Genetic Alterations and Personalized Medicine in Melanoma: Progress and Future Prospects
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Genetic Alterations and Personalized Medicine in Melanoma: Progress and Future Prospects
Authors
Keywords
-
Journal
JNCI-Journal of the National Cancer Institute
Volume 106, Issue 2, Pages djt435-djt435
Publisher
Oxford University Press (OUP)
Online
2014-02-08
DOI
10.1093/jnci/djt435
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours
- (2013) K G Griewank et al. BRITISH JOURNAL OF CANCER
- Rare BRAF mutations in melanoma patients: implications for molecular testing in clinical practice
- (2013) L Heinzerling et al. BRITISH JOURNAL OF CANCER
- Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11
- (2013) A E Koopmans et al. BRITISH JOURNAL OF CANCER
- Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal, Acral, and Chronically Sun-Damaged Skin
- (2013) F. Stephen Hodi et al. JOURNAL OF CLINICAL ONCOLOGY
- Predictive Gene Signature in MAGE-A3 Antigen-Specific Cancer Immunotherapy
- (2013) Fernando Ulloa-Montoya et al. JOURNAL OF CLINICAL ONCOLOGY
- MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study
- (2013) Paolo A Ascierto et al. LANCET ONCOLOGY
- Integrated genomic characterization of endometrial carcinoma
- (2013) Gad Getz et al. NATURE
- IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors
- (2013) Katherine L Jameson et al. NATURE MEDICINE
- Hepatotoxicity with Combination of Vemurafenib and Ipilimumab
- (2013) Antoni Ribas et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nivolumab plus Ipilimumab in Advanced Melanoma
- (2013) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
- (2013) NEW ENGLAND JOURNAL OF MEDICINE
- Secondary c-Kit mutations confer acquired resistance to RTK inhibitors in c-Kit mutant melanoma cells
- (2013) Jason R. Todd et al. Pigment Cell & Melanoma Research
- TERT Promoter Mutations in Familial and Sporadic Melanoma
- (2013) S. Horn et al. SCIENCE
- Highly Recurrent TERT Promoter Mutations in Human Melanoma
- (2013) F. W. Huang et al. SCIENCE
- A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition
- (2013) Steven R. Whittaker et al. Cancer Discovery
- HIV-1 Antiretroviral Drug Therapy
- (2013) E. J. Arts et al. Cold Spring Harbor Perspectives in Medicine
- GNAQ and GNA11 mutations in melanocytomas of the central nervous system
- (2012) Rajmohan Murali et al. ACTA NEUROPATHOLOGICA
- A Proposal for Improving Multicolor FISH Sensitivity in the Diagnosis of Malignant Melanoma Using New Combined Criteria
- (2012) Katrin Kerl et al. AMERICAN JOURNAL OF DERMATOPATHOLOGY
- A Distinct Subset of Atypical Spitz Tumors is Characterized by BRAF Mutation and Loss of BAP1 Expression
- (2012) Thomas Wiesner et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- A Highly Specific and Discriminatory FISH Assay for Distinguishing Between Benign and Malignant Melanocytic Neoplasms
- (2012) Pedram Gerami et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Prognostic significance of chromosome 3 alterations determined by microsatellite analysis in uveal melanoma: a long-term follow-up study
- (2012) S Thomas et al. BRITISH JOURNAL OF CANCER
- Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors
- (2012) Y Xu et al. BRITISH JOURNAL OF CANCER
- Cutaneous manifestations of dabrafenib (GSK2118436): a selective inhibitor of mutant BRAF in patients with metastatic melanoma
- (2012) R.M. Anforth et al. BRITISH JOURNAL OF DERMATOLOGY
- Epigenetic biomarkers in skin cancer
- (2012) Edward S. Greenberg et al. CANCER LETTERS
- A Landscape of Driver Mutations in Melanoma
- (2012) Eran Hodis et al. CELL
- Sunitinib Therapy for Melanoma Patients withKITMutations
- (2012) David R. Minor et al. CLINICAL CANCER RESEARCH
- Distinguishing Clinicopathologic Features of Patients with V600E and V600K BRAF-Mutant Metastatic Melanoma
