Article
Cell Biology
Hyo-Jung Lee, Ju-Young Choi, Jaeho Lee, Donghoon Kim, Jin-Young Min, Kyoung-Bok Min
Summary: This study revealed a negative association between serum uric acid and serum klotho levels, indicating that an increase in uric acid levels is associated with a decrease in klotho levels.
Article
Chemistry, Medicinal
Katsunori Yanai, Keiji Hirai, Shohei Kaneko, Yuko Mutsuyoshi, Taisuke Kitano, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Susumu Ookawara, Yoshiyuki Morishita
Summary: We retrospectively analyzed the efficacy and safety of dotinurad, a selective urate reabsorption inhibitor, in hyperuricemic patients with advanced CKD. The results showed that dotinurad was able to decrease uric acid levels and might attenuate renal function decline.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Liyi Liu, Lili You, Kan Sun, Feng Li, Yiqin Qi, Chaogang Chen, Chuan Wang, Guojuan Lao, Shengneng Xue, Juying Tang, Na Li, Wanting Feng, Chuan Yang, Mingtong Xu, Yan Li, Li Yan, Meng Ren, Diaozhu Lin
Summary: This study found that lowering uric acid levels is associated with changes in renal function, reducing the risk of renal function decline and increasing the likelihood of renal function improvement. Management of serum uric acid levels should be emphasized in clinical practice, and it may be a part of chronic kidney disease treatment.
Article
Transplantation
Shijie Wu, Wen Xue, Hanqing Yu, Hanjie Yu, Zhaoqiang Shi, Ling Wang, Ai Peng
Summary: This study investigated the relationship between serum uric acid concentrations and mortality risk among patients with chronic kidney disease (CKD). The results demonstrated J-shaped non-linear relationships between uric acid concentrations and all-cause and cardiovascular disease mortality, with inflection points at 311.65 mu mol/L and 392.34 mu mol/L, respectively. Furthermore, a negative linear correlation with cancer mortality was observed. The study suggests that maintaining appropriate uric acid concentrations may improve long-term health outcomes among CKD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Integrative & Complementary Medicine
Siyao Sang, Lufei Wang, Taotao Liang, Mingjie Su, Hui Li
Summary: Different types of tea have different effects on hyperuricaemia, with yellow tea significantly improving hyperuricaemia by regulating the inflammatory response, autophagy, and apoptosis.
Article
Environmental Sciences
Xu Tang, Lu Xu, Ruo Gu Meng, Yi Qing Du, Shi Jun Liu, Si Yan Zhan, Tao Xu
Summary: This study aimed to evaluate the association between serum uric acid (SUA) and kidney function decline. The results showed a significant dose-response relationship between SUA and kidney function decline, with a 14% increased risk per 1 mg/dL increase in SUA. Subgroup analysis showed that this relationship was only observed among women, those aged < 60 years, and those without hypertension and diabetes.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2023)
Article
Biophysics
Insu Kim, Young Im Kim, Sang Won Lee, Hyo Gi Jung, Gyudo Lee, Dae Sung Yoon
Summary: The study found that the uric acid transporter 1 (URAT1) abundant in kidney cell membranes can be utilized to develop a biosensor capable of selectively detecting uric acid.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Medicine, General & Internal
Peng-Tzu Liu, Jong-Dar Chen
Summary: This study evaluated the association of HHcy and hyperuricemia with CKD in middle-aged and elderly populations in Taiwan, finding that both HHcy and hyperuricemia are independent risk factors for CKD with a significant synergistic association. The odds ratios of CKD increased with the quartiles of Hcy, independent of hyperuricemia, and hyperuricemia and HHcy showed a synergistic association with CKD.
Article
Plant Sciences
Qian Ren, Sibei Tao, Fan Guo, Bo Wang, Letian Yang, Liang Ma, Ping Fu
Summary: Fisetin can regulate the expression of urate transporters, reduce uric acid levels, alleviate renal inflammation, prevent kidney fibrosis, and protect against hyperuricemic nephropathy.
