Review
Immunology
Weidong Zhang, Ling Gao, Wenhao Ren, Shaoming Li, Jingjing Zheng, Shasha Li, Chunmiao Jiang, Shuying Yang, Keqian Zhi
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse drug effect, with hypotheses involving reduced bone remodeling, infection, inflammation, and bisphosphonates-induced immune dysfunction. Treatment with bisphosphonates disrupts mucosal and osteo immune homeostasis, impairing the body's ability to resist infection and repair from injury, contributing to the development of MRONJ.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Wen Pan, Jianyu Gu, Shihan Xu, Chunmei Zhang, Jinsong Wang, Songlin Wang, Junji Xu
Summary: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication in patients with osteoporosis or metastatic bone cancer. The study found that dietary nitrate, abundant in green vegetables, can protect against BRONJ-like lesions in mice. Nitrate intake increased plasma nitric oxide levels, reducing monocyte necrosis and inflammatory cytokine production. The findings suggest that dietary nitrate can inhibit monocyte necroptosis in BRONJ and promote bone remodeling after injury.
CELL PROLIFERATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Angela Tempesta, Saverio Capodiferro, Simona Di Nanna, Silvia D'Agostino, Marco Dolci, Antonio Scarano, Gianluca Gambarini, Eugenio Maiorano, Gianfranco Favia, Luisa Limongelli
Summary: This study describes the association between endodontic treatment failure and MRONJ in oncologic patients. The results showed that teeth with failed endodontic treatment may be a risk factor for the development of MRONJ before receiving antiresorptive and antiangiogenic drug therapies. Therefore, careful evaluation of these patients is necessary prior to the initiation of drug treatment.
Article
Medicine, General & Internal
Gabor Kammerhofer, Daniel Vegh, Dorottya Banyai, Adam Vegh, Arpad Joob-Fancsaly, Peter Hermann, Zoltan Geczi, Tamas Hegedus, Kata Sara Somogyi, Bulcsu Bencze, Zita Biczo, Donat Huba Juhasz, Peter Zaborszky, Marta Ujpal, Mihaly Tamas Vaszilko, Zsolt Nemeth
Summary: This study aimed to evaluate the association between hyperglycemia and medication-related osteonecrosis of the jaw (MRONJ). The results showed a significant association between hyperglycemia and MRONJ, suggesting that hyperglycemia may lead to vascular anomaly and immune dysfunction, resulting in necrosis after tooth extraction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Stephane Odet, Christophe Meyer, Camille Gaudet, Elise Weber, Julie Quenot, Stephane Derruau, Sebastien Laurence, Lisa Bompy, Marine Girodon, Brice Chatelain, Cedric Mauprivez, Esteban Brenet, Halima Kerdjoudj, Narcisse Zwetyenga, Philippe Marchetti, Anne-Sophie Hatzfeld, David Toubeau, Fabienne Pouthier, Xavier Lafarge, Heinz Redl, Mathilde Fenelon, Jean-Christophe Fricain, Roberta Di Pietro, Charlotte Ledouble, Thomas Gualdi, Anne-Laure Parmentier, Aurelien Louvrier, Florelle Gindraux
Summary: The use of human amniotic membrane (hAM) can promote tissue regeneration and healing in patients with medication-related osteonecrosis of the jaw (MRONJ). By using cryopreserved hAM, MRONJ can be effectively treated, leading to improved quality of life for patients.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Hironobu Hata, Kenji Imamachi, Michihiro Ueda, Masashi Matsuzaka, Hiroaki Hiraga, Toshihisa Osanai, Toru Harabayashi, Katsuya Fujimoto, Satoshi Oizumi, Masato Takahashi, Kazuhito Yoshikawa, Jun Sato, Yutaka Yamazaki, Yoshimasa Kitagawa
Summary: The study aimed to clarify the incidence of MRONJ and the corresponding survival rate of patients treated with zoledronic acid for different types of cancer. The results showed that patients with shorter survival times did not develop MRONJ, and dentists need to be aware of prognosis-related factors to predict MRONJ risk for effective dental management planning.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Dentistry, Oral Surgery & Medicine
Angela Tempesta, Saverio Capodiferro, Rodolfo Mauceri, Dorina Lauritano, Eugenio Maiorano, Gianfranco Favia, Luisa Limongelli
Summary: This study described cases of patients diagnosed with peri-implantitis who were later found to have PI-MRONJ. Histopathological analysis confirmed the diagnosis, highlighting the importance of considering PI-MRONJ in at-risk patients and providing appropriate treatment to avoid delays in diagnosis.
