Article
Physics, Applied
Nishtha Gaur, Hirofumi Kurita, Jun-Seok Oh, Saki Miyachika, Masafumi Ito, Akira Mizuno, Allison J. Cowin, Sarah Allinson, Robert D. Short, Endre J. Szili
Summary: The study investigates the potential role of hydroxyl radicals in cold atmospheric plasma (CAP) jet treatment, showing correlation between CAP jet-induced DNA damage and the presence of hydroxyl radicals. A 'plasma screen' based on a hydrogel film is demonstrated to significantly reduce DNA damage while facilitating the delivery of hydrogen peroxide, which could be beneficial for applications focusing on DNA damage such as cancer treatment, as well as in situations where DNA damage should be minimized, such as open-wound treatment and dermatology.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Multidisciplinary Sciences
Liqun Chen, Zhuo Mao, Yang Wang, Yong Kang, Ying Wang, Lin Mei, Xiaoyuan Ji
Summary: By constructing a two-dimensional interplanar heterojunction, the lifetime of excited electrons and holes is prolonged, and the selectivity of substrates is extended, resulting in high-performance cancer therapy.
Article
Food Science & Technology
Toshifumi Yuji, Kenichi Nakabayashi, Hiroyuki Kinoshita, Narong Mungkung, Yoshifumi Suzaki, Sarizam Mamat, Hiroshi Akatsuka
Summary: This study demonstrates that the decontamination performance against viable bacteria and coliform bacteria in dry powder food ingredients using an atmospheric-pressure nonequilibrium DC pulse discharge Ar + O-2 mixture gas plasma jet is proportional to the plasma irradiation time, showing a correlation between plasma irradiation time and DC pulse frequency increase.
JOURNAL OF FOOD QUALITY
(2021)
Article
Cell Biology
Mahmuda Akter, Jun Sup Lim, Eun Ha Choi, Ihn Han
Summary: Glioblastoma multiforme (GBM) is a highly malignant and rapidly advancing astrocytic brain tumor in adults, with current treatment options including chemotherapy, surgical resection, and radiation. However, challenges such as drug release, tumor resistance, and limitations of conventional methods call for new therapies. Non-thermal biocompatible plasma has shown promise in selectively targeting cancer cells while sparing normal cells, making it a potential efficient and safe clinical device for brain cancer therapy.
Article
Biotechnology & Applied Microbiology
Qi Zhang, Xiao Feng, Mingming Zhang, Wenjing Sun, Yuqing Zhai, Shuangshuang Qing, Ying Liu, Haoran Zhao, Jing Sun, Yi Zhang, Chaoqun Ma
Summary: This study systematically analyzed the gene expression and clinical information of colon cancer patients, identifying five pivotal genes related to plasma cells that have excellent prognostic value and significance in immunotherapy.
Review
Biotechnology & Applied Microbiology
Haiqin Liao, Chengcheng Niu
Summary: This article introduces the mechanisms by which cancer evades immunological surveillance and the CD47-SIRPα signaling pathway, as well as the applications of nanocarriers developed for this signaling pathway in anticancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Editorial Material
Oncology
Jean-Lu Teillauo, Marie-Caroline Dieu-Nosjean
Summary: Increased plasma cell signatures are found to be predictive of extended overall survival in non-small-cell lung cancer patients treated with a PD-L1 inhibitor, and these cells are associated with the presence of tertiary lymphoid structures.
Review
Oncology
Ruby Limanowski, Dayun Yan, Lin Li, Michael Keidar
Summary: Cold atmospheric plasma (CAP), generated under atmospheric pressure conditions, is an ionized gas with reactive components and near-room temperature nature. CAP has promising applications in various medical fields, including microorganism sterilization, biofilm inactivation, wound healing, and cancer therapy. In vitro demonstrations of CAP-based cancer treatments have been reported, but preclinical and in vivo studies are crucial for achieving clinical application. This article summarizes the current status and development of preclinical usage of CAP in cancer treatment, primarily focusing on in vivo studies over the past decade. It presents research strategies and discusses the underlying mechanism based on the latest understanding.
