Article
Psychology, Multidisciplinary
Marcin Koculak, Michal Wierzchon
Summary: This paper argues that exploring the relationship between complexity and conscious content is necessary for understanding the importance of information-theoretic measures in consciousness research.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Plant Sciences
Xiuxiu Zhang, Hui Li, Hai Lu, Inhwan Hwang
Summary: This article summarizes the two types of vacuoles in plant cells and the recent progress in studying their protein trafficking mechanisms, discusses the commonalities and specificities between lytic vacuoles and protein storage vacuoles, as well as the interconnection provided by the protein trafficking machinery between these organelles.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Environmental Sciences
Chris M. Roelfsema, Mitchell B. Lyons, Carolina Castro-Sanguino, Eva M. Kovacs, David Callaghan, Magnus Wettle, Kathryn Markey, Rodney Borrego-Acevedo, Paul Tudman, Meredith Roe, Emma Kennedy, Manuel Gonzalez-Rivero, Nicholas Murray, Stuart R. Phinn
Summary: The geomorphic and benthic composition of Australia's Great Barrier Reef are understudied, but crucial for understanding disturbance impacts and recovery potential. Through new research methods and high-resolution maps, there is now a more comprehensive understanding of the spatial extent and ecological characteristics of the Great Barrier Reef.
Article
Biochemistry & Molecular Biology
Maret G. Traber, Brian Head
Summary: This narrative review focuses on the structures, functions, biological determinants, and deficiency symptoms of vitamin E in humans, discussing the mechanisms for alpha-T tissue enrichment, potential new biomarkers, pharmacokinetic data, and approaches to evaluate alpha-T dietary requirements. The possible role of alpha-T supplements in delaying chronic diseases and the evaluation of vitamin E safety are also considered in this review.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Editorial Material
Multidisciplinary Sciences
Ira Leifer
Summary: The extent of human-caused marine oil pollution is much more significant than previously believed.
Article
Nutrition & Dietetics
Melanie Kok, Astrid Compagner, Ina Panneman, Aline Sprikkelman, Berber Vlieg-Boerstra
Summary: The study aimed to estimate the amount of allergenic protein in commonly consumed foods in the Netherlands, showing that most foods contain 2-3g of allergenic protein, with significant variations. A single bite or sip may contain enough allergenic protein to trigger an allergic reaction.
Article
Computer Science, Interdisciplinary Applications
Dan Givoli
Summary: This review paper discusses the research progress of a seminal paper by Germund Dahlquist, a Swedish mathematician, in the past 60 years. It starts by examining Dahlquist's barriers, which are theoretical limitations on the accuracy and stability properties of Linear Multistep (LMS) methods in solving initial value problems. The paper also explores time-stepping methods that seemingly break Dahlquist's barriers and reviews advanced time-integration techniques that deviate from the LMS format.
JOURNAL OF COMPUTATIONAL PHYSICS
(2023)
Article
Business, Finance
Kenneth J. Singleton
Summary: The study indicates that the forecast errors of professional forecasters and Bayesian econometrician are comparable over the business cycle, but their beliefs about macroeconomic fundamentals are not significantly related.
JOURNAL OF FINANCE
(2021)
Article
Energy & Fuels
Christoph Heilmann, David Wozabal
Summary: This paper explores how smart-charging of PEVs can mitigate challenges presented by VRES expansion and reduce distribution grid costs. A heuristic policy is proposed for Germany in 2035, leading to potential savings of €6.2 billion and a 19% reduction in total costs. The potential of smart charging is higher in rural areas than urban centers, and curtailing VRES production is only economically viable in rare circumstances.
Article
Social Sciences, Interdisciplinary
Terry A. Beehr, Minseo Kim, Ian W. Armstrong
Summary: Previous research has focused on reasons for and ways to avoid low response rates, but ignored the importance of response rates. This study examined survey research in the domain of organizational behavior and found that response rates have no noticeable effect on effect sizes.
INTERNATIONAL JOURNAL OF SOCIAL RESEARCH METHODOLOGY
(2022)
Article
Environmental Studies
Caroline Veldhuizen, Kevin C. Desouza, Wasana Bandara, Artemis Chang
Summary: The resources sector is facing increasing demands to address environmental and social issues, and calls for responsibility and transparency are growing louder. The existing discourse lacks a coherent reference framework to consider how companies respond to various stakeholder demands and the impact on value creation.
Editorial Material
Multidisciplinary Sciences
Ruth Ley
Summary: The survey of humanity's 'second genome' is crucial and needs to be more comprehensive.
Editorial Material
Hematology
Charles T. Quinn
Summary: In this study, Abdullahi et al provide evidence that fixed low- and moderate-dose daily hydroxyurea regimens can be effective in preventing secondary stroke for patients with sickle cell anemia living in low-resource settings, as an alternative to chronic transfusion therapy.
Article
Economics
Anil K. Kashyap, Natalia Kovrijnykh, Jian Li, Anna Pavlova
Summary: In this paper, we propose a tractable model of asset management where benchmarking arises endogenously and analyze its welfare consequences. Fund managers' portfolios are not contractible and incur private costs. Incentive contracts for fund managers produce a pecuniary externality through their impact on asset prices. Benchmarking inflates asset prices and leads to crowded trades. This crowding reduces the effectiveness of benchmarking in incentive contracts for others, which fund investors fail to consider. A social planner, recognizing the crowding, chooses contracts with less benchmarking and less incentive provision. The planner also achieves lower asset management costs.
AMERICAN ECONOMIC REVIEW
(2023)
Editorial Material
Hematology
Christine L. Kempton
Summary: The study evaluated prophylactic factor replacement therapy in patients with hemophilia A by targeting two distinct factor VIII trough levels, aiming to prevent bleeding episodes.