Article
Biochemistry & Molecular Biology
Ye Chen, Chaoying Pei, Ying Chen, Xiaoyi Xiao, Xingyuan Zhang, Kaiwei Cai, Song Deng, Rongyao Liang, Zhiyong Xie, Pei Li, Qiongfeng Liao
Summary: Kidney tea, a Chinese herbal medicine, can lower uric acid levels and alleviate gout, but the mechanism is not clear. This study investigated the changes in intestinal flora and metabolome to explore the mechanism of kidney tea in lowering uric acid. The results showed that kidney tea significantly reduced serum uric acid levels and mitigated renal damage caused by hyperuricemia. Additionally, kidney tea improved the structure of the intestinal flora and regulated metabolic disorders. These findings provide a theoretical basis for the use of kidney tea as a uric acid-lowering drug.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Peripheral Vascular Disease
Stella Stabouli, Katerina Chrysaidou, Athanasia Chainoglou, Dimos Gidaris, Vasilios Kotsis, Dimitrios Zafeiriou
Summary: Observational studies have shown that high serum uric acid levels are associated with worse executive performance in children and adolescents at risk for primary hypertension. Further longitudinal studies are needed to determine whether elevated uric acid levels increase the risk of cognitive decline in youth.
Article
Rheumatology
Sunao Kojima, Kazuaki Uchiyama, Naoto Yokota, Eiichi Tokutake, Yutaka Wakasa, Shinya Hiramitsu, Masako Waki, Hideaki Jinnouchi, Hirokazu Kakuda, Takahiro Hayashi, Naoki Kawai, Masahiro Sugawara, Hisao Mori, Kenichi Tsujita, Kunihiko Matsui, Ichiro Hisatome, Yusuke Ohya, Kazuo Kimura, Yoshihiko Saito, Hisao Ogawa
Summary: Hyperuricaemia is a risk marker for cardiovascular and renal diseases, but excessive reduction of uric acid levels may be harmful. This study explored the feasibility of interventional treatments and determined the optimal uric acid level for asymptomatic hyperuricaemia patients.
Article
Multidisciplinary Sciences
Young-Bin Son, Ji Hyun Yang, Myung-Gyu Kim, Sang Kyung Jo, Won Yong Cho, Se Won Oh
Summary: The study found that serum uric acid is positively correlated with systolic blood pressure, triglycerides, body mass index, and body fat percentage. Additionally, it is inversely associated with high density lipoprotein (HDL) and is an independent risk factor for the development of diabetes, hypertension, and obesity. High levels of uric acid are also associated with increased risk of chronic kidney disease (CKD) development and decline in estimated glomerular filtration rate (eGFR) in individuals with normal kidney function.
Article
Urology & Nephrology
Fengqin Li, Hui Guo, Jianan Zou, Chensheng Fu, Song Liu, Jing Xiao, Zhibin Ye
Summary: The classification of hyperuricemia (HUA) with chronic kidney disease (CKD) can be varied significantly based on different combinations of parameters such as urinary uric acid excretion rate with uric acid clearance rate or 24-hour urinary uric acid with fractional excretion of uric acid. Further research is needed to determine the most applicable classification method for HUA patients with CKD.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Pediatrics
Yuanyuan Xu, Xiaohong Zheng, Hongjie Zhuang, Hongyi Liao, Ying Mo, Xiaoyun Jiang, Wen Li
Summary: This study aims to explore potential biomarkers and risk factors in children with IgA nephropathy (IgAN). The results showed that hyperuricemia is closely related to the progression and poor renal outcome of IgAN in children. It is important to pay attention to hyperuricemia in children with IgAN, especially in females.
PEDIATRIC RESEARCH
(2023)
Article
Pathology
Jennifer A. Schaub, Christopher L. O'Connor, Jian Shi, Roger C. Wiggins, Kerby Shedden, Jeffrey B. Hodgin, Markus Bitzer
Summary: Detection of one segmentally sclerosed glomerulus (SSG) is important for identifying patients with focal segmental glomerulosclerosis (FSGS), but rare SSGs may be missed in kidney biopsies. Quantitative morphometrics, such as podocyte density and mesangial index, can help identify patients with infrequent SSG and serve as clinical markers for FSGS diagnosis. Overall, more than half of FSGS patients had SSG, with 30% having infrequent SSG lesions.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Hematology
Ryann Sohaney, Salma Shaikhouni, John Travis Ludwig, Anca Tilea, Markus Bitzer, Lenar Yessayan, Michael Heung
Summary: This study reviewed the chart of 32 patients with COVID-19 and acute kidney injury who were managed with continuous venovenous hemodiafiltration with regional citrate anticoagulation. The results showed that the median CRRT circuit life was 53.5 hours. There was no association between circuit life and inflammatory or pro-thrombotic laboratory values, or with fluid balance and respiratory parameters.
