Review
Medicine, General & Internal
Zheyu Zhang, Ruozheng Pi, Jieya Luo, Ji Liu, Aihua Zhang, Baofei Sun
Summary: This study found that levels of inflammatory cytokines were altered in individuals with arsenic exposure, indicating that arsenic exposure may trigger a cell-mediated inflammatory response. Therefore, regular examination of immune function, such as inflammatory cytokines, in individuals at risk of arsenic exposure is crucial for maintaining human health.
Article
Biochemistry & Molecular Biology
Arik Sheinenzon, Mona Shehadeh, Regina Michelis, Ety Shaoul, Ohad Ronen
Summary: This study examined the correlation between albumin levels and inflammatory indices in hospitalized patients, showing negative correlations between albumin and CRP/white blood cell levels and positive correlations with platelets/hemoglobin levels. The strongest negative correlation between albumin and CRP was found in the Internal Medicine departments. Linear regression analysis revealed a minor effect of CRP on albumin levels, particularly at very high CRP levels. Further exploration of the mechanisms underlying this negative correlation is needed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Public, Environmental & Occupational Health
Hend Alqaderi, Fahad Hegazi, Fahd Al-Mulla, Chung-Jung Chiu, Alpdogan Kantarci, Ebaa Al-Ozairi, Mohamed Abu-Farha, Saadoun Bin-Hasan, Aishah Alsumait, Jehad Abubaker, Sriraman Devarajan, J. Max Goodson, Hatice Hasturk, Mary Tavares
Summary: This study evaluated the relationship between specific salivary biomarkers, obesity, and intermediate hyperglycemia in children. Longitudinal analyses showed that higher salivary CRP and insulin levels were predictive of hyperglycemia and obesity.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Health Care Sciences & Services
Aleksandra Makarewicz, Malgorzata Jamka, Jakub Geltz, Angelika Smidowicz, Marta Kokot, Nina Kaczmarek, Edyta Madry, Jaroslaw Walkowiak
Summary: This meta-analysis compared the effects of endurance, strength, and combined training on inflammatory markers and adipokine concentrations in overweight and obese adults. The findings suggest that endurance training is more effective than strength training in reducing CRP, IL-6, and visfatin concentrations, while combined training is more beneficial in reducing TNF-alpha levels. There were no differences between the effects of different types of training on adiponectin and leptin concentrations. Further studies are needed to determine the optimal training for adiponectin and leptin concentrations in this population.
Article
Clinical Neurology
Silvia Fraga, Sara Soares, Ana Cristina Santos, Henrique Barros
Summary: Children who experience physical abuse from their parents are more likely to have elevated levels of high sensitivity C-reactive protein (hs-CRP), with a positive correlation between the severity of violence and hs-CRP levels. This suggests that parental violence may have a negative impact on children's health, influencing inflammatory processes even at an early age.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Immunology
Michael Drozd, Mar Pujades-Rodriguez, Ann W. Morgan, Patrick J. Lillie, Klaus K. Witte, Mark T. Kearney, Richard M. Cubbon
Summary: Systemic inflammation assessed using C-reactive protein is common in many chronic diseases and is associated with increased long-term risk of fatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Geriatrics & Gerontology
Xin Ma, Xinchun Mei, Tianyi Tang, Meijuan Wang, Xiaoyi Wei, Hailin Zheng, Jing Cao, Hui Zheng, Kathryn Cody, Lize Xiong, Edward R. Marcantonio, Zhongcong Xie, Yuan Shen
Summary: This study aimed to compare the role of preoperative homocysteine versus postoperative CRP blood concentration in predicting postoperative delirium. The results showed that the postoperative plasma concentration of CRP was associated with the incidence and severity of postoperative delirium. Furthermore, the preoperative plasma concentration of homocysteine modified this association.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Nutrition & Dietetics
Stefan Zivkovic, Gorica Maric, Natasa Cvetinovic, Danijela Lepojevic-Stefanovic, Bojana Bozic Cvijan
Summary: Cardiovascular diseases (CVD) are the leading cause of death worldwide. Lipid-lowering agents used in the treatment of CVD may also have anti-inflammatory and immunomodulatory properties. This review aims to evaluate the anti-inflammatory properties of currently available lipid-lowering medications, dietary supplements, and novel drugs.
