A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-Cells in Type 2 Diabetic Mice

Differential requirements of arrestin-3 and clathrin for ligand-dependent and -independent internalization of human G protein-coupled receptor 40

(2014) Jing Qian et al.   CELLULAR SIGNALLING

Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreaticβ-cells

(2014) B. M. Moran et al.   DIABETES OBESITY & METABOLISM

Comparative Effectiveness and Safety of Medications for Type 2 Diabetes: An Update Including New Drugs and 2-Drug Combinations

(2013) Wendy L. Bennett et al.   ANNALS OF INTERNAL MEDICINE

Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold

(2013) Junjie Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The DPP-4 Inhibitor Linagliptin Restores β-Cell Function and Survival in Human Isolated Islets Through GLP-1 Stabilization

(2013) Payal Shah et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel GPR40 agonist AS2575959 exhibits glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion

(2013) Hirotsugu Tanaka et al.   LIFE SCIENCES

Incretin secretion stimulated by ursodeoxycholic acid in healthy subjects

(2013) Masanori Murakami et al.   SpringerPlus

Effects of saxagliptin and sitagliptin on glycaemic control and pancreatic β-cell mass in a streptozotocin-induced mouse model of type 2 diabetes

(2012) S. M. Poucher et al.   DIABETES OBESITY & METABOLISM

A review of the efficacy and safety of oral antidiabetic drugs

(2012) Stephanie Aleskow Stein et al.   Expert Opinion On Drug Safety

Design, Synthesis, and Antidiabetic Activity of 4-Phenoxynicotinamide and 4-Phenoxypyrimidine-5-carboxamide Derivatives as Potent and Orally Efficacious TGR5 Agonists

(2012) Hongliang Duan et al.   JOURNAL OF MEDICINAL CHEMISTRY

GPR119 as a fat sensor

(2012) Harald S. Hansen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Potential New Approaches to Modifying Intestinal GLP-1 Secretion in Patients with Type 2 Diabetes Mellitus

(2011) Jens Juul Holst et al.   CLINICAL DRUG INVESTIGATION

Identification of a Potent and Selective Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist with Favorable Physicochemical and in Vitro ADME Properties

(2011) Elisabeth Christiansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Self-inducible secretion of glucagon-like peptide-1 (GLP-1) that allows MIN6 cells to maintain insulin secretion and insure cell survival

(2011) Koji Nakashima et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling

(2011) Tingting Li et al.   MOLECULAR ENDOCRINOLOGY

Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes?

(2010) Filip K. Knop   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5

(2010) Mark R. Herbert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The value of glycosylated hemoglobin (HbA1c) as a predictive risk factor in the diagnosis of diabetes mellitus (DM) in the elderly

(2009) M. Motta et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet

(2009) T. Kusakabe et al.   DIABETOLOGIA

Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists

(2009) Karen A. Evans et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glucose Sensing in L Cells: A Primary Cell Study

(2008) Frank Reimann et al.   Cell Metabolism

Islet cell function: α and β cells - partners towards normoglycaemia

(2008) B. Göke   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

(2008) Hiroyuki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY