b was identified as the most promising prototype for the development of new antitumor agents.
BIOORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Qiao-Qiao Cheng, Shi-Long Mao, Li-Na Yang, Li Chen, Jin-Zhi Zhu, Xuan Liu, An-Ji Hou, Rong-Rong Zhang
Summary: The study aimed to investigate the effects of Fuzheng Xiaoai Decoction 1 (FZXAD1) in colon 26 (C26) cancer cachexia mice and clarify its mechanisms in ameliorating cancer cachexia symptoms. The results showed that FZXAD1 effectively alleviated muscle wasting and kidney atrophy, and increased body weight in cancer cachexia mice. AKT1, MTOR, MAPK3, HIF1A, and MAPK1 were predicted as the core targets of FZXAD1, and Western blotting confirmed the activation of the Akt-mTOR pathway by FZXAD1. These findings suggest that FZXAD1 could be a potential treatment for cancer cachexia by mitigating muscle atrophy.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Food Science & Technology
Adrian Pedreira, Yesim Taskin, Miriam R. Garcia
Summary: The food industry has made significant efforts to control the indirect transmission of SARS-CoV-2, updating cleaning and disinfection protocols to effectively inactivate pathogens while minimizing negative impacts on the environment and human health.
Article
Automation & Control Systems
Ixbalank Torres-Zuniga, Fernando Lopez-Caamal, Hector Hernandez-Escoto, Victor Alcaraz-Gonzalez
Summary: This article presents an optimization algorithm based on Super-Twisting for extremum seeking of a continuous-time dynamical system with a single input and a single output. The algorithm requires the input-output gradient of the system's response and is demonstrated feasible through two simulation examples.
JOURNAL OF PROCESS CONTROL
(2021)
Article
Automation & Control Systems
Yamin Yan, Zhiyong Chen, Richard H. Middleton
Summary: This article introduces a new type of synchronization problem for heterogeneous multiagent systems, called autonomous synchronization, where synchronized agent dynamics and states are autonomously determined by agent properties and initial states. Novel dynamics update law and synchronizing control law are proposed for achieving autonomous synchronization, with sufficient solvability conditions explicitly revealed and supported by theoretical analysis and numerical simulation.
IEEE TRANSACTIONS ON CONTROL OF NETWORK SYSTEMS
(2021)
Article
Marine & Freshwater Biology
T. T. Yen Le, Daniel Grabner, Milen Nachev, Miriam R. Garcia, Eva Balsa-Canto, Willie J. G. M. Peijnenburg, A. Jan Hendriks, Bernd Sures
Summary: A toxicokinetic-toxicodynamic model based on subcellular metal partitioning is presented for simulating chronic toxicity of copper. The study indicates ineffective detoxification at high exposure levels and spill-over effects of detoxification.
AQUATIC TOXICOLOGY
(2021)
Article
Automation & Control Systems
Phuong T. H. Nguyen, Sonja Studli, Julio H. Braslavsky, Richard H. Middleton
Summary: This paper presents an analytic stability analysis method for (PMSG) wind turbines. It introduces a Lyapunov function constructed from an analytic expression of the system Jacobian to identify regions of operation and parameter values for stable operation. A feedback linearisation control strategy is adopted to handle the nonlinear relationship in the turbine. Simulation tests comparing the proposed methodology with a conventional PI control design demonstrate better closed-loop response performance.
EUROPEAN JOURNAL OF CONTROL
(2022)
Article
Microbiology
Adrian Pedreira, Jose A. Vazquez, Miriam R. Garcia
Summary: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) are standard indexes for determining disinfection effectiveness. However, they do not take into account the dynamic processes at sub-MIC concentrations. Understanding these processes is crucial for designing effective disinfection strategies. This study used mathematical models to study the kinetics of Bacillus cereus and Escherichia coli cells exposed to sub-MIC concentrations of didecyldimethylammonium chloride (DDAC), and found that only the mechanistic model accurately reproduced the concentration dependence of the bactericidal activity.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Food Science & Technology
Miriam R. Garcia, Jose Antonio Ferez-Rubio, Carlos Vilas
Summary: This article provides a comprehensive review of the mathematical models used to describe and predict the changes in key quality indicators in fresh fish and shellfish during storage. It also discusses the relevant indicators and stress factors affecting the quality of fresh fish.
Article
Computer Science, Information Systems
Tung Thanh Vu, Duy Trong Ngo, Hien Quoc Ngo, Minh Ngoc Dao, Nguyen Hoang Tran, Richard H. Middleton
Summary: This article proposes a method to reduce the total execution time of the federated learning (FL) process in cell-free massive MIMO (CFmMIMO) structures. By considering link conditions, an algorithm is developed to select users, transmit power, and processing frequency through joint optimization. Numerical results demonstrate significant time reduction, particularly in scenarios with low access point deployment density.
IEEE INTERNET OF THINGS JOURNAL
(2022)
Editorial Material
Food Science & Technology
Jose A. Egea, Miriam R. Garcia, Carlos Vilas
Article
Food Science & Technology
Irene Falco, Juan A. Tudela, Natalia Hernandez, Alba Perez-Cataluna, Miriam R. Garcia, Pilar Truchado, Agustin Garrido, Ana Allende, Gloria Sanchez, Maria Isabel Gil
Summary: This study evaluates the disinfection efficacy of chlorine, chlorine dioxide, and peracetic acid on human enteric viruses in produce process water. The results showed that chlorine and chlorine dioxide can effectively inactivate bacteria and coliphages, but had limited efficacy against hepatitis A virus. Peracetic acid was unable to completely inactivate viruses in any type of water. Therefore, it is important to select the most effective sanitizer and ensure sufficient concentration and contact time to prevent viral cross-contamination during washing operations.
Article
Biochemistry & Molecular Biology
Martin Perez-Rodriguez, Marta Lopez Cabo, Eva Balsa-Canto, Miriam R. Garcia
Summary: Understanding the mechanisms of action of disinfectants is crucial for optimizing dosing regimes and reducing the emergence of antimicrobial resistance. This study investigated the mechanisms of action of a commonly used disinfectant-benzalkonium chloride (BAC)-on L. monocytogenes, a major foodborne pathogen. Molecular modeling revealed that the integration of BAC into the cell membrane involves three phases and potentially destabilizes the membrane. A kinetic model was developed to describe time-kill curves of a large population of cells, and it was validated using experimental data. The findings from this study can guide the rational design of novel disinfection processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Adrian Pedreira, Nerea Martinez-Lopez, Jose Antonio Vazquez, Miriam R. Garcia
Summary: Food preservatives have a weak antimicrobial effect that is difficult to mathematically describe. In this study, a new mathematical model is proposed to describe the dynamics of bacteria in the presence of preservatives, and it successfully determines the minimum inhibitory concentration (MIC) as well as the bacteriostatic and bactericidal effects. The model is validated through experiments and proves to be reliable and applicable.
JOURNAL OF FOOD ENGINEERING
(2024)
Article
Automation & Control Systems
Sonja Studli, Yamin Yan, Maria M. Seron, Richard H. Middleton
Summary: The letter proposes algorithms for connecting and disconnecting nodes in an existing graph while maintaining graph regularity and requiring minimal network reconfiguration. Simulations indicate that these algorithms maintain a minimum bound on the algebraic connectivity of the graph. These algorithms are suitable for plug-and-play networks.
IEEE CONTROL SYSTEMS LETTERS
(2022)
Proceedings Paper
Computer Science, Cybernetics
Christian Uribe-Mora, Fernando Lopez-Caamal, Guillermo Martinez-Rodriguez, Amanda L. Fuentes-Silva
Summary: The paper discusses the utilization of solar energy for industrial applications and presents a mathematical model to predict the output temperature of a collector under various changing factors such as solar irradiance, ambient temperature, and wind speed.
2021 IEEE 5TH COLOMBIAN CONFERENCE ON AUTOMATIC CONTROL (CCAC): TECHNOLOGICAL ADVANCES FOR A SUSTAINABLE REGIONAL DEVELOPMENT
(2021)
Article
Food Science & Technology
Konstantinos Koutsoumanis, Ana Allende, Avelino Alvarez-Ordonez, Declan Bolton, Marianne Chemaly, Robert Davies, Alessandra De Cesare, Lieve Herman, Friederike Hilbert, Roland Lindqvist, Maarten Nauta, Luisa Peixe, Giuseppe Ru, Marion Simmons, Panagiotis Skandamis, Elisabetta Suffredini, Karen Bekaert, Janna Cropotova, Miriam R. Garcia, Winy Messens, Sara Bover-Cid
Summary: Superchilling involves lowering fish temperature to 1-2 degrees Celsius below the initial freezing point, and ensuring a minimum degree of superchilling can guarantee that the fish temperature is lower or equal to traditionally iced products.
