Article
Nutrition & Dietetics
Jiaying Ge, Jiangping Zeng, Huihui Ma, Siqi Sun, Zheng Zhao, Yujie Jing, Chunhua Qian, Zhaoliang Fei, Ran Cui, Shen Qu, Ge Zhang, Hui Sheng
Summary: This study evaluated the effectiveness of serum sarcopenia index and creatinine/cystatin C ratio in diagnosing sarcopenia and predicting future falls and fractures. The results showed that serum sarcopenia index had a better predictive ability than creatinine/cystatin C ratio for sarcopenia. The study also found that lower serum sarcopenia index and creatinine/cystatin C ratio were independent risk factors for sarcopenia, new falls, and fractures in the low-BMD population.
Article
Medical Laboratory Technology
Yu Guan, Yi-Hua Lu, Shu-Feng Lei
Summary: This study found a positive correlation between serum creatinine and bone mineral density in Chinese elderly individuals with normal renal function. Physical activity was found to mediate this correlation, with medium physical activity showing the most significant moderation effect.
CLINICA CHIMICA ACTA
(2022)
Article
Nutrition & Dietetics
Ting Gao, Fupeng Liu, Bo Ban, Yue Hou, Guangxin Li, Mingming Jiang, Qing Yang, Mei Zhang
Summary: This study found that in patients with type 2 diabetes, the ratio of creatinine to cystatin C (Cre/CysC) is positively associated with bone mineral density (BMD), indicating that a high Cre/CysC value may serve as a valuable marker of osteoporosis.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Lulu Han, Shenghai Wang, Jingjing Ma, Ningning Song, Zhao Wang, Mingyan Yao
Summary: This study compares the changes in serum bone metabolism indexes and ultrasonic bone mineral density in patients with diabetic nephropathy at different stages and their effects on diabetic renal microvascular complications. The results show that bone metabolism indexes and ultrasound bone mineral density are abnormally expressed in patients with diabetic nephropathy at different stages and are closely related to the urine protein of patients.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Zhenwei Wang, Weibin Du, Yuanbin Ou, Meichun Han, Jintao Hu, Renfu Quan
Summary: A positive correlation was found between CCR and total BMD in middle-aged and older adults aged 50-85 years, with the most significant positive correlation observed in the older 'other Hispanic' population. No significant correlation was observed among participants of 'other race'.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jakob Starup-Linde, Marie Juul Ornstrup, Thomas Nordstrom Kjaer, Simon Lykkeboe, Aase Handberg, Soren Gregersen, Torben Harslof, Steen Bonlokke Pedersen, Peter Vestergaard, Bente Lomholt Langdahl
Summary: This study compared bone structure, bone density, and bone turnover markers between non-diabetic overweight men with MetS and overweight men with T1D or T2D. The results showed lower bone turnover in men with T2D, but no clinically significant differences in bone density or structure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jia Chen, Geng Liu, Quan Li, Wei Deng
Summary: In patients with type 2 diabetes mellitus, increased prolactin levels are associated with better bone mineral density, especially in men.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hai-yan Huang, Zhi-qi Huang, Ling-yan Hua, Wang-shu Liu, Feng Xu, Xiao-qin Ge, Chun-feng Lu, Jian-bin Su, Xue-qin Wang
Summary: The study found a significant association between low-normal serum sodium levels and low bone turnover, as well as a positive correlation between high serum sodium levels and high bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Tao Zhou, Xue Dai, Yu Yuan, Qiaochu Xue, Xiang Li, Mengying Wang, Hao Ma, Yoriko Heianza, Lu Qi
Summary: A study found that autoimmune diseases, which are more common among people with unhealthy sleep behaviors, are linked to aging-related bone health. The research used a newly developed sleep pattern and found that adhering to this healthy sleep pattern can reduce the risks of falls and fractures.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Sport Sciences
Stephanie A. Kliethermes, Mikel R. Stiffler-Joachim, Christa M. Wille, Jennifer L. Sanfilippo, Pedro Zavala, Bryan C. Heiderscheit
Summary: In collegiate cross country runners, low step rate is an important risk factor for bone stress injury. Increasing step rate is associated with decreased risk of BSI.