- (2012) A. M. Menzies et al. CLINICAL CANCER RESEARCH
- BRAFV600Eremodels the melanocyte transcriptome and inducesBANCRto regulate melanoma cell migration
- (2012) Ross J. Flockhart et al. GENOME RESEARCH
- Fluorescencein situhybridization for the differential diagnosis between Spitz naevus and spitzoid melanoma
- (2012) Celia Requena et al. HISTOPATHOLOGY
- Phase II Study of the MEK1/MEK2 Inhibitor Trametinib in Patients With MetastaticBRAF-Mutant Cutaneous Melanoma Previously Treated With or Without a BRAF Inhibitor
- (2012) Kevin B. Kim et al. JOURNAL OF CLINICAL ONCOLOGY
- BRAF Mutation, NRAS Mutation, and the Absence of an Immune-Related Expressed Gene Profile Predict Poor Outcome in Patients with Stage III Melanoma
- (2012) Graham J. Mann et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Frequency and Spectrum of BRAF Mutations in a Retrospective, Single-Institution Study of 1112 Cases of Melanoma
- (2012) Wesley O. Greaves et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial
- (2012) Gerald S Falchook et al. LANCET
- Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
- (2012) Axel Hauschild et al. LANCET
- Melanoma molecular classes and prognosis in the postgenomic era
- (2012) Elisa Tremante et al. LANCET ONCOLOGY
- Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial
- (2012) Gerald S Falchook et al. LANCET ONCOLOGY
- Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial
- (2012) Jeffrey R Infante et al. LANCET ONCOLOGY
- Marked genetic differences between BRAF and NRAS mutated primary melanomas as revealed by array comparative genomic hybridization
- (2012) Viktória Lázár et al. MELANOMA RESEARCH
- Intratumoral Molecular Heterogeneity in a BRAF-Mutant, BRAF Inhibitor-Resistant Melanoma: A Case Illustrating the Challenges for Personalized Medicine
- (2012) J. S. Wilmott et al. MOLECULAR CANCER THERAPEUTICS
- An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background
- (2012) Devarati Mitra et al. NATURE
- Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
- (2012) Ravid Straussman et al. NATURE
- Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
- (2012) Timothy R. Wilson et al. NATURE
- BAP1 loss defines a new class of renal cell carcinoma
- (2012) Samuel Peña-Llopis et al. NATURE GENETICS
- Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
- (2012) Michael Krauthammer et al. NATURE GENETICS
- Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations
- (2012) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib
- (2012) Jeffrey A. Sosman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
- (2012) Marco Gerlinger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
- (2012) Julie R. Brahmer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- Novel Somatic Mutations to PI3K Pathway Genes in Metastatic Melanoma
- (2012) Austin Y. Shull et al. PLoS One
- Melanoma whole-exome sequencing identifies V600E B-RAF amplification-mediated acquired B-RAF inhibitor resistance
- (2012) Hubing Shi et al. Nature Communications
- Elucidating Distinct Roles for NF1 in Melanomagenesis
- (2012) Ophélia Maertens et al. Cancer Discovery
- 12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?
- (2012) Jane L. Messina et al. Scientific Reports
- Assessment of Copy Number Status of Chromosomes 6 and 11 by FISH Provides Independent Prognostic Information in Primary Melanoma
- (2011) Jeffrey P. North et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Enhanced Detection of Spitzoid Melanomas Using Fluorescence In Situ Hybridization With 9p21 as an Adjunctive Probe
- (2011) Bryan Gammon et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- NRAS mutation status is an independent prognostic factor in metastatic melanoma
- (2011) John A. Jakob et al. CANCER
- PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression
- (2011) K. H. T. Paraiso et al. CANCER RESEARCH
- Large-Scale Analysis of KIT Aberrations in Chinese Patients with Melanoma
- (2011) Y. Kong et al. CLINICAL CANCER RESEARCH
- Nilotinib in patients with metastatic melanoma harboring KIT gene aberration
- (2011) Jin Hyun Cho et al. INVESTIGATIONAL NEW DRUGS
- KIT as a Therapeutic Target in Metastatic Melanoma
- (2011) Richard D. Carvajal JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling
- (2011) Nikhil Wagle et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase II, Open-Label, Single-Arm Trial of Imatinib Mesylate in Patients With Metastatic Melanoma Harboringc-KitMutation or Amplification
- (2011) Jun Guo et al. JOURNAL OF CLINICAL ONCOLOGY
- Prognostic and Clinicopathologic Associations of OncogenicBRAFin Metastatic Melanoma
- (2011) Georgina V. Long et al. JOURNAL OF CLINICAL ONCOLOGY
- Major Response to Everolimus in Melanoma With Acquired Imatinib Resistance
- (2011) Lu Si et al. JOURNAL OF CLINICAL ONCOLOGY
- Review and Cross-Validation of Gene Expression Signatures and Melanoma Prognosis
- (2011) Sarah-Jane Schramm et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers
- (2011) M. H. Abdel-Rahman et al. JOURNAL OF MEDICAL GENETICS
- EZH2-Dependent Suppression of a Cellular Senescence Phenotype in Melanoma Cells by Inhibition of p21/CDKN1A Expression
- (2011) T. Fan et al. MOLECULAR CANCER RESEARCH
- Tumour evolution inferred by single-cell sequencing
- (2011) Nicholas Navin et al. NATURE
- RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
- (2011) Poulikos I. Poulikakos et al. NATURE
- A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
- (2011) Satoru Yokoyama et al. NATURE
- A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
- (2011) Corine Bertolotto et al. NATURE
- The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma
- (2011) Matthew Bott et al. NATURE GENETICS
- Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing
- (2011) Mitchell S Stark et al. NATURE GENETICS
- Exome sequencing identifies GRIN2A as frequently mutated in melanoma
- (2011) Xiaomu Wei et al. NATURE GENETICS
- Germline mutations in BAP1 predispose to melanocytic tumors
- (2011) Thomas Wiesner et al. NATURE GENETICS
- Germline BAP1 mutations predispose to malignant mesothelioma
- (2011) Joseph R Testa et al. NATURE GENETICS
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma
- (2011) Caroline Robert et al. NEW ENGLAND JOURNAL OF MEDICINE
- BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site
- (2011) Jürgen Bauer et al. Pigment Cell & Melanoma Research
- Molecular Profiling of Melanoma and the Evolution of Patient-Specific Therapy
- (2011) Thomas F. Gajewski SEMINARS IN ONCOLOGY
- Sensitivity of Fluorescence In Situ Hybridization for Melanoma Diagnosis Using RREB1, MYB, Cep6, and 11q13 Probes in Melanoma Subtypes
- (2010) Pedram Gerami et al. ARCHIVES OF DERMATOLOGY
- SWI/SNF chromatin remodeling complex is critical for the expression of microphthalmia-associated transcription factor in melanoma cells
- (2010) Jiri Vachtenheim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma
- (2010) Jill C Rubinstein et al. BMC Medical Genomics
- A phase 2 trial of dasatinib in advanced melanoma
- (2010) Harriet M. Kluger et al. CANCER
- Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting
- (2010) Geoffrey Y. Ku et al. CANCER
- Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K
- (2010) Jessie Villanueva et al. CANCER CELL
- NF1 Is a Tumor Suppressor in Neuroblastoma that Determines Retinoic Acid Response and Disease Outcome
- (2010) Michael Hölzel et al. CELL
- A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth
- (2010) Alexander Roesch et al. CELL
- Gene signature of the metastatic potential of cutaneous melanoma: too much for too little?