Article
Biology
Iain Hunter, Raz Leib
Summary: Natural movement is related to health, but it is difficult to measure. Existing methods cannot capture the full range of natural movement. Comparing movement across different species helps identify common biomechanical and computational principles. Developing a system to quantify movement in freely moving animals in natural environments and relating it to life quality is crucial. This study proposes a theoretical framework based on movement ability and validates it in Drosophila.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Andy Gardner
Summary: Fisher's geometric model is a useful tool for predicting key properties of Darwinian adaptation, and here it is applied to predict differences between the evolution of altruistic versus nonsocial phenotypes. The results suggest that the effect size maximizing probability of fixation is smaller in the context of altruism and larger in the context of nonsocial phenotypes, leading to lower overall probability of fixation for altruism and higher overall probability of fixation for nonsocial phenotypes.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Thomas F. Pak, Joe Pitt-Francis, Ruth E. Baker
Summary: Cell competition is a process where cells interact in multicellular organisms to determine a winner or loser status, with loser cells being eliminated through programmed cell death. The winner cells then populate the tissue. The outcome of cell competition is context-dependent, as the same cell type can win or lose depending on the competing cell type. This paper proposes a mathematical framework to study the emergence of winner or loser status, highlighting the role of active cell death and identifying the factors that drive cell competition in a cell-based modeling context.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Haruto Tomizuka, Yuuya Tachiki
Summary: Batesian mimicry is a strategy in which palatable prey species resemble unpalatable prey species to avoid predation. The evolution of this mimicry plays a crucial role in protecting the unpalatable species from extinction.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Jason W. Olejarz, Martin A. Nowak
Summary: Gene drive technology shows potential for population control, but its release may have unpredictable consequences. The study suggests that the failure of suppression is a natural outcome, and there are complex dynamics among wild populations.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Hamid Ravaee, Mohammad Hossein Manshaei, Mehran Safayani, Javad Salimi Sartakhti
Summary: Gene expression analysis is valuable for cancer classification and phenotype identification. IP3G, based on Generative Adversarial Networks, enhances gene expression data and discovers phenotypes in an unsupervised manner. By converting gene expression profiles into images and utilizing IP3G, new phenotype profiles can be generated, improving classification accuracy.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Beatrix Rahnsch, Leila Taghizadeh
Summary: This study forecasts the evolution of the COVID-19 pandemic in Germany using a network-based inference method and compares it with other approaches. The results show that the network-inference based approach outperforms other methods in short-to mid-term predictions, even with limited information about the new disease. Furthermore, predictions based on the estimation of the reproduction number in Germany can yield more reliable results with increasing data availability, but still cannot surpass the network-inference based algorithm.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Rongsheng Huang, Qiaojun Situ, Jinzhi Lei
Summary: Maintaining tissue homeostasis requires appropriate regulation of stem cell differentiation. Random inheritance of epigenetic states plays a pivotal role in stem cell differentiation. This computational model provides valuable insights into the intricate mechanism governing stem cell differentiation and cell reprogramming, offering a promising path for enhancing the field of regenerative medicine.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Patrick Vincent N. Lubenia, Eduardo R. Mendoza, Angelyn R. Lao
Summary: This study compares insulin signaling in healthy and type 2 diabetes states using reaction network analysis. The results show similarities and differences between the two conditions, providing insights into the mechanisms of insulin resistance, including the involvement of other complexes, less restrictive interplay between species, and loss of concentration robustness in GLUT4.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Nuverah Mohsin, Heiko Enderling, Renee Brady-Nicholls, Mohammad U. Zahid
Summary: Mathematical modeling is crucial in understanding radiobiology and designing treatment approaches in radiotherapy for cancer. This study compares three tumor volume dynamics models and analyzes the implications of model selection. A new metric, the point of maximum reduction of tumor volume (MRV), is introduced to quantify the impact of radiotherapy. The results emphasize the importance of caution in selecting models of response to radiotherapy due to the artifacts imposed by each model.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Armindo Salvador
Summary: Michael Savageau's Biochemical Systems Analysis papers have had a significant impact on Systems Biology, generating core concepts and tools. This article provides a brief summary of these papers and discusses the most relevant developments in Biochemical Systems Theory since their publication.
JOURNAL OF THEORETICAL BIOLOGY
(2024)