Article
Orthopedics
Shuangjun He, Yijian Zhang, Zhangzhe Zhou, Xiaofeng Shao, Kangwu Chen, Shouqian Dai, Ting Liang, Zhonglai Qian, Zongping Luo
Summary: The purpose of this study was to investigate the changes in micromorphology and mechanical properties of intervertebral discs degeneration induced by aging and puncture. The results showed that the disc height ratio decreased in the PDG and ADG groups, histological scores increased, T2 signal gray value decreased, MMP-3 and TNF-positive cells proportion in intervertebral disc tissues was higher, and COL-2 IOD values were lower. The fiber diameter increased in the ADG group, indicating chronic inflammation, while PDG suffered from severe extracellular matrix loss. These findings provide a foundation for clinical research.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yi Xu, Youquan Jia, Carlo Antonini, Yakang Jin, Longquan Chen
Summary: By immersing substrate-supported polymeric nanofilms in water, interfacial nanoblisters are formed as natural platforms for evaluating their mechanical properties. High-resolution force spectroscopy studies reveal that indentation tests must be conducted on the freestanding region around the nanoblister apex under an appropriate loading force to obtain load-independent, linear elastic deformations. The stiffness of the nanoblister increases with decreasing size or increasing covering film thickness, and this size effect can be explained by an energy-based theoretical model. This proposed methodology can provide an exceptional determination of the elastic modulus of the film and has potential applications in relevant fields.
Article
Mechanics
Linh Thi Phuong Nguyen, Bernard Haochih Liu
Summary: A supervised machine learning regression framework was proposed to determine the elastic modulus of materials without the need for contact model fitting. Experimental results showed that the framework achieved high accuracy in predicting the elastic modulus of both homogeneous and heterogeneous materials.
INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
(2022)
Article
Biochemistry & Molecular Biology
Megan E. Dempsey, Graylen R. Chickering, Rafael D. Gonzalez-Cruz, Vera C. Fonseca, Eric M. Darling
Summary: This study demonstrates a workflow for surface protein discovery associated with cellular mechanophenotype. The method allows for the sorting and enrichment of live cells based on their mechanophenotype using surface protein biomarkers, followed by further characterization and differentiation studies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Nada Alharbi, Supontep Teerakanok, Julian D. Satterthwaite, Russel Giordano, Nick Silikas
Summary: This in vitro investigation compared the surface characteristics and nanomechanics of model polymer infiltrated ceramic network (PICN) materials and CAD/CAM resin composite blocks. The results showed that CAD/CAM resin composite blocks had smoother surfaces compared to PICN materials. PICN materials exhibited variation in terms of nanomechanical mapping and had at least two different phases. The sintering temperature had a significant effect on material topography and nanomechanical properties.
Article
Anatomy & Morphology
Wenting Wang, Wenhao Zhang, Yuhang Chen
Summary: In this study, a cantilever that enables a near linear relationship between contact resonance frequency and contact stiffness is designed and validated for mechanical characterization and subsurface nano-imaging applications.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Article
Chemistry, Multidisciplinary
Lutz Fleischhauer, Dominique Muschter, Zsuzsanna Farkas, Susanne Graessel, Attila Aszodi, Hauke Clausen-Schaumann, Paolo Alberton
Summary: This study used nano-scale IT-AFM to assess the nanostiffness of cartilage after DMM surgery in mice. The results showed significant stiffening of the DMM cartilage at 2 weeks compared to Sham, with the most pronounced changes in the superficial zone. At 8 weeks, the differences in nanostiffness between DMM and Sham were reduced, and the proteoglycan and collagen phases changed in a similar manner.
APPLIED SCIENCES-BASEL
(2022)
Article
Dermatology
Laura Prigent, Perrine Mercier-Gouy, Simone Bovio, Alexandre Aubert, Sophie Liot, Elise Lambert, Ulrich Valcourt
Summary: An in-depth understanding of the mechanical properties of the dermis is crucial for wound healing and skin aging. However, little is known about the nanoscale mechanical behavior of the dermis. This study measures the mechanical properties of mouse dermis and finds differences between female and male dermis samples, as well as changes with depth in male dermis. The findings highlight the importance of considering sex-related cutaneous differences to improve dermatological treatments and cosmetic interventions.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Chemistry, Physical
Ryan M. Khan, Martin Rejhon, Yanxiao Li, Nitika Parashar, Elisa Riedo, Ryan R. Wixom, Frank W. DelRio, Remi Dingreville
Summary: As the field of low-dimensional materials continues to grow, there is a need for techniques to characterize the mechanical properties of these materials at the nanoscale. This paper presents a modulated nanomechanical measurement technique based on atomic-force microscopy, which enables non-destructive measurements of the elasticity of ultra-thin materials with high resolution. The technique is used to study the stiffness dependence of graphene thin films and discover a peak transverse modulus in two-layer graphene.
