Article
Orthopedics
Anne-Christine Hick, Misch Fonck, Berenice Costes, Elisabeth Cobraiville, Sebastien Pirson, Laetitia Garcia, Alain Labasse, Steven Vander Poelen, Yves Henrotin
Summary: The serum Coll2-1 biomarker value showed minimal variation under different sampling conditions, but significantly elevated in patients with osteoarthritis, indicating its association with cartilage degradation.
Review
Rheumatology
Melanie A. Holden, Kate Button, Natalie J. Collins, Yves Henrotin, Rana S. Hinman, Jesper B. Larsen, Ben Metcalf, Hiral Master, Soren T. Skou, Louise M. Thoma, Elizabeth Wellsandt, Daniel K. White, Kim Bennell
Summary: Therapeutic exercise is a safe and effective treatment for patients with knee and hip osteoarthritis, with various types of exercise contributing to pain and function improvement. Implementation should consider different dosages and settings to optimize clinical benefits.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Medicine, General & Internal
Yves Henrotin, Yvan Dierckxsens, Gaelle Delisse, Laurence Seidel, Adelin Albert
Summary: The study demonstrated that adding a food supplement containing Curcuma longa and Boswellia serrata extracts significantly improved symptoms in patients with tendinopathy, with good safety profile. Pain and functional limitation were significantly reduced with treatment duration, and the need for concomitant treatments decreased among patients.
CURRENT MEDICAL RESEARCH AND OPINION
(2021)
Review
Orthopedics
Y. Henrotin
Summary: Recent studies have focused on the application of protein-derived soluble biomarkers in osteoarthritis, with research areas including disease burden, investigative biomarkers, prognosis, treatment efficacy, and the diagnostic and phenotyping value of these biomarkers. These studies contribute to a more targeted management of patients suffering from osteoarthritis.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Pharmacology & Pharmacy
Cecile Lambert, Gaelle Bellemere, Gaetan Boyer, Frank Ponelle, Thierry Bauer, Marie-Christine Legeny, Caroline Baudouin, Yves Henrotin
Summary: This study compared the composition and pharmacological activity of seven commercially available ASU products on human osteoarthritis chondrocytes. It was found that PIASCLEDINE-ExpASU(R) had a specific composition and exhibited better pharmacological activity, including higher inhibitory effect on pro-inflammatory factors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Marie-Noelle Horcajada, Maurice Beaumont, Nicolas Sauvageot, Laure Poquet, Madleen Saboundjian, Berenice Costes, Peter Verdonk, Geoffrey Brands, Jean Brasseur, Didier Urbin-Choffray, Marc Vandenberghe, Karl Brabants, Kurt De Vlam, Werner Fache, Bernard Jandrain, Vincent Grek, Michel Malaise, Yves Henrotin
Summary: The study found that olive leaf extract (OLE) has limited effects on knee functionality and biomarkers of bone/cartilage metabolism and inflammation, but may be effective in patients with severe walking pain. OLE can be used to relieve knee joint pain and enhance mobility.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Article
Rheumatology
Federico Angelini, Pawel Widera, Ali Mobasheri, Joseph Blair, Andre Struglics, Melanie Uebelhoer, Yves Henrotin, Anne Ca Marijnissen, Margreet Kloppenburg, Francisco J. Blanco, Ida K. Haugen, Francis Berenbaum, Christoph Ladel, Jonathan Larkin, Anne C. Bay-Jensen, Jaume Bacardit
Summary: The study found three dominant endotypes associated with three phenotypes: low tissue turnover, structural damage, and systemic inflammation. Each endotype presented different disease characteristics, indicating the potential for personalized treatment strategies in the future.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Orthopedics
Yves Henrotin, Romain Le Cozannet, Pascale Fanca-Berthon, Romain Truillet, Martine Cohen-Solhal, Gillian DunnGalvin, Jean-Marie Grouin, Andrea Doolan
Summary: This study suggests that Rubus idaeus leaf extract is safe and effective in relieving pain in patients with knee osteoarthritis. However, it does not show significant effects on other symptoms and functions.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Rheumatology
Yves E. Henrotin, Christoph Michlmayr, Stefanie M. Rau, Anne-Marie Quirke, Marco Bigoni, Michael A. Ueberall
Summary: Osteoarthritis is a common joint disorder affecting millions of people worldwide. The current standard treatment using NSAIDs has side effects, leading to a search for alternative treatments. Oral enzyme combinations may be an effective alternative to NSAIDs, providing similar efficacy without the adverse effects.
