Article
Multidisciplinary Sciences
Giorgio Ciminata, Claudia Geue, Olivia Wu, Manuela Deidda, Noemi Kreif, Peter Langhorne
Summary: This study aimed to explore the methodological challenges of using real-world evidence (RWE) to estimate comparative effectiveness of anticoagulants in Scotland. The results showed that different methods, such as propensity score (PS) matching, inverse probability weighting (IPW), and covariate adjustment with PS, performed well in different subgroups of the study population.
Article
Medicine, General & Internal
Gregory Y. H. Lip, Allison Keshishian, Yan Zhang, Amiee Kang, Amol D. Dhamane, Xuemei Luo, Christian Klem, Mauricio Ferri, Jenny Jiang, Huseyin Yuce, Steven Deitelzweig
Summary: In this study of patients with NVAF and high risk of GI bleed, NOACs were associated with lower rates of stroke and/or SE, but NOACs had varying risks of MB compared with warfarin. These results may help inform treatment options in this patient population.
Article
Medicine, General & Internal
Gregory F. Michaud, William G. Stevenson
Summary: A 63-year-old healthy male with atrial fibrillation presents with symptoms of dyspnea and irregular heartbeat. Physical examination reveals high blood pressure, irregular pulse, and ECG confirms atrial fibrillation. Further evaluation and treatment plan are needed.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Economics
Charles Okafor, Joshua Byrnes, Simon Stewart, Paul Scuffham, Clifford Afoakwah
Summary: This study aimed to evaluate the cost effectiveness of treatment strategies to manage atrial fibrillation (AF) in adults living in low-, middle-, and high-income countries. The findings showed that different strategies were cost-effective in different resource settings. In high-income countries, apixaban and left atrial appendage closure were effective for stroke prevention, while propranolol, catheter ablation, and the convergent procedure were options for rate or rhythm control. In middle-income countries, apixaban and high-dose edoxaban were effective for stroke prevention, and radiofrequency catheter ablation was an option for rhythm control.
Article
Medicine, General & Internal
Kueiyu Joshua Lin, Daniel E. Singer, Katsiaryna Bykov, Lily G. Bessette, Julianna M. Mastrorilli, Alexander Cervone, Dae Hyun Kim
Summary: This study aimed to assess the safety and effectiveness of specific oral anticoagulants (OACs) in older patients with atrial fibrillation (AF) with dementia. The study found that apixaban was associated with lower rates of major bleeding and ischemic stroke compared with other OACs. The increased absolute risks associated with other OACs compared with apixaban were greater among patients with dementia, particularly for major bleeding. These findings support the use of apixaban for anticoagulation therapy in patients living with dementia who have AF.
Article
Cardiac & Cardiovascular Systems
Ju Hee Choi, Woojin Kim, Yun Tae Kim, Jaelim Cho, Seung Yong Shin, Changsoo Kim, Jin-Bae Kim
Summary: This study investigated the cost-effectiveness of DOACs versus warfarin in non-valvular AF patients with intermediate stroke risk. The findings showed that DOACs were more cost-effective than warfarin in this patient population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Malik Elharram, Michelle Samuel, Ahmed AlTurki, Michael Quon, Hassan Behlouli, Amal Bessissow, Louise Pilote
Summary: This study aimed to investigate the association between oral anticoagulation (OAC) use and thromboembolic events and major bleeding in patients with new postoperative atrial fibrillation (POAF) after noncardiac surgery. The results showed that OAC was not associated with a reduction in long-term thromboembolic events in these patients, but it did increase the risk for major bleeding. Future prospective clinical studies are needed to better understand the efficacy and safety of anticoagulation therapy in the setting of POAF after noncardiac surgery.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
So-Ryoung Lee, Eue-Keun Choi, Sang-Hyun Park, Kyung-Do Han, Seil Oh, Khaled Abdelgawwad, Gregory Y. H. Lip
Summary: The study found that rivaroxaban was associated with a lower risk of adverse renal outcomes compared with warfarin in Korean patients with atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yazed AlRuthia, Bushra Q. AlOtaibi, Reem M. AlOtaibi, Najla Q. AlOtaibi, Miteb Alanazi, Ghadah Asaad Assiri
Summary: Through retrospective chart review, it was found that rivaroxaban is cost-effective in reducing hospitalization and mortality risks compared to warfarin among nonvalvular atrial fibrillation patients in Saudi Arabia.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Ji Yun Lee, Il-Young Oh, Ju-Hyeon Lee, Seok Kim, Jihoon Cho, Charg Hyun Park, Sooyoung Yoo, Soo-Mee Bang
Summary: This study examined the impact of potential drug-drug interactions on the risk of ischemic stroke and major bleeding in atrial fibrillation patients treated with DOACs. It was found that an increased number of DDIs significantly raised the risk of both ischemic stroke and hospitalization for major bleeding in these patients.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Paul L. Hess, Kensey L. Gosch, Sandeep M. Jani, Paul D. Varosy, Steven M. Bradley, Thomas M. Maddox, P. Michael Ho, Salim S. Virani
Summary: This study analyzed the use of oral anticoagulants among patients with valvular atrial fibrillation from 2013 to 2019 using the PINNACLE Registry. The results showed variations in the use of direct oral anticoagulants and warfarin, but consistent trends in their usage over time.
AMERICAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Johan Lyth, Emma Svennberg, Lars Bernfort, Mattias Aronsson, Viveka Frykman, Faris Al-Khalili, Leif Friberg, Marten Rosenqvist, Johan Engdahl, Lars-Ake Levin
Summary: This study aimed to evaluate the cost-effectiveness of population-based screening for atrial fibrillation (AF) using clinical outcomes. The analysis showed that the screening intervention group had higher gained life years and gained quality-adjusted life years at a lower cost.
EUROPEAN HEART JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Carlos Escobar, Vivencio Barrios, Gregory Y. H. Lip, Alpesh N. Amin, Ariadna Auladell-Rispau, Marilina Santero, Josefina Salazar, Carolina Requeijo
Summary: This systematic review and meta-analysis assessed the use of dabigatran in non-Asian patients with non-valvular atrial fibrillation, compared to vitamin K antagonists. The results showed that dabigatran reduced the risk of various outcomes globally, demonstrating favorable effectiveness and safety compared to vitamin K antagonists.
CLINICAL DRUG INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Dong Lin, Yequn Chen, Jian Yong, Shiwan Wu, Yan Zhou, Weiping Li, Xuerui Tan, Ruisheng Liu
Summary: This study found that the use of low-dose rivaroxaban and low-intensity warfarin in Asian patients with atrial fibrillation can provide survival benefits, although the effects are smaller than those observed with recommended optimal anticoagulation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Darae Ko, Kueiyu Joshua Lin, Lily G. Bessette, Su Been Lee, Allan J. Walkey, Susan Cheng, Erin Kim, Robert J. Glynn, Dae Hyun Kim
Summary: Undertreatment of anticoagulation therapy in older adults with atrial fibrillation is a significant issue. The introduction of direct oral anticoagulants (DOACs) has improved treatment initiation, but there is still room for improvement. Further research and strategies are needed to enhance stroke prophylaxis in this population.