Article
Obstetrics & Gynecology
Hengameh Keshtmandi, Majid Mirmohammadkhani, Mojgan Rahmanian
Summary: We conducted a double-blind, randomized, placebo-controlled clinical trial to evaluate the efficacy of oral dydrogesterone (DG) in the treatment of preterm labor. The study included 100 nulliparous mothers with normal pregnancy who had preterm labor pain. The results showed that DG adjuvant to magnesium sulfate could not be effective in improving the incidence of preterm labor, rate of recurrent uterine contraction, latency period, pregnancy outcomes, and maternal and neonatal outcomes when compared with the placebo group.
REPRODUCTIVE SCIENCES
(2023)
Article
Immunology
Lifang Wen, Xiaoru Dong, Qing Li, Gabriele Schramm, Bing Zhang, Detlef Zillikens, Ralf J. Ludwig, Frank Petersen, Xinhua Yu
Summary: The study suggests that scratching behavior may contribute to the initiation phase of disease manifestation in experimental EBA, and mechanical irritation may promote the induction of inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
E. Hascoet, J. Mahe, H. Meillard, H. Theophile, A. Cloitre, P. Lesclous
Summary: The study found a very low incidence of type I-IgE-mediated reactions to local anesthetics (LAs) in dental practice. Lidocaine was the most frequently involved LA, with reactions mostly being of grade II and III severity. Overall, out of 416 anaphylactic reactions identified, there were 11 cases of fatal anaphylaxis, but none in dental practice.
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Medicine, General & Internal
Olivera Iordache, Doru Mihai Anastasiu, Manaswini Kakarla, Ayesha Ali, Felix Bratosin, Radu Neamtu, Catalin Dumitru, Flavius Olaru, Izabella Erdelean, Angelica Gherman, Cecilia Roberta Avram, Lavinia Stelea
Summary: This systematic review examined the relationship between antiphospholipid antibody-associated thrombophilia and adverse pregnancy outcomes, such as preterm birth and impaired fetal development. It found that multiple aPL antibody positivity is associated with a higher risk of preterm birth. Additionally, treatment during pregnancy can significantly reduce the risk of preterm birth.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Manoj Kumar, Marwa Saadaoui, Souhaila Al Khodor
Summary: Pregnancy brings about physiological and immunological adaptations that enable precise communication between the mother and fetus, promoting a healthy pregnancy. However, these adaptations may also make pregnant women more prone to infections and lead to various pregnancy complications. Certain microbial pathogens have evolved mechanisms to bypass the placental barrier and cause congenital diseases. Recent studies have shed light on the significant role of maternal microbiota in pregnancy outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Andrea M. Weckman, Robyn E. Elphinstone, John M. Ssenkusu, Vanessa Tran, Kathleen Zhong, Mwayiwawo Madanitsa, Carole Khairallah, Linda Kalilani-Phiri, Victor Mwapasa, Andrea L. Conroy, Feiko O. Ter Kuile, Chloe R. McDonald, Kevin C. Kain
Summary: Preterm birth is a leading cause of death in children under five. Sequential disruptions to inflammatory and angiogenic pathways during pregnancy increase the risk of placental insufficiency and preterm labor. Study findings suggest a potential causal link between early inflammation, subsequent angiogenic dysregulation, and preterm birth, highlighting the importance of interventions before 24 weeks gestation.
Article
Dentistry, Oral Surgery & Medicine
Anna Miroshnychenko, Sara Ibrahim, Maria Azab, Yetiani Roldan, Juan Pablo Diaz Martinez, Divyalakshmi Tamilselvan, Leon He, Olivia Urquhart, Malavika Tampi, Deborah E. Polk, Paul A. Moore, V. Elliott Hersh, Alonso Carrasco-Labra, Romina Brignardello-Petersen
Summary: This study assessed the comparative effect of local anesthetics on acute dental pain and symptomatic irreversible pulpitis. The results suggest that bupivacaine may be more effective than lidocaine with epinephrine and mepivacaine, and benzocaine may be more effective than placebo in reducing pain.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2023)
Article
Chemistry, Analytical
Somayeh Mohammadi Far, Matin Beiramvand, Mohammad Shahbakhti, Piotr Augustyniak
Summary: Timely prediction of preterm labor is crucial for neonate survival, mother's mental health, and reducing financial burdens on the family. This study proposes a reliable method using electrohysterogram (EHG) signals to predict preterm labor based on different pregnancy weeks. EHG signals from 300 subjects were split into two groups and analyzed using empirical mode decomposition (EMD), feature extraction, oversampling, and feature selection techniques. The AdaBoost classifier achieved high accuracy and performance for both groups. The results indicate the feasibility of the proposed method for preterm labor prediction.