RHEUMATOLOGY AND THERAPY
(2022)
Article
Orthopedics
M. A. Holden, B. Metcalf, B. J. Lawford, R. S. Hinman, M. Boyd, K. Button, N. J. Collins, E. Cottrell, Y. Henrotin, J. B. Larsen, H. Master, S. T. Skou, L. M. Thoma, R. Rydz, E. Wellsandt, D. K. White, K. Bennell
Summary: This study developed evidence-informed recommendations for the delivery of best practice therapeutic exercise for people with knee and/or hip osteoarthritis. The final recommendations comprised 54 specific proposition statements across 11 broad domains.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Plant Sciences
Yves Henrotin, Yvan Dierckxsens, Gaelle Delisse, Nathalie Maes, Adelin Albert
Summary: This study suggests that a food supplement containing Curcuma longa and Boswellia serrata resin may have potential in relieving pain and reducing the use of nonsteroidal anti-inflammatory drugs in patients with hand osteoarthritis.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Orthopedics
Thierry Conrozier, Demirhan Diracoglu, Jordi Monfort, Xavier Chevalier, Herve Bard, Dominique Baron, Joerg Jerosch, Alberto Migliore, Pascal Richette, Yves Henrotin
Summary: This study provides recommendations for decision-making in knee Viscosupplementation (VS) based on literature review and expert opinions. It includes recommendations on pain assessment, the necessity of imaging tests, treatment goals, etc. These recommendations are helpful for physicians to make informed decisions.
Article
Rheumatology
Belinda J. Lawford, Hiral Master, Jesper B. Larsen, Cecilie Bartholdy, Patrick Corrigan, Elisabeth Ginnerup-Nielsen, Christina Le, Anthony Teoli, Kim L. Bennell, Ben Metcalf, Rana S. Hinman, Kate Button, Natalie J. Collins, Elizabeth Cottrell, Yves Henrotin, Soren T. Skou, Louise M. Thoma, Elizabeth Wellsandt, Daniel K. White, Melanie A. Holden
Summary: This study aimed to identify important components and practical resources for a toolkit to aid exercise delivery for people with hip/knee osteoarthritis. An online survey involving clinicians, patients, and researchers yielded nine broad domains of resources, including accessibility, quality, stakeholder involvement, different modes of information delivery, resources for exercise and non-exercise self-management, recommended exercises and progression, motivation and progress tracking tools, individual tailoring, and access to professional and peer support. These findings lay the foundation for developing a toolkit aligned with international recommendations.
MUSCULOSKELETAL CARE
(2023)
Review
Biotechnology & Applied Microbiology
Melanie Maillard, Octave Nadile Bandiaky, Suzanne Maunoury, Charles Alliot, Brigitte Alliot-Licht, Samuel Serisier, Emmanuelle Renard
Summary: This systematic review evaluates the ability of different formulations of calcium phosphate to reduce dentin hypersensitivity pain level in clinical studies. The results show that calcium phosphates have properties that reduce dentin hypersensitivity pain. The biomimetic and non-toxic characteristics of these materials make them a major asset in treating dentin hypersensitivity.
BIOENGINEERING-BASEL
(2023)
Article
Cell & Tissue Engineering
Jeremie Zappia, Qiao Tong, Renee Van der Cruyssen, Frederique M. F. Cornelis, Cecile Lambert, Tiago Pinto Coelho, Juliane Grisart, Erika Kague, Rik J. Lories, Marc Muller, Dirk Elewaut, Chrissy L. Hammond, Christelle Sanchez, Yves Henrotin
Summary: Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis. Osteomodulin (OMD), a proteoglycan, is associated with the sclerotic phenotype. This study found that OMD binds to RANKL and inhibits osteoclastogenesis, thus regulating bone remodeling and contributing to bone and cartilage homeostasis. Targeting OMD may be a promising personalized approach for osteoarthritis.