Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 70, Issue 3, Pages 549-554Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2013.10.032
Keywords
BAP1 protein; B-raf; epithelioid and spindle cell; human; nevus; proto-oncogene proteins
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The dermatologic hallmark of a recently described BAP1-associated cancer susceptibility syndrome is a dome-shaped nevus with distinct clinicopathological features, first delineated by Wiesner and colleagues. Here we describe the leading histopathological criteria of Wiesner nevus. Wiesner nevus is composed of various nevomelanocytic populations all showing different degrees of atypia ranging from hyperchromatic nevus cell-like to large atypical epithelioid cells. Immunohistochemically, Wiesner nevus is BAP1 negative and VE1 positive.
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