Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial

American Gastroenterological Association Institute Technical Review on the Pharmacological Management of Irritable Bowel Syndrome

(2014) Lin Chang et al.   GASTROENTEROLOGY

Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI

(2013) Kathryn Murray et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Emerging treatments for chronic constipation

(2013) Vineet S Gudsoorkar et al.   EXPERT OPINION ON EMERGING DRUGS

Rome III Functional Constipation and Irritable Bowel Syndrome With Constipation Are Similar Disorders Within a Spectrum of Sensitization, Regulated by Serotonin

(2013) Chander Shekhar et al.   GASTROENTEROLOGY

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

(2013) Joel Castro et al.   GASTROENTEROLOGY

Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation

(2013) Inmaculada Silos-Santiago et al.   PAIN

Abdominal Bloating: Pathophysiology and Treatment

(2013) A Young Seo et al.   Journal of Neurogastroenterology and Motility

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

(2012) William D Chey et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

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Abdomino-Phrenic Dyssynergia in Patients With Abdominal Bloating and Distension

(2011) Albert Villoria et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Bloating in constipation: Relevance of intraluminal gas handling

(2011) Lesley A. Houghton   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Two Randomized Trials of Linaclotide for Chronic Constipation

(2011) Anthony J. Lembo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inability of the Rome III Criteria to Distinguish Functional Constipation From Constipation-Subtype Irritable Bowel Syndrome

(2010) Reuben K Wong et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

(2010) Robert W. Busby et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacologic Management of Chronic Constipation

(2010) Siddharth Singh et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

(2010) Alexander P. Bryant et al.   LIFE SCIENCES

Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain

(2009) h. eutamene et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Bloating and Distention in Irritable Bowel Syndrome: The Role of Visceral Sensation

(2008) Anurag Agrawal et al.   GASTROENTEROLOGY

Prevalence and risk factors for abdominal bloating and visible distention: a population-based study

(2008) X Jiang et al.   GUT