Article
Oncology
Arjan Kol, Xiaoyu Fan, Marta. A. A. Wazynska, Sander M. J. van Duijnhoven, Danique Giesen, Annechien Plat, Hans Van Eenennaam, Philip. H. H. Elsinga, Hans. W. W. Nijman, Marco de Bruyn
Summary: This study focuses on generating and radiolabeling monoclonal antibodies targeting human CD103 for non-invasive immune PET imaging, demonstrating their potential as biomarkers for effective anticancer immune responses. The results show high specificity and sensitivity of the CD103 immuno-PET tracers in visualizing T cell infiltration, indicating their suitability for future applications in cancer immunotherapy assessment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Shingo Maeda, Tomoki Motegi, Aki Iio, Kenjiro Kaji, Yuko Goto-Koshino, Shotaro Eto, Namiko Ikeda, Takayuki Nakagawa, Ryohei Nishimura, Tomohiro Yonezawa, Yasuyuki Momoi
Summary: Anti-Treg treatment, through CCR4 blockade, may be a promising therapeutic approach for advanced prostate cancer in dogs and some population of human patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Environmental Sciences
Vikas Rathore, Shruti Patel, Akanksha Pandey, Jignasa Savjani, Shital Butani, Heman Dave, Sudhir Kumar Nema
Summary: The rising global cancer rate has led to an increased consumption of anticancer drugs, resulting in elevated levels of these drugs in wastewater. Conventional methods have difficulty degrading methotrexate due to its complex organic structure. A non-thermal pencil plasma jet treatment was proposed for the degradation of methotrexate, which proved to be effective. The plasma treatment completely degraded the drug solution and resulted in the formation of smaller compounds, while also showing lower toxicity to freshwater algae compared to the untreated solution.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Stergios Boussios, Perry Devo, Iain C. A. Goodall, Konstantinos Sirlantzis, Aruni Ghose, Sayali D. Shinde, Vasileios Papadopoulos, Elisabet Sanchez, Elie Rassy, Saak V. Ovsepian
Summary: This article reviews the characteristics and functions of extracellular vesicles (EVs), particularly exosomes, in renal cell carcinoma (RCC). It emphasizes the pivotal role of EVs in tumorigenesis, metastasis, immune evasion, and drug response, as well as their potential as biomarkers and therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Qian Wu, Chang Qu, Lin Xin, Fan Yang, Ling Xu
Summary: Breast cancer, caused by genetic and environmental factors, is one of the most common malignancies in the world. Breast cancer stem cells play a crucial role in tumor aggressiveness and pose challenges for cancer treatment. Research has found differential expression of SIK2 gene in breast cancer tumor samples and high expression of SIK2 in epithelial cells, which may serve as potential therapeutic targets for breast cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Kunpeng Lv, Mengyao Sun, Hanji Fang, Jieti Wang, Chao Lin, Hao Liu, Heng Zhang, He Li, Hongyong He, Yun Gu, Ruochen Li, Fei Shao, Jiejie Xu
Summary: In gastric cancer, Siglec-10 positive tumor-associated macrophages (TAMs) contribute to immune evasion by exhibiting an immunosuppressive phenotype and hindering CD8+ T cell-mediated antitumor immune response. Blocking Siglec-10 can reinvigorate the antitumor immune response and synergistically enhance the efficacy of anti-PD-1 immunotherapy in an ex vivo gastric cancer tumor fragment platform.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Stanley Ly, Vivek Anand, Fouad El-Dana, Khoa Nguyen, Yiming Cai, Shirong Cai, Helen Piwnica-Worms, Debasish Tripathy, Aysegul A. Sahin, Michael Andreeff, Venkata Lokesh Battula
Summary: GD2 is expressed in around 60% of primary TNBC tumors at variable levels and is associated with worse overall survival of patients with TNBC. Treatment with dinutuximab significantly decreased adhesion and migration of TNBC cells, inhibited mTOR signaling, and reduced tumor growth in both cell-line xenografts and PDX models. Our data provide proof-of-concept for the critical role of GD2 in BCSCs and demonstrate the potential of dinutuximab as a novel therapeutic approach for TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Sander Bekeschus, Dorothee Meyer, Kevin Arlt, Thomas von Woedtke, Lea Miebach, Eric Freund, Ramona Clemen
Summary: The study found that plasma treatment increased the expression levels of activation markers and cytokines in human dendritic cells, which may have beneficial effects on the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sander Bekeschus, Axel Kramer, Anke Schmidt
Summary: Skin damage is inevitable and wound healing is crucial for restoring body integrity. In recent years, targeting defective wound healing has become increasingly important due to rising diseases like diabetes and vascular insufficiencies. Gas plasma technology has emerged as a promising tool for promoting wound healing by generating reactive oxygen and nitrogen species in a controlled manner.
Article
Oncology
Aydar Khabipov, Eric Freund, Kim Rouven Liedtke, Andre Kaeding, Janik Riese, Julia van der Linde, Stephan Kersting, Lars-Ivo Partecke, Sander Bekeschus
Summary: Gas plasma treatment of pancreatic cancer cells can alter the inflammatory profile of macrophages in a beneficial way, reducing tumor growth and metastasis without causing immunosuppression or excessive inflammation. This suggests that gas plasma therapy may be a promising approach for pancreatic cancer treatment.
Article
Oncology
Sander Bekeschus, Steffen Emmert, Ramona Clemen, Lars Boeckmann
Summary: The first Therapeutic ROS and Immunity in Cancer (TRIC) meeting was organized by the ZIK plasmatis research center and ONKOTHER-H research program in Germany, bringing together 66 scientists from 12 countries and 5 continents to discuss cutting-edge research on therapeutic ROS and immunology in cancer treatment, with a focus on gas plasma technology. The conference aimed to facilitate interdisciplinary discussions and explore innovative applications of gas plasma technology in cancer therapy.
