Article
Chemistry, Multidisciplinary
Balakrishnan S. Anju, Neeraja R. Nair, Subrata Kundu
Summary: This study demonstrates the importance of the interconversion between nitrite and nitric oxide in maintaining optimal NO flux in mammalian physiology. The research also reveals potential applications of copper-based catalysts in nitrite reduction and deepens our understanding of the involvement of red copper proteins in denitrification.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Jinghua Chen, Peilu Xie, Yujia Huang, Haichun Gao
Summary: Nitrite and nitric oxide are critical nitrogen oxides in the nitrogen biogeochemical cycle, capable of interacting with heme-copper oxidases for enzymatic interconversion and inhibition. While they show similar biochemical properties, they are treated as distinct molecules by bacterial cells and have different effects on enzymes and sensing systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pritam Mondal, Garrett B. Tolbert, Gayan B. Wijeratne
Summary: This study investigates the low temperature reactivities of high-valent heme intermediates with nitric oxide (NO), revealing two different reaction pathways. The findings highlight the potential of high-valent heme species in catalyzing efficient NOx interconversions, shedding light on unexplored territory central to human physiology and therapeutics.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yunlong Zheng, Wenwen Deng, Di Liu, Youheng Li, Kang Peng, George H. Lorimer, Jun Wang
Summary: In this review, the authors summarize the redox and spectroscopic properties of nitrite reductase-like hemoproteins in mammals. These proteins exhibit nitrite reductase-like activity in vitro and are closely related to their redox and spectroscopic properties and protein structure, although the physiological roles of Ngb, Cygb, and IDO1 remain unclear.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
John Ukeri, Michael T. Wilson, Brandon J. Reeder
Summary: Cytoglobin has physiological roles that are not clearly understood, but may include regulation of nitric oxide, oxygen sensing, and protection against oxidative stress. Specific mutations can affect the nitric oxide binding and metabolism activities of cytoglobin, helping to understand its precise role under physiological and pathophysiological conditions.
Article
Nutrition & Dietetics
Barbora Piknova, Ji Won Park, Samantha M. Thomas, Khalid J. Tunau-Spencer, Alan N. Schechter
Summary: Nitric oxide (NO) (co)regulates physiological processes in the body and its availability is affected by aging. Aging leads to changes in nitrate and nitrite contents in tissues, with higher nitrate levels and lower nitrite levels in old rats compared to young rats. However, the nitrate reduction pathway is not affected by aging. Further investigation is needed to understand the changes in NO accessibility during aging.
Article
Biochemistry & Molecular Biology
Arnab Ghosh, Mamta P. Sumi, Blair Tupta, Toshihiro Okamoto, Kulwant Aulak, Masato Tsutsui, Hiroaki Shimokawa, Serpil C. Erzurum, Dennis J. Stuehr
Summary: Low doses of NO have a dual effect on the maturation of key hemeproteins, acting both to promote and inhibit heme-insertion, while high NO doses inhibit heme-insertion. This phenomenon is observed in soluble guanylyl cyclase, globins, nitric oxide synthases, and Myeloperoxidase. The effects of low NO on hemeprotein maturation require the presence of the NO-sGC-cGMP signal pathway.
Article
Biochemistry & Molecular Biology
Tijana Suboticki, Olivera Mitrovic Ajtic, Dragoslava Djikic, Marijana Kovacic, Juan F. Santibanez, Milica Tosic, Vladan P. Cokic
Summary: In various systems, hydroxyurea has been shown to stimulate the release of nitric oxide or activate nitric oxide synthase. Through inhibiting nitric oxide metabolites, hydroxyurea is able to inhibit the growth of mature erythroid colonies and impact the presence of iNOS immunoreactive CFU-E.
Article
Chemistry, Multidisciplinary
Wenjie Tao, Curtis E. Moore, Shiyu Zhang
Summary: A redox-neutral S-nitrosation of thiol has been achieved at a dicopper(I,I) center, providing new insights into the mechanism of S-nitrosation. The reaction yielded thiol and di-S-nitrosothiol complexes, indicating that S-nitrosation proceeds through similar intermediate species.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Cinzia Verde, Daniela Giordano, Stefano Bruno
Summary: Heme proteins exhibit dual reactivity towards nitric oxide (NO) and cysteine residues, resulting in heme-dependent nitrosylation and S-nitrosylation. This interplay between heme proteins and NO plays a crucial role in the production, scavenging, and transport of nitrogen compounds. Understanding the biological functions associated with heme nitrosylation and S-nitrosylation is important in elucidating signaling pathways.
Article
Pharmacology & Pharmacy
Rose I. M. Batista, Renato C. Nogueira, Graziele C. Ferreira, Gustavo H. Oliveira-Paula, Lucas C. Pinheiro, Jose E. Tanus-Santos
Summary: Supplementation with L-arginine has been shown to have beneficial effects in hypertension by increasing nitric oxide formation and enhancing nitrate concentrations, but these effects may be prevented by antiseptic mouthwash. Alteration of the nitrate cycle in the body by mouthwash can impact endothelial dysfunction, antihypertensive effects, and antioxidant effects of L-arginine in hypertensive rats. The findings suggest a new mechanism where antibacterial mouth rinse can affect arterial blood pressure and the development of cardiovascular diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elizabeth A. Sweeny, Andrew P. Hunt, Allison E. Batka, Simon Schlanger, Nicolai Lehnert, Dennis J. Stuehr
Summary: Nitric oxide (NO) serves as a ubiquitous cell signaling molecule, mediating various processes by activating or inactivating protein targets. Research shows that NO can increase NOX5 activity through heme-dependent effects, shedding light on NOX5 regulation and the impact of NO on hemeprotein activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Mamta P. Sumi, Blair Tupta, Arnab Ghosh
Summary: NO acts as a vasodilator and triggers heme insertion into hemoglobin and myoglobin. This process is dose-dependent, with better efficiency at lower doses. It involves both transcriptional and translational events.