Review
Toxicology
Bhumrapee Srivichit, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Bisphosphonates are commonly used in the treatment of bone and joint diseases, but long-term use can lead to osteonecrosis. Osteonecrosis is characterized by cell death and impaired cell functions, with medication-related osteonecrosis of the jaw being the most concerning condition. In addition to surgical treatment, non-surgical interventions have been explored to mitigate bisphosphonate-induced osteonecrosis.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Judith Everts-Graber, Daniel Lehmann, John-Patrik Burkard, Benoit Schaller, Brigitta Gahl, HansJoerg Haeuselmann, Ueli Studer, Hans-Rudolf Ziswiler, Stephan Reichenbach, Thomas Lehmann
Summary: This study aimed to determine the risk of ONJ in a real-world population, showing a higher incidence rate in patients receiving denosumab therapy compared to those receiving BPs, with previous BP therapy potentially being an additional risk factor for ONJ development.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Athanasios D. Anastasilakis, Jessica Pepe, Nicola Napoli, Andrea Palermo, Christos Magopoulos, Aliya A. Khan, M. Carola Zillikens, Jean-Jacques Body
Summary: This study evaluates the differences of MRONJ among different patient categories and provides recommendations on how to mitigate the risk and optimally manage MRONJ. The results indicate that patients with advanced malignancies are at a higher risk for MRONJ compared to those with benign bone diseases, but the overall risk is considerably lower than the benefits of treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jie Liu, Nikos Mattheos, Chuanxi Deng, Cheng Su, Zekun Wang, Nanyu Luo, Hua Tang
Summary: Icariin benefits MRONJ by improving soft tissue wound area and empty bone lacuna ratio, while teriparatide activates RANKL expression and reduces bone necrosis area and empty lacuna ratio. These findings suggest potential therapeutic benefits for patients with MRONJ.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Medicine, General & Internal
Xiao-Hong Wu, Shi-Wei Chen
Summary: This report presents a case of multiple myeloma (MM) identified in a surgical specimen previously diagnosed as medication-related osteonecrosis of the jaw (MRONJ) in a patient with MM. The patient exhibited symptoms of both MRONJ and MM, suggesting that MM and MRONJ can occur simultaneously at the same site.
Article
Environmental Sciences
Guillermo Pardo-Zamora, Yanet Martinez, Jose Antonio Moreno, Antonio J. Ortiz-Ruiz
Summary: MRONJ is a rare and severe disease with unclear exact cause and potential multifactorial origins. A case series of three stage 2 MRONJ patients showed complete healing within 12 months of therapeutic protocol application, with radiography demonstrating slow but progressive healing with normal bone structure. Conservative treatment and minimally invasive surgical intervention are effective for stage 2 MRONJ, while application of PRF-L in refractory cases can improve outcomes in soft tissue healing and bone regeneration, though further research is needed to confirm effectiveness.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Se Hwa Kim, Young-Kyun Lee, Tae-Young Kim, Yong-Chan Ha, Sunmee Jang, Ha Young Kim
Summary: The study aimed to estimate the incidence of osteonecrosis of the jaw (ONJ) in Korean osteoporosis patients treated with bisphosphonates (BPs) and identified clinical risk factors such as advanced age, diabetes, and rheumatoid arthritis that increase the risk for ONJ.
Article
Pathology
Mark A. Lerman, Soulafa Almazrooa, Neal Lindeman, Dimity Hall, Alessandro Villa, Sook-Bin Woo
Article
Medicine, General & Internal
Nada O. Binmadi, Soulafa A. Almazrooa
SAUDI MEDICAL JOURNAL
(2017)
Editorial Material
Dentistry, Oral Surgery & Medicine
Soulafa Almazrooa, Nada Binmadi, Hanadi Khalifa, Awatif Jamal, Mohamad H. Qari, Maisa O. Al-Sebaei
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Soulafa A. Almazrooa, Ghada A. Mansour, Sana A. Alhamed, Sarah A. Ali, Sara K. Akeel, Nada A. Alhindi, Osama M. Felemban, Hani H. Mawardi, Nada O. Binmadi
Summary: The study found that although teledentistry has not been fully implemented in the Saudi dental community, the majority of dentists believe that it can improve daily dental practice, particularly in the field of oral radiology.
