Article
Clinical Neurology
Rebecca E. Woodrow, Stefan Winzeck, Andrea Luppi, Isaac R. Kelleher-Unger, Lennart R. B. Spindler, J. T. Lindsay Wilson, Virginia F. J. Newcombe, Jonathan P. Coles, David K. Menon, Emmanuel A. Stamatakis
Summary: Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and are difficult to predict or treat. The study found acute thalamic hyperconnectivity in mTBI, even without structural changes. These acute changes in thalamic connectivity can serve as early markers for persistent symptoms and have associations with specific emotional and cognitive symptoms.
Article
Neurosciences
Eva Keatley, Kathleen Bechtold, Kevin Psoter, Matthew E. Peters, Allen Everett, Vani Rao, Timothy E. Van Meter, Hayley Falk, Frederick K. Korley, Durga Roy
Summary: This study utilized group-based trajectory modeling (GBTM) to identify distinct patterns of symptom recovery following mild traumatic brain injury (TBI) in the first 6 months after injury. The findings identified four distinct trajectories of recovery, which can be helpful for understanding the natural history of recovery and developing targeted interventions.
Review
Clinical Neurology
Adriano Mollica, Rachel Greben, Chika Oriuwa, Shan H. Siddiqi, Matthew J. Burke
Summary: This article reviews recent research on neuromodulation for mild traumatic brain injury (mTBI). It suggests that transcranial magnetic stimulation (TMS) shows promise as a potential treatment strategy for post-concussive symptoms, such as depression and headaches, while transcranial direct current stimulation (tDCS) has more mixed results. Further studies are needed to explore new stimulation protocols, personalized approaches, and the role of placebo effects.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Neurosciences
Jackie L. Gottshall, Amma A. Agyemang, Maya O'Neil, Guo Wei, Angela Presson, Bryson Hewins, Daniel Fisher, Sara Mithani, Pashtun Shahim, Mary Jo Pugh, Elisabeth A. Wilde, Christina Devoto, Kristine Yaffe, Jessica Gill, Kimbra Kenney, J. Kent Werner
Summary: Following mild traumatic brain injury (mTBI), the severity of symptoms reported by individuals is positively correlated with biomarker levels of neurodegeneration. The associations between biomarkers and symptoms do not significantly change when sleep items are included or excluded. The Pittsburgh Sleep Quality Index demonstrates strong correlations with both sleep and non-sleep items of all symptom scales.
Article
Sport Sciences
Todd W. Lyons, Rebekah Mannix, Ken Tang, Keith Owen Yeates, Gurinder Sangha, Emma C. M. Burns, Darcy Beer, Alexander S. Dubrovsky, Isabelle Gagnon, Jocelyn Gravel, Stephen B. Freedman, William Craig, Kathy Boutis, Martin H. Osmond, Gerard Gioia, Roger Zemek
Summary: This study aimed to assess the occurrence and clustering of post-concussive symptoms in children and identify distinct patient phenotypes based on symptom type and severity. The results showed that post-concussive symptoms occur in distinct clusters and five patient groups were identified based on symptom type and severity.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Critical Care Medicine
Jonathan E. Elliott, Nadir M. Balba, Alisha A. McBride, Megan L. Callahan, Kendall T. Street, Matthew P. Butler, Mary M. Heinricher, Miranda M. Lim
Summary: This study examined the effectiveness of different methods for evaluating history of traumatic brain injury (TBI), finding that the Head Trauma Events Characteristics (HTEC) method had the highest sensitivity. It also noted that the results and conclusions may significantly differ depending on the diagnostic method used.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neuroimaging
Julie M. Joyce, Leah J. Mercier, Mehak Stokoe, Parker L. La, Tiffany Bell, Julia M. Batycky, Chantel T. Debert, Ashley D. Harris
Summary: This study aimed to investigate the pathophysiology of persistent post-concussive symptoms (PPCS). The study found that anterior cingulate glutamate (Glu) was significantly reduced in PPCS patients compared to controls, while higher anterior cingulate gamma-aminobutyric acid (GABA) was significantly associated with a higher number of lifetime mild traumatic brain injuries (mTBIs). In addition, glutathione (GSH) in both regions of interest was positively associated with symptoms of sleepiness and headache burden.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Jamie N. Hershaw, Candace A. Hill-Pearson
Summary: This study explores the efficacy of neurofeedback therapy based on Live Z-Score Training for patients with persistent post-concussive symptoms. The results indicate that specific changes in EEG patterns can predict symptom improvement, with the ability to predict reduction in pain and cognitive symptoms, as well as improvement in affective symptoms.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Julian Takagi-Stewart, Ashleigh M. Johnson, Mallory B. Smith, Jin Wang, Lyscha A. Marcynyszyn, Douglas F. Zatzick, Carolyn A. McCarty, Frederick P. Rivara, Monica S. Vavilala
Summary: This study examined the association between physician recommended school accommodations and student outcomes among youth experiencing persistent post-concussive symptoms (PPCS). The results showed that physicians recommend more school accommodations for students experiencing more school problems post-concussion. However, there were no significant associations found between recommended school accommodations and GPA, health-related quality of life, anxiety symptoms, or depressive symptoms.