Article
Chemistry, Physical
Shu-Wen W. Chen, Jean-Marie Teulon, Harinderbir Kaur, Christian Godon, Jean-Luc Pellequer
Summary: Measuring the structural stiffness is a method to study the elastic response of materials under external indentation, with the goal of revealing how nanostructured components or physiological circumstances affect the material's elastic behavior. In this study, atomic force microscopy (AFM) was used with a nano-scale pyramidal tip to indent the surfaces of polyacrylamide gels and Arabidopsis thaliana seedling roots with different softness. The stiffness-depth curve derived from the measured force showed heterogeneous elasticity. The responding force was decomposed into depth-impact, Hookean, and tip-shape components, called trimechanic, allowing the researchers to observe how these three restoring nanomechanics change with depth. The trimechanic theory provides insights into the restoring nanomechanics of indented materials and can differentiate the softness between different gel categories.
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Physical
Paul C. Uzoma, Xiaolei Ding, Xiaolei Wen, Lansheng Zhang, Oleksiy Penkov, Huan Hu
Summary: The mechanical and tribological properties of a newly invented nano-spherical silicon tip were investigated in this study, showing good durability and stable elastic modulus, making it suitable for AFM operations and nanoscale tribology measurements.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
T. Shan, L. Huang, F. R. Tay, L. Gu
Summary: The concept of extrafibrillar demineralization involves selectively removing apatite crystallites from the spaces between mineralized dentin fibers without affecting the minerals within the collagen fibers. Quaternized carboxymethyl chitosan (QCMC)-based demineralization is effective in improving resin-dentin bond durability by retaining intrafibrillar minerals, preserving the elastic modulus of collagen fibers, reducing proteolytic activity, and inhibiting bacteria biofilms.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Polymer Science
Olivia M. McIntee, Brian C. Welch, Alan R. Greenberg, Steven M. George, Victor M. Bright
Summary: Molecular layer deposition (MLD) is a gas-phase deposition technique that can create ultra-thin films with controlled composition and thickness. In this study, MLD was used to fabricate crosslinked polyamide films, and their elastic modulus was determined using atomic force microscopy. The results showed that the modulus was independent of film thickness, comparable to thicker polyamide films.
Article
Materials Science, Multidisciplinary
Y. Lun, J. Liu, B. Wei, Z. Gao, X. Wang, J. Hong
Summary: The Halide double perovskite Cs2AgBiBr6 has promising potential in next-generation photovoltaic devices. Strain engineering has been proven as a reliable method to improve its performance. This study measured the full elastic tensor of Cs2AgBiBr6 using various techniques including nanoindentation and contact resonance atomic force microscopy.
EXPERIMENTAL MECHANICS
(2022)
Article
Engineering, Chemical
Zeinab Al-Rekabi, Suzanne L. Davies, Charles A. Clifford
Summary: The study characterized the nanomechanical properties of two types of industrial potato flakes using atomic force microscopy and showed that optimal samples were stiffer than sub-optimal samples. This suggests that probing the elastic properties of potato flakes can provide a differential assessment between optimal and sub-optimal samples for food industries.
JOURNAL OF FOOD ENGINEERING
(2021)
Article
Ophthalmology
Michael Peng, Tyler J. Margetts, Chenna Kesavulu Sugali, Naga Pradeep Rayana, Jiannong Dai, Tasneem P. Sharma, Vijay Krishna Raghunathan, Weiming Mao
Summary: The study introduces a glue-based method for utilizing human corneal rims in perfusion culture experiments, providing a low-cost alternative to traditional models. The method allows for evaluation of outflow facility, TM stiffness, and TM morphology, with implications for glaucoma research.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Kamesh Dhamodaran, Hasna Baidouri, Andrews Nartey, Julia Staverosky, Kate Keller, Ted Acott, Janice A. Vranka, Vijay Krishna Raghunathan
Summary: The study compared the expression of Notch pathway molecules in trabecular meshwork (TM) cells from glaucomatous and non-glaucomatous donors, and investigated the effects of stiffness and cyclical strain on Notch expression. The results showed that Notch expression and phagocytic ability of TM cells were lower on stiffer substrates. These findings suggest that the Notch pathway may play different roles in disease and homeostasis.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Krista M. Cosert, Soohyun Kim, Iman Jalilian, Maggie Chang, Brooke L. Gates, Kent E. Pinkerton, Laura S. Van Winkle, Vijay Krishna Raghunathan, Brian C. Leonard, Sara M. Thomasy
Summary: This review provides an update on the ocular toxicity of metallic nanomaterials (ENMs) in vitro and in vivo, as well as the risks and benefits of therapeutic applications of metallic ENMs in ophthalmology.
