Article
Immunology
Tamara Hernandez-Beeftink, Beatriz Guillen-Guio, Hector Rodriguez-Perez, Itahisa Marcelino-Rodriguez, Jose M. Lorenzo-Salazar, Almudena Corrales, Miryam Prieto-Gonzalez, Aurelio Rodriguez-Perez, Demetrio Carriedo, Jesus Blanco, Alfonso Ambros, Elena Gonzalez-Higueras, Nancy G. Casanova, Manuel Gonzalez-Garay, Elena Espinosa, Arturo Muriel, David Dominguez, Abelardo Garcia de Lorenzo, Jose M. Anon, Marina Soro, Javier Belda, Joe G. N. Garcia, Jesus Villar, Carlos Flores
Summary: This study analyzed the association of whole-blood mtDNA copies with 28-day survival in patients with sepsis and sepsis-associated ARDS. The findings suggest that wb-mtDNA copies at sepsis diagnosis could serve as an early prognostic biomarker for patients with sepsis-associated ARDS. Further research is needed to explore the mechanisms underlying this observation in the pathogenesis of ARDS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Naixin Liang, Zichen Jiao, Cong Zhang, Yifan Wu, Tao Wang, Shanqing Li, Yadong Wang, Tianqiang Song, Jian-Qun Chen, Hongwei Liang, Qihan Chen
Summary: This study confirms that red blood cells (RBC) contain long DNA fragments, which differ significantly from nucleated cells, and can be used as a novel liquid biopsy technology platform for early cancer screening and diagnosis of malignancy.
Article
Medicine, Research & Experimental
Wei Peng, Fei Peng, Yuanlei Lou, Yong Li, Ning Zhao, Qiang Shao, Jiaquan Chen, Kejian Qian, Zhenguo Zeng, Yian Zhan, Rong Jiang, Fen Liu
Summary: After treatment with MTDs, the levels of inflammatory cytokines and NLRP3 inflammasome-associated proteins were gradually increased in vitro and in vivo. Enhancing autophagy with rapamycin significantly reduced inflammation cytokine secretion, lung injury, and NLRP3 inflammasome-associated proteins in the MTDs-induced mouse model. Autophagy serves as an effective way to alleviate inflammation in MTDs-induced ALI by inhibiting NLRP3 inflammasome and may be a potential therapeutic target for modulating MTDs-induced inflammatory response.
Review
Respiratory System
Pearl Toy, Mark R. Looney, Mark Popovsky, Miodrag Palfi, Gosta Berlin, Catherine E. Chapman, Paula Bolton-Maggs, Michael A. Matthay
Summary: Transfusion-related acute lung injury (TRALI) is a condition characterized by acute respiratory distress syndrome (ARDS) after blood transfusion, often associated with donor leukocyte antibodies or plasma from multiparous donors. While there have been successful measures to reduce TRALI, there are still unanswered questions regarding non-antibody TRALI mechanisms, the impact of blood products on ARDS in massive transfusion patients, and accurate diagnosis of TRALI.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Physiology
Wolfgang M. Kuebler, Nishaka William, Martin Post, Jason P. Acker, Mark J. Mcvey
Summary: Respiratory transfusion reactions, especially transfusion-related acute lung injury (TRALI), have significant morbidity and mortality. Current methods of diagnosing and treating TRALI are limited. EVs play a role in mediating TRALI by acting as triggers for the first and/ or second hit. Further research is needed to explore EVs as therapeutic targets and biomarkers for TRALI diagnosis.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Immunology
Jia-Xi Duan, Hui-Ling Jiang, Xin-Xin Guan, Chen-Yu Zhang, Wen-Jing Zhong, Cheng Zu, Jia-Hao Tao, Jin-Tong Yang, Yu-Biao Liu, Yong Zhou, Ping Chen, Hui-Hui Yang
Summary: The research found that extracellular citrate exacerbates lung injury induced by LPS and acts by activating the NLRP3 inflammasome.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Meng-Jing Xiao, Xiao-Fang Zou, Bin Li, Bao-Long Li, Shi-Jian Wu, Bo Zhang
Summary: This study using a rat burn model found that hypobaric hypoxia exposure may exacerbate burn-induced lung injuries, which can be alleviated by reducing mtDNA release and systemic inflammatory responses.
