‘N-of-1-pathways’ unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: towards precision medicine

Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study

(2014) Vincent Gardeux et al.   BMC Medical Genomics

Curation-free biomodules mechanisms in prostate cancer predict recurrent disease

(2013) James L Chen et al.   BMC Medical Genomics

New Pathologic Classification of Lung Cancer: Relevance for Clinical Practice and Clinical Trials

(2013) William D. Travis et al.   JOURNAL OF CLINICAL ONCOLOGY

Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases

(2013) Younghee Lee et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas

(2013) Il-Jin Kim et al.   Nature Communications

Why Your New Cancer Biomarker May Never Work: Recurrent Patterns and Remarkable Diversity in Biomarker Failures

(2012) S. E. Kern   CANCER RESEARCH

Complex-disease networks of trait-associated single-nucleotide polymorphisms (SNPs) unveiled by information theory

(2012) Haiquan Li et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Single Sample Expression-Anchored Mechanisms Predict Survival in Head and Neck Cancer

(2012) Xinan Yang et al.   PLoS Computational Biology

Variants Affecting Exon Skipping Contribute to Complex Traits

(2012) Younghee Lee et al.   PLoS Genetics

Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations

(2012) Krishna R. Kalari et al.   Frontiers in Oncology

Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence

(2011) James L Chen et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Principal component analysis-based filtering improves detection for Affymetrix gene expression arrays

(2011) Jun Lu et al.   NUCLEIC ACIDS RESEARCH

The n-of-1 clinical trial: the ultimate strategy for individualizing medicine?

(2011) Elizabeth O Lillie et al.   Personalized Medicine

Prediction of breast cancer prognosis using gene set statistics provides signature stability and biological context

(2010) Gad Abraham et al.   BMC BIOINFORMATICS

Individual (N-of-1) trials can be combined to give population comparative treatment effect estimates: methodologic considerations

(2010) Deborah R. Zucker et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Clinical assessment incorporating a personal genome

(2010) Euan A Ashley et al.   LANCET

Lung Adenocarcinoma: Lessons in Translation from Bench to Bedside

(2010) Jaya Sangodkar et al.   MOUNT SINAI JOURNAL OF MEDICINE

An integrative pathway-based clinical–genomic model for cancer survival prediction

(2010) Xi Chen et al.   STATISTICS & PROBABILITY LETTERS

Network Modeling Identifies Molecular Functions Targeted by miR-204 to Suppress Head and Neck Tumor Metastasis

(2010) Younghee Lee et al.   PLoS Computational Biology

Estimating accuracy of RNA-Seq and microarrays with proteomics

(2009) Xing Fu et al.   BMC GENOMICS

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

The Gene Ontology in 2010: extensions and refinements

(2009)   NUCLEIC ACIDS RESEARCH

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional classification analysis of somatically mutated genes in human breast and colorectal cancers

(2008) Thomas W. Chittenden et al.   GENOMICS

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Whole genome exon arrays identify differential expression of alternatively spliced, cancer-related genes in lung cancer

(2008) Liqiang Xi et al.   NUCLEIC ACIDS RESEARCH