期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 70, 期 3, 页码 549-554出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2013.10.032
关键词
BAP1 protein; B-raf; epithelioid and spindle cell; human; nevus; proto-oncogene proteins
类别
The dermatologic hallmark of a recently described BAP1-associated cancer susceptibility syndrome is a dome-shaped nevus with distinct clinicopathological features, first delineated by Wiesner and colleagues. Here we describe the leading histopathological criteria of Wiesner nevus. Wiesner nevus is composed of various nevomelanocytic populations all showing different degrees of atypia ranging from hyperchromatic nevus cell-like to large atypical epithelioid cells. Immunohistochemically, Wiesner nevus is BAP1 negative and VE1 positive.
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