Article
Oncology
Venkatakrishna Rao Jala, Sobha Rani Bodduluri, Sweta Ghosh, Zinal Chheda, Rajbir Singh, Michelle E. Smith, Paula M. Chilton, Christopher J. Fleming, Steven Paul Mathis, Rajesh Kumar Sharma, Rob Knight, Jun Yan, Bodduluri Haribabu
Summary: The CCL2/CCR2 axis plays a crucial role in the development of spontaneous intestinal tumorigenesis, with CCR2(-/-)Apc(Min/+) mice showing increased overall survival and reduced tumor burden. These mice also showed decreased myeloid cell population and increased IFN-gamma producing T cells. Tumors in CCR2(-/-)Apc(Min/+) mice exhibited reduced IL-17 and IL-23 levels but increased IFN-gamma and Granzyme B levels compared to Apc(Min/+) tumors.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Megumi Sasatani, Tsutomu Shimura, Kazutaka Doi, Elena Karamfilova Zaharieva, Jianxiang Li, Daisuke Iizuka, Shinpei Etoh, Yusuke Sotomaru, Kenji Kamiya
Summary: Age is a crucial factor in radiation-induced carcinogenesis, as shown in mouse models. The susceptibility to radiation-induced tumorigenesis is higher in infant mice, possibly due to increased proliferative potential of oncogenic mutations in infant stem cells. Furthermore, the morphology and dynamics of intestinal crypts also play a role in age-dependent susceptibility to radiation-induced tumorigenesis.
Article
Biochemistry & Molecular Biology
Paola Briata, Luca Mastracci, Ettore Zapparoli, Luca Caputo, Elisa Ferracci, Alessandra Silvestri, Anna Garuti, Meriem Hadjer Hamadou, Alberto Inga, Elisa Marcaccini, Federica Grillo, Gabriele Bucci, Pier Lorenzo Puri, Galina Beznoussenko, Alexander Mironov, Fulvio Chiacchiera, Roberto Gherzi
Summary: The long non-coding RNA EPR regulates various biological activities in mouse mammary gland cells and is highly expressed in the intestine. The specific deletion of EPR in the colon of mice results in hyperproliferation of epithelial cells, impaired mucus production and secretion, inflammatory infiltration, and increased vulnerability to colitis and tumor formation. EPR interacts with genes involved in mucus metabolism and its deletion causes changes in chromatin organization.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Cell & Tissue Engineering
Semir Beyaz, Charlie Chung, Haiwei Mou, Khristian E. Bauer-Rowe, Michael E. Xifaras, Ilgin Ergin, Lenka Dohnalova, Moshe Biton, Karthik Shekhar, Onur Eskiocak, Katherine Papciak, Kadir Ozler, Mohammad Almeqdadi, Brian Yueh, Miriam Fein, Damodaran Annamalai, Eider Valle-Encinas, Aysegul Erdemir, Karoline Dogum, Vyom Shah, Aybuke Alici-Garipcan, Hannah V. Meyer, Deniz M. Ozata, Eran Elinav, Alper Kucukural, Pawan Kumar, Jeremy P. McAleer, James G. Fox, Christoph A. Thaiss, Aviv Regev, Jatin Roper, Stuart H. Orkin, Omer H. Yilmaz
Summary: A high-fat diet reduces MHC class II gene expression in intestinal epithelial cells, affecting microbiome diversity. The expression of epithelial MHC class II is regulated by intestinal flora through PRR and IFNg signaling. MHC-II-ISCs have greater tumor-initiating capacity compared to MHC-II+ counterparts under the influence of a high-fat diet, showing the role of immune surveillance in suppressing tumorigenesis.
Article
Microbiology
Andrea Proano-Vasco, Theresa Baumeister, Amira Metwaly, Sandra Reitmeier, Karin Kleigrewe, Chen Meng, Michael Gigl, Thomas Engleitner, Rupert Oellinger, Roland Rad, Katja Steiger, Akanksha Anand, Julia Strangmann, Robert Thimme, Roland M. Schmid, Timothy C. Wang, Michael Quante
Summary: High-fructose diet alters the balance of gut microbiota and induces a less pronounced acceleration in esophageal adenocarcinoma progression.