MILITARY MEDICAL RESEARCH
(2021)
Article
Critical Care Medicine
Adam Gyedu, Stephanie K. Goodman, Robert Quansah, Maxwell Osei-Ampofo, Peter Donkor, Charles Mock
Summary: The study revealed that among injured patients requiring surgical intervention at a tertiary hospital in Ghana, inappropriate blood transfusion practices were observed in 31%-39% of cases. The findings suggest a need for clearer guidelines on blood transfusion in Ghana and similar low- and middle-income countries to prevent inappropriate use of blood as a scarce resource.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Environmental Sciences
Sanaa M. Aly, Samar Elfiky, Yasmine G. Mohamed, Radwa A. M. Soliman, Nancy Shalaby, Nicolas Beauval, Jean-Michel Gaulier, Delphine Allorge, Ahmed Omran
Summary: This study aimed to determine the concentrations of lead (Pb), mercury (Hg), and cadmium (Cd) in various blood products to explore the probability of concurrent exposure of these heavy metals (HMs) and to identify the metal load per transfusion with risk assessment. The results showed that Pb and Cd levels were higher than normal in a certain percentage of blood units, and the concentrations of Pb and Cd surpassed the recommended levels for premature neonates in some cases. The study also revealed significant concurrent exposure of neonates to Pb, Hg, and Cd, and the potential developmental neurotoxicity associated with these heavy metals.
Article
Immunology
Luis Almeida, Ayesha Dhillon-LaBrooy, Carla N. Castro, Nigatu Adossa, Guilhermina M. Carriche, Melanie Guderian, Saskia Lippens, Sven Dennerlein, Christina Hesse, Bart N. Lambrecht, Luciana Berod, Leif Schauser, Bruce R. Blazar, Markus Kalesse, Rolf Mueller, Luis F. Moita, Tim Sparwasser
Summary: Linezolid and other ribosomal-targeting antibiotics effectively inhibit T cell activity, disrupt mitochondrial function, reduce oxidative phosphorylation levels, and prevent the occurrence of autoimmune diseases.
Article
Hematology
Aarany Sivakaanthan, Fiona Swain, Gail Pahn, Kathryn Goodison, Naadir Gutta, Rhonda Holdsworth, Shoma Baidya, John-Paul Tung
Summary: This study retrospectively evaluated cases of transfusion-related acute lung injury (TRALI) reported in Queensland, Australia from 1999 to 2019. The results showed a lower incidence rate of TRALI compared to international studies, but a relatively higher proportion of non-antibody mediated TRALI and possible TRALI cases in recent years.
Article
Multidisciplinary Sciences
Sandor Pal, Barbara Reger, Hussain Alizadeh, Arpad Szomor, Andras Vereczkei, Tamas Kiss, Attila Miseta, Margit Solymar, Zsuzsanna Faust
Summary: The COVID-19 outbreak in Hungary resulted in a significant impact on healthcare, particularly on inpatient and outpatient care as well as blood supply. A study evaluated the use of blood products during the first five months of the pandemic and found a reduction in hospitalizations and changes in the frequency of diagnoses. The usage of red blood cell concentrates, platelet concentrates, and fresh frozen plasma significantly decreased.
Article
Environmental Sciences
Erin L. LaCasella, Michael P. Jensen, Christine A. Madden Hof, Ian P. Bell, Amy Frey, Peter H. Dutton
Summary: The study successfully traced the origin of hawksbill turtle products by extracting DNA and obtaining informative mtDNA control region sequences, showing that many tortoiseshell products are from turtles in the Solomon Islands, while 23% of market samples have haplotypes only documented in foraging populations.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Hematology
Floor L. F. van Baarle, Sanne de Bruin, Esther B. Bulle, Niels van Mourik, Endry H. T. Lim, Anita M. Tuip-de Boer, Annabel Bongers, Marit B. de Wissel, Robin van Bruggen, Dirk de Korte, Christie Vermeulen, Khik Wie Tan, Rene E. Jonkers, Peter Bonta, Rene Lutter, Tamara Dekker, Barbara S. Dierdorp, Anna L. Peters, Bart J. Biemond, Alexander P. J. Vlaar
Summary: In a human endotoxemia model of autologous platelet transfusion, transfusion of 7-day-old PC does not increase pulmonary inflammation compared with 2-day-old PC.
Review
Pharmacology & Pharmacy
Steven N. Austad, Scott Ballinger, Thomas W. Buford, Christy S. Carter, Daniel L. Smith, Victor Darley-Usmar, Jianhua Zhang
Summary: Alzheimer's disease, the most common form of dementia in the elderly, has no cure. Strategies targeting the reduction of amyloid beta or hyperphosphorylated Tau protein have largely failed in clinical trials, highlighting the need for novel therapeutic targets and strategies. Recent data suggest that mitochondria initiate an integrated stress response (ISR) in response to environmental stress, which has shown benefits for healthy aging and neuroprotection. Partial inhibition of mitochondrial complex I has emerged as a promising strategy for multiple human conditions, including Alzheimer's disease, with ongoing clinical trials. Additionally, there is increasing awareness of the differential risk and potential targeting strategies related to biological sex, microbiome, and circadian regulation. Understanding the molecular mechanisms involved in mitochondrial bioenergetics, quality control mechanisms, and mitochondria-linked inflammatory responses is crucial for AD therapeutic interventions.
ACTA PHARMACEUTICA SINICA B
(2022)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)