Article
Clinical Neurology
Rebecca E. Woodrow, Stefan Winzeck, Andrea Luppi, Isaac R. Kelleher-Unger, Lennart R. B. Spindler, J. T. Lindsay Wilson, Virginia F. J. Newcombe, Jonathan P. Coles, David K. Menon, Emmanuel A. Stamatakis
Summary: Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and are difficult to predict or treat. The study found acute thalamic hyperconnectivity in mTBI, even without structural changes. These acute changes in thalamic connectivity can serve as early markers for persistent symptoms and have associations with specific emotional and cognitive symptoms.
Review
Clinical Neurology
Adriano Mollica, Rachel Greben, Chika Oriuwa, Shan H. Siddiqi, Matthew J. Burke
Summary: This article reviews recent research on neuromodulation for mild traumatic brain injury (mTBI). It suggests that transcranial magnetic stimulation (TMS) shows promise as a potential treatment strategy for post-concussive symptoms, such as depression and headaches, while transcranial direct current stimulation (tDCS) has more mixed results. Further studies are needed to explore new stimulation protocols, personalized approaches, and the role of placebo effects.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Neurosciences
Eva Keatley, Kathleen Bechtold, Kevin Psoter, Matthew E. Peters, Allen Everett, Vani Rao, Timothy E. Van Meter, Hayley Falk, Frederick K. Korley, Durga Roy
Summary: This study utilized group-based trajectory modeling (GBTM) to identify distinct patterns of symptom recovery following mild traumatic brain injury (TBI) in the first 6 months after injury. The findings identified four distinct trajectories of recovery, which can be helpful for understanding the natural history of recovery and developing targeted interventions.
Article
Clinical Neurology
Isabel Rosalie Arianne Retel Helmrich, David van Klaveren, Nada Andelic, Hester Lingsma, Andrew Maas, David Menon, Suzanne Polinder, Cecilie Roe, Ewout W. Steyerberg, Ernest Van Veen, Lindsay Wilson
Summary: This study aimed to examine the relationship between disability and health-related quality of life (HRQoL) following traumatic brain injury (TBI), while considering variation in personal, injury-related, and environmental factors.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Neurosciences
Jackie L. Gottshall, Amma A. Agyemang, Maya O'Neil, Guo Wei, Angela Presson, Bryson Hewins, Daniel Fisher, Sara Mithani, Pashtun Shahim, Mary Jo Pugh, Elisabeth A. Wilde, Christina Devoto, Kristine Yaffe, Jessica Gill, Kimbra Kenney, J. Kent Werner
Summary: Following mild traumatic brain injury (mTBI), the severity of symptoms reported by individuals is positively correlated with biomarker levels of neurodegeneration. The associations between biomarkers and symptoms do not significantly change when sleep items are included or excluded. The Pittsburgh Sleep Quality Index demonstrates strong correlations with both sleep and non-sleep items of all symptom scales.
Article
Sport Sciences
Todd W. Lyons, Rebekah Mannix, Ken Tang, Keith Owen Yeates, Gurinder Sangha, Emma C. M. Burns, Darcy Beer, Alexander S. Dubrovsky, Isabelle Gagnon, Jocelyn Gravel, Stephen B. Freedman, William Craig, Kathy Boutis, Martin H. Osmond, Gerard Gioia, Roger Zemek
Summary: This study aimed to assess the occurrence and clustering of post-concussive symptoms in children and identify distinct patient phenotypes based on symptom type and severity. The results showed that post-concussive symptoms occur in distinct clusters and five patient groups were identified based on symptom type and severity.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Critical Care Medicine
Jonathan E. Elliott, Nadir M. Balba, Alisha A. McBride, Megan L. Callahan, Kendall T. Street, Matthew P. Butler, Mary M. Heinricher, Miranda M. Lim
Summary: This study examined the effectiveness of different methods for evaluating history of traumatic brain injury (TBI), finding that the Head Trauma Events Characteristics (HTEC) method had the highest sensitivity. It also noted that the results and conclusions may significantly differ depending on the diagnostic method used.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Critical Care Medicine
Ana Mikolic, Suzanne Polinder, Ewout W. Steyerberg, Isabel R. A. Retel Helmrich, Joseph T. Giacino, Andrew I. R. Maas, Joukje van der Naalt, Daphne C. Voormolen, Nicole von Steinbuechel, Lindsay Wilson, Hester F. Lingsma, David van Klaveren
Summary: Prognostic models for early prediction of outcomes after mild TBI lack both good calibration and discrimination, and future studies should focus on tailoring these models to the specific population with mild TBI.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neuroimaging
Julie M. Joyce, Leah J. Mercier, Mehak Stokoe, Parker L. La, Tiffany Bell, Julia M. Batycky, Chantel T. Debert, Ashley D. Harris
Summary: This study aimed to investigate the pathophysiology of persistent post-concussive symptoms (PPCS). The study found that anterior cingulate glutamate (Glu) was significantly reduced in PPCS patients compared to controls, while higher anterior cingulate gamma-aminobutyric acid (GABA) was significantly associated with a higher number of lifetime mild traumatic brain injuries (mTBIs). In addition, glutathione (GSH) in both regions of interest was positively associated with symptoms of sleepiness and headache burden.