NEUROREHABILITATION
(2022)
Article
Critical Care Medicine
Emily R. Fisher, Janelle J. Montroy, Gerardo Duque, Charles S. Cox, Linda Ewing-Cobbs
Summary: This study investigated the persistence of PCS and PTSS in children and adolescents following TBI and EI, finding that the two types of symptoms varied among different TBI severity groups. Shared vulnerability factors included female sex, milder TBI, and poorer pre-injury adjustment, while older age was a unique vulnerability factor for PTSS.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Ergonomics
John P. K. Bernstein, William P. Milberg, Regina E. McGlinchey, Catherine B. Fortier
Summary: Human factors are responsible for most motor vehicle accidents on the road. Symptoms of posttraumatic stress disorder (PTSD) are linked to reduced driving safety, although there is limited research on this topic. A review of 22 studies found associations between PTSD and driving behaviors, including increased hostile driving behaviors, unintentional driving errors, and negative thoughts and emotions while driving. Few studies explored the risk of motor vehicle accidents and driving-related legal issues. Future research should focus on concurrent PTSD symptom and driving-related changes, comprehensive assessment of PTSD and driving, and the impact of comorbid traumatic brain injury history and other neurological and psychiatric conditions on driving outcomes.
ACCIDENT ANALYSIS AND PREVENTION
(2022)
Article
Critical Care Medicine
Sara M. Lippa, Louis M. French, Tracey A. Brickell, Angela E. Driscoll, Megan E. Glazer, Corie E. Tippett, Jamie K. Sullivan, Rael T. Lange
Summary: This study found that PTSD symptoms were more strongly related to cognitive performance in individuals with a history of complicated mild/moderate TBI compared to those with severe/penetrating TBI. The impact of PTSD symptoms on cognition should be considered in individuals with complicated mild/moderate TBI.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
Anna Igoe, Deirdre M. Twomey, Niamh Allen, Simone Carton, Nuala Brady, Fiadhnait O'Keeffe
Summary: Post-Traumatic Growth (PTG) is a positive psychological change that occurs after traumatic experiences, particularly among survivors of acquired brain injury (ABI). This study investigated the factors associated with long-term PTG in individuals with moderate to severe ABIs. The results showed that fewer symptoms of depression, more symptoms of anxiety, and use of adaptive coping strategies were related to PTG one year post-ABI, while fewer symptoms of depression, fewer ongoing symptoms of brain injury, better psychological quality of life, and use of adaptive coping strategies were related to PTG eight years post-ABI. Long-term neuropsychological support may promote PTG by facilitating adaptive coping, supporting psychological wellbeing, and helping individuals find meaning after ABI.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Clinical Neurology
Josh W. Faulkner, Alice Theadom, Deborah L. Snell, Matt N. Williams
Summary: This study applied network analysis to investigate post-concussion symptoms after mild traumatic brain injury (mTBI) and found that frustration, blurred vision, and concentration difficulties were central symptoms in two different mTBI samples. These symptoms may play an influential role in the experience and maintenance of post-concussion symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Katherine E. Miller, James P. MacDonald, Lindsay Sullivan, Lakshmi Prakruthi Rao Venkata, Junxin Shi, Keith Owen Yeates, Su Chen, Enas Alshaikh, H. Gerry Taylor, Amanda Hautmann, Nicole Asa, Daniel M. Cohen, Thomas L. Pommering, Elaine R. Mardis, Jingzhen Yang, NCH Concuss Res Grp
Summary: This study conducted a long-term assessment of salivary miRNA expression levels in concussed children and found differences in expression levels between children with and without PPCS.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Lisa A. Jacobson, E. Mark Mahone, Keith O. Yeates, M. Douglas Ris