Article
Biochemistry & Molecular Biology
Corey J. White, Jeremey M. Schwartz, Nicolai Lehnert, Mark E. Meyerhoff
Summary: Electrocatalytic nitric oxide generation from nitrite within a dual-lumen catheter was successfully demonstrated, showing potent antimicrobial and antithrombotic properties. However, the sensitivity of the catalysts to oxygen and the reaction between oxygen and diffused nitric oxide limited the effectiveness of this approach under aerobic conditions. A new oxygen-tolerant catalyst and an immobilized glucose oxidase enzyme-coating approach were developed to overcome this limitation, achieving effective nitric oxide fluxes even in the presence of oxygen.
BIOELECTROCHEMISTRY
(2023)
Review
Clinical Neurology
Yicong Wang, Weiqi Chen, Jian Zhou, Yongjun Wang, Hao Wang, Yilong Wang
Summary: This review aims to describe the relationship between nitrate metabolism and cerebrovascular disease, providing a basis for further advances in laboratory and clinical medicine.
FRONTIERS IN NEUROLOGY
(2022)
Review
Chemistry, Multidisciplinary
Shabnam Hematian, Isaac Garcia-Bosch, Kenneth D. Karlin
ACCOUNTS OF CHEMICAL RESEARCH
(2015)
Article
Chemistry, Multidisciplinary
Shabnam Hematian, Isabell Kenkel, Tatyana E. Shubina, Maximilian Duerr, Jeffrey J. Liu, Maxime A. Siegler, Ivana Ivanovic-Burmazovic, Kenneth D. Karlin
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Article
Chemistry, Multidisciplinary
Sudipta Chatterjee, Kushal Sengupta, Shabnam Hematian, Kenneth D. Karlin, Abhishek Dey
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Article
Chemistry, Multidisciplinary
Gayan B. Wijeratne, Shabnam Hematian, Maxime A. Siegler, Kenneth D. Karlin
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Biochemistry & Molecular Biology
Shabnam Hematian, Maxime A. Siegler, Kenneth D. Karlin
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2014)
Article
Chemistry, Multidisciplinary
Maria C. Carrasco, Shabnam Hematian
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2019)
Article
Plant Sciences
Laura Flores-Bocanegra, Huzefa A. Raja, Tyler N. Graf, Mario Augustinovic, E. Diane Wallace, Shabnam Hematian, Joshua J. Kellogg, Daniel A. Todd, Nadja B. Cech, Nicholas H. Oberlies
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Chemistry, Inorganic & Nuclear
Sarmistha Bhunia, Atanu Rana, Shabnam Hematian, Kenneth D. Karlin, Abhishek Dey
Summary: The presence of proton-transfer groups near the catalyst can enhance the efficiency of the hydrogen evolution reaction (HER). Investigations show that a simple iron porphyrin can catalyze the HER at FeI state without being reduced to its formal Fe-0 state, and the rate of HER becomes almost independent of the pK(a) of the external acid used in the presence of protonated distal residues.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Maria C. Carrasco, Katherine J. Dezarn, Firoz Shah Tuglak Khan, Shabnam Hematian
Summary: This study synthesized a new mu-oxo-heme/Cu complex and investigated the protonation events of three mu-oxo-heme/Cu complexes, reporting the pK(a) values for the first protonation event. The mu-aquo-heme/Cu complexes described were the first examples of such systems.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Organic
Zeinab Y. Al Subeh, Amy L. Waldbusser, Huzefa A. Raja, Cedric J. Pearce, Kin Lok Ho, Michael J. Hall, Michael R. Probert, Nicholas H. Oberlies, Shabnam Hematian
Summary: This study isolated and characterized the long-postulated biosynthetic precursor of class B fungal perylenequinones from a Shiraia-like sp. Furthermore, it investigated the structural relationship and redox behaviors of hypocrellins and hypomycins. The study found that hypocrellins can undergo reversible reduction and reoxidation under aerobic conditions, and can undergo ring closing metathesis under anaerobic conditions.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Runzi Li, Firoz Shah Tuglak Khan, Shabnam Hematian
Summary: This study investigates the reactivities of transition metals such as manganese and copper under oxidation by dioxygen (O-2), revealing the formation of unique intermediates and products under specific conditions.
Article
Chemistry, Inorganic & Nuclear
Runzi Li, Firoz Shah Tuglak Khan, Marcos Tapia, Shabnam Hematian
Summary: Copper-dioxygen interactions, important for reversible dioxygen binding, activation, and reduction, were investigated with mononuclear copper(I) complexes. The study revealed the formation of various copper-O2 intermediates and adducts, with their electronic properties affected by the ligand framework.
JOURNAL OF COORDINATION CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Firoz Shah Tuglak Khan, Amy L. Waldbusser, Maria C. Carrasco, Hadi Pourhadi, Shabnam Hematian
Summary: This study presents a facile strategy for preparing a series of ferricenium complexes with weakly coordinating anions, and thoroughly investigates their ground state electronic structures, revealing the significant impact of substituents on metal-ligand separations in oxidized species.
DALTON TRANSACTIONS
(2021)