NEUROIMAGE-CLINICAL
(2022)
Review
Critical Care Medicine
David Hacker, Christopher A. Jones, Eyrsa Yasin, Sophie Preece, Holly Davies, Andrew Hawkins, Antonio Belli, Emily Paton
Summary: Cognitive outcomes were compared between mild traumatic brain injury (mTBI) with positive brain imaging (complicated mTBI) and mTBI with normal imaging (uncomplicated mTBI) as well as moderate to severe TBI. The findings showed that complicated mTBI had poorer cognitive outcomes than uncomplicated mTBI, but the deficits were not as severe as in moderate-severe TBI. The deficits in complicated mTBI were present in processing speed, memory, executive function, and language beyond 3 months post-injury.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Jamie N. Hershaw, Candace A. Hill-Pearson
Summary: This study explores the efficacy of neurofeedback therapy based on Live Z-Score Training for patients with persistent post-concussive symptoms. The results indicate that specific changes in EEG patterns can predict symptom improvement, with the ability to predict reduction in pain and cognitive symptoms, as well as improvement in affective symptoms.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Julian Takagi-Stewart, Ashleigh M. Johnson, Mallory B. Smith, Jin Wang, Lyscha A. Marcynyszyn, Douglas F. Zatzick, Carolyn A. McCarty, Frederick P. Rivara, Monica S. Vavilala
Summary: This study examined the association between physician recommended school accommodations and student outcomes among youth experiencing persistent post-concussive symptoms (PPCS). The results showed that physicians recommend more school accommodations for students experiencing more school problems post-concussion. However, there were no significant associations found between recommended school accommodations and GPA, health-related quality of life, anxiety symptoms, or depressive symptoms.
NEUROREHABILITATION
(2022)
Article
Critical Care Medicine
Emily R. Fisher, Janelle J. Montroy, Gerardo Duque, Charles S. Cox, Linda Ewing-Cobbs
Summary: This study investigated the persistence of PCS and PTSS in children and adolescents following TBI and EI, finding that the two types of symptoms varied among different TBI severity groups. Shared vulnerability factors included female sex, milder TBI, and poorer pre-injury adjustment, while older age was a unique vulnerability factor for PTSS.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Medicine, General & Internal
Natascha Ekdahl, Alison K. Godbolt, Catharina Nygren Deboussard, Marianne Lannsjo, Britt-Marie Stalnacke, Maud Stenberg, Trandur Ulfarsson, Marika C. Moller
Summary: The study investigates the relationship between early global cognitive functioning and cognitive flexibility in severe traumatic brain injury patients. The results show a significant correlation between early global cognitive functioning, cognitive flexibility, and long-term outcome.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Ergonomics
John P. K. Bernstein, William P. Milberg, Regina E. McGlinchey, Catherine B. Fortier
Summary: Human factors are responsible for most motor vehicle accidents on the road. Symptoms of posttraumatic stress disorder (PTSD) are linked to reduced driving safety, although there is limited research on this topic. A review of 22 studies found associations between PTSD and driving behaviors, including increased hostile driving behaviors, unintentional driving errors, and negative thoughts and emotions while driving. Few studies explored the risk of motor vehicle accidents and driving-related legal issues. Future research should focus on concurrent PTSD symptom and driving-related changes, comprehensive assessment of PTSD and driving, and the impact of comorbid traumatic brain injury history and other neurological and psychiatric conditions on driving outcomes.