CHILD NEUROPSYCHOLOGY
(2019)
Article
Critical Care Medicine
Brian L. Brooks, Vickie Plourde, Miriam H. Beauchamp, Ken Tang, Keith Owen Yeates, Michelle Keightley, Peter Anderson, Naddley Desire, Nick Barrowman, Roger Zemek
JOURNAL OF NEUROTRAUMA
(2019)
Review
Clinical Neurology
Vivian Kwan, Nicoline Bihelek, Vicki Anderson, Keith Yeates
JOURNAL OF HEAD TRAUMA REHABILITATION
(2019)
Article
Clinical Neurology
Jessica M. Aguilar, Amy E. Cassedy, Emily L. Shultz, Michael W. Kirkwood, Terry Stancin, Keith Owen Yeates, H. Gerry Taylor, Shari L. Wade
JOURNAL OF HEAD TRAUMA REHABILITATION
(2019)
Article
Clinical Neurology
Sean C. Rose, Keith O. Yeates, Darren R. Fuerst, Patrick M. Ercole, Joseph T. Nguyen, Natalie M. Pizzimenti
JOURNAL OF HEAD TRAUMA REHABILITATION
(2019)
Article
Critical Care Medicine
Nanhua Zhang, Eloise E. Kaizar, Megan E. Narad, Brad G. Kurowski, Keith Owen Yeates, H. Gerry Taylor, Shari L. Wade
JOURNAL OF NEUROTRAUMA
(2019)
Article
Critical Care Medicine
Keith Owen Yeates, Kenneth Tang, Nick Barrowman, Stephen B. Freedman, Jocelyn Gravel, Isabelle Gagnon, Gurinder Sangha, Kathy Boutis, Darcy Beer, William Craig, Emma Burns, Ken J. Farion, Angelo Mikrogianakis, Karen Barlow, Alexander S. Dubrovsky, Willem Meeuwisse, Gerard Gioia, William P. Meehan, Miriam H. Beauchamp, Yael Kamil, Anne M. Grool, Blaine Hoshizaki, Peter Anderson, Brian L. Brooks, Michael Vassilyadi, Terry Klassen, Michelle Keightley, Lawrence Richer, Carol DeMatteo, Martin H. Osmond, Roger Zemek, Jialing Xie, Jennifer Chatfield, Nadia Dow, Rena Papadimitropoulos, Tracey Levesque, Cindy Langford, Tinh Trung Tran, Candice McGahern, Vanessa DiGirolamo, Joanna Mazza, Maryse Lagace, Ramona Cook, Eleanor Fitzpatrick, Jessica MacIntyre, Jill Moore
JOURNAL OF NEUROTRAUMA
(2019)
Article
Clinical Neurology
Chantel Teresa Debert, Joan Stilling, Meng Wang, Tolulope Sajobi, Kristina Kowalski, Brian Walter Benson, Keith Yeates, Sean Peter Dukelow
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2019)
Article
Rehabilitation
Emily Schorr, Shari L. Wade, H. Gerry Taylor, Terry Stancin, Keith Owen Yeates
DISABILITY AND REHABILITATION
(2020)
Article
Clinical Neurology
Miriam H. Beauchamp, Ken Tang, Keith Owen Yeates, Peter Anderson, Brian L. Brooks, Michelle Keightley, Naddley Desire, Kathy Boutis, Isabelle Gagnon, Jocelyn Gravel, Alexander Sasha Dubrovsky, Roger Zemek
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2019)
Article
Clinical Neurology
Christianne Laliberte Durish, Keith Owen Yeates, Brian L. Brooks
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2019)
Editorial Material
Clinical Neurology
Miriam H. Beauchamp, Keith O. Yeates
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2019)
Article
Medicine, General & Internal
Jingzhen Yang, Keith Yeates, Lindsay Sullivan, Bhavna Singichetti, Alison Newton, Pengcheng Xun, H. Gerry Taylor, James MacDonald, Thomas Pommering, Michael Tiso, Daniel Cohen, Yungui Huang, Jeremy Patterson, Zhong-lin Lu
Article
Environmental Sciences
Heather A. Shepherd, Taffin Evans, Srijal Gupta, Meghan H. McDonough, Patricia Doyle-Baker, Kathy L. Belton, Shazya Karmali, Samantha Pawer, Gabrielle Hadly, Ian Pike, Stephanie A. Adams, Shelina Babul, Keith Owen Yeates, Daniel C. Kopala-Sibley, Kathryn J. Schneider, Stephanie Cowle, Pamela Fuselli, Carolyn A. Emery, Amanda M. Black
Summary: COVID-19 restrictions have impacted the physical activity, social connections, and mental health of high school student-athletes, with changes in resources, routines, online classes, and social support all playing a role in affecting their engagement in physical activities and overall well-being.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Sport Sciences
Andree-Anne Ledoux, Nicholas J. Barrowman, Kathy Boutis, Adrienne Davis, Sarah Reid, Gurinder Sangha, Ken J. Farion, Kevin Belanger, Mark S. Tremblay, Keith Owen Yeates, Carol DeMatteo, Nick Reed, Roger Zemek
BRITISH JOURNAL OF SPORTS MEDICINE
(2019)