Article
Oncology
Qun Zhao, Jian Guo, Xinran Cheng, Yingying Liao, Yun Bi, Yingxia Gong, Xudong Zhang, Yang Guo, Xianhui Wang, Wei Yu, Shu Jin, Yan Tan, Xianjun Yu
Summary: RIPK3 plays a critical role in the progression of spontaneous intestinal tumorigenesis, and its deficiency can enhance tumor formation. Reduced expression of RIPK3 is associated with poor prognosis in CRC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoxing Wu, Zhaoxia Li, Hongyu Zhang, Fang He, Min Qiao, Huaxiu Luo, Jing Zhang, Meng Zhang, Yukun Mao, William Wagstaff, Yongtao Zhang, Changchun Niu, Xia Zhao, Hao Wang, Linjuan Huang, Deyao Shi, Qing Liu, Na Ni, Kai Fu, Rex C. Haydon, Russell R. Reid, Hue H. Luu, Tong-Chuan He, Ziwei Wang, Houjie Liang, Bing-Qiang Zhang, Ning Wang
Summary: In this study, a conditionally immortalized mouse intestinal crypt (ciMIC) cell line was established using a piggyBac transposon-based SV40 T antigen expression system. The ciMICs maintained long-term proliferative activity under a two-dimensional niche factor-containing culture condition, retained the biological characteristics of intestinal epithelial stem cells, and could form intestinal organoids in three-dimensional culture. Additionally, ciMICs overexpressing oncogenic beta-catenin and/or KRAS exhibited high proliferative activity and developed intestinal adenoma-like pathological features in vivo, suggesting their potential as a valuable tool cell line for studying genetic and/or epigenetic mechanisms of intestinal tumorigenesis.
Article
Oncology
Olusola O. Faluyi, Mark A. Hull, Alexander F. Markham, Constanze Bonifer, P. Louise Coletta
Summary: Advanced colorectal cancer requires new treatment strategies, with most MMR-proficient CRC showing resistance to checkpoint inhibitor therapy. Further studies are needed to determine the impact of immune surveillance on colorectal adenomas or MMR-proficient CRC resistance to CKI therapy.
Article
Biochemistry & Molecular Biology
Diana Abu-Halaka, Ofer Gover, Einat Rauchbach, Shira Zelber-Sagi, Betty Schwartz, Oren Tirosh
Summary: This study investigated the metabolic effects of hemin and nitrite added to a high fat diet as nutritional models for red meat and processed red meat. The results showed that nitrite impaired the ability to use fat for energy and had an impact on the progression of metabolic diseases when added to meat.
Article
Medicine, Research & Experimental
Ryoko Semba, Takamitsu Morioka, Hiromi Yanagihara, Kenshi Suzuki, Hirotaka Tachibana, Takahiro Hamoya, Yoshiya Horimoto, Tatsuhiko Imaoka, Mitsue Saito, Shizuko Kakinuma, Masami Arai
Summary: This study found that the macrolide antibiotic azithromycin has inhibitory effects on intestinal tumorigenesis in mice with a nonsense mutation in the Apc gene. It suppresses tumor growth and adenocarcinoma formation, while also restoring the levels of full-length Apc protein and downregulating β-catenin and cyclin D1. However, the impact of azithromycin on the diversity of intestinal microbiota depends on the concentration used.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Gabriel Matos-Rodrigues, Emmanuelle Martini, Bernard S. Lopez
Summary: Homologous recombination (HR) is a crucial DNA repair pathway for genome stability, and mutations in many HR genes are associated with cancer risk. Transgenic mouse models are important for studying HR in tumorigenesis, but invalidating HR genes can lead to embryonic lethality in mammals. Complex strategies have been developed to overcome this challenge and investigate the impact of HR defects on tumorigenesis in vivo. The central HR factor, RAD51, has not been fully characterized in vivo and its inactivation is not linked to cancer predisposition, highlighting the RAD51 paradox. Mouse models can be valuable for developing targeted cancer therapies and understanding the mechanisms of HR inactivation-driven tumorigenesis in vivo.