ACCIDENT ANALYSIS AND PREVENTION
(2022)
Article
Rehabilitation
Danielle M. Dobney, Isabelle Gagnon
Summary: The study aimed to estimate concussion management practices for youth used by Canadian rehabilitation clinicians and the use of aerobic exercise as a management strategy. A survey completed by 555 clinicians found that the top treatment options were education, sleep recommendations, goal setting, energy management, and manual therapy. Only a third of clinicians prescribed aerobic exercise, with a high caseload of concussion patients being a significant predictor.
PHYSIOTHERAPY CANADA
(2021)
Review
Neurosciences
Eda Cinar, Shikha Saxena, Isabella Gagnon
Summary: This study systematically analyzed the effects of dual-task on gait in typically developing children, finding that different concurrent tasks have varying impacts on different gait parameters.
JOURNAL OF MOTOR BEHAVIOR
(2021)
Article
Pediatrics
Jacquie van Ierssel, Andree-Anne Ledoux, Ken Tang, Rhonda Correll, Keith Owen Yeates, Gerald Gioia, Stephen B. Freedman, Gurinder Sangha, Kathy Boutis, Darcy Beer, William Craig, Emma Burns, Angelo Mikrogianakis, Alexander S. Dubrovsky, Isabelle Gagnon, Jocelyn Gravel, Candice McGahern, Martin H. Osmond, Roger Zemek
Summary: Most youth are symptom-free and fully recovered 1 year following concussion. Some children with repeat concussion have worse outcomes and experience delays in returning to normal school routines and sports.
JOURNAL OF PEDIATRICS
(2021)
Review
Clinical Neurology
Adrienne Crampton, Elizabeth Teel, Mathilde Chevignard, Isabelle Gagnon
Summary: Mild traumatic brain injury is a common injury that can result in various symptoms and deficits, including abnormalities to the vestibulo-ocular reflex. Early diagnosis and treatment of vestibulo-ocular reflex deficits following mTBI may greatly improve recovery outcomes and a patient's quality of life.
Review
Clinical Neurology
Christophe Alarie, Isabelle Gagnon, Enrico Quilico, Elizabeth Teel, Bonnie Swaine
Summary: This study investigated the characteristics and effectiveness of physical activity interventions for individuals with mild traumatic brain injuries. Five types of interventions were identified, but there was significant variability in the reporting of intervention characteristics across studies, with many details necessary for intervention replication missing.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2021)
Article
Clinical Neurology
Andree-Anne Ledoux, Ken Tang, Isabelle Gagnon, Martin H. Osmond, Keith O. Yeates, Katherine Healey, Gerard A. Gioia, Roger L. Zemek
Summary: This study found that preinjury physical symptoms were associated with persistent postconcussion symptoms (PPCS) at 4 weeks, independent of age and sex. Providers should consider preinjury symptoms to inform prognosis and recovery management.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Clinical Neurology
Dominique Dupont, Cindy Beaudoin, Naddley Desire, Maria Tran, Isabelle Gagnon, Miriam H. Beauchamp
Summary: This study reports preliminary empirical data on a novel observational postconcussive symptoms inventory for infants, toddlers, and preschoolers. Different patterns of postconcussive symptoms were reported by age group, with behavioral manifestations particularly salient in younger children. These findings suggest the need for developmentally appropriate measures to identify and address postconcussive symptoms in children.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Environmental Sciences
Heather A. Shepherd, Taffin Evans, Srijal Gupta, Meghan H. McDonough, Patricia Doyle-Baker, Kathy L. Belton, Shazya Karmali, Samantha Pawer, Gabrielle Hadly, Ian Pike, Stephanie A. Adams, Shelina Babul, Keith Owen Yeates, Daniel C. Kopala-Sibley, Kathryn J. Schneider, Stephanie Cowle, Pamela Fuselli, Carolyn A. Emery, Amanda M. Black
Summary: COVID-19 restrictions have impacted the physical activity, social connections, and mental health of high school student-athletes, with changes in resources, routines, online classes, and social support all playing a role in affecting their engagement in physical activities and overall well-being.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Editorial Material