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)
Article
Endocrinology & Metabolism
Wei Zhang, Wei Zhao, Wei Li, Qi Geng, Rui Zhao, Yungui Yang, Luyan Lv, Weiwen Chen
Summary: Osteoporosis is a debilitating disease that is often overlooked and poorly studied in elderly male patients. This study aims to investigate molecular alterations in immune cells in men with osteoporosis and identify potential immunomodulatory strategies for treatment. The results show that there are molecular changes in immune cells of male osteoporotic patients and suggest potential therapeutic value of immunomodulation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Zihao Qu, Fangkun Yang, Yishang Yan, Jianqiao Hong, Wei Wang, Sihao Li, Guangyao Jiang, Shigui Yan
Summary: The study found that serum levels of calcium and selenium are associated with bone mineral density at specific skeletal sites, indicating that these nutritional factors play crucial roles in bone metabolism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
ChenYu Wang, Xiang Zhang, Bo Qiu
Summary: This study used Mendelian randomization (MR) analysis to investigate the causal relationship between circulating serum homocysteine (Hcy) levels and osteoporosis (OP) using public datasets from genome-wide association studies (GWAS). The results showed no causal effects of Hcy on forearm bone mineral density and lumbar bone mineral density, but a causal relationship was found between genetically predicted Hcy and heel bone mineral density (H-BMD). The study concluded that there is evidence of a causal relationship between circulating serum Hcy levels and H-BMD, but not OP, in the European population.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Anjali Sharma, Donald R. Hoover, Qiuhu Shi, Phyllis C. Tien, Kathleen M. Weber, Jayesh G. Shah, Michael T. Yin
Summary: Among pre-, peri-, and postmenopausal women, low bone mineral density (BMD) was more common in women with HIV compared to those without HIV. HIV infection and menopausal stage were independent predictors of lower BMD and had additive effects on lumbar spine and total hip BMD.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Igor Gouveia Pietrobom, Ana Cristina Carvalho de Matos, Martin H. H. De Borst, Ita Pfeferman Heilberg
Summary: The study investigated the association of urinary calcium with serum sclerostin, bone mineral density, and body composition in stone formers. The results showed that serum sclerostin is associated with urinary calcium levels, suggesting a potential additional role of sclerostin in calcium reabsorption in the kidneys.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
H. M. Kim, B. R. Lee, E. S. Lee, M. H. Kwon, J. H. Huh, B-E Kwon, E-K Park, S-Y Chang, M-N Kweon, P-H Kim, H-J Ko, C. H. Chung
INTERNATIONAL JOURNAL OF OBESITY
(2018)
Article
Endocrinology & Metabolism
Ji Hye Huh, Hong Min Kim, Eun Soo Lee, Mi Hye Kwon, Bo Ra Lee, Hyun-Jeong Ko, Choon Hee Chung
Article
Neurosciences
Sungjin Park, Sung-Kyung Kim, Jae-Yeop Kim, Kyungsuk Lee, Jung Ran Choi, Sei-Jin Chang, Choon Hee Chung, Kyu-Sang Park, Sung-Soo Oh, Sang-Baek Koh
Article
Endocrinology & Metabolism
Eun Soo Lee, Mi-Hye Kwon, Hong Min Kim, Nami Kim, You Mi Kim, Hyeon Soo Kim, Eun Young Lee, Choon Hee Chung
JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Cell Biology
So-Young Kim, Samel Park, Seong-Woo Lee, Ji-Hye Lee, Eun Soo Lee, Miri Kim, Youngjo Kim, Jeong Suk Kang, Choon Hee Chung, Jong-Seok Moon, Eun Young Lee
Summary: Fabry disease is a lysosomal storage disease caused by deficient or reduced activity of the enzyme alpha-galactosidase A. In Fabry nephropathy, kidney damage is a significant factor in patient morbidity and mortality. The study shows that RIPK3, a protein kinase involved in necroptosis, plays a crucial role in the pathogenesis of Fabry nephropathy, affecting cell viability, ROS generation, and cytoskeleton rearrangement.
Article
Cell Biology
Eun Soo Lee, Jeong Suk Kang, Hong Min Kim, Su Jin Kim, Nami Kim, Jung Ok Lee, Hyeon Soo Kim, Eun Young Lee, Choon Hee Chung
Summary: The study confirmed the efficacy of dehydrozingerone (DHZ) in diabetic nephropathy, showing that DHZ can reduce renal glycerol accumulation and albuminuria excretion by improving renal morphology and molecular changes, thereby reducing oxidative stress and inflammation responses to prevent kidney damage.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Jung Eun Kim, Hye Ran Kim, Jin Cheol Kim, Eun Soo Lee, Choon Hee Chung, Eun Young Lee, Bo Young Chung
Summary: The study found that a high-fat diet can lead to increased skin inflammation, oxidative stress, and autophagy levels. Tetrahydrocurcumin (THC) was shown to reduce inflammatory factors and oxidative stress, but it also suppressed autophagy markers.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Weerapon Sangartit, Kyung Bong Ha, Eun Soo Lee, Hong Min Kim, Upa Kukongviriyapan, Eun Young Lee, Choon Hee Chung
Summary: The study found that THU could alleviate kidney injury in type 2 diabetic mice induced by HFD, possibly by suppressing intrarenal RAAS activation, improving insulin sensitivity, and reducing SBP.
ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Hye Soon Kim, Jae Myung Yu, Hak Chul Jang, Eui Kwang Choi, Jeong Hyun Park, Ho Sang Shon, Choon Hee Chung, Keun-Gyu Park, Jae Hyoung Cho, Won Kim, Kyoung Hwa Lee, Jee Hyun Lee, Soon Jib Yoo
Summary: This study explored the pattern and clinical effectiveness of the use of rapid-acting insulins (RAIs) in Korean patients with type 2 diabetes mellitus (T2DM). The results showed that the use of insulin glulisine significantly reduced glycated hemoglobin, fasting plasma glucose, and post prandial blood glucose levels, but led to an increase in body weight. Additionally, the intensive regimen (basal insulin+>= 2 RAI injections/day) was more effective in achieving glycemic targets.
DIABETES METABOLIC SYNDROME AND OBESITY
(2022)
Article
Endocrinology & Metabolism
Kyung Bong Ha, Weerapon Sangartit, Ah Reum Jeong, Eun Soo Lee, Hong Min Kim, Soyeon Shim, Upa Kukongyiriyapan, Dae-Kee Kim, Eun Young Lee, Choon Hee Chung
Summary: EW-7197 exhibits renoprotective effect in diabetic nephropathy by inhibiting TGF-β signaling, thereby alleviating renal fibrosis and inflammation, and retarding the progression of the disease.
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Yong-ho Lee, Doo-Man Kim, Jae Myung Yu, Kyung Mook Choi, Sin Gon Kim, Kang Seo Park, Hyun-Shik Son, Choon Hee Chung, Kyu Jeung Ahn, Soon Hee Lee, Ki-Ho Song, Su Kyoung Kwon, Hyeong Kyu Park, Kyu Chang Won, Hak Chul Jang
Summary: This study compared the effects of anagliptin 100 mg BID versus sitagliptin 100 mg QD on managing glycaemic variability and found that the anagliptin BID regimen was superior in blood glucose control after dinner, as indicated by MAGE and TIR, but was equivalent to the QD regimen in terms of HbA1c and FPG.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Soo Heon Kwak, Kyung Ah Han, Kyung-Soo Kim, Jae Myung Yu, EunSook Kim, Jong Chul Won, Jun Goo Kang, Choon Hee Chung, Seungjoon Oh, Sung Hee Choi, Kyu Chang Won, Sin Gon Kim, Seung Ah Cho, Bo Young Cho, Kyong Soo Park
Summary: This study evaluated the efficacy and safety of enavogliflozin 0.3 mg as a monotherapy for Korean patients with inadequately controlled type 2 diabetes through diet and exercise. The results showed that enavogliflozin 0.3 mg improved glycemic control in patients with T2DM, and also had beneficial effects on body weight, blood pressure, and lipid profile.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hyeong Kyu Park, Kyoung-Ah Kim, Kyung-Wan Min, Tae-Seo Sohn, In Kyung Jeong, Chul Woo Ahn, Nan-Hee Kim, Ie Byung Park, Ho Chan Cho, Choon Hee Chung, Sung Hee Choi, Kang Seo Park, Seoung-Oh Yang, Kwan Woo Lee
Summary: This study evaluated the effects of dapagliflozin compared with glimepiride on body composition in Korean patients with type 2 diabetes. The results showed that dapagliflozin had a greater impact on reducing total body fat mass, abdominal visceral adipose tissue, and subcutaneous adipose tissue compared to glimepiride. This 52-week study also found that dapagliflozin had better glycemic control and safety profile when added to metformin monotherapy.
DIABETES OBESITY & METABOLISM
(2023)
Article
Biochemical Research Methods
Jaehoon Kim, Hyunho Kim, Jeong Suk Kang, Eun Soo Lee, Choon Hee Chung, Hyun Jeong Oh, YongTae Kim, Seok Chung, Eun Young Lee
Summary: We have developed a microfluidic model that replicates the physiology of the glomerular filtration barrier (GFB) through tunable glomerular basement membrane (gBM) deposition and 3D co-culture of podocytes with glomerular endothelial cells (gECs). By controlling the thickness of the gBM, our model successfully reproduces the biphasic response of the GFB and facilitates dynamic crosstalk between gECs and podocytes. The interaction of gECs and podocytes plays a significant role in drug-induced injury and regulation of barrier properties.
Article
Medicine, General & Internal
Na Won Park, Eun Soo Lee, Kyung Bong Ha, Su Ho Jo, Hong Min Kim, Mi-Hye Kwon, Choon Hee Chung
Summary: This study evaluated the efficacy of umbelliferone in hepatic steatosis and palmitate-induced hepatocellular lipotoxicity. The results showed that umbelliferone improved insulin resistance by inhibiting lipid accumulation and regulating endoplasmic reticulum stress. These findings suggest that umbelliferone may be a potential therapeutic compound against non-alcoholic fatty liver disease.
YONSEI MEDICAL JOURNAL
(2023)