Article
Thermodynamics
Quan Wang, Kyung-Bum Kim, Sang Bum Woo, Sung Min Ko, Yooseob Song, Tae Hyun Sung
Summary: Magneto piezoelectric harvesters (MPHs) operating under an AC magnetic field have attracted attention for their importance in portable industrial applications. This study presents a spring-supported magneto piezoelectric harvester (SMPH) operating under an AC magnetic field, demonstrating enhanced electrical performance. By using a magnetic tip to scavenge the AC magnetic field, the SMPH achieved higher output power compared to conventional rigidly supported MPHs.
Article
Chemistry, Multidisciplinary
Seong-Joo Lee, Kwon Kyu Yu, Seong-min Hwang, Sangwon Oh, Nam Woong Song, Hak-Sung Jung, Oc Hee Han, Jeong Hyun Shim
Summary: Low-field nuclear magnetic resonance spectroscopy provides limited spectral information, but the use of isotopically labeled molecules can overcome this limitation. This study investigates the correlation spectroscopy of 1-C-13-ethanol at low-field, demonstrating that even with a moderate spectral line width, a low-field 2D spectrum can reveal the coupling networks of isotopically labeled molecules.
Article
Cell Biology
Alessandro Venturino, Rouven Schulz, Hector De Jesus-Cortes, Margaret E. Maes, Balint Nagy, Francis Reilly-Andujar, Gloria Colombo, Ryan John A. Cubero, Florianne E. Schoot Uiterkamp, Mark F. Bear, Sandra Siegert
Summary: This study demonstrates that repeated use of ketamine can effectively reduce PNN coating in the healthy adult brain, promoting juvenile-like plasticity. Microglia play a critical role in PNN loss, and 60-Hz light-flickering entrainment can recapitulate microglia-mediated PNN removal.
Article
Biochemistry & Molecular Biology
Yixin Guo, Yiti Fu, Wenjun Sun
Summary: This study found that exposure to a 50-Hz magnetic field inhibited spontaneous movement in zebrafish larvae, with a significant effect observed at an intensity of 200 mu T. Furthermore, exposure to the magnetic field resulted in abnormal brain morphology, condensed cell nucleus and cytoplasm, and increased intercellular space. The magnetic field exposure suppressed syn2a gene transcription and expression, and increased reactive oxygen species (ROS) levels. Overexpression of syn2a effectively rescued the decreased spontaneous movement induced by the magnetic field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lin Tang, Xiaojia Wu, Huan Liu, Faqi Wu, Rao Song, Wei Zhang, Dajing Guo, Junbang Feng, Chuanming Li
Summary: This study aimed to develop and validate radiomics models and multipredictor nomogram for predicting the time to progression from MCI to AD. Radiomic features were extracted from MR images and models were established using LASSO Cox regression, with high accuracy for individual TTP prediction achieved through a multipredictor nomogram.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Engineering, Biomedical
Kai Yuan, Cheng Chen, Wu-Tao Lou, Ahsan Khan, Eden Chun-Hang Ti, Cathy Choi-Yin Lau, Xin Wang, Winnie Chiu-Wing Chu, Raymond Kai-Yu Tong
Summary: This study aimed to investigate the frequency-specific effects of tACS on chronic stroke. Through tACS and fMRI experiments, it was found that 10 Hz tACS can enhance activation in the ipsilesional precentral area during paretic hand movements, while both 10 Hz and 20 Hz tACS can enhance activation in the contralesional precentral area during non-paretic hand movements. Resting-state seed-based functional connectivity analysis showed that 10 Hz tACS mainly modulates functional connectivity within motor-related regions, while 20 Hz tACS also modulates connectivity in regions beyond motor-related areas. Graph theory analysis further demonstrated the modulation of functional interaction by tACS in the whole-brain level.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2022)
Article
Medicine, General & Internal
Almir Bitencourt, Varadan Sevilimedu, Elizabeth A. Morris, Katja Pinker, Sunitha B. Thakur
Summary: Altered metabolism, including lipid metabolism, is an emerging hallmark of breast cancer. Results of this study showed that breast tumors have significantly lower concentrations of lipid metabolites and PUFA compared to normal fibroglandular tissue. The measure best separating normal and tumor tissues was L21 + L23, indicating the potential of MRS- based lipid measurements in increasing the specificity of breast cancer characterization.
