☆ 4.2 Article

A Highly Efficient Protocol for the Synthesis of N-Aryl Nucleobases Using Zinc Oxide in Ionic Liquids

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY (2010)

Journal

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY

Volume 7, Issue 2, Pages 461-469

Publisher

SPRINGER

DOI: 10.1007/BF03246033

Keywords

N-Aryl nucleobase; Zinc oxide; Ionic liquid; N-Arylation; Microwave

Categories

Chemistry, Multidisciplinary

Funding

Payame Noor University (PNU) Research Council

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Abstract

A highly efficient and simple method for the synthesis of N-aryl derivatives of pyrimidine and purine nucleobases via N-arylation of nucleobases using zinc oxide in 1-butyl-3-methylimidazolium bromide ([bmim]Br) under microwave as well as thermal conditions is described. In both conditions, the title compounds were produced in high to excellent yields and in short reaction times.

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