- (2010) József Tímár et al. CLINICAL & EXPERIMENTAL METASTASIS
- Gene Expression Profiling-Based Identification of Molecular Subtypes in Stage IV Melanomas with Different Clinical Outcome
- (2010) G. Jonsson et al. CLINICAL CANCER RESEARCH
- Clinical Correlates of NRAS and BRAF Mutations in Primary Human Melanoma
- (2010) J. A. Ellerhorst et al. CLINICAL CANCER RESEARCH
- SWItching on the transcriptional circuitry in melanoma
- (2010) Srinivas Vinod Saladi et al. Epigenetics
- Somatic alterations in the melanoma genome: A high-resolution array-based comparative genomic hybridization study
- (2010) Andreas Gast et al. GENES CHROMOSOMES & CANCER
- Fluorescence in situ hybridization, a diagnostic aid in ambiguous melanocytic tumors: European study of 113 cases
- (2010) Beatrice Vergier et al. MODERN PATHOLOGY
- Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
- (2010) Johanna C. Scheuermann et al. NATURE
- The patterns and dynamics of genomic instability in metastatic pancreatic cancer
- (2010) Peter J. Campbell et al. NATURE
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
- (2010) Gideon Bollag et al. NATURE
- COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
- (2010) Cory M. Johannessen et al. NATURE
- Distant metastasis occurs late during the genetic evolution of pancreatic cancer
- (2010) Shinichi Yachida et al. NATURE
- Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
- (2010) Ramin Nazarian et al. NATURE
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
- (2010) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mutations inGNA11in Uveal Melanoma
- (2010) Catherine D. Van Raamsdonk et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure
- (2010) Despina Handolias et al. Pigment Cell & Melanoma Research
- Genetic and morphologic features for melanoma classification
- (2010) Sigrid M. C. Broekaert et al. Pigment Cell & Melanoma Research
- Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas
- (2010) J. W. Harbour et al. SCIENCE
- Gatekeeper Mutations Mediate Resistance to BRAF-Targeted Therapies
- (2010) S. Whittaker et al. Science Translational Medicine
- Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system
- (2009) Heidi V. N. Küsters-Vandevelde et al. ACTA NEUROPATHOLOGICA
- Fluorescence In Situ Hybridization (FISH) as an Ancillary Diagnostic Tool in the Diagnosis of Melanoma
- (2009) Pedram Gerami et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Tumor Self-Seeding by Circulating Cancer Cells
- (2009) Mi-Young Kim et al. CELL
- Inferring tumor progression from genomic heterogeneity
- (2009) N. Navin et al. GENOME RESEARCH
- Methylation of PTEN as a Prognostic Factor in Malignant Melanoma of the Skin
- (2009) Christoph Lahtz et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- A germline mutation of p14/ARF in a melanoma kindred
- (2009) Zaida Garcia-Casado et al. MELANOMA RESEARCH
- Activity of dasatinib against L576P KIT mutant melanoma: Molecular, cellular, and clinical correlates
- (2009) S. E. Woodman et al. MOLECULAR CANCER THERAPEUTICS
- Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4
- (2009) Todd D Prickett et al. NATURE GENETICS
- BrafV600E cooperates with Pten loss to induce metastatic melanoma
- (2009) David Dankort et al. NATURE GENETICS
- Functions and Regulatory Mechanisms of Gq-Signaling Pathways
- (2009) Norikazu Mizuno et al. NEUROSIGNALS
- Phase II trial of imatinib mesylate in patients with metastatic melanoma
- (2008) K B Kim et al. BRITISH JOURNAL OF CANCER
- Elevated CRAF as a Potential Mechanism of Acquired Resistance to BRAF Inhibition in Melanoma
- (2008) C. Montagut et al. CANCER RESEARCH
- BRCA1-Associated Protein-1 Is a Tumor Suppressor that Requires Deubiquitinating Activity and Nuclear Localization
- (2008) K. H. Ventii et al. CANCER RESEARCH
- Integrative Genomic Analysis of Aneuploidy in Uveal Melanoma
- (2008) J. P. Ehlers et al. CLINICAL CANCER RESEARCH
- Predicting Clinical Outcome through Molecular Profiling in Stage III Melanoma
- (2008) T. John et al. CLINICAL CANCER RESEARCH
- MC1R variants, melanoma and red hair color phenotype: A meta-analysis
- (2008) Sara Raimondi et al. INTERNATIONAL JOURNAL OF CANCER
- Major Response to Imatinib Mesylate in KIT-Mutated Melanoma
- (2008) F. Stephen Hodi et al. JOURNAL OF CLINICAL ONCOLOGY
- Heterogeneity of kinase inhibitor resistance mechanisms in GIST
- (2008) B Liegl et al. JOURNAL OF PATHOLOGY
- Loss of BMI-1 expression is associated with clinical progress of malignant melanoma
- (2008) Ingeborg M Bachmann et al. MODERN PATHOLOGY
- Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas
- (2008) K. S.M. Smalley et al. MOLECULAR CANCER THERAPEUTICS
- Somatic mutations affect key pathways in lung adenocarcinoma
- (2008) Li Ding et al. NATURE
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- (2008) Roger McLendon et al. NATURE
- Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
- (2008) Catherine D. Van Raamsdonk et al. NATURE
- Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation
- (2008) Jose Lutzky et al. Pigment Cell & Melanoma Research
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
- Improving Melanoma Classification by Integrating Genetic and Morphologic Features
- (2008) Amaya Viros et al. PLOS MEDICINE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started