Article
Multidisciplinary Sciences
Gabriel Martinon-Gutierrez, Maria Luna-Castro, Rolando Hernandez-Munoz
Summary: A single exposure to a 60-Hz EMF induces hyperglycaemia and alters serum levels of lipids and energy parameters in male rats. The effects are closely related to changes in cellular redox state and the insulin/glucagon ratio. Additionally, chronic exposure to EMFs prior to the single exposure did not modify these effects.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Ehab Mustafa, Leonardo Makinistian, Jukka Luukkonen, Jukka Juutilainen, Jonne Naarala
Summary: The study revealed that exposure to 50 and 60 Hz magnetic fields may lead to a slight increase in expression of ROS-related genes, but had no significant effects on cytosolic O-2(center dot-) levels, DNA damage, and repair rate. Additionally, exposure to magnetic fields did not exceed the expected rate of false positive findings for changes in the expression of DNA damage-signaling genes.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yunxi Zheng, Shouxin Gu, Jingyao Ruan, Xiaofang Yi, Congjian Xu
Summary: This study demonstrates the clinical significance of MRI features in diagnosing bowel endometriosis (BE) pre-operatively. Patients with deep endometriosis and a rectal wall thickness exceeding 6.0 mm have a higher probability of BE.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Shuaihu Wang, Charlotte A. Guertler, Ruth J. Okamoto, Curtis L. Johnson, Matthew D. J. McGarry, Philip V. Bayly
Summary: This study used MRE and DTI data to estimate anisotropic mechanical properties in six young female Yucatan minipigs. The results showed that white matter is more dissipative and anisotropic than gray matter, and brain development has a significant impact on brain stiffness and structural anisotropy.
Article
Clinical Neurology
T. Takamura, U. Motosugi, M. Ogiwara, Y. Sasaki, K. J. Glaser, R. L. Ehman, H. Kinouchi, H. Onishi
Summary: In managing meningiomas, tumor consistency can be predicted by stiffness, while relative MTT may be correlated with tumor stiffness and differentiate among different histologic subtypes of meningioma.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Thermodynamics
A. M. Aliev, A. G. Gamzatov, N. Z. Abdulkadirova, P. Gebara
Summary: This study measured the direct adiabatic temperature change (Delta Tad) in cyclic magnetic fields with a frequency of up to 30 Hz in the La0.9Pr0.1Fe11.2Co0.7Si1.1 alloy. The magnetocaloric effect (MCE) of the alloy is 2.8 K under a magnetic field change of 1.8 T, with temperature hysteresis not exceeding 0.5 K. The MCE shows weak frequency dependence at lower magnetic field changes but becomes more pronounced at higher magnetic field changes. Prolonged exposure to low-frequency cyclic magnetic fields does not affect the MCE value, but degradation is observed at frequencies higher than 10 Hz.
INTERNATIONAL JOURNAL OF REFRIGERATION
(2023)
Article
Virology
Mayu Higuchi, Nobuharu Tamaki, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Koji Yamashita, Yuka Hayakawa, Shuhei Sekiguchi, Leona Osawa, Kenta Takaura, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Nobuyuki Enomoto, Namiki Izumi
Summary: Most patients achieved sustained virological response (SVR) with direct-acting antivirals (DAA) therapy, but some patients, especially those with advanced fibrosis, did not show improvement in liver stiffness after achieving SVR. Despite obtaining SVR, improvement in liver stiffness could not be obtained in some cases.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Anke Busse, Catharina Nesselmann, Felix Streckenbach, Ebba Beller, Ann-Christin Klemenz, Pascal Dohmen, Alper oener, Marc-Andre Weber, Felix G. Meinel
Summary: We assessed the feasibility and image quality of ECG-gated MR angiography in post-surgical follow-up of the ascending aorta. A cohort of 19 patients underwent MRA, and the examinations were analyzed for image quality and diagnostic findings. Abnormal findings had consequences for clinical management.
Article
Engineering, Biomedical
Julien Modolo, Mahmoud Hassan, Giulio Ruffini, Alexandre Legros
JOURNAL OF NEURAL ENGINEERING
(2020)
Article
Engineering, Biomedical
Maxime Yochum, Julien Modolo
Summary: Neural mass models are popular mathematical models for brain activity, allowing rapid simulation of large-scale networks. However, creating equations for specific neuronal network architectures can be tedious and error-prone, limiting their use. A user-friendly software has been developed to help a wider audience of scientists develop NMM corresponding to their specific neuroscience research questions.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Marouan Arrais, Julien Modolo, David Mogul, Fabrice Wendling
Summary: This study provides a rational method for designing brain stimulation protocols in epilepsy using biologically-inspired models of brain activity and a graph-theory based approach. The results suggest that targeting populations with the highest eigenvector centrality values can achieve the best therapeutic effects.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Clinical Neurology
Mathieu Kuchenbuch, Rima Nabbout, Maxime Yochum, Paul Sauleau, Julien Modolo, Fabrice Wendling, Pascal Benquet
Summary: This study investigates the impact of gain of function of slack channel due to a KCNT1 pathogenic variant on abnormal neuronal cortical network activity and specific EEG patterns of epilepsy in infancy. The results show that the pathogenic variants of KCNT1 decrease firing rate properties of certain neurons, leading to hyperexcitability and synchronization in the cortical micronetwork, ultimately causing epilepsy with migrating focal seizures. The multiscale approach used in this study provides a framework for identifying potential innovative therapies based on biomathematical models.