BLOOD PURIFICATION
(2022)
Article
Multidisciplinary Sciences
Joonsang Lee, Elisa Warner, Salma Shaikhouni, Markus Bitzer, Matthias Kretzler, Debbie Gipson, Subramaniam Pennathur, Keith Bellovich, Zeenat Bhat, Crystal Gadegbeku, Susan Massengill, Kalyani Perumal, Jharna Saha, Yingbao Yang, Jinghui Luo, Xin Zhang, Laura Mariani, Jeffrey B. Hodgin, Arvind Rao
Summary: Pathologists use visual classification to assess kidney biopsy samples, but current methods lack reproducibility. To overcome this, we developed an unsupervised bag-of-words model and successfully predicted kidney function levels in chronic kidney disease patients. Our study ranked important morphological features as diagnostic markers for kidney disease.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Hongyang Li, Ridvan Eksi, Daiyao Yi, Bradley Godfrey, Lisa R. Mathew, Christopher L. O'Connor, Markus Bitzer, Matthias Kretzler, Rajasree Menon, Yuanfang Guan
Summary: Studying isoform expression at the microscopic level is a challenging task. In this study, a pipeline combining experimental and computational methods was developed to identify isoforms in the glomerular and tubulo-interstitial compartments of the kidney. Distinct functional pathways were found in these two compartments, providing important resources for kidney research.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Douglas K. Atchison, Christopher L. O'Connor, Kimber Converso-Baran, Ingrid L. Bergin, Hongyu Zhang, Yu Wang, John R. Hartman, Wenjun Ju, Alan V. Smrcka, Santhi K. Ganesh, Markus Bitzer
Summary: Phospholipase C epsilon deficiency may play a role in the development of thoracic aortic aneurysm and dissection. The study found that PLC epsilon-deficient mice developed aortic dilation and sudden death after treatment with angiotensin II. In addition, PLCE1 gene variants were identified in patients with aortic disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Jiahao Liu, Viji Nair, Yi-Yang Zhao, Dong-Yuan Chang, Christine Limonte, Nisha Bansal, Damian Fermin, Felix Eichinger, Emily C. Tanner, Keith A. Bellovich, Susan Steigerwalt, Zeenat Bhat, Jennifer J. Hawkins, Lalita Subramanian, Sylvia E. Rosas, John R. Sedor, Miguel A. Vasquez, Sushrut S. Waikar, Markus Bitzer, Subramaniam Pennathur, Frank C. Brosius, Ian De Boer, Min Chen, Matthias Kretzler, Wenjun Ju
Summary: The study identified plasma angiopoietin 2 (ANGPT2) as a promising prognostic endothelial biomarker with potential functional impact on glomerular pathogenesis in diabetic kidney disease (DKD).
Article
Biochemistry & Molecular Biology
Baohai Shao, Farsad Afshinnia, Anna V. Mathew, Graziella E. Ronsein, Carissa Thornock, Angela D. Irwin, Mayank Kansal, Panduranga S. Rao, Mirela Dobre, Sadeer Al-Kindi, Matthew R. Weir, Alan Go, Jiang He, Jing Chen, Harold Feldman, Karin E. Bornfeldt, Subramaniam Pennathur
Summary: Patients with chronic kidney disease (CKD) are at high risk for cardiovascular disease (CVD), but traditional risk factors cannot fully explain the increased risk. In CKD patients, altered HDL proteome is linked with incident CVD, but the association of other HDL metrics with incident CVD in this population remains unclear.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Urology & Nephrology
Linda Wang, Bayle Smith-Salzberg, Kevin E. C. Meyers, Dorey A. Glenn, Katherine R. Tuttle, Vimal K. Derebail, Tammy M. Brady, Keisha Gibson, Abigail R. Smith, Michelle M. O'Shaughnessy, Tarak Srivastava, Gentzon Hall, Jarcy Zee, Markus Bitzer, Christine B. Sethna
Summary: This study found an association between tobacco exposure and a higher risk for cardiovascular disease (CVD) and worse kidney disease outcomes in patients with proteinuric glomerulopathies. The findings indicate the importance of preventive strategies to reduce tobacco exposure in order to protect against future cardiovascular and kidney morbidity and mortality in these patients.