Psychology, Developmental
Amanda S. Newton, Kassi Prisnie, Lee A. Macdonald, Mohamed Eltorki, Yaron Finkelstein, Eleanor Fitzpatrick, Isabelle Gagnon, Brian Greenfield, Gary I. Joubert, Laurence Y. Katz, Ellen L. Lipman, Ahmed Mater, Laurie H. Plotnick, Robert Porter, Scott Sawyer, Kimberly A. St John, Javeed Sukhera, Peter Szatmari, Jananee Rasiah, Margaret Steele, Patricia Hall, Jennifer Thull-Freedman, Monica Taljaard, Mario Cappelli, Sharon E. Clark, Katherine T. Cost, Jeff Round, Jonathan Cherry, Suneeta Monga, Jitender Sareen, Terry P. Klassen, Stephen B. Freedman
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Neurosciences
Eda Cinar, Bradford J. J. McFadyen, Isabelle Gagnon
Summary: This study investigated the role of resource conflict in the dual-task effects on gait and concurrent tasks in children and adolescents. Gait was evaluated with different concurrent tasks, and the effects of condition and type of task on dual-task performance were analyzed. The results showed significant changes in gait parameters and concurrent task performance between single and dual-task conditions, indicating that resource conflict plays a role in dual-task performance.
JOURNAL OF MOTOR BEHAVIOR
(2023)
Review
Sport Sciences
Kathryn J. Schneider, Meghan L. Critchley, Vicki Anderson, Gavin A. Davis, Chantel T. Debert, Nina Feddermann-Demont, Isabelle Gagnon, Kevin M. Guskiewicz, K. Alix Hayden, Stanley Herring, Corson Johnstone, Michael Makdissi, Christina L. Master, Rosemarie Scolaro Moser, Jon S. Patricios, Johna K. Register-Mihalik, Paul E. Ronksley, Noah D. Silverberg, Keith Owen Yeates
Summary: This systematic review evaluated interventions for recovery in children, adolescents, and adults with a sport-related concussion (SRC). The results suggest that individualized cervicovestibular rehabilitation may decrease the time to return to sport for adolescents and adults with dizziness, neck pain, and/or headaches lasting more than 10 days. Vestibular rehabilitation may decrease the time to medical clearance for adolescents with vestibular symptoms/impairments. Active rehabilitation and collaborative care may decrease symptoms for adolescents with persisting symptoms lasting more than 30 days.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Editorial Material
Sport Sciences
Kathryn J. Schneider, Jon S. Patricios
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Marie-Eve Bolduc, Janet E. Rennick, Isabelle Gagnon, Eva Sokol, Annette Majnemer, Marie Brossard-Racine
Summary: This study aimed to explore the perspectives of parents of children and adolescents with complex CHD in Canada regarding developmental follow-up. The results revealed that the current developmental follow-up practices may not timely identify challenges, leading to additional burden on parents and affecting parent-child relationships. Parents emphasized the importance of implementing a universal and systematic approach to developmental follow-up to enable timely identification of challenges and promote positive parent-child relationships.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Pediatrics
Eda Cinar, Lisa Grilli, Debbie Friedman, Isabelle Gagnon
Summary: This study compared balance function in children with sports-related or non-sports-related concussions, finding that children with non-sports-related concussions exhibited higher levels of postural instability compared to those with sports-related concussions.
TURKISH JOURNAL OF PEDIATRICS
(2021)
Article
Clinical Neurology
Elizabeth Teel, Marie Brossard-Racine, Laurie-Ann Corbin-Berrigan, Isabelle Gagnon
Summary: The study concluded that prescribing 3D-MOT training for acute rehabilitation in pediatric patients with concussion did not show significant benefits in symptom improvement. Clinicians should focus on more effective programs for concussion rehabilitation.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2021)