Article
Biochemistry & Molecular Biology
Rafael Grande-Aztatzi, Elena Formoso, Jon Mujika, David de Sancho, Xabier Lopez
JOURNAL OF INORGANIC BIOCHEMISTRY
(2020)
Article
Chemistry, Physical
Sandhyaa Subramanian, Hemashree Golla, Kalivarathan Divakar, Adithi Kannan, David de Sancho, Athi N. Naganathan
JOURNAL OF PHYSICAL CHEMISTRY B
(2020)
Article
Chemistry, Multidisciplinary
Carmen Suay-Corredera, Maria Rosaria Pricolo, Diana Velazquez-Carreras, Divya Pathak, Neha Nandwani, Carolina Pimenta-Lopes, David Sanchez-Ortiz, Inigo Urrutia-Irazabal, Silvia Vilches, Fernando Dominguez, Giulia Frisso, Lorenzo Monserrat, Pablo Garcia-Pavia, David de Sancho, James A. Spudich, Kathleen M. Ruppel, Elias Herrero-Galan, Jorge Alegre-Cebollada
Summary: Hypertrophic cardiomyopathy (HCM) is a disease caused by mutations in sarcomeric proteins, with many mutations not affecting protein structure or stability. Research shows that these mutations may disrupt the nanomechanics of cMyBP-C, affecting its regulatory role in actomyosin filaments.
Article
Chemistry, Physical
Ion Mitxelena, Xabier Lopez, David de Sancho
Summary: Markov state models (MSMs) are a preferred method for analyzing and interpreting molecular dynamics simulations of conformational transitions in biopolymers. By utilizing hierarchical density-based clustering, it is possible to define slow dynamics more effectively and consistently with the assumption of Markovianity.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Chemistry, Physical
Christina Felbek, Federica Arrigoni, David de Sancho, Aurore Jacq-Bailly, Robert B. Best, Vincent Fourmond, Luca Bertini, Christophe Leger
Summary: The study investigates the inhibitory mechanism of hydrogen sulfide on FeFe hydrogenase through a combination of various experimental and theoretical methods, revealing the underlying mechanisms and providing insights into the oxidation and reduction of the enzyme. Additionally, it was observed that the inhibition by sulfide may lead to irreversible inactivation of the hydrogenase.
Article
Chemistry, Physical
Asier Urriolabeitia, David De Sancho, Xabier Lopez
Summary: In this study, computer simulations were used to investigate the influence of mimosine on peptide structure. The results showed that the dipole nature of mimosine leads to a preference for stacked conformations. Quantum mechanical calculations were employed to validate the results.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Biophysics
David De Sancho
Summary: Macromolecular phase separation plays a crucial role in the formation of membraneless organelles and cellular organization. The formation of condensate-spanning networks in protein solutions is determined by the interplay between two classes of residues, stickers and spacers, with multivalency and sequence patterning being the main determinants for phase separation. Atomistic molecular dynamics simulations demonstrate that ternary amino acid mixtures involving both sticker and spacer types can undergo phase separation, resulting in phases with intermediate compaction and greater fluidity compared to sticker-only condensates.
BIOPHYSICAL JOURNAL
(2022)
Article
Physics, Multidisciplinary
Antonio Reifs, Irene Ruiz Ortiz, Amaia Ochandorena Saa, Jorg Schonfelder, David De Sancho, Victor Munoz, Raul Perez-Jimenez
Summary: Ultrafast folding proteins have low energetic barriers and fast kinetics, making them suitable for study by both experiments and simulations. However, single molecule force spectroscopy experiments on these proteins are challenging due to the lack of mechanical fingerprints. In this study, the unfolding of an ultrafast protein is investigated using atomic force microscopy experiments.
COMMUNICATIONS PHYSICS
(2023)
Article
Chemistry, Physical
David Silva-Brea, David de Sancho, Xabier Lopez
Summary: Quantum mechanical calculations are used to understand the preferred modes of chelation in metal-binding peptides and determine binding affinities. While increasing coordination of a metal leads to higher stabilization energies, it also results in reduced conformational freedom of the polypeptide chain and a penalty in entropy. The negative correlation between stabilization energy and entropy suggests a delicate interplay between enthalpic and entropic forces in determining the most favorable species, and this finding has implications for the Metal Ion Hypothesis.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Asier Urriolabeitia, David De Sancho, Xabier Lopez
Summary: This study investigates the influence of the nonprotein amino acid mimosine on peptide structure using computer simulations. The results show that mimosine prefers a stacked conformation of the amino acid rings. Quantum mechanical calculations validate the findings of the simulations.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Physical
Irene Ruiz-Ortiz, David De Sancho
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)
Meeting Abstract
Biophysics
Carla Huerta-Lopez, Diana Velazquez-Carreras, Luis Gutierrez-Rus, Francisco M. Martin-Zamora, Elias Herrero Galan, Alvaro Martinez-del-Pozo, David de Sancho, Gustavo R. Plaza, Jorge Alegre-Cebollada
BIOPHYSICAL JOURNAL
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
D. De Sancho
Meeting Abstract
Biophysics
D. De Sancho
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2019)
Article
Chemistry, Multidisciplinary
Nerea Barruetabena, Borja Alonso-Lerma, Albert Galera-Prat, Nadeem Joudeh, Leire Barandiaran, Leire Aldazabal, Maria Arbulu, Miguel Alcalde, David De Sancho, Jose A. Gavira, Mariano Carrion-Vazquez, Raul Perez-Jimenez
COMMUNICATIONS CHEMISTRY
(2019)