Article
Nursing
Rebecca Hoban, Hadar Nir, Emily Somerset, Jordan Lewis, Sharon Unger, Deborah L. O'Connor
Summary: This study investigated the cytokines and inflammatory markers in the breastmilk of parents of very preterm infants, as well as their correlations with infant's stool calprotectin. The results showed detectable inflammatory markers in the breastmilk, some of which changed over time, but no correlation was found with infant's stool calprotectin.
JOURNAL OF HUMAN LACTATION
(2023)
Article
Behavioral Sciences
Maryam Pourhassan, Nina Babel, Lars Sieske, Timm Henning Westhoff, Rainer Wirth
Summary: This study found that certain cytokines, particularly IL-18, were associated with poor appetite in acutely ill older hospitalized patients, indicating that they may be considered as potential targets for the prevention and treatment of malnutrition.
Article
Immunology
Raid S. Al-Baradie, Shuang Pu, Donghui Liu, Yasmin Zeinolabediny, Glenn Ferris, Coral Sanfeli, Ruben Corpas, Elisa Garcia-Lara, Suliman A. Alsagaby, Bader M. Alshehri, Ahmed M. Abdel-hadi, Fuzail Ahmad, Psalm Moatari, Nima Heidari, Mark Slevin
Summary: mCRP accumulation in brain tissues is closely associated with neurodegenerative processes related to injury and inflammation, likely playing a direct role in promoting tissue damage and supporting the progression of AD after injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Ronnie Meilik, Hadas Ben-Assayag, Ahuva Meilik, Shlomo Berliner, David Zeltser, Itzhak Shapira, Ori Rogowski, Ilana Goldiner, Shani Shenhar-Tsarfaty, Asaf Wasserman
Summary: This study found a clear association between CRP concentration at admission and 7-day mortality, with higher CRP levels indicating higher mortality rates. Additionally, CRP values obtained 24 hours after hospital admission improved diagnostic accuracy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Marios K. Georgakis, Rainer Malik, Tom G. Richardson, Joanna M. M. Howson, Christopher D. Anderson, Stephen Burgess, G. Kees Hovingh, Martin Dichgans, Dipender Gill
Summary: The study found that genetically predicted IL-6 signaling is positively associated with CVD risk, and the increase in CVD risk is linearly related to baseline hsCRP levels. There is no heterogeneity in the association of genetically predicted IL-6 signaling with CVD risk when stratifying the population by sex, age, body mass index, estimated glomerular filtration rate, or systolic blood pressure, but there is evidence of greater associations in individuals with low-density lipoprotein cholesterol >= 160 mg/dL.
Article
Neurosciences
Wei Zhang, Jerrel Rutlin, Sarah A. Eisenstein, Yong Wang, Deanna M. Barch, Tamara Hershey, Ryan Bogdan, Janine D. Bijsterbosch
Summary: This study found associations among depression, peripheral inflammation, and neuroinflammation in the amygdala using data from the UK Biobank. Peripheral inflammation and neuroinflammation in the amygdala were independently associated with depression.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Geriatrics & Gerontology
Ha-Jung Kim, Sooho Lee, Sung-Hoon Kim, Sangho Lee, Ji-Hoon Sim, Young-Jin Ro
Summary: This study aimed to assess the association of an elevated C-reactive protein (CRP)/albumin ratio with the increased incidence of postoperative delirium in elderly people who had undergone hip fracture surgery. The study found that a high CRP/albumin ratio was significantly associated with a higher incidence of postoperative delirium and a higher rate of overall mortality in elderly patients undergoing hip fracture surgery.