Article
Chemistry, Multidisciplinary
Monireh Golpour, Mina Alimohammadi, Alireza Mohseni, Ehsan Zaboli, Farshad Sohbatzadeh, Sander Bekeschus, Alireza Rafiei
Summary: This study evaluated the effects of cold plasma or plasma-treated solutions on the hematologic parameters of CLL patients. The results showed that these treatments did not significantly affect the blood parameters of the patients but increased lipid peroxidation and RNS deposition, while decreasing the metabolic activity of white blood cells.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Zahra Nasri, Mohsen Ahmadi, Johanna Striesow, Mehdi Ravandeh, Thomas von Woedtke, Kristian Wende
Summary: Cold physical plasma, as a new field of oxidative stress-based therapy, has the potential to generate a variety of reactive oxygen and nitrogen species (RONS), making it a promising tool for biomedical applications. However, the impact of plasma-derived RONS on cell membrane lipids and properties is not fully understood. This study investigated the changes in lipid bilayer functionality and revealed the strong impact of cholesterol on membrane permeabilization by plasma-derived species. Additionally, the chemical composition of the head group was found to influence the maintenance of barrier properties, with phosphatidylcholines being more susceptible than other lipid classes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pradeep Bhartiya, Neha Kaushik, Linh N. Nguyen, Sander Bekeschus, Kai Masur, Klaus-Dieter Weltmann, Nagendra Kumar Kaushik, Eun Ha Choi
Summary: Excessive redox stress is associated with skin pathophysiologic conditions. This study explores the effect of periodic redox stress on fibroblast cells and finds that stress above a certain threshold leads to alterations in cellular processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Andreas Nitsch, Silas Strakeljahn, Josephine M. Jacoby, Konrad F. Sieb, Alexander Mustea, Sander Bekeschus, Axel Ekkernkamp, Matthias B. Stope, Lyubomir Haralambiev
Summary: In this study, it was found that cold atmospheric pressure plasma treatment inhibits the growth, motility, and metabolism of chondrosarcoma cells by initiating apoptotic processes.
Article
Immunology
Ramona Clemen, Kevin Arlt, Thomas von Woedtke, Sander Bekeschus
Summary: Protein vaccines can induce immune responses, but inflammation caused by reactive oxygen species (ROSs) can modify proteins and affect their functionality or immunogenicity. Gas plasma technology is used to study the immunogenicity of oxidized protein antigens. The findings suggest that gas plasma-modified proteins can induce dendritic cell maturation and activation.
Article
Biochemistry & Molecular Biology
Debora Singer, Verena Ressel, Matthias B. Stope, Sander Bekeschus
Summary: Under oxidative stress conditions, Hsp27 is highly expressed in prostate cancer cells, playing a crucial role in anti-oxidative effects and blocking apoptosis. The presence of prostate cancer cells leads to ambiguous effects of Hsp27 on myeloid cells, altering their secretion profiles and surface marker profiles, promoting differentiation.
Article
Cell Biology
Ramona Clemen, Kevin Arlt, Lea Miebach, Thomas von Woedtke, Sander Bekeschus
Summary: This study investigated the effects of oxidized and native proteins on cell surface marker expression and cytokine release in human monocyte-derived cells. The results showed that oxidized proteins led to elevated expression levels of cell surface markers and modified release of cytokines. These findings are important for further exploring the application of oxidized proteins in cancer therapy.
Article
Biochemistry & Molecular Biology
Mohsen Ahmadi, Debora Singer, Felix Potlitz, Zahra Nasri, Thomas von Woedtke, Andreas Link, Sander Bekeschus, Kristian Wende
Summary: Cold physical plasma is a partially ionized gas that operates at body temperature and has applications in heat-sensitive technical and medical fields. It can be used to introduce oxidative modifications to biomolecules, including the activation of anticancer prodrugs. In a proof-of-concept study, a boronic pinacol ester fenretinide prodrug was activated using an atmospheric pressure argon plasma jet. The study demonstrated that the activation of the prodrug led to enhanced cytotoxic effects in vitro, making cold physical plasma-mediated prodrug activation a promising approach for combination cancer treatment studies.
Article
Chemistry, Physical
Katharina Witzke, Renko Kensbock, Caroline Ulrike Willsch, Katja Fricke, Sander Bekeschus, Hans-Robert Metelmann
Summary: This study evaluated the effects of sandblasting and plasma electrolytic polishing on Co-Cr-Mo dental alloy samples. Results showed that plasma electrolytic polishing can achieve nanometer-level surface roughness on Co-Cr-Mo surfaces, comparable to conventional mechanical polishing.
Article
Cell Biology
Felix Wittig, Liza Pannenberg, Rico Schwarz, Sander Bekeschus, Robert Ramer, Burkhard Hinz
Summary: In this study, it was found that the MAGL inhibitor JZL184 has anti-angiogenic effects in lung cancer cells and can reduce the expression of VEGF. This effect may be associated with increased levels of 2-AG and partial involvement of cannabinoid receptors.
Article
Biochemistry & Molecular Biology
Ramona Clemen, Lara Minkus, Debora Singer, Paul Schulan, Thomas von Woedtke, Kristian Wende, Sander Bekeschus
Summary: The study found that MPO activity significantly decreased under various reactive species conditions, with changes in protein structure indicated by oligomerization. Various oxPTMs were detected using mass spectrometry, suggesting MPO inactivation could be due to conformational changes mediated by oxidation modifications.