Article
Chemistry, Medicinal
Romel P. Dator, Kevin J. Murray, Matthew W. Luedtke, Foster C. Jacobs, Fekadu Kassie, Hai Dang Nguyen, Peter W. Villalta, Silvia Balbo
Summary: Research has discovered that the lung carcinogen NNK present in tobacco products can lead to the formation of DNA-RNA cross-links, which has significant implications for NNK-induced carcinogenesis.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Immunology
Bruce A. Rosa, Caroline Snowden, John Martin, Kerstin Fischer, Jonah Kupritz, Ethiopia Beshah, Taniawati Supali, Lincoln Gankpala, Peter U. Fischer, Joseph F. Urban, Makedonka Mitreva
Summary: This study utilized a combined 16S rRNA gene OTU analysis approach to identify bacterial taxa associated with whipworm infection in both humans and mice, revealing differences across host species and infection status. The study identified bacterial taxa of interest for future association and mechanistic studies, providing valuable insights into the interaction between whipworm infection and the host intestinal microbiome.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Oncology
Xiaoman Hou, Yali Zhai, Kevin Hu, Chia-Jen Liu, Aaron Udager, Celeste L. Pearce, Eric R. Fearon, Kathleen R. Cho
Summary: This study validated the mouse model for tubo-ovarian high-grade serous carcinoma (HGSC) and demonstrated that age is a major risk factor for HGSC, while multiparity can delay the development and/or progression of HGSC in certain genetic contexts.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Akanksha Anand, Hsin-Yu Fang, Donja Mohammad-Shahi, Jonas Ingermann, Theresa Baumeister, Julia Strangmann, Roland M. Schmid, Timothy C. Wang, Michael Quante
Summary: Chronic inflammation leads to Barrett's Esophagus (BE) and can progress to esophageal adenocarcinoma. Elevated levels of interleukins and NF-kappaB activation play a crucial role in tumorigenesis. Inhibiting NF-kappaB signaling in myofibroblasts (MFs) can reduce inflammation, increase differentiation, and decrease the risk of esophageal adenocarcinoma development.
Article
Chemistry, Applied
G. Yi, V. Grabez, M. Bjelanovic, E. Slinde, K. Olsen, O. Langsrud, V. T. Phung, A. Haug, M. Oostindjer, B. Egelandsdal
Article
Oncology
Marianne Sodring, Gjermund Gunnes, Jan Erik Paulsen
INTERNATIONAL JOURNAL OF CANCER
(2016)
Article
Microbiology
Ozgun C. O. Umu, Jeremy A. Frank, Jonatan U. Fangel, Marije Oostindjer, Carol Souza da Silva, Elizabeth J. Bolhuis, Guido Bosch, William G. T. Willats, Phillip B. Pope, Dzung B. Diep
Article
Oncology
Christina Steppeler, Marianne Sodring, Jan Erik Paulsen
Review
Food Science & Technology
Marije Oostindjer, Jessica Aschemann-Witzel, Qing Wang, Silje Elisabeth Skuland, Bjorg Egelandsdal, Gro V. Amdam, Alexander Schjoll, Mark C. Pachucki, Paul Rozin, Jarrett Stein, Valerie Lengard Almli, Ellen Van Kleef
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2017)
Article
Health Care Sciences & Services
Qing Wang, Bjorg Egelandsdal, Gro V. Amdam, Valerie L. Almli, Marije Oostindjer
JMIR MHEALTH AND UHEALTH
(2016)
Article
Environmental Sciences
K. E. Aa Hansen, S. M. Johanson, C. Steppeler, M. Sodring, G. C. Ostby, H. F. Berntsen, K. E. Zimmer, M. Aleksandersen, J. E. Paulsen, E. Ropstad
Letter
Food Science & Technology
Lars O. Dragsted, Jan Alexander, Gro Amdam, Nathan Bryan, Duan Chen, Anna Haug, Anders H. Karlsson, Theo de Kok, Bard Erik Kulseng, Roy J. Martin, Andrew Milkowski, Anne-Maria Pajari, Jana Pickowa, Knut Rudi, Marianne Sundt Sodring, Marije Oostindjer, Bjorg Egelandsdal
Article
Food Science & Technology
Marije Oostindjer, Jan Alexander, Gro V. Amdam, Grethe Andersen, Nathan S. Bryan, Duan Chen, Denis E. Corpet, Stefaan De Smet, Lars Ove Dragsted, Anna Haug, Anders H. Karlsson, Gijs Kleter, Theo M. de Kok, Bard Kulseng, Andrew L. Milkowski, Roy J. Martin, Anne-Maria Pajari, Jan Erik Paulsen, Jana Pickova, Knut Rudi, Marianne Sodring, Douglas L. Weed, Bjorg Egelandsdal
Article
Multidisciplinary Sciences
Christina Steppeler, Marianne Sodring, Bjorg Egelandsdal, Bente Kirkhus, Marije Oostindjer, Ole Alvseike, Lars Erik Gangsei, Ellen-Margrethe Hovland, Fabrice Pierre, Jan Erik Paulsen
Article
Public, Environmental & Occupational Health
Marije Oostindjer, Gro V. Amdam, Bjorg Egelandsdal
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2015)
Article
Veterinary Sciences
Marianne Sodring, Ola Nafstad, Torunn Thauland Haseth
ACTA VETERINARIA SCANDINAVICA
(2020)
Article
Oncology
Marianne Sodring, Gjermund Gunnes, Jan Erik Paulsen
ANTICANCER RESEARCH
(2016)