Review
Urology & Nephrology
Guoming Gao, Emily S. Sumrall, Sethuramasundaram Pitchiaya, Markus Bitzer, Simon Alberti, Nils G. Walter
Summary: The regulation of solute microenvironments is crucial for cellular homeostasis. In the kidney, biomolecular condensates formed through hyperosmotic phase separation play important roles in kidney physiology and disease.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Joonsang Lee, Elisa Warner, Salma Shaikhouni, Markus Bitzer, Matthias Kretzler, Debbie Gipson, Subramaniam Pennathur, Keith Bellovich, Zeenat Bhat, Crystal Gadegbeku, Susan Massengill, Kalyani Perumal, Jharna Saha, Yingbao Yang, Jinghui Luo, Xin Zhang, Laura Mariani, Jeffrey B. Hodgin, Arvind Rao
Summary: In this study, a novel computational framework called CluSA was developed to leverage unsupervised learning and assess kidney function and diagnose the underlying cause of CKD. The framework minimized the need for expert annotations and accurately predicted the degree of kidney function and renal prognosis.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Natalya Kaverina, R. Allen Schweickart, Gek Cher Chan, Joseph C. Maggiore, Diana G. Eng, Yuting Zeng, Sierra R. McKinzie, Hannah S. Perry, Adilijiang Ali, Christopher O'Connor, Beatriz Maria Veloso Pereira, Ashleigh B. Theberge, Joshua C. Vaughan, Carol J. Loretz, Anthony Chang, Neil A. Hukriede, Markus Bitzer, Jeffrey W. Pippin, Oliver Wessely, Stuart J. Shankland
Summary: The lifespan and health-span of podocytes in healthy aging kidneys decrease, leading to changes in their structure, physiology, and function. The ability to reverse these changes becomes important when disease occurs in an aged kidney. RNA-sequencing of podocytes in middle-aged mice and humans revealed an upregulation of inflammatory pathways, including the NLRP3 inflammasome, which is associated with aging. Inhibition of NLRP3 showed promising results in reducing podocyte senescence and improving their lifespan, suggesting a critical role for NLRP3 in podocyte and liver aging.
Article
Medicine, Research & Experimental
Dennis G. Moledina, Wassim Obeid, Rex N. Smith, Ivy Rosales, Meghan E. Sise, Gilbert Moeckel, Michael Kashgarian, Michael Kuperman, Kirk N. Campbell, Sean Lefferts, Kristin Meliambro, Markus Bitzer, Mark A. Perazella, Randy L. Luciano, Jordan S. Pober, Lloyd G. Cantley, Robert B. Colvin, F. Perry Wilson, Chirag R. Parikh
Summary: In this study, urinary CXCL9 was identified as a diagnostic biomarker for acute tubulointerstitial nephritis (AIN) using urine proteomics. This finding was confirmed in multiple validation cohorts and higher expression of CXCL9 was observed in kidney biopsies from AIN patients. This discovery has important implications for the early diagnosis and treatment of AIN.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Jennifer A. Schaub, Fadhl M. AlAkwaa, Phillip J. McCown, Abhijit S. Naik, Viji Nair, Sean Eddy, Rajasree Menon, Edgar A. Otto, Dawit Demeke, John Hartman, Damian Fermin, Christopher L. O'Connor, Lalita Subramanian, Markus Bitzer, Roger Harned, Patricia Ladd, Laura Pyle, Subramaniam Pennathur, Ken Inoki, Jeffrey B. Hodgin, Frank C. Brosius III, Robert G. Nelson, Matthias Kretzler, Petter Bjornstad
Summary: This study analyzed kidney biopsies from type 2 diabetes patients and healthy controls, and found that SGLT2 inhibitor treatment mitigates diabetes-induced metabolic perturbations through suppression of the mTORC1 signaling pathway in kidney tubules. The treatment with SGLT2 inhibitors also affected transcriptional processes in different segments of the renal tubules.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Jeffrey W. Pippin, Natalya Kaverina, Yuliang Wang, Diana G. Eng, Yuting Zeng, Uyen Tran, Carol J. Loretz, Anthony Chang, Shreeram Akilesh, Chetan Poudel, Hannah S. Perry, Christopher O'Connor, Joshua C. Vaughan, Markus Bitzer, Oliver Wessely, Stuart J. Shankland
Summary: With an aging population, kidney health becomes an important medical and socioeconomic factor. The study found that PD-1 signaling plays a crucial role in kidney aging and in the development of focal segmental glomerulosclerosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Physiology
Markus Bitzer, Wenjun Ju, Lalita Subramanian, Jonathan P. Troost, Joseph Tychewicz, Becky Steck, Roger C. Wiggins, Debbie S. Gipson, Crystal A. Gadegbeku, Frank C. Brosius III, Matthias Kretzler, Subramaniam Pennathur
Summary: The research on kidney diseases is changing due to the rapid growth and advancements in omics technologies. However, the analysis, integration, and interpretation of big data have been a challenge in using these technologies. To address this issue, the University of Michigan's MKTC has established the Applied Systems Biology Core to provide support and services for the global kidney research community.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