Review
Endocrinology & Metabolism
Manuel S. Vidal, Ryan C. V. Lintao, Mary Elise L. Severino, Ourlad Alzeus G. Tantengco, Ramkumar Menon
Summary: Survivors of preterm birth face various disabilities, and addressing the rates of low birth weight, neonatal and maternal morbidities and mortalities is crucial. Research has provided theories on risk factors and clinical manifestations, but there is a lack of biomarkers for early diagnosis. To overcome current limitations, an integrated approach studying the network interaction between different tissues and organs is needed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Brahm Seymour Coler, Oksana Shynlova, Adam Boros-Rausch, Stephen Lye, Stephen McCartney, Kelycia B. Leimert, Wendy Xu, Sylvain Chemtob, David Olson, Miranda Li, Emily Huebner, Anna Curtin, Alisa Kachikis, Leah Savitsky, Jonathan W. Paul, Roger Smith, Kristina M. Adams Waldorf
Summary: Preterm birth remains a significant cause of infant morbidity and mortality, with limited therapeutic options despite 50 years of research. The global need for better tocolytic agents is particularly urgent, with newer therapeutics targeting inflammatory checkpoints for more effective tocolysis. However, regulatory hurdles and a small market for new PTB therapeutics have hindered pharmaceutical interest in this area.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Michelle Coleman, Blair Armistead, Austyn Orvis, Phoenicia Quach, Alyssa Brokaw, Claire Gendrin, Kavita Sharma, Jason Ogle, Sean Merillat, Matthew Dacanay, Tsung-Yen Wu, Jeff Munson, Audrey Baldessari, Jay Vornhagen, Anna Furuta, Shayla Nguyen, Kristina M. Adams Waldorf, Lakshmi Rajagopal
Summary: Invasive bacterial infections during pregnancy, such as Group B streptococci (GBS), can lead to preterm birth, stillbirth, and fetal injury. Using a nonhuman primate model, researchers found that GBS expressing hyaluronidase can cause microbial invasion into the amniotic cavity and preterm labor, shedding light on virulence factors and potential therapeutic strategies. Understanding how bacteria evade host defenses during pregnancy is crucial for developing preventive therapies against adverse outcomes.
Review
Cell Biology
Maciej W. Socha, Wojciech Flis, Milosz Pietrus, Mateusz Wartega, Martyna Stankiewicz
Summary: Cervical ripening is a crucial process in late pregnancy, primarily caused by enzymatic breakdown and inflammatory response. The cellular pathways responsible for regulating this process are still poorly understood, but gaining a greater understanding can help address dysfunctional labor issues.
Review
Microbiology
Milan Terzic, Gulzhanat Aimagambetova, Sanja Terzic, Milena Radunovic, Gauri Bapayeva, Antonio Simone Lagana
Summary: Preterm labor refers to birth before 37 weeks of gestation, occurring in 5-20% of pregnancies. Influenced by maternal, fetal, and environmental factors, infectious pathogens may account for 25-40% of preterm birth. The association between maternal periodontal disease, pathogenic oral bacteria in the placenta, and preterm delivery is still controversial in spite of extensive research.