Article
Clinical Neurology
Sahar Allouch, Maxime Yochum, Aya Kabbara, Joan Duprez, Mohamad Khalil, Fabrice Wendling, Mahmoud Hassan, Julien Modolo
Summary: Understanding brain-scale functional networks through EEG source connectivity is crucial for neuroscience research. A recently developed model named COALIA provides realistic simulations for analyzing cortical networks. High electrode density and specific algorithms for solving inverse problems, along with functional connectivity measures, have shown promising results for accurately estimating cortical networks in the context of epileptiform activity.
Article
Neurosciences
Joan Duprez, Judie Tabbal, Mahmoud Hassan, Julien Modolo, Aya Kabbara, Ahmad Mheich, Sophie Drapier, Marc Verin, Paul Sauleau, Fabrice Wendling, Pascal Benquet, Jean-Francois Houvenaghel
Summary: This study identified the dynamic functional brain networks observed during cognitive action control (CAC), but did not highlight PD-related changes in these networks that might explain behavioral changes.
Article
Biology
Nicolas Bouisset, Sebastien Villard, Alexandre Legros
Summary: The study suggests that there are small differences between AC and ELF-MF vestibular stimulations, indicating a potential contribution from the utricle.
BIOELECTROMAGNETICS
(2022)
Article
Engineering, Biomedical
Edmundo Lopez-Sola, Roser Sanchez-Todo, Elia Lleal, Elif Koksal-Ersoz, Maxime Yochum, Julia Makhalova, Borja Mercadal, Maria Guasch-Morgades, Ricardo Salvador, Diego Lozano-Soldevilla, Julien Modolo, Fabrice Bartolomei, Fabrice Wendling, Pascal Benquet, Giulio Ruffini
Summary: The study utilizes neural mass models to simulate epileptic seizures and successfully reproduces the recorded brain electrical activity in epilepsy patients. The model generates various types of seizure patterns and lays the foundation for personalized methods based on NMMs.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Gabriel Gaugain, Lorette Queguiner, Marom Bikson, Ronan Sauleau, Maxim Zhadobov, Julien Modolo, Denys Nikolayev
Summary: This study analyzes and quantifies the validity of the quasi-static approximation (QSA) for numerical modeling of electric fields induced by transcranial alternating current stimulation (tACS). The results demonstrate that the QSA is valid in the frequency range currently used for tACS, but neglecting permittivity introduces significant error in both harmonic and non-harmonic signals.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fabiola Alonso, Borja Mercadal, Ricardo Salvador, Giulio Ruffini, Fabrice Bartolomei, Fabrice Wendling, Julien Modolo
Summary: Intracranial electrodes are used clinically for various purposes, such as drug-refractory epilepsy. However, quantifying the electric fields induced by electrical stimulation is challenging due to various factors. This study aimed to evaluate different biophysical models for characterizing the electric fields in patients undergoing pre-surgical evaluation. The results provide insights into developing accurate patient-specific models for neuromodulation and neurostimulation procedures.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2023)
Article
Engineering, Electrical & Electronic
Zain Haider, Julien Modolo, Micaela Liberti, Francesca Apollonio, Maxim Zhadobov
Summary: In this study, the microscale heating of cutaneous nerves and capillaries caused by continuous and pulsed plane-wave exposure at 60 GHz was quantified. The thermal properties of the nerves and capillaries were derived using mixture equations based on their water content. Finite element method was used to solve the electromagnetic problem in conjunction with Pennes bioheat equation and Arrhenius equation to evaluate the spatial and temporal evolution of temperature and thermal damage within the nerves and capillaries. The results provide valuable insights into local millimeter-wave induced heating within various skin substructures.
IEEE JOURNAL OF MICROWAVES
(2023)
Article
Computer Science, Information Systems
Nicolas Bouisset, Andres Carvallo, Perrine Dumur, Sofiane Ramdani, Alexandre Legros
Summary: This study investigated the impact of vestibular-specific electric fields on manual pointing accuracy in high ELF-MF environments. The results suggest that even at high levels, ELF exposure is not able to modulate hand pointing performance in humans. This provides useful knowledge for the safety and performance of workers in high ELF-MF environments.
Proceedings Paper
Engineering, Biomedical
Sahar Allouch, Mahmoud Hassan, Maxime Yochum, Joan Duprez, Mohamad Khalil, Fabrice Wendling, Julien Modolo, Aya Kabbara
Summary: The study introduces a physiologically-grounded computational model called COALIA, which can generate realistic simulations of brain activity to provide ground-truth models for the EEG source connectivity pipeline. Increasing the number of electrodes leads to higher accuracy in reconstructing cortical networks, and the choice of connectivity measure also plays a significant role in the results.
2021 SIXTH INTERNATIONAL CONFERENCE ON ADVANCES IN BIOMEDICAL ENGINEERING (ICABME)
(2021)
Article
Computer Science, Information Systems
Nicolas Bouisset, Sebastien Villard, Alexandre Legros
Article
Computer Science, Information Systems
Nicolas Bouisset, Sebastien Villard, Alexandre Legros