JOURNAL OF DENTAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ahmad Al Ramil, Soulafa Almazrooa, Nada Binmadi, Hani Mawardi
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2020)
Review
Medicine, General & Internal
Nada O. Binmadi, Maram Bawazir, Nada Alhindi, Hani Mawardi, Ghada Mansour, Sana Alhanned, Sarah Alfarabi, Sara Akeel, Soulafa Almazrooa
PATIENT PREFERENCE AND ADHERENCE
(2020)
Article
Integrative & Complementary Medicine
Hani Mawardi, Shaima Ghazalh, Ahmad Shehatah, Amnah Abdelwahid, Amin Aljohani, Osama Felemban, Soulafa Almazrooa, Lena Elbadawi, Hazem Shawky
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Education & Educational Research
Waleed A. Alamoudi, Azza F. Alhelo, Soulafa A. Almazrooa, Osama M. Felemban, Nada O. Binmadi, Nada A. Alhindi, Sarah A. Ali, Sara K. Akeel, Sana A. Alhamed, Ghadah M. Mansour, Hani H. Mawardi
Summary: A survey at KAU-FD found that approximately 44.3% of dental students were more likely to skip two classes or less per month. Second-year students were more likely to be absent from classroom lectures, while third-year students were less likely to do so. Reasons for missing classes included early morning classes, exam preparation, and lecturer's weak presentation skills.
BMC MEDICAL EDUCATION
(2021)
Correction
Education & Educational Research
Waleed A. Alamoudi, Azza F. Alhelo, Soulafa A. Almazrooa, Osama M. Felemban, Nada O. Binmadi, Nada A. Alhindi, Sarah A. Ali, Sara K. Akeel, Sana A. Alhamed, Ghadah M. Mansour, Hani H. Mawardi
BMC MEDICAL EDUCATION
(2021)
Article
Medicine, General & Internal
Nada O. Binmadi, Suad Aljohani, Maha T. Alsharif, Soulafa A. Almazrooa, Amal M. Sindi
Summary: This study found that oral manifestations of COVID-19 were common among patients, particularly in female patients. These manifestations were associated with certain general COVID-19 symptoms, but not with the severity of the disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Nada Binmadi, Maha Alsharif, Soulafa Almazrooa, Suad Aljohani, Sara Akeel, Samira Osailan, Muhammad Shahzad, Wael Elias, Yasmin Mair
Summary: This systematic review and meta-analysis summarize the current evidence regarding the prognostic role of perineural invasion (PNI) in patients with oral squamous cell carcinoma (OSCC). The findings suggest that PNI is associated with worse survival rates and recurrence, with Asian patients and peritumoral or peripheral PNI invasion having a poorer prognosis.
Article
Dentistry, Oral Surgery & Medicine
Soulafa A. Almazrooa, Nada O. Binmadi
Summary: The study highlighted the lack of knowledge among medical practitioners in Saudi Arabia regarding oral medicine specialty, with most physicians not referring cases to oral medicine specialists and some being unaware of their existence. Efforts are needed to increase awareness of the specialty for improved healthcare quality.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2021)
Article
Pathology
Chia-Cheng Li, Soulafa Almazrooa, Ingrid Carvo, Alfonso Salcines, Sook-Bin Woo
Summary: The study proposes new diagnostic criteria for oral epithelial dysplasia (ED) based on architectural, organizational, and cytologic features. The defined architectural alterations are as important as the currently used criteria for the diagnosis of ED. Clinicopathologic correlation plays a crucial role in accurate diagnosis of oral ED.
HEAD & NECK PATHOLOGY
(2021)
Article
Medicine, General & Internal
Reham O. Filfilan, Soulafa A. Almazrooa
JOURNAL OF MEDICAL CASE REPORTS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Renad Abdulkarim, Aliyah Al-subhi, Renad Bukhari, Nehhal Alkhattabi, Rolla Mira, Osama Felemban, Lena Elbadawi, Soulafa Almazrooa, Hani Mawardi
SAUDI DENTAL JOURNAL
(2019)