Article
Cell Biology
Haiyan Li, VijayKrishna Raghunathan, W. Daniel Stamer, Preethi S. Ganapathy, Samuel Herberg
Summary: Progression of primary open-angle glaucoma is associated with increased trabecular meshwork (HTM) stiffness and elevated TGF beta 2 levels. YAP/TAZ, important factors in mechanotransduction, play a role in glaucomatous HTM cell dysfunction. Increased ECM stiffness elevates nuclear localization of YAP/TAZ, potentially through modulating focal adhesions and cytoskeletal rearrangement. TGF beta 2 also increases nuclear YAP/TAZ in HTM cells, which can be prevented by inhibiting ERK and ROCK signaling pathways. Inactivation of YAP/TAZ with verteporfin partially blocks TGF beta 2-induced hydrogel contraction and stiffening. This study provides evidence for the pathological role of aberrant YAP/TAZ signaling in glaucomatous HTM cell dysfunction and suggests potential strategies for preventing progressive ocular hypertension in glaucoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Ophthalmology
Michael Peng, Naga Pradeep Rayana, Jiannong Dai, Chenna Kesavulu Sugali, Hasna Baidouri, Ayush Suresh, Vijay Krishna Raghunathan, Weiming Mao
Summary: This study provides evidence that cross-linked actin networks (CLANs) in trabecular meshwork (TM) cells may contribute to increased intraocular pressure (IOP) by altering cell function and stiffness. The researchers developed transformed TM cells with spontaneous fluorescently labelled CLANs and found that these cells exhibited elevated stiffness and compromised phagocytosis. Additionally, they confirmed that primary human TM cells treated with dexamethasone or TGF beta 2 also showed increased stiffness and reduced phagocytosis. These findings support the hypothesis that CLANs play a role in glaucomatous phenotypes of TM cells.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Iman Jalilian, Santoshi Muppala, Maryam Ali, Johnathon D. Anderson, Brett Phinney, Michelle Salemi, Phillip A. Wilmarth, Christopher J. Murphy, Sara M. Thomasy, VijayKrishna Raghunathan
Summary: This study investigates the effects of TGF-beta and ascorbic acid (AA) on the composition and stiffness of the extracellular matrix (ECM) secreted by corneal endothelial cells (CECs). It finds that TGF-beta decreases matrix stiffness while AA modulates the oxidative stress pathway in the matrix. These findings provide insights into the molecular mechanisms of Fuchs endothelial corneal dystrophy (FECD).
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Ophthalmology
A. L. Minella, M. I. Casanova, T. J. Chokshi, J. Kang, K. Cosert, M. M. Gragg, M. A. Bowman, M. E. Mccorkell, N. L. Daley, B. C. Leonard, C. J. Murphy, V. K. Raghunathan, S. M. Thomasy
Summary: This study aimed to assess the safety, effects, and efficacy of cysteamine hydrochloride (CH) as a TGM2 inhibitor on corneal wound healing and scarring. The results showed that CH had no adverse effects on corneal wound healing in a rabbit model and did not decrease corneal fibrosis.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Ophthalmology
VijayKrishna Raghunathan, Andrews Nartey, Kamesh Dhamodaran, Hasna Baidouri, Julia A. Staverosky, Kate E. Keller, Keith Zientek, Ashok Reddy, Ted Acott, Janice A. Vranka
Summary: Through studying the interaction between matrix and cells, we found that cells in different pressure and stiffening conditions have different responses. Although the mechanism of matrix stiffness cannot be directly determined, it is still an effective tool for studying cell-matrix interactions.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Bret A. Moore, Iman Jalilian, Soohyun Kim, Makiko Mizutani, Madison Mukai, Connor Chang, Alec M. Entringer, Kamesh Dhamodaran, Vijay Krishna Raghunathan, Leandro B. C. Teixeira, Christopher J. Murphy, Sara M. Thomasy
Summary: The purpose of this study is to evaluate the elastic modulus, keratocyte-fibroblast-myocyte transformation, and haze formation of the corneal stroma following combined PTK and epithelium-off CXL using an in vivo rabbit model. The results showed that stromal haze formation and stiffness significantly increased following CXL, regardless of whether it is performed at or before the time of PTK. This study is important for understanding scar formation following CXL and for the development of improved therapeutic options.