EXPERIMENTAL GERONTOLOGY
(2023)
Meeting Abstract
Psychiatry
R. Goncalves, A. Machado, D. Loureiro, J. Cerejeira
EUROPEAN PSYCHIATRY
(2015)
Meeting Abstract
Psychiatry
D. Loureiro, J. L. Pio-Abreu, A. Machado, R. Goncalves, J. Cerejeira
EUROPEAN PSYCHIATRY
(2015)
Meeting Abstract
Psychiatry
E. Albuquerque, S. Fernandes, J. Cerejeira
EUROPEAN PSYCHIATRY
(2016)
Meeting Abstract
Psychiatry
P. Sa Esteves, D. Loureiro, E. Albuquerque, F. Vieira, L. Lagarto, S. Neves, J. Cerejeira
EUROPEAN PSYCHIATRY
(2016)
Article
Psychology, Clinical
Luisa Lagarto, Joaquim Cerejeira
INTERNATIONAL PSYCHOGERIATRICS
(2016)
Article
Geriatrics & Gerontology
Alessandro Morandi, Jin H. Han, David Meagher, Eduard Vasilevskis, Joaquim Cerejeira, Wolfgang Hasemann, Alasdair M. J. MacLullich, Giorgio Annoni, Marco Trabucchi, Giuseppe Bellelli
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2016)
Article
Psychology, Clinical
Sarah J. Richardson, Daniel H. J. Davis, Giuseppe Bellelli, Wolfgang Hasemann, David Meagher, Stefan H. Kreisel, Alasdair M. J. MacLullich, Joaquim Cerejeira, Alessandro Morandi
INTERNATIONAL PSYCHOGERIATRICS
(2017)
Article
Psychology, Developmental
Ana Machado, Diana Rafaela, Tania Silva, Tania Veigas, Joaquim Cerejeira
JOURNAL OF ATTENTION DISORDERS
(2020)
Article
Endocrinology & Metabolism
Joaquim Cerejeira, Luisa Lagarto, Elizabeta B. Mukaetova-Ladinska
NEUROIMMUNOMODULATION
(2014)
Article
Geriatrics & Gerontology
Luisa Lagarto, Elisabete Albuquerque, Diana Loureiro, Filipe Vieira, Pedro Esteves, Sandra Neves, Manuel Teixeira-Verissimo, Joaquim Cerejeira
AGING & MENTAL HEALTH
(2020)
Article
Geriatrics & Gerontology
Patricia Sofia Soares Regueira, Joaquim Manuel Soares Cerejeira
Review
Geriatrics & Gerontology
Ana Rita Silva, Patricia Regueira, Elisabete Albuquerque, Ines Baldeiras, Ana Luisa Cardoso, Isabel Santana, Joaquim Cerejeira
Summary: Delirium is common among older adults undergoing noncardiac surgery, with postoperative delirium estimates increasing by 3% per year from 1995 to 2020. Type of anesthesia and preoperative cognitive status are significant moderators of delirium frequency. It is suggested that more resources should be allocated to delirium prevention and management in surgical settings.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Psychiatry
Ana Rita Silva, Patricia Regueira, Ana Luisa Cardoso, Ines Baldeiras, Isabel Santana, Joaquim Cerejeira
Summary: Dementia is a known risk factor for delirium and acute systemic infections, leading to cognitive decline in older patients. The study found that presence of delirium in individuals with prior dementia during hospitalization predicted cognitive decline at 1 year following admission. The findings suggest a pathophysiological interaction between neurodegenerative changes, acute infection, and delirium.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Developmental
Diana Loureiro, Ana Machado, Tania Silva, Tania Veigas, Carlos Ramalheira, Joaquim Cerejeira
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2018)
Meeting Abstract
Psychiatry
P. Sa Esteves, D. Mota, J. Cerejeira, F. Mendes
EUROPEAN PSYCHIATRY
(2015)