Article
Biochemistry & Molecular Biology
Emma E. Don, Anadeijda J. E. M. C. Landman, Guus Vissers, Ekaterina S. Jordanova, Emiel D. Post Uiterweer, Christianne J. M. de Groot, Marjon A. de Boer, Judith A. F. Huirne
Summary: Recent studies indicate that uterine fibroids increase the risk of preterm birth. It is hypothesized that fibroid necrosis may induce preterm birth through an inflammatory response, similar to spontaneous preterm birth. This new hypothesis opens up possibilities for future research and preventive strategies for preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Hsiao-Ying Hung, Pei-Fang Su, Meng-Hsing Wu, Ying-Ju Chang
Summary: The study found that women with threatened preterm labor resting at home experience higher levels of perceived stress and distress compared to healthy pregnant women. Common distress factors include the inability to provide self-care and family care, as well as concerns about the baby's health and safety. Positive personalities, gestational age, preterm birth history, follow-up status, and employment are related to the psychological status of women with threatened preterm labor.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Dentistry, Oral Surgery & Medicine
J. A. Shariff, B. Cheng, P. N. Papapanou
JOURNAL OF DENTAL RESEARCH
(2020)
Letter
Dentistry, Oral Surgery & Medicine
Panos N. Papapanou, Ken S. Kornman
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2020)
Article
Immunology
Abdulrahman Almubarak, Kranthi Kiran Kishore Tanagala, Panos N. Papapanou, Evanthia Lalla, Fatemeh Momen-Heravi
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Mariano Sanz, David Herrera, Moritz Kebschull, Iain Chapple, Soren Jepsen, Tord Beglundh, Anton Sculean, Maurizio S. Tonetti
JOURNAL OF CLINICAL PERIODONTOLOGY
(2020)
Editorial Material
Dentistry, Oral Surgery & Medicine
Mariano Sanz, Panos N. Papapanou, Maurizio S. Tonetti, Henry Greenwell, Ken Kornman
JOURNAL OF PERIODONTOLOGY
(2020)
Review
Dentistry, Oral Surgery & Medicine
Harvey A. Schenkein, Panos N. Papapanou, Robert Genco, Mariano Sanz
PERIODONTOLOGY 2000
(2020)
Article
Dentistry, Oral Surgery & Medicine
Joseph Wang, Gila Lerman, Nurit Bittner, Weijia Fan, Evanthia Lalla, Panos N. Papapanou
JOURNAL OF CLINICAL PERIODONTOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Panos N. Papapanou, Heekuk Park, Bin Cheng, Alexis Kokaras, Bruce Paster, Sandra Burkett, Caitlin Wei-Ming Watson, Medini K. Annavajhala, Anne-Catrin Uhlemann, James M. Noble
JOURNAL OF PERIODONTOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Aderonke A. Akinkugbe, Panos N. Papapanou
Summary: Although oral diseases may impact overall health, the causation between oral diseases and systemic health conditions is not singular. Chronic diseases associated with periodontitis have multifactorial etiologies.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
F. Momen-Heravi, R. A. Friedman, S. Albeshri, A. Sawle, M. Kebschull, A. Kuhn, P. N. Papapanou
Summary: Genome-wide transcriptomic analyses in whole tissues may not accurately identify cell type-specific information. This study utilized computational methods to decompose gene expression in gingival tissues into cell type-specific signatures, identifying differentially expressed genes and dysregulated pathways in periodontitis. Validation of these findings highlighted the potential roles of these genes in the pathogenesis of periodontitis.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Francesco DeMayo, Rebecca Molinsky, Muna J. Tahir, Sumith Roy, Jeanine M. Genkinger, Panos N. Papapanou, David R. Jacobs, Ryan T. Demmer
Summary: This study found no association between overall diet quality scores and periodontal status. However, higher nut consumption and red meat consumption were associated with lower probing depth and higher odds of periodontitis. Future studies are needed to replicate these associations to minimize the risk of false discovery.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Editorial Material
Dentistry, Oral Surgery & Medicine
Panos N. Papapanou
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qing Meng, Qiuqiang Gao, Shebli Mehrazarin, Kamonchanok Tangwanichgapong, Yu Wang, Yiming Huang, Yutong Pan, Samuel Robinson, Ziwen Liu, Amirali Zangiabadi, Renate Lux, Panos N. Papapanou, X. Edward Guo, Harris Wang, Luke E. Berchowitz, Yiping W. Han
Summary: Fusobacterium nucleatum secretes an adhesin with amyloid properties to enhance virulence, inducing periodontal bone loss and promoting colorectal cancer progression in mice. Virulence can be attenuated by amyloid-binding compounds.
Article
Dentistry, Oral Surgery & Medicine
Hyunjin Kim, Fatemeh Momen-Heravi, Steven Chen, Per Hoffmann, Moritz Kebschull, Panos N. Papapanou
Summary: The study investigated differential DNA methylation in gingival tissues in periodontal health, gingivitis, and periodontitis, and its association with differential mRNA expression. The concomitant study of DNA methylation and gene expression patterns may identify genes whose expression is epigenetically regulated in periodontitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Eli E. Machtei, Georgios Romanos, Philip Kang, Suncica Travan, Stephan Schmidt, Evangelos Papathanasiou, Nikolaos Tatarakis, Moshik Tandlich, Leila H. Liberman, Jacob Horwitz, Seyed Hossein Bassir, Srinivas Myneni, Harlan J. Shiau, Lior Shapira, Nikos Donos, Athena Papas, Joerg Meyle, William V. Giannobile, Panos N. Papapanou, David M. Kim
Summary: The study compared the safety and efficacy of Chlorhexidine gluconate chips as an adjunctive treatment to sub-gingival debridement in patients afflicted with periimplantitis. The group using CHX chips showed significant reduction in implant pocket depths and gingival recession at 24 weeks, compared to the control group.
JOURNAL OF PERIODONTOLOGY
(2021)