Article
Ophthalmology
Brian C. Leonard, Sangwan Park, Soohyun Kim, Laura J. Young, Iman Jalilian, Krista Cosert, Xunzhi Zhang, Jessica M. Skeie, Hanna Shevalye, Nayeli Echeverria, Vanessa Rozo, Xin Gong, Chao Xing, Christopher J. Murphy, Mark A. Greiner, V. Vinod Mootha, Vijay Krishna Raghunathan, Sara M. Thomasy
Summary: This study examines the role of Wwtr1 in murine ocular structure and function, and its relationship with FECD. The results suggest that Wwtr1 deficient mice exhibit phenotypic abnormalities similar to FECD-affected patients, indicating that they could serve as a murine model for late-onset FECD.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Meeting Abstract
Ophthalmology
Sara M. Thomasy, Sangwan Park, Krista Cosert, Michelle Mccorkell, Nayeli Echeverria, Sophie M. Le, Christopher J. Murphy, Vijaykrishna Raghunathan, Brian C. Leonard
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Sangwan Park, Brian C. Leonard, Michelle Ferneding, Sophie M. Le, Monica Ardon, Christopher J. Murphy, Vijaykrishna Raghunathan, Sara M. Thomasy
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Rachel W. Kuchtey, Lauren Wareham, Hangjing Wu, Evan Krystofiak, Yusheng Wu, Cynthia Reinhart-King, Vijaykrishna Raghunathan, Elena Pokidysheva, Sergei Budko, John Kuchtey
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Weiming Mao, Michael Peng, Tyler J. Margetts, Chenna Kesavulu Sugali, Naga Pradeep Rayana, Jiannong Dai, Tasneem Putliwala Sharma, Vijaykrishna Raghunathan
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Colleen M. McDowell, Krishnakumar Kizhatil, Michael H. Elliott, Darryl R. Overby, Joseph Van Batenburg-Sherwood, J. Cameron Millar, Markus H. Kuehn, Gulab Zode, Ted S. Acott, Michael G. Anderson, Sanjoy K. Bhattacharya, Jacques A. Bertrand, Terete Borras, Diane E. Bovenkamp, Lin Cheng, John Danias, Michael Lucio De Ieso, Yiqin Du, Jennifer A. Faralli, Rudolf Fuchshofer, Preethi S. Ganapathy, Haiyan Gong, Samuel Herberg, Humberto Hernandez, Peter Humphries, Simon W. M. John, Paul L. Kaufman, Kate E. Keller, Mary J. Kelley, Ruth A. Kelly, David Krizaj, Ajay Kumar, Brian C. Leonard, Raquel L. Lieberman, Paloma Liton, Yutao Liu, Katy C. Liu, Navita N. Lopez, Weiming Mao, Timur Mavlyutov, Fiona McDonnell, Gillian J. McLellan, Philip Mzyk, Andrews Nartey, Louis R. Pasquale, Gaurang C. Patel, Padmanabhan P. Pattabiraman, Donna M. Peters, Vijaykrishna Raghunathan, Ponugoti Vasantha Rao, Naga Rayana, Urmimala Raychaudhuri, Ester Reina-Torres, Ruiyi Ren, Douglas Rhee, Uttio Roy Chowdhury, John R. Samples, E. Griffen Samples, Najam Sharif, Joel S. Schuman, Val C. Sheffield, Cooper H. Stevenson, Avinash Soundararajan, Preeti Subramanian, Chenna Kesavulu Sugali, Yang Sun, Carol B. Toris, Karen Y. Torrejon, Amir Vahabikashi, Janice A. Vranka, Ting Wang, Colin E. Willoughby, Chen Xin, Hongmin Yun, Hao F. Zhang, Michael P. Fautsch, Ernst R. Tamm, Abbot F. Clark, C. Ross Ethier, W. Daniel Stamer
Summary: This article highlights the importance of using mice as a valuable model system for studying conventional outflow resistance and intraocular pressure. It also outlines the minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. These standards are expected to enhance scientific rigor and replicability of research findings.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
